Pthlh

Summary

Gene Symbol: Pthlh
Description: parathyroid hormone-like hormone
Alias: PLP, parathyroid hormone-related protein, PTH-rP, PTHrP, parathyroid hormone-like peptide, parathyroid hormone-like protein, parathyroid-like peptide
Species: rat
Products:     Pthlh

Top Publications

  1. Karaplis A, Luz A, Glowacki J, Bronson R, Tybulewicz V, Kronenberg H, et al. Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev. 1994;8:277-89 pubmed
    The parathyroid hormone-related peptide (PTHrP) gene was disrupted in murine embryonic stem cells by homologous recombination, and the null allele was introduced into the mouse germ line...
  2. Hashimoto H, Azuma Y, Kawasaki M, Fujihara H, Onuma E, Yamada Okabe H, et al. Parathyroid hormone-related protein induces cachectic syndromes without directly modulating the expression of hypothalamic feeding-regulating peptides. Clin Cancer Res. 2007;13:292-8 pubmed
    Parathyroid hormone-related protein (PTHrP) is a causative factor of humoral hypercalcemia of malignancy (HHM) and concurrent anorexia and wasting...
  3. Lee K, Lanske B, Karaplis A, Deeds J, Kohno H, Nissenson R, et al. Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development. Endocrinology. 1996;137:5109-18 pubmed
    To test the hypothesis that PTH-related peptide (PTHrP) is a paracrine regulator of endochondral bone development, we localized PTHrP and its cognate receptor during normal skeletal development at both messenger RNA (mRNA) and protein ..
  4. Filipović N, Vrdoljak M, Vuica A, Jerić M, Jeličić Kadić A, Utrobičić T, et al. Expression of PTHrP and PTH/PTHrP receptor 1 in the superior cervical ganglia of rats. Neuropeptides. 2014;48:353-9 pubmed publisher
    b>PTHrP and its receptor PTHR1 are found in the CNS and peripheral nervous system...
  5. Torday J, Rehan V. Up-regulation of fetal rat lung parathyroid hormone-related protein gene regulatory network down-regulates the Sonic Hedgehog/Wnt/betacatenin gene regulatory network. Pediatr Res. 2006;60:382-8 pubmed
    ..to mesodermal Wingless/int/beta catenin (Wnt/betacatenin), followed by parathyroid hormone-related protein (PTHrP) signaling from endoderm to mesoderm...
  6. Schordan E, Welsch S, Rothhut S, Lambert A, Barthelmebs M, Helwig J, et al. Role of parathyroid hormone-related protein in the regulation of stretch-induced renal vascular smooth muscle cell proliferation. J Am Soc Nephrol. 2004;15:3016-25 pubmed
    ..Parathyroid hormone-related protein (PTHrP) is a locally produced poly-protein that regulates cell growth...
  7. Röthig A, Schreckenberg R, Weber K, Conzelmann C, da Costa Rebelo R, Schluter K. Effects of nicotine on PTHrP and PTHrP receptor expression in rat coronary endothelial cells. Cell Physiol Biochem. 2012;29:485-92 pubmed publisher
    The study was aimed to investigate whether nicotine affects endothelial expression of PTHrP and PTHrP receptor, a peptide system involved in endothelial protection against apoptosis...
  8. Mau E, Whetstone H, Yu C, Hopyan S, Wunder J, Alman B. PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms. Dev Biol. 2007;305:28-39 pubmed
    ..Although it is known that parathyroid hormone related protein (PTHrP) and Indian hedgehog regulate the differentiation of growth plate chondrocytes, how these ..
  9. Thiede M, Rodan G. Expression of a calcium-mobilizing parathyroid hormone-like peptide in lactating mammary tissue. Science. 1988;242:278-80 pubmed
    ..These findings suggest that PTH-LP plays a physiological role in lactation, possibly as a hormone for the mobilization or transfer (or both) of calcium to the milk. ..

