Gene Symbol: Pth1r
Description: parathyroid hormone 1 receptor
Alias: PTHrel, Pthr, Pthr1, parathyroid hormone/parathyroid hormone-related peptide receptor, PTH/PTHr receptor, PTH/PTHrP type I receptor, PTH1 receptor, parathyroid hormone receptor 1
Species: rat
Products:     Pth1r

Top Publications

  1. Welsch S, Schordan E, Coquard C, Massfelder T, Fiaschi Taesch N, Helwig J, et al. Abnormal renovascular parathyroid hormone-1 receptor in hypertension: Primary defect or secondary to angiotensin ii type 1 receptor activation?. Endocrinology. 2006;147:4384-91 pubmed
    ..impaired in mature spontaneously hypertensive rats (SHR) through down-regulation of the type 1 PTH/PTHrP receptor (PTH1R), a feature that contributes to the high renal vascular resistance in SHR...
  2. Decker E, Stellzig Eisenhauer A, Fiebig B, Rau C, Kress W, Saar K, et al. PTHR1 loss-of-function mutations in familial, nonsyndromic primary failure of tooth eruption. Am J Hum Genet. 2008;83:781-6 pubmed publisher the gene encoding the G protein-coupled receptor for parathyroid hormone and parathyroid hormone-like hormone (PTHR1). Three distinct mutations, namely c.1050-3C > G, c.543+1G > A, and c...
  3. Duchatelet S, Ostergaard E, Cortes D, Lemainque A, Julier C. Recessive mutations in PTHR1 cause contrasting skeletal dysplasias in Eiken and Blomstrand syndromes. Hum Mol Genet. 2005;14:1-5 pubmed the C-terminal cytoplasmic tail of the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) type 1 receptor (PTHR1) gene as the cause of this syndrome...
  4. Schneider H, Feyen J, Seuwen K, Movva N. Cloning and functional expression of a human parathyroid hormone receptor. Eur J Pharmacol. 1993;246:149-55 pubmed
    ..5) and is functionally coupled to adenylate cyclase (pEC50 = 9.4). At high concentrations of agonist, the receptor also activates phosphoinositide turnover. ..
  5. Schipani E, Langman C, Parfitt A, Jensen G, Kikuchi S, Kooh S, et al. Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen's metaphyseal chondrodysplasia. N Engl J Med. 1996;335:708-14 pubmed
    ..The expression of constitutively active PTH-PTHrp receptors in kidney, bone, and growth-plate chondrocytes provides a plausible genetic explanation for mineral-ion abnormalities and metaphyseal changes in patients with Jansen's disease. ..
  6. Abou Samra A, Juppner H, Force T, Freeman M, Kong X, Schipani E, et al. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases int. Proc Natl Acad Sci U S A. 1992;89:2732-6 pubmed
    ..These properties could explain the diversity of PTH action without the need to postulate other receptor subtypes. ..
  7. Wheeler D, Garrido J, Bisello A, Kim Y, Friedman P, Romero G. Regulation of parathyroid hormone type 1 receptor dynamics, traffic, and signaling by the Na+/H+ exchanger regulatory factor-1 in rat osteosarcoma ROS 17/2.8 cells. Mol Endocrinol. 2008;22:1163-70 pubmed publisher
    ..regulatory factor-1 (NHERF1) on the distribution, dynamics, and signaling properties of the PTH type 1 receptor (PTH1R) were studied in rat osteosarcoma cells ROS 17/2.8...
  8. Guo J, Chung U, Yang D, Karsenty G, Bringhurst F, Kronenberg H. PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways. Dev Biol. 2006;292:116-28 pubmed
    ..These data indicate that the delayed hypertrophy induced by PTHrP is mediated by both Runx2-dependent and -independent mechanisms. ..
  9. Song G, Fiaschi Taesch N, Bisello A. Endogenous parathyroid hormone-related protein regulates the expression of PTH type 1 receptor and proliferation of vascular smooth muscle cells. Mol Endocrinol. 2009;23:1681-90 pubmed publisher
    The PTH type 1 receptor (PTH1R) and PTHrP are expressed in vessels, where they contribute to regulating vascular smooth muscle cell (VSMC) function. Elevated PTHrP levels in VSMC are often associated with hyperplasia...

