Gene Symbol: Ptgfr
Description: prostaglandin F receptor
Alias: PF2AR, prostaglandin F2-alpha receptor, PGF receptor, PGF2-alpha receptor, prostanoid FP receptor
Species: rat
Products:     Ptgfr

Top Publications

  1. Olofsson J, Leung C, Bjurulf E, Ohno T, Selstam G, Peng C, et al. Characterization and regulation of a mRNA encoding the prostaglandin F2alpha receptor in the rat ovary. Mol Cell Endocrinol. 1996;123:45-52 pubmed
  2. Kitanaka J, Hasimoto H, Sugimoto Y, Negishi M, Aino H, Gotoh M, et al. Cloning and expression of a cDNA for rat prostaglandin F2 alpha receptor. Prostaglandins. 1994;48:31-41 pubmed
    ..A significant 4.7-kb mRNA transcript was detected in cultured rat astrocytes and whole brain and pregnant ovary of adult rats by Northern blot analysis. ..
  3. Orlicky D. Negative regulatory activity of a prostaglandin F2 alpha receptor associated protein (FPRP). Prostaglandins Leukot Essent Fatty Acids. 1996;54:247-59 pubmed
    ..Here I report on the activity of this prostaglandin F2 alpha receptor (FP) associated protein (FPRP)...
  4. Katsuyama M, Fan C, Yabe Nishimura C. NADPH oxidase is involved in prostaglandin F2alpha-induced hypertrophy of vascular smooth muscle cells: induction of NOX1 by PGF2alpha. J Biol Chem. 2002;277:13438-42 pubmed
    ..PGF(2alpha) and (+)-fluprostenol, a selective agonist of the PGF receptor, significantly increased intracellular O(2)(-) in A7r5...
  5. Suzuki Yamamoto T, Toida K, Sugimoto Y, Ishimura K. Colocalization of prostaglandin F(2alpha) receptor FP and prostaglandin F synthase-I in the spinal cord. J Lipid Res. 2009;50:1996-2003 pubmed publisher
    ..These findings suggest that prostaglandin F(2alpha) synthesized in the neuronal somata and dendrites exert an autocrine action there. ..
  6. Ueno T, Fujimori K. Novel suppression mechanism operating in early phase of adipogenesis by positive feedback loop for enhancement of cyclooxygenase-2 expression through prostaglandin F2? receptor mediated activation of MEK/ERK-CREB cascade. FEBS J. 2011;278:2901-12 pubmed publisher
    ..Thus, PGF(2?) forms a positive feedback loop that coordinately suppresses the early phase of adipogenesis through the increased production of anti-adipogenic PGF(2?) and PGE(2) . ..
  7. Dong Y, Yallampalli C. Pregnancy and exogenous steroid treatments modulate the expression of relaxant EP(2) and contractile FP receptors in the rat uterus. Biol Reprod. 2000;62:533-9 pubmed
    ..Therefore, we conclude that steroid hormones modulate the mRNA for relaxant EP(2) and contractile FP receptors for PGs in the uterus and thus regulate uterine activity during pregnancy and labor. ..
  8. Almirza W, Dernison M, Peters P, van Zoelen E, Theuvenet A. Role of the prostanoid FP receptor in action potential generation and phenotypic transformation of NRK fibroblasts. Cell Signal. 2008;20:2022-9 pubmed publisher
    ..Furthermore, our data provide the first direct evidence that activity of PGF(2alpha) by putative pacemaker cells underlies the generation of calcium action potentials in NRK monolayers. ..
  9. Anadol E, Kanca H, Yar A, Helvacioglu F, Menevse S, Calguner E, et al. Prostaglandin F receptor expression in intrauterine tissues of pregnant rats. J Vet Sci. 2014;15:125-31 pubmed
    ..These findings indicate a role for uterine FP receptors in the mediation of uterine contractility at term. ..

More Information


  1. Yonekura H, Sakurai S, Liu X, Migita H, Wang H, Yamagishi S, et al. Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis. J Biol Chem. 1999;274:35172-8 pubmed
    ..Furthermore, antisense inhibition of PlGF protein production lowered the endothelial cell synthesis of DNA under hypoxic conditions. The results suggest that these VEGF family members may also take active parts in angiogenesis. ..
  2. Mu J, Kanzaki T, Si X, Tomimatsu T, Fukuda H, Shioji M, et al. Apoptosis and related proteins in placenta of intrauterine fetal death in prostaglandin f receptor-deficient mice. Biol Reprod. 2003;68:1968-74 pubmed
    ..Thus, significantly increased apoptosis in the mouse placenta and decidua might be involved in the pathophysiologic mechanism of intrauterine fetal death. ..
  3. Wang S, Yang Q, Fung K, Lin H. AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells. Mol Cell Endocrinol. 2008;289:60-6 pubmed publisher
    ..Overexpression of AKR1C2 or AKR1C3 did not alter levels of PGF receptor (FP) expression...
  4. Liang Y, Woodward D, Guzman V, Li C, Scott D, Wang J, et al. Identification and pharmacological characterization of the prostaglandin FP receptor and FP receptor variant complexes. Br J Pharmacol. 2008;154:1079-93 pubmed publisher
    ..Hence, FP-altFP complexes may represent the underlying basis of bimatoprost pharmacology. ..
  5. Fukuda M, Aoki T, Manabe T, Maekawa A, Shirakawa T, Kataoka H, et al. Exacerbation of intracranial aneurysm and aortic dissection in hypertensive rat treated with the prostaglandin F-receptor antagonist AS604872. J Pharmacol Sci. 2014;126:230-42 pubmed
  6. Lake S, Gullberg H, Wahlqvist J, Sjögren A, Kinhult A, Lind P, et al. Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor. FEBS Lett. 1994;355:317-25 pubmed
    ..Using [3H]PGF2 alpha, binding of PGs showed the rank order of fluprostenol > PhXA70 > PGF2 alpha > or = PhXA85 > PGD2 > PGE2. ..
  7. Takayama K, Yuhki K, Ono K, Fujino T, Hara A, Yamada T, et al. Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia. Nat Med. 2005;11:562-6 pubmed
    ..Our results show that inflammatory tachycardia is caused by a direct action on the heart of TXA(2) and PGF(2alpha) formed under systemic inflammatory conditions. ..