More Information

Publications39

  1. Wysolmerski J, Philbrick W, Dunbar M, Lanske B, Kronenberg H, Broadus A. Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development. Development. 1998;125:1285-94 pubmed
    Parathyroid hormone-related protein (PTHrP) was originally discovered as a tumor product that causes humoral hypercalcemia of malignancy...
  2. Chou C, Fritz R, Chou F, Kibler R. The immune response of Lewis rats to peptide 68-88 of guinea pig myelin basic protein. I. T cell determinants. J Immunol. 1979;123:1540-3 pubmed
    ..e., residues 71-85. ..
  3. Wang Y, Duan X, Zhao Z, Zhang X, Wang H, Liu D, et al. Fluoride Affects Calcium Homeostasis by Regulating Parathyroid Hormone, PTH-Related Peptide, and Calcium-Sensing Receptor Expression. Biol Trace Elem Res. 2015;165:159-66 pubmed publisher
    Parathyroid hormone (PTH), PTH-related peptide (PTHrP), and calcium-sensing receptor (CaSR) play important roles in maintaining calcium homeostasis...
  4. Nishikawa N, Kanematsu A, Negoro H, Imamura M, Sugino Y, Okinami T, et al. PTHrP is endogenous relaxant for spontaneous smooth muscle contraction in urinary bladder of female rat. Endocrinology. 2013;154:2058-68 pubmed publisher
    ..We aimed to investigate the physiologic role of PTHrP, which is up-regulated in an acute bladder distension model in female rats...
  5. Amaya Y, Nakai T, Miura S. Evolutionary well-conserved region in the signal peptide of parathyroid hormone-related protein is critical for its dual localization through the regulation of ER translocation. J Biochem. 2016;159:393-406 pubmed publisher
    Parathyroid hormone-related protein (PTHrP) has two different targeting signals: an N-terminal signal peptide for the endoplasmic reticulum (ER) targeting and an internal nuclear localization signal...
  6. Karaplis A, Yasuda T, Hendy G, Goltzman D, Banville D. Gene-encoding parathyroid hormone-like peptide: nucleotide sequence of the rat gene and comparison with the human homologue. Mol Endocrinol. 1990;4:441-6 pubmed
    ..The overall exon/intron organization of the rat parathyroid hormone-like peptide (PLP) gene is similar to that of the PTH gene and emphasizes the likelihood that PLP and PTH arose from a common ..
  7. Amling M, Neff L, Tanaka S, Inoue D, Kuida K, Weir E, et al. Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development. J Cell Biol. 1997;136:205-13 pubmed
    Parathyroid hormone-related peptide (PTHrP) appears to play a major role in skeletal development. Targeted disruption of the PTHrP gene in mice causes skeletal dysplasia with accelerated chondrocyte maturation (Amizuka, N., H...
  8. Suwa H, Hirano M, Kawarada K, Nagayama M, Ehara M, Muraki T, et al. Pthlh, a promising cancer modifier gene in rat tongue carcinogenesis. Oncol Rep. 2014;31:3-12 pubmed publisher
    ..TCs in F1 rats and revealed significant upregulation of 2 cancer-related genes, parathyroid hormone-like hormone (Pthlh) and Kras2...
  9. Meziani F, Tesse A, Welsch S, Kremer H, Barthelmebs M, Andriantsitohaina R, et al. Expression and biological activity of parathyroid hormone-related peptide in pregnant rat uterine artery: any role for 8-iso-prostaglandin F2alpha?. Endocrinology. 2008;149:626-33 pubmed
    b>PTHrP is produced in vessels and acts as a local modulator of tone...
  10. Bruder E, Hoof J, Young J, Raff H. Epidermal growth factor and parathyroid hormone-related peptide mRNA in the mammary gland and their concentrations in milk: effects of postpartum hypoxia in lactating rats. Horm Metab Res. 2008;40:446-53 pubmed publisher
    ..The concentration of parathyroid hormone-related protein (PTHrp) was unchanged in milk and decreased in pup stomach contents; however, mammary PTHLH mRNA was increased by hypoxia...
  11. Yasuda T, Banville D, Rabbani S, Hendy G, Goltzman D. Rat parathyroid hormone-like peptide: comparison with the human homologue and expression in malignant and normal tissue. Mol Endocrinol. 1989;3:518-25 pubmed