More Information


  1. Gentili C, Morelli S, de Boland A. Characterization of PTH/PTHrP receptor in rat duodenum: effects of ageing. J Cell Biochem. 2003;88:1157-67 pubmed
    In rat enterocytes, signaling through the parathyroid hormone (PTH)/PTH-related peptide receptor type 1(PTHR1) includes stimulation of adenylyl cyclase, increases of intracellular calcium, activation of phospholipase C, and the MAP ..
  2. Mannstadt M, Luck M, Gardella T, Juppner H. Evidence for a ligand interaction site at the amino-terminus of the parathyroid hormone (PTH)/PTH-related protein receptor from cross-linking and mutational studies. J Biol Chem. 1998;273:16890-6 pubmed
    ..Thus, the convergence of photoaffinity cross-linking and mutational data demonstrates that the extreme amino-terminus of the rP1R participates in ligand binding. ..
  3. Filipović N, Vrdoljak M, Vuica A, Jerić M, Jeličić Kadić A, Utrobičić T, et al. Expression of PTHrP and PTH/PTHrP receptor 1 in the superior cervical ganglia of rats. Neuropeptides. 2014;48:353-9 pubmed publisher
    PTHrP and its receptor PTHR1 are found in the CNS and peripheral nervous system...
  4. Kuwahara M, Inoshita S, Nakano Y, Terada Y, Takano Y, Sasaki S. Expression of bone type 1 PTH receptor in rats with chronic renal failure. Clin Exp Nephrol. 2007;11:34-40 pubmed
    Some researchers have speculated that a decrease in bone type 1 PTH receptor (PTH1R) may be among the causes of "skeletal resistance" in chronic renal failure (CRF)...
  5. Lee K, Lanske B, Karaplis A, Deeds J, Kohno H, Nissenson R, et al. Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development. Endocrinology. 1996;137:5109-18 pubmed
  6. Ardura J, Wang B, Watkins S, Vilardaga J, Friedman P. Dynamic Na+-H+ exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains. J Biol Chem. 2011;286:35020-9 pubmed publisher
    ..The parathyroid hormone receptor (PTHR), which regulates mineral ion homeostasis and bone turnover, is a G protein-coupled receptor harboring a PDZ-..
  7. Lanske B, Divieti P, Kovacs C, Pirro A, Landis W, Krane S, et al. The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone. Endocrinology. 1998;139:5194-204 pubmed
    ..The PTH/PTHrP receptor, therefore, mediates distinct physiologic actions of both PTH and PTHrP. ..
  8. Kovacs C, Chafe L, Fudge N, Friel J, Manley N. PTH regulates fetal blood calcium and skeletal mineralization independently of PTHrP. Endocrinology. 2001;142:4983-93 pubmed
    ..lack parathyroids and PTH (Hoxa3 null) with the effects of loss of PTHrP (Pthrp null), loss of PTH/PTHrP receptor (Pthr1 null), and loss of both PTH and PTHrP (Hoxa3 null x Pthrp null)...
  9. Lee M, Partridge N. Parathyroid hormone signaling in bone and kidney. Curr Opin Nephrol Hypertens. 2009;18:298-302 pubmed publisher
    ..Recent studies demonstrate the involvement of novel factors as well as additional roles for previously identified downstream factors of PTH. ..
  10. Shimada M, Mahon M, Greer P, Segre G. The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit. Endocrinology. 2005;146:2336-44 pubmed
    We show calcium-dependent, direct binding between the N-terminal portion of the PTH/PTHrP receptor (PTH1R) C-terminal intracellular tail and the calpain small subunit...
  11. Wang B, Yang Y, Abou Samra A, Friedman P. NHERF1 regulates parathyroid hormone receptor desensitization: interference with beta-arrestin binding. Mol Pharmacol. 2009;75:1189-97 pubmed publisher
    Type 1 parathyroid hormone receptor (PTH1R) activation, desensitization, internalization, and recycling proceed in a cyclical manner...
