Gene Symbol: Prmt5
Description: protein arginine methyltransferase 5
Alias: Hrmt1l5, Skb1, protein arginine N-methyltransferase 5, HMT1 hnRNP methyltransferase-like 5, SKB1 homolog
Species: rat
Products:     Prmt5

Top Publications

  1. Fabbrizio E, El Messaoudi S, Polanowska J, Paul C, Cook J, Lee J, et al. Negative regulation of transcription by the type II arginine methyltransferase PRMT5. EMBO Rep. 2002;3:641-5 pubmed
    ..Purification of native CERC reveals the presence of the type II arginine methyltransferase PRMT5, which can mono- or symetrically dimethylate arginine residues in proteins...
  2. Miranda T, Khusial P, Cook J, Lee J, Gunderson S, Pestka S, et al. Spliceosome Sm proteins D1, D3, and B/B' are asymmetrically dimethylated at arginine residues in the nucleus. Biochem Biophys Res Commun. 2004;323:382-7 pubmed
    ..In reactions in which Sm D1 or Sm D3 was methylated in vitro with a hemagglutinin-tagged PRMT5 purified from HeLa cells, we detected both symmetric omega-NG,NG'-dimethylarginine and asymmetric omega-NG,NG-..
  3. Liang J, Wang Z, Chiriboga L, Greco M, Shapiro E, Huang H, et al. The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors. J Urol. 2007;177:1918-22 pubmed
    ..Further studies are needed to confirm the functional relevance of these findings. ..
  4. Andreu Pérez P, Esteve Puig R, de Torre Minguela C, López Fauqued M, Bech Serra J, Tenbaum S, et al. Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF. Sci Signal. 2011;4:ra58 pubmed publisher ERK1/2 phosphorylation depended on methylation of RAF proteins by protein arginine methyltransferase 5 (PRMT5)...
  5. Friesen W, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, et al. A novel WD repeat protein component of the methylosome binds Sm proteins. J Biol Chem. 2002;277:8243-7 pubmed
    ..S) protein arginine methyltransferase complex, termed the methylosome, that contains the methyltransferase JBP1 (PRMT5) and the pICln protein...
  6. Bedford M, Richard S. Arginine methylation an emerging regulator of protein function. Mol Cell. 2005;18:263-72 pubmed
    ..This review describes recent insights into the molecular processes regulated by arginine methylation in normal and diseased cells. ..
  7. Hou Z, Peng H, Ayyanathan K, Yan K, Langer E, Longmore G, et al. The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression. Mol Cell Biol. 2008;28:3198-207 pubmed publisher
    ..Here, we describe the identification of the protein arginine methyltransferase 5 (PRMT5) as an effector recruited to SNAIL through an interaction with AJUBA that functions to repress the SNAIL target ..
  8. Jansson M, Durant S, Cho E, Sheahan S, Edelmann M, Kessler B, et al. Arginine methylation regulates the p53 response. Nat Cell Biol. 2008;10:1431-9 pubmed publisher
    ..Furthermore, PRMT5 depletion triggers p53-dependent apoptosis...
  9. Zhou Z, Sun X, Zou Z, Sun L, Zhang T, Guo S, et al. PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130. Cell Res. 2010;20:1023-33 pubmed publisher
    ..Here, we show that the protein arginine methyltransferase 5 (PRMT5) localizes to the GA and forms complexes with several components involved in GA ribbon formation and vesicle ..

