prokineticin receptor 2
Gene Symbol: prokineticin receptor 2
Description: prokineticin receptor 2
Alias: Gpr73l1, prokineticin receptor 2, G protein-coupled receptor 73-like 1, G protein-coupled receptor I5E, PK-R2
Cheng M, Bullock C, Li C, Lee A, Bermak J, Belluzzi J, et al
. Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature. 2002;417:405-10 pubmed
..The high expression of PKR2 mRNA within the SCN and the positive feedback of PK2 on its own transcription through activation of PKR2 suggest that PK2 may also function locally within the SCN to synchronize output. ..
Qiu C, Liu Y, Qiu F, Wu J, Zhou Q, Hu W. Prokineticin 2 potentiates acid-sensing ion channel activity in rat dorsal root ganglion neurons. J Neuroinflammation. 2012;9:108 pubmed publisher
..Our findings support that PK2 is a proalgesic factor and its signaling likely contributes to acidosis-evoked pain by sensitizing acid-sensing ion channels. ..
Masuda Y, Takatsu Y, Terao Y, Kumano S, Ishibashi Y, Suenaga M, et al
. Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors. Biochem Biophys Res Commun. 2002;293:396-402 pubmed
..The mRNAs of both EG-VEGF/PK-R1 and -R2 were expressed in BACE. The identification of the receptors for EG-VEGF/prokineticins may provide a novel molecular basis for the regulation of angiogenesis in endocrine glands. ..
Masumoto K, Nagano M, Takashima N, Hayasaka N, Hiyama H, Matsumoto S, et al
. Distinct localization of prokineticin 2 and prokineticin receptor 2 mRNAs in the rat suprachiasmatic nucleus. Eur J Neurosci. 2006;23:2959-70 pubmed
..In the present study, using in situ hybridization methods, we investigated the localization of PK2 and prokineticin receptor 2 (PKR2), a specific receptor for PK2, in the rat SCN...
Monnier C, Dode C, Fabre L, Teixeira L, Labesse G, Pin J, et al
. PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity. Hum Mol Genet. 2009;18:75-81 pubmed publisher
..This argues against a dominant negative effect of the mutations in vivo...