  12. Ortega A, Rámila D, Ardura J, Esteban V, Ruiz Ortega M, Barat A, et al. Role of parathyroid hormone-related protein in tubulointerstitial apoptosis and fibrosis after folic acid-induced nephrotoxicity. J Am Soc Nephrol. 2006;17:1594-603 pubmed
    ..Our findings indicate that this peptide, by interaction with the PTH1 receptor, can increase tubulointerstitial cell survival and seems to act as a proinflammatory and profibrogenic factor ..
  13. Nishikawa N, Kanematsu A, Negoro H, Imamura M, Sugino Y, Okinami T, et al. PTHrP is endogenous relaxant for spontaneous smooth muscle contraction in urinary bladder of female rat. Endocrinology. 2013;154:2058-68 pubmed publisher
    ..Localization of PTHrP and its functional receptor, PTH/PTHrP receptor 1 (PTH1R), were analyzed in the untreated rat bladders and cultured bladder cells using real-time RT-PCR and immunoblotting,..
  14. Gardella T, Luck M, Fan M, Lee C. Transmembrane residues of the parathyroid hormone (PTH)/PTH-related peptide receptor that specifically affect binding and signaling by agonist ligands. J Biol Chem. 1996;271:12820-5 pubmed
  15. Iida Klein A, Guo J, Takemura M, Drake M, Potts J, Abou Samra A, et al. Mutations in the second cytoplasmic loop of the rat parathyroid hormone (PTH)/PTH-related protein receptor result in selective loss of PTH-stimulated phospholipase C activity. J Biol Chem. 1997;272:6882-9 pubmed
  16. Katsumata S, Masuyama R, Koshihara M, Matsuzaki H, Uehara M, Suzuki K. Effect of high phosphorus diet on phosphorus metabolism in parathyroidectomized rats. Biofactors. 2004;22:33-7 pubmed
    ..In conclusion, high P diet did not change PTH action in PTX rats and increased urinary excretion of P and bone resorption regardless of PTH action. ..
  17. Patterson E, Watson P, Hodsman A, Hendy G, Canaff L, Bringhurst F, et al. Expression of PTH1R constructs in LLC-PK1 cells: protein nuclear targeting is mediated by the PTH1R NLS. Bone. 2007;41:603-10 pubmed
    This study demonstrates that the PTH1R NLS can target a fusion protein to the nucleus, and that this is blocked by sequences downstream of the NLS...
  18. Meerovitch K, Wing S, Goltzman D. Preproparathyroid hormone-related protein, a secreted peptide, is a substrate for the ubiquitin proteolytic system. J Biol Chem. 1997;272:6706-13 pubmed
  19. Emami Nemini A, Gohla A, Urlaub H, Lohse M, Klenk C. The guanine nucleotide exchange factor Vav2 is a negative regulator of parathyroid hormone receptor/Gq signaling. Mol Pharmacol. 2012;82:217-25 pubmed publisher
    The parathyroid hormone receptor (PTHR) is a class B G protein-coupled receptor (GPCR) that mediates the endocrine and paracrine effects of parathyroid hormone and related peptides through the activation of phospholipase C?-, adenylyl ..
  20. Li M, Seki Y, Freitas P, Nagata M, Kojima T, Sultana S, et al. FGFR3 down-regulates PTH/PTHrP receptor gene expression by mediating JAK/STAT signaling in chondrocytic cell line. J Electron Microsc (Tokyo). 2010;59:227-36 pubmed publisher
    ..Altogether, these findings suggest that FGFR3 down-regulates PTH/PTHrP receptor gene expression via the JAK/STAT signaling in chondrocytic cells. ..
  21. Röthig A, Schreckenberg R, Weber K, Conzelmann C, da Costa Rebelo R, Schluter K. Effects of nicotine on PTHrP and PTHrP receptor expression in rat coronary endothelial cells. Cell Physiol Biochem. 2012;29:485-92 pubmed publisher
    ..Nicotine induces PTHrP expression in endothelial cells but excessive concentrations of nicotine reduce PTHrP receptor expression thereby attenuating any protective effects of PTHrP against apoptosis. ..
