Ptgs1

Summary

Gene Symbol: Ptgs1
Description: prostaglandin-endoperoxide synthase 1
Alias: Cox-1, Cox-3, Cox1, Cox3, Pghs-1, prostaglandin G/H synthase 1, PGH synthase 1, PHS 1, cyclooxygenase 3, cyclooxygenase-1, prostaglandin G/H synthase and cyclooxygenase, prostaglandin H2 synthase 1
Species: rat

Top Publications

  1. ncbi Cyclooxygenase-1 in the spinal cord plays an important role in postoperative pain
    Xiaoying Zhu
    Program of Neuroscience, Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Pain 104:15-23. 2003
  2. ncbi Altered expression of COX-1, COX-2, and mPGES in rats with nephrogenic and central diabetes insipidus
    Primoz Kotnik
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 288:F1053-68. 2005
  3. doi Brain neuronal/inducible nitric oxide synthases and cyclooxygenase-1 are involved in the bombesin-induced activation of central adrenomedullary outflow in rats
    Lianyi Lu
    Department of Pharmacology, School of Medicine, Kochi University, Nankoku, Kochi 783 8505, Japan
    Eur J Pharmacol 590:177-84. 2008
  4. doi Polarized light microscopic analysis of bone formation after inhibition of cyclooxygenase 1 and 2
    Luciana Borges Retamoso
    Pontifical Catholic University of Parana, Curitiba, Brazil
    Anat Rec (Hoboken) 293:195-9. 2010
  5. pmc Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes
    Miriam Font-Nieves
    Department of Brain Ischemia and Neurodegeneration, Institute for Biomedical Research of Barcelona, Consejo Superior de Investigaciones Cientificas, Institut d Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain
    J Biol Chem 287:6454-68. 2012
  6. ncbi Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer
    Rajnish A Gupta
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Cancer Res 63:906-11. 2003
  7. pmc Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid
    Sang Ho Choi
    Molecular Neuroscience Unit, Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Aging (Albany NY) 1:234-44. 2009
  8. ncbi Peripheral formalin injection induces long-lasting increases in cyclooxygenase 1 expression by microglia in the spinal cord
    Fei Yu Zhang
    Center for Temporomandibular Disorders and Orofacial Pain, Peking University School and Hospital of Stomatology, Beijing, China
    J Pain 8:110-7. 2007
  9. doi Endothelial microsomal prostaglandin E synthase-1 exacerbates neuronal loss induced by kainate
    Takako Takemiya
    Medical Research Institute, Tokyo Women s Medical University, Shinjuku, Tokyo, Japan
    J Neurosci Res 88:381-90. 2010
  10. ncbi Involvement of cyclooxygenase-1 and -2 in the sciatic nerve of rats with experimental autoimmune neuritis
    Taekyun Shin
    Department of Veterinary Medicine, College of Agriculture and Life Science, Cheju National University, Jeju, South Korea
    Immunol Invest 32:123-30. 2003

Scientific Experts

Detail Information

Publications111 found, 100 shown here

  1. ncbi Cyclooxygenase-1 in the spinal cord plays an important role in postoperative pain
    Xiaoying Zhu
    Program of Neuroscience, Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Pain 104:15-23. 2003
    ..Increased COX-1 activity could precede the up-regulation of COX-1 protein, and spinally administered specific COX-1 inhibitors may be useful to treat postoperative pain...
  2. ncbi Altered expression of COX-1, COX-2, and mPGES in rats with nephrogenic and central diabetes insipidus
    Primoz Kotnik
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 288:F1053-68. 2005
    ..These results identify markedly reduced expression of COX-1, COX-2, and mPGES in IM in lithium-induced NDI. Furthermore, there were major changes in the expression of COX-1, COX-2, and mPGES in rats with CDI...
  3. doi Brain neuronal/inducible nitric oxide synthases and cyclooxygenase-1 are involved in the bombesin-induced activation of central adrenomedullary outflow in rats
    Lianyi Lu
    Department of Pharmacology, School of Medicine, Kochi University, Nankoku, Kochi 783 8505, Japan
    Eur J Pharmacol 590:177-84. 2008
    ..6 micromol/animal, i.c.v.). These results suggest that the brain neuronal NOS/COX-1 and inducible NOS/COX-1 are respectively involved in the bombesin-induced secretion of noradrenaline and adrenaline from the adrenal medulla in rats...
  4. doi Polarized light microscopic analysis of bone formation after inhibition of cyclooxygenase 1 and 2
    Luciana Borges Retamoso
    Pontifical Catholic University of Parana, Curitiba, Brazil
    Anat Rec (Hoboken) 293:195-9. 2010
    ..On the third day, the C group showed better collagen organization than the PD group. Potassium diclofenac interfered in collagen maturation, reducing fibril organization in the initial phase of orthodontic movement...
  5. pmc Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes
    Miriam Font-Nieves
    Department of Brain Ischemia and Neurodegeneration, Institute for Biomedical Research of Barcelona, Consejo Superior de Investigaciones Cientificas, Institut d Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain
    J Biol Chem 287:6454-68. 2012
    ..These effects might induce cerebral blood flow responses to brain inflammation...
  6. ncbi Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer
    Rajnish A Gupta
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Cancer Res 63:906-11. 2003
    ....
  7. pmc Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid
    Sang Ho Choi
    Molecular Neuroscience Unit, Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Aging (Albany NY) 1:234-44. 2009
    ..These results indicate that inhibition of COX-1 activity may be valid therapeutic strategy to reduce brain inflammatory response and neurodegeneration...