  12. Lanske B, Divieti P, Kovacs C, Pirro A, Landis W, Krane S, et al. The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone. Endocrinology. 1998;139:5194-204 pubmed
    PTH and PTH-related peptide (PTHrP) have been shown to bind to and activate the same PTH/PTHrP receptor. Recent studies have demonstrated, however, the presence of additional receptors specific for each ligand...
  13. Ortega A, Rámila D, Ardura J, Esteban V, Ruiz Ortega M, Barat A, et al. Role of parathyroid hormone-related protein in tubulointerstitial apoptosis and fibrosis after folic acid-induced nephrotoxicity. J Am Soc Nephrol. 2006;17:1594-603 pubmed
    Parathyroid hormone-related protein (PTHrP) is shortly upregulated in acute renal injury, but its pathophysiologic role is unclear...
  14. Alvarez J, Sohn P, Zeng X, Doetschman T, Robbins D, Serra R. TGFbeta2 mediates the effects of hedgehog on hypertrophic differentiation and PTHrP expression. Development. 2002;129:1913-24 pubmed
    ..A signaling cascade involving Indian hedgehog (Ihh) and parathyroid hormone related peptide (PTHrP) has been described in which hypertrophic differentiation is limited by a signal secreted from chondrocytes as ..
  15. Lin F, Xia C, Zhang B, Huang J, Zheng X, Yi T, et al. [Effects of PTHrP and Notch signaling on the proliferation of epiphysis stem cells]. Zhonghua Yi Xue Za Zhi. 2011;91:2073-6 pubmed
    To study the regulation of the proliferation of epiphysis stem cells by the PTHrP (parathyroid hormone related peptide) and Notch signaling systems. An organ culture system of femurs of SD rat in 24 h after birth was employed...
  16. Kim S, Im G. The expressions of the SOX trio, PTHrP (parathyroid hormone-related peptide)/IHH (Indian hedgehog protein) in surgically induced osteoarthritis of the rat. Cell Biol Int. 2011;35:529-35 pubmed publisher
    This study was performed to investigate the expressions of the SOX trio, PTHrP (parathyroid hormone-related peptide) and IHH (Indian hedgehog protein) in OA (osteoarthritis) using surgically induced rat OA model...
  17. Rubin L, Kovacs C, De Paepe M, Tsai S, Torday J, Kronenberg H. Arrested pulmonary alveolar cytodifferentiation and defective surfactant synthesis in mice missing the gene for parathyroid hormone-related protein. Dev Dyn. 2004;230:278-89 pubmed
    Parathyroid hormone-related protein (PTHrP) and PTH/PTHrP receptor expression are developmentally regulated in lung epithelium and adepithelial mesenchyme, respectively...
  18. Aeimlapa R, Wongdee K, Charoenphandhu N, Suntornsaratoon P, Krishnamra N. Premature chondrocyte apoptosis and compensatory upregulation of chondroregulatory protein expression in the growth plate of Goto-Kakizaki diabetic rats. Biochem Biophys Res Commun. 2014;452:395-401 pubmed publisher
    ..immunohistochemical analysis further confirmed the overexpression of parathyroid hormone-related protein (PTHrP), Runx2 and VEGF, but not Indian hedgehog (Ihh) in the HZ...
  19. Okazaki K, Jingushi S, Ikenoue T, Urabe K, Sakai H, Iwamoto Y. Expression of parathyroid hormone-related peptide and insulin-like growth factor I during rat fracture healing. J Orthop Res. 2003;21:511-20 pubmed
    Parathyroid hormone-related peptide (PTHrP) and insulin-like growth factor I (IGF-I) are both involved in the regulation of bone and cartilage metabolisms and their interaction has been reported in osteoblasts...
  20. Kovacs C, Chafe L, Fudge N, Friel J, Manley N. PTH regulates fetal blood calcium and skeletal mineralization independently of PTHrP. Endocrinology. 2001;142:4983-93 pubmed
    PTH and PTHrP both act in the regulation of fetal mineral metabolism. PTHrP regulates placental calcium transfer, fetal blood calcium, and differentiation of the cartilaginous growth plate into endochondral bone...