  22. Shimomura Kuroki J, Farooq M, Sekimoto T, Amizuka N, Shimomura Y. Characterization of a PTH1R missense mutation responsible for Jansen type metaphyseal chondrodysplasia. Odontology. 2017;105:150-154 pubmed publisher
    Parathyroid hormone and parathyroid hormone-related peptide (PTHrP), and its receptor (PTH1R) play an important role in differentiation of bone and cartilage in the developing stages...
  23. Lewin E, Garfia B, Almaden Y, Rodriguez M, Olgaard K. Autoregulation in the parathyroid glands by PTH/PTHrP receptor ligands in normal and uremic rats. Kidney Int. 2003;64:63-70 pubmed
    ..Thus, it is hypothesized that PTH during hypocalcemia might have a positive auto-feedback regulatory role on its own secretion. ..
  24. Pickard B, Hodsman A, Fraher L, Watson P. Type 1 parathyroid hormone receptor (PTH1R) nuclear trafficking: association of PTH1R with importin alpha1 and beta. Endocrinology. 2006;147:3326-32 pubmed
    Previous studies have shown that the type 1 PTH receptor (PTH1R), a class B G protein-coupled receptor, appears in the nucleus of target cells...
  25. Katsumata S, Masuyama R, Uehara M, Suzuki K. Decreased mRNA expression of the PTH/PTHrP receptor and type II sodium-dependent phosphate transporter in the kidney of rats fed a high phosphorus diet accompanied with a decrease in serum calcium concentration. Biosci Biotechnol Biochem. 2004;68:2484-9 pubmed
    ..Furthermore, an increase in the urinary excretion of P might have been caused by decreased NaPi-2 mRNA expression without the effects of PTH and 1,25(OH)(2)D(3). ..
  26. Guo J, Chung U, Kondo H, Bringhurst F, Kronenberg H. The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C. Dev Cell. 2002;3:183-94 pubmed
  27. Mahon M, Shimada M. Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors. FEBS Lett. 2005;579:803-7 pubmed
    Parathyroid hormone (PTH) binds to its receptor (PTH 1 receptor, PTH1R) and activates multiple pathways. The PTH1R, a class b GPCR, contains consensus calmodulin-binding motifs...
  28. Tawfeek H, Abou Samra A. Negative regulation of parathyroid hormone (PTH)-activated phospholipase C by PTH/PTH-related peptide receptor phosphorylation and protein kinase A. Endocrinology. 2008;149:4016-23 pubmed publisher
    ..Altogether, these data suggest that PTH signaling to PLC is negatively regulated by PTH/PTHrP receptor phosphorylation and PKA. Furthermore, phosphorylation at Ser1105 is demonstrated as a regulatory mechanism of PLCbeta3 by PKA. ..
  29. Vilardaga J, Romero G, Friedman P, Gardella T. Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm. Cell Mol Life Sci. 2011;68:1-13 pubmed publisher
    The parathyroid hormone (PTH) receptor type 1 (PTHR), a G protein-coupled receptor (GPCR), transmits signals to two hormone systems-PTH, endocrine and homeostatic, and PTH-related peptide (PTHrP), paracrine-to regulate different ..
  30. Pioszak A, Parker N, Gardella T, Xu H. Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides. J Biol Chem. 2009;284:28382-91 pubmed publisher
    ..calcium/phosphate homeostasis and bone development, respectively, through activation of the PTH/PTHrP receptor (PTH1R), a class B G protein-coupled receptor...
  31. Song G, Barrick S, Leslie K, Sicari B, Fiaschi Taesch N, Bisello A. EBP50 inhibits the anti-mitogenic action of the parathyroid hormone type 1 receptor in vascular smooth muscle cells. J Mol Cell Cardiol. 2010;49:1012-21 pubmed publisher
    Parathyroid hormone-related protein (PTHrP) and the parathyroid hormone type 1 receptor (PTH1R) are important regulators of vascular remodeling...