  8. ncbi Peripheral formalin injection induces long-lasting increases in cyclooxygenase 1 expression by microglia in the spinal cord
    Fei Yu Zhang
    Center for Temporomandibular Disorders and Orofacial Pain, Peking University School and Hospital of Stomatology, Beijing, China
    J Pain 8:110-7. 2007
    ..Our study also suggests that spinal microglial activation may play a role in long-term hyperalgesia through the increased expression of COX-1...
  9. doi Endothelial microsomal prostaglandin E synthase-1 exacerbates neuronal loss induced by kainate
    Takako Takemiya
    Medical Research Institute, Tokyo Women s Medical University, Shinjuku, Tokyo, Japan
    J Neurosci Res 88:381-90. 2010
    ..These findings suggest that endothelial cells may control neuronal excitotoxicity, most likely by regulating astrocytes via inducible PGE(2)...
  10. ncbi Involvement of cyclooxygenase-1 and -2 in the sciatic nerve of rats with experimental autoimmune neuritis
    Taekyun Shin
    Department of Veterinary Medicine, College of Agriculture and Life Science, Cheju National University, Jeju, South Korea
    Immunol Invest 32:123-30. 2003
    ..Furthermore, COX-2 is enhanced in some Schwann cells and neural elements, possibly mediating peripheral nervous system inflammation...
  11. pmc Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice
    Matthew L Kelso
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA
    BMC Neurosci 10:108. 2009
    ..The purpose of the current study was to determine the role of the COX isoforms in contributing to pathological processes resulting from TBI by utilizing mice deficient in COX-1 or COX-2...
  12. pmc Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer
    Takiko Daikoku
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Cancer Res 65:3735-44. 2005
    ..The growth inhibitory effects of SC-560 result from reduced cell proliferation and/or accelerated apoptosis. Our results imply COX-1 as a target for the prevention and/or treatment of EOC...
  13. ncbi Cyclooxygenases-1 and -2 are differentially localized to microglia and endothelium in rat EAE and glioma
    M H Deininger
    Institute of Brain Research, University of Tuebingen, Medical School, Germany
    J Neuroimmunol 95:202-8. 1999
    ....
  14. ncbi Profiling of eicosanoid production in the rat hippocampus during kainic acid-induced seizure: dual phase regulation and differential involvement of COX-1 and COX-2
    Keisuke Yoshikawa
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 281:14663-9. 2006
    ..The present study demonstrates a dual phase regulatory mechanism of eicosanoid production during KA-induced seizure, providing a biochemical basis for understanding the biosynthesis and roles of eicosanoids in the brain...
  15. ncbi Increased gene expression and production of spinal cyclooxygenase 1 and 2 during experimental osteoarthritis pain
    M Prochazkova
    Department of Pharmacology, Third Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 58:419-25. 2009
    ..Thus, in contrast to inflammatory pain, the upregulation of spinal COX-1 may be important in osteoarthritis pain...
  16. pmc Localization of COX-1 and COX-2 in the intracranial dura mater of the rat
    Xi Chun Zhang
    Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, United States
    Neurosci Lett 452:33-6. 2009
    ..The findings suggest that NSAIDs may abort headache, at least in part, by inhibiting either neuronal or non-neuronal COX activity in the dura mater...
  17. ncbi Increased susceptibility to ischemic brain injury in cyclooxygenase-1-deficient mice
    C Iadecola
    Center for Clinical and Molecular Neurobiology, Department of Neurology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Cereb Blood Flow Metab 21:1436-41. 2001
    ..Thus, the vascular effects of COX-1 may contribute to maintain cerebral blood flow in the postischemic brain and, as such, play a protective role in ischemic brain injury...
  18. ncbi Bradykinin-induced nociceptor sensitisation to heat depends on cox-1 and cox-2 in isolated rat skin
    Steffi Mayer
    Department of Physiology and Pathophysiology, Friedrich Alexander University of Erlangen Nuremberg, Universitaetsstr 17, D 91054 Erlangen, Germany
    Pain 130:14-24. 2007
    ..This study shows that both cox isoforms are present in skin and that they have an important role in mediating bradykinin-evoked heat sensitisation of C-MH sensitive fibres through cox-1 and cox-2 dependent prostaglandin synthesis...
  19. ncbi Cyclooxygenase-1-derived prostaglandins in the periaqueductal gray differentially control C- versus A-fiber-evoked spinal nociception
    J Lianne Leith
    Department of Physiology, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 27:11296-305. 2007
    ..Thus, effects of centrally acting prostaglandins are pivotal, we suggest, to both the understanding of nociceptive processing and the development of new analgesic drugs...
  20. pmc Thromboxane A(2) contributes to the mediation of flow-induced responses of skeletal muscle venules: role of cyclooxygenases 1 and 2
    A Racz
    Department of Pathophysiology, Semmelweis University, Budapest, Hungary
    J Vasc Res 46:397-405. 2009
    ..We hypothesized that - in addition to nitric oxide (NO) and dilator prostaglandins (PGI(2)/ PGE(2)) - thromboxane A(2) (TxA(2)) contributes to the mediation of flow-induced responses of venules...
  21. pmc Cyclooxygenase-1 or -2--which one mediates lipopolysaccharide-induced hypothermia?
    Alexandre A Steiner
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, 350 W Thomas Road, Phoenix, AZ 85013, USA
    Am J Physiol Regul Integr Comp Physiol 297:R485-94. 2009
    ..The expression of splenic COX-1 was unaffected by LPS. We conclude that COX-1, but not COX-2, mediates LPS hypothermia, and that both COX isoforms are required for LPS hypotension...