More Information


  1. Huang J, Vogel G, Yu Z, Almazan G, Richard S. Type II arginine methyltransferase PRMT5 regulates gene expression of inhibitors of differentiation/DNA binding Id2 and Id4 during glial cell differentiation. J Biol Chem. 2011;286:44424-32 pubmed publisher
    b>PRMT5 is a type II protein arginine methyltranferase that catalyzes monomethylation and symmetric dimethylation of arginine residues...
  2. Sun Q, Jiao F, Yang X, Zhong B, Jiang M, Li G, et al. [Expression of protein arginine N-methyltransferases in E3 rat models of acute asthma]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:716-9 pubmed
    ..01), PRMT2 (P<0.01), PRMT3 (P<0.05) and PRMT5 (P<0.05) were significantly increased, but the expression of PRMT4 gene (P<0...
  3. Zhao D, Gish G, Braunschweig U, Li Y, Ni Z, Schmitges F, et al. SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination. Nature. 2016;529:48-53 pubmed publisher
    ..This R1810me2s modification requires protein arginine methyltransferase 5 (PRMT5) and recruits the Tudor domain of the survival of motor neuron (SMN, also known as GEMIN1) protein, which is ..
  4. Takai H, Masuda K, Sato T, Sakaguchi Y, Suzuki T, Suzuki T, et al. 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. Cell Rep. 2014;9:48-60 pubmed publisher
  5. Gayatri S, Bedford M. Readers of histone methylarginine marks. Biochim Biophys Acta. 2014;1839:702-10 pubmed publisher
    ..This article is part of a Special Issue entitled: Molecular mechanisms of histone modification function. ..
  6. Bandyopadhyay S, Harris D, Adams G, Lause G, McHugh A, Tillmaand E, et al. HOXA9 methylation by PRMT5 is essential for endothelial cell expression of leukocyte adhesion molecules. Mol Cell Biol. 2012;32:1202-13 pubmed publisher
    ..alpha (TNF-?) and show an unexpected requirement for arginine methylation by protein arginine methyltransferase 5 (PRMT5). PRMT5 was identified as a TNF-?-dependent binding partner of HOXA9 by mass spectrometry...
  7. Di Lorenzo A, Bedford M. Histone arginine methylation. FEBS Lett. 2011;585:2024-31 pubmed publisher
    ..Importantly, arginine methylation of histone tails can promote or prevent the docking of key transcriptional effector molecules, thus playing a central role in the orchestration of the histone code. ..
  8. Gonsalvez G, Tian L, Ospina J, Boisvert F, Lamond A, Matera A. Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins. J Cell Biol. 2007;178:733-40 pubmed
    ..Several lines of evidence suggest that the methyltransferase protein arginine methyltransferase 5 (PRMT5) is responsible for sDMA modification of Sm proteins...
  9. Sun L, Wang M, Lv Z, Yang N, Liu Y, Bao S, et al. Structural insights into protein arginine symmetric dimethylation by PRMT5. Proc Natl Acad Sci U S A. 2011;108:20538-43 pubmed publisher
    ..Here we analyzed the structure of a prototypic symmetric arginine dimethylase, PRMT5, and discovered that a conserved phenylalanine in the active site is critical for specifying symmetric addition of ..
  10. Gu Z, Li Y, Lee P, Liu T, Wan C, Wang Z. Protein arginine methyltransferase 5 functions in opposite ways in the cytoplasm and nucleus of prostate cancer cells. PLoS ONE. 2012;7:e44033 pubmed publisher
    Protein arginine methyltransferase 5 (PRMT5) plays multiple roles in a large number of cellular processes, and its subcellular localization is dynamically regulated during mouse development and cellular differentiation...
  11. Antonysamy S, Bonday Z, Campbell R, Doyle B, Druzina Z, Gheyi T, et al. Crystal structure of the human PRMT5:MEP50 complex. Proc Natl Acad Sci U S A. 2012;109:17960-5 pubmed publisher
    ..b>PRMT5 symmetrically di-methylates the two-terminal ?-guanidino nitrogens of arginine residues on substrate proteins...
  12. Costa Y, Speed R, Gautier P, Semple C, Maratou K, Turner J, et al. Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?. Hum Mol Genet. 2006;15:2324-34 pubmed
    ..The presence of MAEL in these critical compartments of male germ cells and its interactions provide a link suggesting the involvement of the miRNA pathway in MSUC...
  13. Likhite N, Jackson C, Liang M, Krzyzanowski M, Lei P, Wood J, et al. The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling. Sci Signal. 2015;8:ra115 pubmed publisher
    ..DOP-3 receptor in the nematode Caenorhabditis elegans, were methylated by protein arginine methyltransferase 5 (PRMT5)...
  14. Lim Y, Kwon Y, Won N, Min B, Park I, Paik W, et al. Multimerization of expressed protein-arginine methyltransferases during the growth and differentiation of rat liver. Biochim Biophys Acta. 2005;1723:240-7 pubmed
    ..We investigated the expressions of PRMT1 and PRMT5 in relation to their catalytic activities in rat liver during growth and differentiation as well as in the ..
  15. Chittka A, Nitarska J, Grazini U, Richardson W. Transcription factor positive regulatory domain 4 (PRDM4) recruits protein arginine methyltransferase 5 (PRMT5) to mediate histone arginine methylation and control neural stem cell proliferation and differentiation. J Biol Chem. 2012;287:42995-3006 pubmed publisher
    ..We discovered that SC1 recruits the chromatin modifier PRMT5, an arginine methyltransferase that catalyzes symmetric dimethylation of histone H4 arginine 3 (H4R3me2s) and that ..
  16. Na J, Lee K, Kim H, Shin J, Na W, Jeong H, et al. Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene. PLoS ONE. 2012;7:e48152 pubmed publisher
    ..In this study, we identified the type II protein arginine methyltransferase 5 (PRMT5) as an interacting molecule of CRY1...