  32. Dean T, Vilardaga J, Potts J, Gardella T. Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor. Mol Endocrinol. 2008;22:156-66 pubmed
    PTH and PTHrP use the same G protein-coupled receptor, the PTH/PTHrP receptor (PTHR), to mediate their distinct biological actions. The extent to which the mechanisms by which the two ligands bind to the PTHR differ is unclear...
  33. Risom L, Christoffersen L, Daugaard Jensen J, Hove H, Andersen H, Andresen B, et al. Identification of six novel PTH1R mutations in families with a history of primary failure of tooth eruption. PLoS ONE. 2013;8:e74601 pubmed publisher
    ..Failure of tooth Eruption (PFE) is a non-syndromic disorder which can be caused by mutations in the parathyroid hormone receptor 1 gene (PTH1R)...
  34. Kong X, Schipani E, Lanske B, Joun H, Karperien M, Defize L, et al. The rat, mouse and human genes encoding the receptor for parathyroid hormone and parathyroid hormone-related peptide are highly homologous. Biochem Biophys Res Commun. 1994;200:1290-9 pubmed
    ..Therefore, the PTH/PTHrP receptor gene contains alternative 3' sequences that allow cleavage and polyadenylation of its transcript. ..
  35. Mahon M. The parathyroid hormone 1 receptor directly binds to the FERM domain of ezrin, an interaction that supports apical receptor localization and signaling in LLC-PK1 cells. Mol Endocrinol. 2009;23:1691-701 pubmed publisher
    PTH 1 receptor (PTH1R) regulates mineral ion homeostasis. Both apical and basolateral PTH1R subpopulations exist within the renal proximal tubule...
  36. Lanske B, Karaplis A, Lee K, Luz A, Vortkamp A, Pirro A, et al. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science. 1996;273:663-6 pubmed
    ..These results suggest that the PTH/PTHrP receptor mediates the effects of Indian Hedgehog and PTHrP on chondrocyte differentiation. ..
  37. Doi T, Lukošiūtė A, Ruttenstock E, Dingemann J, Puri P. Disturbance of parathyroid hormone-related protein signaling in the nitrofen-induced hypoplastic lung. Pediatr Surg Int. 2010;26:45-50 pubmed publisher
  38. Mahon M. The parathyroid hormone receptorsome and the potential for therapeutic intervention. Curr Drug Targets. 2012;13:116-28 pubmed
    The parathyroid hormone 1 receptor (PTH1R) is activated by parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP), hormones that mediate mineral ion homeostasis and tissue development, respectively...
  39. Kato A, Suzuki M, Karasawa Y, Sugimoto T, Doi K. PTHrP and PTH/PTHrP receptor 1 expression in odontogenic cells of normal and HHM model rat incisors. Toxicol Pathol. 2005;33:456-64 pubmed
    ..We examined PTHrP and its receptor (PTHR1) expression patterns in odontogenic cells in normal and HHM model rat incisors...
  40. Shimomura Kuroki J, Ubaidus S, Hl Freitas P, Li M, Ishida Y, Saito N, et al. Rat wild-type parathyroid hormone receptor (PTH-R) and mutant PTH-R(P132L) show the different intracellular localization in vitro. Biomed Res. 2008;29:61-9 pubmed
    ..In summary, these findings indicate that defective transport of PTH-R(P132L) to the cell surface would be a molecular basis for Blomstrand's chondrodysplasia. ..
  41. Pausova Z, Bourdon J, Clayton D, Mattei M, Seldin M, Janicic N, et al. Cloning of a parathyroid hormone/parathyroid hormone-related peptide receptor (PTHR) cDNA from a rat osteosarcoma (UMR 106) cell line: chromosomal assignment of the gene in the human, mouse, and rat genomes. Genomics. 1994;20:20-6 pubmed
    ..DNAs spanning the entire coding region of the rat parathyroid hormone/parathyroid hormone-related peptide receptor (PTHR) were isolated from a rat osteosarcoma (UMR 106) cell-line cDNA library...