  22. ncbi Cyclooxygenase-1 in human Alzheimer and control brain: quantitative analysis of expression by microglia and CA3 hippocampal neurons
    A V Yermakova
    Department of Neurobiology, University of Rochester, New York, USA
    J Neuropathol Exp Neurol 58:1135-46. 1999
    ..Currently used NSAIDs inhibit both isoforms of cyclooxygenase. The present study shows that COX-1 is widely expressed in human brain, and raises the possibility that COX-1 may contribute to CNS pathology...
  23. ncbi Selective accumulation of cyclooxygenase-1-expressing microglial cells/macrophages in lesions of human focal cerebral ischemia
    J M Schwab
    Institute of Brain Research, University of Tubingen, Medical School, Germany
    Acta Neuropathol 99:609-14. 2000
    ..Therefore we suggest that therapeutic approaches based on selective COX-2 blocking might not be sufficient for suppressing the local synthesis of prostanoids...
  24. ncbi Traumatic brain injury induces prolonged accumulation of cyclooxygenase-1 expressing microglia/brain macrophages in rats
    J M Schwab
    Institute of Brain Research, University of Tuebingen, Medical School, Germany
    J Neurotrauma 18:881-90. 2001
    ..Our results suggest that therapeutic approaches based on long-term blocking including COX-1, might be superior to selective COX-2 blocking to suppress the local synthesis of prostanoids...
  25. ncbi Persistent accumulation of cyclooxygenase-1-expressing microglial cells and macrophages and transient upregulation by endothelium in human brain injury
    Jan M Schwab
    Institute of Brain Research, University of Tubingen, Medical School, Germany
    J Neurosurg 96:892-9. 2002
    ..The authors report the differential localization of COX-1 in human traumatic brain injury (TBI)...
  26. ncbi Cyclooxygenase-1 inhibition corrects endothelial dysfunction in cirrhotic rat livers
    Mariona Graupera
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut Malalties Digestives, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    J Hepatol 39:515-21. 2003
    ..The present study evaluates the role of cyclooxygenase (COX)-derived prostanoids, implicated in the pathogenesis of endothelial dysfunction in other settings, in the pathogenesis of endothelial dysfunction in cirrhotic livers...
  27. ncbi Sinusoidal endothelial COX-1-derived prostanoids modulate the hepatic vascular tone of cirrhotic rat livers
    Mariona Graupera
    Hepatic Hemodynamic Laboratory, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
    Am J Physiol Gastrointest Liver Physiol 288:G763-70. 2005
    ..Despite abundant hepatic COX-2 expression, the increased response to Mtx of cirrhotic livers is mainly dependent of COX-1. Upregulation of COX-1 in cirrhotic SEC may be responsible for the hyperesponse to Mtx...
  28. pmc Oxidative stress and COX cause hyper-responsiveness in vascular smooth muscle of the femoral artery from diabetic rats
    Y Shi
    Department of Pharmacology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Br J Pharmacol 154:639-51. 2008
    ..To investigate the dysfunction of vascular smooth muscle in streptozotocin-induced diabetic rats...
  29. ncbi Persistent accumulation of cyclooxygenase-1 (COX-1) expressing microglia/macrophages and upregulation by endothelium following spinal cord injury
    J M Schwab
    Institute of Brain Research, University of Tuebingen, Medical School, Calwer Strasse 3, D 72076, Tuebingen, Germany
    J Neuroimmunol 111:122-30. 2000
    ..Therefore, we suggest that approaches based on: (i) short-term; and (ii) selective COX-2 blocking alone might not be a sufficient tool to suppress the local synthesis of prostanoids...
  30. ncbi Cyclooxygenase-1 and -2 in brains of patients who died with sporadic Creutzfeldt-Jakob disease
    Martin H Deininger
    Institute of Brain Research, University of Tuebingen Medical School, Tuebingen, Germany
    J Mol Neurosci 20:25-30. 2003
    ..These data show that accumulation of COX-1-expressing macrophages/microglial cells and COX-2-expressing neurons might represent important regulatory mechanisms in the complex process of neuronal degeneration in CJD patients...
  31. pmc Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat
    Eduardo Candelario-Jalil
    Department of Neurology, University of New Mexico Health Sciences Center, MSC10 5620, Albuquerque, NM 87131 0001, USA
    J Pharmacol Exp Ther 323:488-98. 2007
    ..Modulation of COX in brain injury by COX inhibitors or agents modulating prostaglandin E(2) formation/signaling may be useful in clinical settings associated with BBB disruption...
  32. ncbi Antithrombin reduces ischemia/reperfusion-induced liver injury in rats by activation of cyclooxygenase-1
    Naoaki Harada
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Honjo 1 1 1 Kumamoto 860 0811, Japan
    Thromb Haemost 92:550-8. 2004
    ..Furthermore, since TNF-alpha is capable of inducing COX-2, inhibition of TNF-alpha production by AT might inhibit COX-2-mediated PGE(2) production. These effects induced by AT might contribute to its anti-inflammatory activity...
  33. doi The effects of intrathecal cyclooxygenase-1, cyclooxygenase-2, or nonselective inhibitors on pain behavior and spinal Fos-like immunoreactivity
    Il Ok Lee
    Department of Anesthesiology, 97 Guro Dong Gil, Guro Gu, Korea University Guro Hospital, College of Medicine, Korea University, Seoul, Korea 152 703
    Anesth Analg 106:972-7, table of contents. 2008
    ..Fos expression is an indicator of spinal neuron activation. We examined the role of intrathecal selective and nonspecific COX inhibitors on spinal C-Fos expression...