  21. Chen X, Macica C, Ng K, Broadus A. Stretch-induced PTH-related protein gene expression in osteoblasts. J Bone Miner Res. 2005;20:1454-61 pubmed
    ..We report that mechanical loading induces PTHrP in osteoblast-like cells and that TREK-2 stretch-activated potassium channels seem to be involved in this ..
  22. Song G, Fiaschi Taesch N, Bisello A. Endogenous parathyroid hormone-related protein regulates the expression of PTH type 1 receptor and proliferation of vascular smooth muscle cells. Mol Endocrinol. 2009;23:1681-90 pubmed publisher
    The PTH type 1 receptor (PTH1R) and PTHrP are expressed in vessels, where they contribute to regulating vascular smooth muscle cell (VSMC) function. Elevated PTHrP levels in VSMC are often associated with hyperplasia...
  23. Pioszak A, Parker N, Gardella T, Xu H. Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides. J Biol Chem. 2009;284:28382-91 pubmed publisher
    Parathyroid hormone (PTH) and PTH-related protein (PTHrP) are two related peptides that control calcium/phosphate homeostasis and bone development, respectively, through activation of the PTH/PTHrP receptor (PTH1R), a class B G protein-..
  24. Conzelmann C, Krasteva G, Weber K, Kummer W, Schluter K. Parathyroid hormone-related protein (PTHrP)-dependent regulation of bcl-2 and tissue inhibitor of metalloproteinase (TIMP)-1 in coronary endothelial cells. Cell Physiol Biochem. 2009;24:493-502 pubmed publisher
    ..Parathyroid hormone-related peptide (PTHrP) is known to protect endothelial cells against apoptosis by the regulation of the anti-apoptotic gene bcl-2...
  25. Rehan V, Dargan Batra S, Wang Y, Cerny L, Sakurai R, Santos J, et al. A paradoxical temporal response of the PTHrP/PPARgamma signaling pathway to lipopolysaccharide in an in vitro model of the developing rat lung. Am J Physiol Lung Cell Mol Physiol. 2007;293:L182-90 pubmed
    ..We determined the effects of lipopolysaccharide (LPS) on parathyroid hormone-related protein (PTHrP)-driven epithelial-mesenchymal interactions that are essential for normal lung development and homeostasis...
  26. Roelen B, Goumans M, Zwijsen A, Mummery C. Identification of two distinct functions for TGF-beta in early mouse development. Differentiation. 1998;64:19-31 pubmed
  27. Funk J, Migliati E, Chen G, Wei H, Wilson J, Downey K, et al. Parathyroid hormone-related protein induction in focal stroke: a neuroprotective vascular peptide. Am J Physiol Regul Integr Comp Physiol. 2003;284:R1021-30 pubmed
    Parathyroid hormone-related protein (PTHrP) is a multifunctional peptide that enhances blood flow in non-central nervous system (CNS) vascular beds by causing vasodilation...
  28. Gentili C, Morelli S, de Boland A. Characterization of PTH/PTHrP receptor in rat duodenum: effects of ageing. J Cell Biochem. 2003;88:1157-67 pubmed
    ..monoclonal anti-PTHR1 antibody revealed that a 85 kDa PTH binding component, the size expected for the mature PTH/PTHrP receptor, localizes in the basolateral (BLM) and brush border (BBM) membranes of the enterocyte, being the protein ..
  29. Chuykin I, Schulz H, Guan K, Bader M. Activation of the PTHRP/adenylate cyclase pathway promotes differentiation of rat XEN cells into parietal endoderm, whereas Wnt/?-catenin signaling promotes differentiation into visceral endoderm. J Cell Sci. 2013;126:128-38 pubmed publisher
    ..forskolin, EMT was prompted upon treatment of rat XEN cells with recombinant parathyroid hormone related peptide (PTHRP), an activator of the cAMP pathway in vivo. Taken together, our data suggest that rat XEN cells are PrE-like cells...
  30. Tfelt Hansen J, MacLeod R, Chattopadhyay N, Yano S, Quinn S, Ren X, et al. Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1/2 in H-500 cells. Am J Physiol Endocrinol Metab. 2003;285:E329-37 pubmed
    ..agonists potentially acting via the calcium-sensing receptor (CaR) increase parathyroid hormone-related peptide (PTHrP) release from H-500 Leydig cells...