Genomes and Genes
Gene Symbol: Prss1
Description: serine protease 1
Alias: PTRYI, RATPTRYI, Try1, anionic trypsin-1, anionic trypsin I, pancreatic trypsin 1, pretrypsinogen I, protease, serine 1, protease, serine, 1 (trypsin 1), protease, serine, 2
- Craik C, Choo Q, Swift G, Quinto C, MacDonald R, Rutter W. Structure of two related rat pancreatic trypsin genes. J Biol Chem. 1984;259:14255-64 pubmed..The nucleotide homologies as well as the similarities of intron positions of the two trypsin genes to those of other serine protease genes clearly support an evolutionary relationship between members of this gene family. ..
- Pasternak A, Ringe D, Hedstrom L. Comparison of anionic and cationic trypsinogens: the anionic activation domain is more flexible in solution and differs in its mode of BPTI binding in the crystal structure. Protein Sci. 1999;8:253-8 pubmed..It is concluded that the activation domain of rat trypsinogen is more flexible than that of bovine trypsinogen, but does not extend further into the protein core. ..
- Hirano -. Cytokine Suppressive Agent Prevents Pancreatic Injuries Induced by Ischemia-Reperfusion in Rats. Int J Angiol. 2000;9:236-240 pubmed
- Fletcher T, Tsukamoto H, Largman C. Immunoenzymometric determination of trypsin/alpha 1-protease inhibitor complex in plasma of rats with experimental pancreatitis. Clin Chem. 1986;32:1738-41 pubmed..985) of the values obtained by size fractionation and by this assay demonstrates the accuracy of the assay, which is the first single-tube method for determining this form of activated cationic trypsin in plasma. ..
- Dakka N, Puigserver A, Wicker C. Regulation by a protein-free carbohydrate-rich diet of rat pancreatic mRNAs encoding trypsin and elastase isoenzymes. Biochem J. 1990;268:471-4 pubmed..In combination with earlier observations of an overall decrease in cationic trypsin biosynthesis during the same nutritional manipulation, these results suggest that formation of this enzyme is also subject to translational control. ..
- Dubick M, Palmer R, Lau P, Morrill P, Geokas M. Altered exocrine pancreatic function in rats treated with nicotine. Toxicol Appl Pharmacol. 1988;96:132-9 pubmed..These data indicate that nicotine treatment, at levels comparable to those expected in moderate cigarette smokers, increases the content of digestive enzymes in rat pancreas, as well as their basal and secretagogue-induced release. ..