  34. ncbi Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer
    D Hwang
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Natl Cancer Inst 90:455-60. 1998
    ..NSAIDs are known to inhibit COX, suggesting that the beneficial effect of NSAIDs in colon cancer may be related to COX overexpression in this disease. This possibility led us to ask whether COX is also overexpressed in breast cancers...
  35. ncbi Cyclooxygenase (COX)-1 expressing macrophages/microglial cells and COX-2 expressing astrocytes accumulate during oligodendroglioma progression
    M H Deininger
    Institute of Brain Research, University of Tuebingen, Medical School, Tuebingen, Germany
    Brain Res 885:111-6. 2000
    ..0471) lower in primary oligodendrogliomas than in high grade oligodendroglioma relapses. These data provide convincing evidence for the differential accumulation of cyclooxygenase isoforms during oligodendroglioma progression in vivo...
  36. ncbi Up-regulation of cyclooxygenase-2 by inhibition of cyclooxygenase-1: a key to nonsteroidal anti-inflammatory drug-induced intestinal damage
    Akiko Tanaka
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto, Japan
    J Pharmacol Exp Ther 300:754-61. 2002
    ..The inhibition of COX-1 up-regulates COX-2 expression, and this may be a key to NSAID-induced intestinal damage...
  37. pmc Pathophysiological basis of acute inflammatory hyperaemia in the rat knee: roles of cyclo-oxygenase-1 and -2
    Colin G Egan
    Department of Biological Sciences, University of Paisley, Paisley PA1 2BE, UK
    J Physiol 539:579-87. 2002
    ..COX-1 but not COX-2 contributes to the maintenance of basal blood flow in the hyperaemic joint at 24 h...
  38. ncbi Role for both spinal cord COX-1 and COX-2 in maintenance of mechanical hypersensitivity following peripheral nerve injury
    Weiya Ma
    Pain Mechanisms Laboratory, Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Brain Res 937:94-9. 2002
    ..Inhibition of spinal COX may be an important mechanism of action in treating some patients with neuropathic pain following peripheral nerve injury...
  39. ncbi Down-regulation of cyclooxygenase-2 expression but up-regulation of cyclooxygenase-1 in renal carcinomas of the Eker (TSC2 gene mutant) rat model
    Toshihiro Okamoto
    Research Laboratories, Nippon Chemiphar Co, Ltd, Saitama 341 0005
    Cancer Sci 94:22-5. 2003
    ..In total, Cox-2 mRNA expression was down-regulated in eight out of ten Eker RCs and cell lines, while Cox-1 mRNA expression was up-regulated in nine out of ten Eker RCs and cell lines...
  40. ncbi Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and Fos expression in rat brain
    Yi Hong Zhang
    Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 463:3-12. 2003
    ..Although COX-2 plays a dominant role in mediating fever responses to i.v. LPS, at least some components of the response, including avoiding hypothermia and the induction of Fos in the NTS, VLM, PB, and PVH, appear to depend on COX-1. J...
  41. ncbi Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury
    Xiaoying Zhu
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Anesthesiology 99:1175-9. 2003
    ..The current study was undertaken to determine whether COX-1 was altered in this model...
  42. ncbi Cyclo-oxygenase-1 and -2 differently contribute to prostaglandin E2 synthesis and lipid peroxidation after in vivo activation of N-methyl-D-aspartate receptors in rat hippocampus
    Olimpia Pepicelli
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    J Neurochem 93:1561-7. 2005
    ..We suggest that both isoforms should be considered as possible therapeutic targets to prevent brain damage caused by excitotoxicity...
  43. ncbi 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury
    Teng Nan Lin
    Neuroscience Division, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Arterioscler Thromb Vasc Biol 26:481-7. 2006
    ..The aim of this study is to assess the effect of 15d-PGJ2 on neuroprotection...
  44. pmc Upregulation of COX-1 and COX-2 in nasal polyps in cystic fibrosis
    J Roca-Ferrer
    Institut d Investigaccions Biomèdiques, August Pi Syuner, IDIBAPS, Barcelona, Spain
    Thorax 61:592-6. 2006
    ..Since abnormalities in prostanoid metabolism occur in the lower airway of patients with cystic fibrosis (CF), it is likely that they could also be detected in the nose...
  45. ncbi Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex
    J S Rao
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 12:151-7. 2007
    ....
  46. ncbi Role of prostacyclin in the development of compression trauma-induced spinal cord injury in rats
    Naoaki Harada
    Department of Biodefense Medicine, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan
    J Neurotrauma 23:1739-49. 2006
    ....
  47. ncbi Spinal prostaglandins facilitate exaggerated A- and C-fiber-mediated reflex responses and are critical to the development of allodynia early after L5-L6 spinal nerve ligation
    Darren D O'Rielly
    Division of Basic Medical Sciences, School of Pharmacy, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Anesthesiology 106:795-805. 2007
    ....
  48. ncbi Aggravation by selective COX-1 and COX-2 inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats
    Mitsuaki Okayama
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607 8414, Japan
    Dig Dis Sci 52:2095-103. 2007
    ....
  49. pmc Gene expression of cyclooxygenase-1 and Ca(2+)-independent phospholipase A(2) is altered in rat hippocampus during normal aging
    Saba Aid
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institute of Health, Bethesda, MD 20892 0947, USA
    Brain Res Bull 73:108-13. 2007
    ..The specific changes in the AA cascade observed in the hippocampus may alter phospholipids homeostasis and possibly increase the susceptibility of the aging brain to neuroinflammation...
