Gene Symbol: Prss12
Description: serine protease 12
Alias: neurotrypsin, peptidase, serine, 12 (neurotrypsin, motopsin), protease, serine 12, protease, serine, 12 neurotrypsin (motopsin)
Gschwend T, Krueger S, Kozlov S, Wolfer D, Sonderegger P. Neurotrypsin, a novel multidomain serine protease expressed in the nervous system. Mol Cell Neurosci. 1997;9:207-19 pubmed
We have cloned a novel murine cDNA encoding a multidomain serine protease, termed neurotrypsin, which exhibits an unprecedented domain composition...
Reif R, Sales S, Hettwer S, Dreier B, Gisler C, Wölfel J, et al
. Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation. FASEB J. 2007;21:3468-78 pubmed
The synaptic serine protease neurotrypsin is thought to be important for adaptive synaptic processes required for cognitive functions, because humans deficient in neurotrypsin suffer from severe mental retardation...
Frischknecht R, Fejtova A, Viesti M, Stephan A, Sonderegger P. Activity-induced synaptic capture and exocytosis of the neuronal serine protease neurotrypsin. J Neurosci. 2008;28:1568-79 pubmed publisher
..The extracellular serine protease neurotrypsin was implicated in cognitive function, because humans lacking a functional form of neurotrypsin suffer from ..
Molinari F, Rio M, Meskenaite V, Encha Razavi F, Auge J, Bacq D, et al
. Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardation. Science. 2002;298:1779-81 pubmed
A 4-base pair deletion in the neuronal serine protease neurotrypsin gene was associated with autosomal recessive nonsyndromic mental retardation (MR)...
Mitsui S, Yamaguchi N, Osako Y, Yuri K. Enzymatic properties and localization of motopsin (PRSS12), a protease whose absence causes mental retardation. Brain Res. 2007;1136:1-12 pubmed
Motopsin (PRSS12) is a mosaic protease expressed in the central nervous system. Truncation of the human motopsin gene causes nonsyndromic mental retardation...
Stephan A, Mateos J, Kozlov S, Cinelli P, Kistler A, Hettwer S, et al
. Neurotrypsin cleaves agrin locally at the synapse. FASEB J. 2008;22:1861-73 pubmed publisher
The synaptic serine protease neurotrypsin is considered to be essential for the establishment and maintenance of cognitive brain functions, because humans lacking functional neurotrypsin suffer from severe mental retardation...
Ozhogina O, Grishaev A, Bominaar E, Patthy L, Trexler M, Llinas M. NMR solution structure of the neurotrypsin Kringle domain. Biochemistry. 2008;47:12290-8 pubmed publisher
b>Neurotrypsin is a multidomain protein that serves as a brain-specific serine protease. Here we report the NMR structure of its kringle domain, NT/K...