  50. ncbi A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-kappaB, COX-1, and COX-2
    Ann S J Yeoh
    Department of Medical Oncology, Royal Adelaide Hospital, South Australia, Australia
    Mol Cancer Ther 6:2319-27. 2007
    ..Further studies investigating the molecular mechanisms underlying radiation-induced mucositis are planned to ultimately achieve anti-mucotoxic-targeted therapies...
  51. doi Possible involvement of microglia containing cyclooxygenase-1 in the accumulation of gonadotrophin-releasing hormone in the preoptic area in female rats
    S Adachi
    Department of Physiology, St Marianna University School of Medicine, Miyamae ku, Kawasaki, Japan
    J Neuroendocrinol 21:1029-37. 2009
    ..These results suggest that microglia in the preoptic area containing COX-1 are responsible for producing PG(s), which, in turn, facilitates the accumulation of GnRH during the gonadotrophin surge in female rats...
  52. doi Effects of No.2 Renal Failure Recipe on expressions of cyclooxygenase-2 and -1 mRNAs in rats with chronic renal failure
    Guan jun Pu
    Department of Nephrology of Shuguang Hospital, Key Laboratory of Liver and Kidney Diseases of Ministry of Education, E Institute of Shanghai Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China
    Zhong Xi Yi Jie He Xue Bao 7:1067-72. 2009
    ..To observe the effects of No. 2 Renal Failure Recipe (No. 2RFR), a compound traditional Chinese herbal medicine, on expressions of cyclooxygenase-2 (COX-2) and cyclooxygenase-1 (COX-1) mRNAs in rats with chronic renal failure (CRF)...
  53. doi Cyclooxygenase (COX)-1 activity precedes the COX-2 induction in Aβ-induced neuroinflammation
    Leila Dargahi
    Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    J Mol Neurosci 45:10-21. 2011
    ....
  54. pmc Expression of COX-1 and COX-2 in the endometrium of cyclic, pregnant and in a model of pseudopregnant rats and their regulation by sex steroids
    Isabelle St-Louis
    Department of Chemistry Biology, Universite du Quebec a Trois Rivieres, Trois Rivieres, Quebec, Canada
    Reprod Biol Endocrinol 8:103. 2010
    ..The aim of the present study was to investigate the expression and regulation of COX-1 and COX-2 and levels of prostaglandins during rat pregnancy, in a model of pseudopregnancy and estrous cycle...
  55. doi In vivo expression of cyclooxygenase-1 in activated microglia and macrophages during neuroinflammation visualized by PET with 11C-ketoprofen methyl ester
    Miho Shukuri
    RIKEN Center for Molecular Imaging Science, Hyogo, Japan
    J Nucl Med 52:1094-101. 2011
    ..In the present study, we performed ex vivo and in vivo imaging studies with (11)C-ketoprofen methyl ester and determined the contributions of the COX isoforms during the neuroinflammatory process...
  56. doi Neuroprotective effect of cyclooxygenase inhibitors in ICV-STZ induced sporadic Alzheimer's disease in rats
    Dinesh Kumar Dhull
    Neuropharmacology Division, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India
    J Mol Neurosci 46:223-35. 2012
    ..In summary, we demonstrate for the first time that both cyclooxygenase-1 and cyclooxygenase-2 isoforms, but not cyclooxygenase-3, are involved in the progression of neuronal damage in intracerebroventricular streptozotocin-treated rats...
  57. pmc Interaction between NO and COX pathways modulating hepatic endothelial cells from control and cirrhotic rats
    Eugenio Rosado
    Hepatic Hemodynamic Laboratory, Liver Unit, IMDiM, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS and Ciberehd, University of Barcelona, Barcelona, Spain
    J Cell Mol Med 16:2461-70. 2012
    ..These strategies may have beneficial effects ameliorating the vasoconstrictor/vasodilator imbalance of the intrahepatic circulation of cirrhotic livers...
  58. pmc Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn
    Batoule H Majed
    Harvard Medical School, Brigham and Women s Hospital, Division of Vascular Surgery, 75 Francis St, Boston, MA 02115, USA
    Pharmacol Rev 64:540-82. 2012
    ..There are two major COX enzymes, COX1 and COX2, that differ in structure, tissue distribution, subcellular localization, and function...
  59. doi Prostanoids as regulators of innate and adaptive immunity
    Takako Hirata
    Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Adv Immunol 116:143-74. 2012
    ..Here, we review the role of prostanoids in regulating immunity, their involvement in immunopathology, and areas of insight that may lead to new therapeutic opportunities...
  60. pmc Integrated proteomics identified novel activation of dynein IC2-GR-COX-1 signaling in neurofibromatosis type I (NF1) disease model cells
    Mio Hirayama
    Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Chuo Ku, Kumamoto 860 8556, Japan
    Mol Cell Proteomics 12:1377-94. 2013
    ....
  61. doi Expression and translation of the COX-1b gene in human cells--no evidence of generation of COX-1b protein
    Christina Reinauer
    Institute for Pharmacology and Clinical Pharmacology, Heinrich Heine University, D 40225 Dusseldorf, Germany
    Biol Chem 394:753-60. 2013
    ....
  62. pmc Diminished neurogenic femoral artery vasoconstrictor response in a Zucker obese rat model: differential regulation of NOS and COX derivatives
    Ana Cristina Martinez
    Departamento de Fisiologia, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
    PLoS ONE 9:e106372. 2014
    ..This study addresses femoral artery regulation in a prediabetic model of obese Zucker rats (OZR) by examining cross-talk between endothelial and neural factors...
  63. pmc Inhibition of COX1/2 alters the host response and reduces ECM scaffold mediated constructive tissue remodeling in a rodent model of skeletal muscle injury
    Christopher L Dearth
    McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, United States Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, United States DoD VA Extremity Trauma and Amputation Center of Excellence, Walter Reed National Military Medical Center, Bethesda, MD 20889, United States Electronic address
    Acta Biomater 31:50-60. 2016
    ..M2-like macrophage phenotype in vitro that includes secretion of downstream products of cycolooxygenases 1 and 2 (COX1/2)...
  64. ncbi Cyclooxygenase-2 (Cox-2) in injured human nerve and a rat model of nerve injury
    Pascal F Durrenberger
    Peripheral Neuropathy Unit, Imperial College, Hammersmith Hospital, London, UK
    J Peripher Nerv Syst 9:15-25. 2004
    ..Selection of patients 4-6 weeks after nerve injury would be more likely to show any efficacy of Cox-2 inhibitors...
  65. pmc Altered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patients
    H W Kim
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Mol Psychiatry 16:419-28. 2011
    ..An upregulated cascade should be considered as a target for drug development and for neuroimaging in BD...
  66. ncbi Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression
    L Feng
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037
    Arch Biochem Biophys 307:361-8. 1993
    ..Thus, the two COX isoforms were differentially expressed, and COX-2 was selectively induced in response to inflammatory stimuli in rats...
  67. ncbi Urethane suppresses rat lung inducible cyclooxygenase and nitric oxide synthase mRNA levels
    F E Martinez
    Department of Pediatrics, University of Calgary, Alberta, Canada
    Inflamm Res 49:727-31. 2000
    ....
  68. ncbi Effects of selective cyclooxygenase enzyme inhibitors on lipopolysaccharide-induced dual thermoregulatory changes in rats
    M Devrim Dogan
    Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Ankara University, Sihhiye 06100 Ankara, Turkey
    Brain Res Bull 57:179-85. 2002
    ..Meanwhile, cyclooxgenase-2 may be critical for the late phase rather than the initiation of the fever response in rats...
  69. ncbi [Changes of the mRNA expression and the intestinal mucosal cyclooxygenase activity in scalded rats]
    Desheng Meng
    Institute of Burn Research, Southwestern Hospital, Third Military Medical University, Chongqing, 400038 P R China
    Zhonghua Shao Shang Za Zhi 18:210-2. 2002
    ..To investigate the changes of the mRNA expression and the intestinal mucosal cyclooxygenase (COXs) activity in scalded rats...
  70. ncbi Key enzymes for renal prostaglandin synthesis: site-specific expression in rodent kidney (rat, mouse)
    Valentina Campean
    Anatomisches Institut, Charite, Humboldt Universitat, Berlin, Germany
    Am J Physiol Renal Physiol 285:F19-32. 2003
    ....
  71. ncbi Increased expression of cyclooxygenase-1 and -2 in the diabetic rat renal medulla
    Rania Nasrallah
    Dept of Cellular and Molecular Medicine, and Kidney Research Centre, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Rm 1337, Ottawa, Ontario, Canada K1H 8M5
    Am J Physiol Renal Physiol 285:F1068-77. 2003
    ..Future studies will determine which COX isoform is contributing to the majority of PGE2 produced in the diabetic IMCD and the significance of these findings to disturbances in IMCD function and to the progression of diabetic nephropathy...
  72. ncbi Role of COX-1 and -2 in prostanoid generation and modulation of angiotensin II responses
    Syed R Baber
    Department of Pharmacology, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Am J Physiol Heart Circ Physiol 285:H2399-410. 2003
    ....
  73. ncbi Cyclooxygenase 1-dependent production of F2-isoprostane and changes in redox status during warm renal ischemia-reperfusion
    Frederic Favreau
    INSERM ERM 324, Ischémie reperfusion en transplantation rénale, Faculte de Medecine et de Pharmacie, IFR59, Universite de Poitiers, and Laboratoire de Biochimie et Toxicologie, CHU de Poitiers, BP 577, 86021 Poitiers, France
    Free Radic Biol Med 36:1034-42. 2004
    ..Therefore the two metabolites of arachidonic acid seemed to be produced via an enzymatic COX1-dependent pathway. Neither COX overexpression nor COX activation was detected...
  74. ncbi Cloning and characterization of cyclooxygenase-1b (putative cyclooxygenase-3) in rat
    James A Snipes
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
    J Pharmacol Exp Ther 313:668-76. 2005
    ....
  75. ncbi Reduced cyclooxygenase involvement in vascular endothelial function in rat renal transplantation
    Annemieke Smit-van Oosten
    Department of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen, The Netherlands
    Nephron Physiol 100:p21-30. 2005
    ..We hypothesized that transplantation-associated risk factors are involved in the development of vascular dysfunction following renal transplantation...
  76. ncbi Expression and function of COX isoforms in renal medulla: evidence for regulation of salt sensitivity and blood pressure
    Wenling Ye
    University of Utah, Bldg 2, Research Service, Salt Lake City, UT 84148, USA
    Am J Physiol Renal Physiol 290:F542-9. 2006
    ..Therefore, we conclude that the two COX isoforms in the renal medulla play a similar role in the stabilization of arterial blood pressure during salt loading...
  77. ncbi Expression of cyclooxygenase isoforms in developing rat placenta, human term placenta, and BeWo human trophoblast model
    Yan Xu
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Mol Pharm 2:481-90. 2005
    ....
  78. ncbi Arachidonic acid induces augmented vasoconstriction via cyclooxygenase 1 in the aorta from rats fed a high-fat diet
    Anita D Smith
    Department of Physiology, Medical College of Georgia, Augusta, GA 30912 3000, USA
    Prostaglandins Leukot Essent Fatty Acids 75:43-9. 2006
    ..We hypothesized that there would be augmented vasoconstriction to AA, mediated via COX 1 in rats fed a high-fat (HF)-diet for 10 weeks (from 3 to 13 weeks old) compared to those fed regular rat chow...
  79. ncbi Renal cortical regulation of COX-1 and functionally related products in early renovascular hypertension (rat)
    F Theilig
    Charite Universitatsmedizin Berlin, Institut für Vegetative Anatomie, Philippstr 12, 10115 Berlin, Germany
    Am J Physiol Renal Physiol 291:F987-94. 2006
    ..We suggest that in 2K1C, COX-1 and PGES expression may fail to oppose the effects of renovascular hypertension through reduced prostaglandin signaling in late distal tubule and cortical collecting duct...
  80. ncbi Selective COX-2 inhibition markedly slows disease progression and attenuates altered prostanoid production in Han:SPRD-cy rats with inherited kidney disease
    Deepa Sankaran
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada R3T 2N2
    Am J Physiol Renal Physiol 293:F821-30. 2007
    ..In summary, COX-2 inhibition attenuated renal injury, reduced the elevated renal COX-2 activity, and ameliorated disease-related alterations in prostanoid production in this rat model of chronic renal disease...
  81. ncbi Expression and activity of cyclooxygenase isoforms in skeletal muscles and myocardium of humans and rodents
    Marco Testa
    Department of Cardiology, Azienda Ospedaliera Sant Andrea, Via di Grottarossa 1035, 00189 Roma, Italy
    J Appl Physiol (1985) 103:1412-8. 2007
    ..In conclusion, COX-1 and COX-2 are expressed and enzymatically active in myocytes of skeletal muscles and hearts of rodents and humans. PGE(2) appears to be the main product of COX activity in striated muscles...
  82. ncbi Immunoexpression of constitutive and inducible cyclo-oxygenase isoforms in the rat foetal and maternal digestive tract
    F Burdan
    Experimental Teratology Unit of the Department of Human Anatomy, Medical University, Lublin, Poland
    Folia Morphol (Warsz) 67:24-31. 2008
    ..In conclusion, constitutive and inducible COX isoforms were detected in the digestive tract of pregnant female and in foetuses. COX-1 was the predominant isoform in both the adult and foetal organs...
  83. doi Upregulation of dorsal horn microglial cyclooxygenase-1 and neuronal cyclooxygenase-2 after thoracic deep muscle incisions in the rat
    Jeffrey S Kroin
    Department of Anesthesiology, Rush Medical College, 1653 West Congress Parkway, Chicago, IL 60612, USA
    Anesth Analg 106:1288-95, table of contents. 2008
    ..Our hypothesis in this study was that a deep thoracic incision causes COX-1 and COX-2 upregulation in the dorsal horn coincident with pain-related behavior, and that specific cell types contribute to this increase in COX expression...
  84. ncbi [Prognostic significance of cyclooxygenase (COX-1 and COX-2) expression in endometrial carcinoma (clinical and immunohistochemical study)]
    N A Boldarian
    Vopr Onkol 54:40-6. 2008
    ....
  85. doi Cyclooxygenase-dependent vasoconstricting factor(s) in remodelled rat femoral arteries
    Akiko Hirao
    Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka 431 3192, Japan
    Cardiovasc Res 79:161-8. 2008
    ..Denudation and regeneration of the vascular endothelium are important in the pathogenesis of atherosclerosis. The aim of this study is to clarify the mechanisms of functional alterations in remodelled arteries following endothelial injury...
  86. ncbi The pathophysiological roles of COX-1 and COX-2 in the intestinal smooth muscle contractility under the anaphylactic condition
    Hiroko Kadowaki
    Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama, Japan
    Biomed Res 29:113-7. 2008
    ....
  87. doi Inhibitors of GSK-3 prevent corticosterone from inducing COX-1 expression in cardiomyocytes
    Haipeng Sun
    Interdisciplinary Graduate Program of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, USA
    Cardiovasc Toxicol 8:93-100. 2008
    ..We conclude that GSK-3 inhibitors block CT from inducing COX-1 gene expression via a mechanism beyond GR and Sp3 transcription factor...
  88. pmc COX-1 vs. COX-2 as a determinant of basal tone in the internal anal sphincter
    Marcio A F de Godoy
    Division of Gastroenterology and Hepatology, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Physiol Gastrointest Liver Physiol 296:G219-25. 2009
    ..05, n = 5). However, basal tone in COX-2(-/-) mice was not significantly different from that in wild-type mice. We conclude that COX-1-related products contribute significantly to IAS tone...
  89. ncbi Effect of polygonum multiflorum on the fluidity of the mitochondria membrane and activity of COX in the hippocampus of rats with Abeta 1-40-induced Alzheimer's disease
    De Ren Hou
    Department of Neurology, Third Xiangya Hospital, Central South University, Changsha 410013, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 33:987-92. 2008
    ..To explore the effect of polygonum multiflorum on the fluidity of mitochondria membrane and activity of cytochrome oxidase (COX) in Alzheimer's disease (AD) model rats...
  90. doi Nasal mucosal expression of the leukotriene and prostanoid pathways in seasonal and perennial allergic rhinitis
    V S Westergren
    Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton, UK
    Clin Exp Allergy 39:820-8. 2009
    ..Leukotrienes (LTs) and prostanoids are potent pro-inflammatory and vasoactive lipid mediators implicated in airway disease, but their cellular sources in the nasal airway in naturally occurring allergic rhinitis (AR) are unclear...
  91. doi Downregulation of cyclooxygenase-1 is involved in gastric mucosal apoptosis via death signaling in portal hypertensive rats
    Bin Wu
    Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat Sen University, 600 Tianhe Road, Guangzhou 510630, China
    Cell Res 19:1269-78. 2009
    ..Our data indicate that downregulation of COX-1 is involved in gastric mucosal apoptosis via death signaling-mediated type-I cell death in PHT rats...
  92. doi Cyclooxygenase and thromboxane/prostaglandin receptor contribute to aortic endothelium-dependent dysfunction in aging female spontaneously hypertensive rats
    Drew A Graham
    Department of Kinesiology, Faculty of Applied Health Sciences, Univ of Waterloo, 200 Univ Ave West, Waterloo, ON, Canada N2L 3G1
    J Appl Physiol (1985) 107:1059-67. 2009
    ..0758). Dramatic deterioration of endothelium-dependent vasomotor function in fSHR across this age range involves COX and thromboxane/prostaglandin receptor, supporting a mechanism of impairment similar to that which occurs in aging mSHR...
  93. doi Suppressing inflammatory cascade by cyclo-oxygenase inhibitors attenuates quinolinic acid induced Huntington's disease-like alterations in rats
    Harikesh Kalonia
    Pharmacology Division, University Institute of Pharmaceutical Sciences, UGC Centre for Advanced Studies, Panjab University, Chandigarh, India
    Life Sci 88:784-91. 2011
    ..The aim of this study was to investigate the protective effects of cyclo-oxygenase inhibitors against quinolinic acid (QA) induced Huntington's disease-like alterations in rats...
  94. doi Cyclooxygenase expression and prostaglandin levels in central nervous system tissues during the course of chronic relapsing experimental autoimmune encephalomyelitis (EAE)
    Samir S Ayoub
    Centre for Biochemical Pharmacology, William Harvey Research Institute, St Bartholomew s and London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Inflamm Res 60:919-28. 2011
    ..In particular, the work investigates the possible relationship between the expression of COX isoenzymes and PG levels during the neurological phases of CR EAE...
  95. ncbi Analysis and quantitation of splicing variants of the TPA-inducible PGHS-1 mRNA in rat tracheal epithelial cells
    J Kitzler
    Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709
    Arch Biochem Biophys 316:856-63. 1995
    ..TPA does not regulate either of the PGHS-1 transcripts in RTE or rat fibroblast cells. These results confirm the induction of functional PGHS-1 mRNA by TPA only in EGV-6 cells...
  96. ncbi Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis
    M M Griffiths
    Department of Veterans Affairs Medical Center, and University of Utah, Salt Lake City, USA
    Arthritis Rheum 43:1278-89. 2000
    ..Collagen-induced arthritis (CIA) is a polygenic model of experimentally induced autoimmunity and chronic joint inflammation. This study maps genetic loci that regulate CIA susceptibility in DA/Bkl (DA) and BN/SsNHsd (BN) rats...
  97. ncbi [Chronic hypoxia altered the mRNA expression of cyclooxygenase in intrapulmonary artery smooth muscle cell]
    W Kong
    Department of Pathophysiology, Tongji Medical College, Science and Technology University of Huazhong, Wuhan 430030, China
    Zhonghua Jie He He Hu Xi Za Zhi 24:531-3. 2001
    ..To elucidate the effect of chronic hypoxia on the cyclooxygenase-2 mRNA expression in pulmonary artery smooth muscle cells of rats...
  98. pmc Post-training cyclooxygenase-2 (COX-2) inhibition impairs memory consolidation
    Lisa A Teather
    Neuroscience Center of Excellence, Louisiana State University Health Center, New Orleans, LA 70112, USA
    Learn Mem 9:41-7. 2002
    ..These findings indicate that COX-2 is a required biochemical component mediating the consolidation of hippocampal-dependent memory...
  99. ncbi Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia in diabetic rats
    Jason D Freshwater
    Department of Pathology, University of California San Diego, La Jolla, CA 92093 0612, USA
    Diabetes 51:2249-55. 2002
    ..Spinal delivery of selective inhibitors of cyclooxygenase-2 or antagonists of prostaglandin receptors may have therapeutic potential for treating painful diabetic neuropathy...
  100. ncbi Expression of cyclooxygenase genes and involvement of endogenous prostaglandin during osteogenesis in the rat tibial bone marrow cavity
    Y Sato
    Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Tokyo Medical and Dental University, Yushima, Japan
    J Med Dent Sci 44:81-92. 1997
    ..Moreover, the present study suggests that COX-2 and COX-1 would both be involved in the early stage of osteogenesis, and COX-2 is likely to be more associated with the maturation of osteoblasts in the later stage...
  101. ncbi Putative cyclooxygenase-3 expression in rat brain cells
    Bela Kis
    Department of Physiology and Pharmacology, Wake Forest University, School of Medicine, Winston Salem, NC 27157, USA
    J Cereb Blood Flow Metab 23:1287-92. 2003
    ..In summary, we report, for the first time to our knowledge, that the putative COX-3 mRNA is detectable in rats and is differentially expressed in various cell types from rat brain, as well as that its expression is not stimulated by LPS...