Prkcz

Summary

Gene Symbol: Prkcz
Description: protein kinase C, zeta
Alias: 14-3-3-zetaisoform, Pkcz, r14-3-3, protein kinase C zeta type, 14 - 3 - 3 - zeta isoform, nPKC-zeta
Species: rat

Top Publications

  1. pmc Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta
    E Berra
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Madrid, Spain
    EMBO J 14:6157-63. 1995
  2. ncbi Arachidonic acid binds 14-3-3zeta, releases 14-3-3zeta from phosphorylated BAD and induces aggregation of 14-3-3zeta
    Thomas G Brock
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Neurochem Res 33:801-7. 2008
  3. ncbi Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa B
    Pierre Olivier Esteve
    INRS Institut Armand Frappier, Universite du Quebec, Laval, Quebec H7V 1B7, Canada
    J Biol Chem 277:35150-5. 2002
  4. ncbi PKC zeta enhances insulin-like growth factor 1-dependent mitogenic activity in the rat clonal beta cell line RIN 1046-38
    Anita M Hennige
    Department of Internal Medicine IV, University of Tubingen, Otfried Mueller Strasse 10, D 72076 Tubingen, Germany
    Biochem Biophys Res Commun 290:85-90. 2002
  5. ncbi Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1
    Klaus Moeschel
    Department of Internal Medicine IV, Endocrinology, Metabolism, Pathobiochemistry and Clinical Chemistry, University Hospital Tubingen, D 72076 Tubingen, Germany
    J Biol Chem 279:25157-63. 2004
  6. ncbi Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance
    Avia Herschkovitz
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Faculty of Agricultural, Food, and Environmental Quality, The Hebrew University of Jerusalem, Rehovot, Israel
    J Biol Chem 282:18018-27. 2007
  7. pmc Protein kinase Czeta and glycogen synthase kinase-3beta control neuronal polarity in developing rodent enteric neurons, whereas SMAD specific E3 ubiquitin protein ligase 1 promotes neurite growth but does not influence polarity
    Bhupinder P S Vohra
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 27:9458-68. 2007
  8. ncbi The structure, expression, and properties of additional members of the protein kinase C family
    Y Ono
    Biotechnology Laboratories, Takeda Chemical Industries, Osaka, Japan
    J Biol Chem 263:6927-32. 1988
  9. pmc Interaction of protein kinase C zeta with ZIP, a novel protein kinase C-binding protein
    A Puls
    Max Delbruck Laboratorium in der Max Planck Gesellschaft, Carl von Linne Weg 10, D 50829 Cologne, Germany
    Proc Natl Acad Sci U S A 94:6191-6. 1997
  10. ncbi Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta
    S Etienne-Manneville
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
    Cell 106:489-98. 2001

Research Grants

  1. Regulation of Nuclear Import/Export of 5-Lipoxygenase
    Thomas Brock; Fiscal Year: 2006
  2. PROTEIN KINASE C AND PHOTORECEPTORS
    ALEXANDRA NEWTON; Fiscal Year: 2002

Scientific Experts

  • Jean Hugues Parmentier
  • Fabien Marchand
  • Joost J F P Luiken
  • Margarita Lorenzo
  • S Kuroda
  • ALEXANDRA NEWTON
  • S Marsigliante
  • Florence Lefranc
  • Oliver Hardt
  • Tatiane C A Nogueira
  • Paola Virginia Migues
  • Ryan G Parsons
  • Thomas Brock
  • Todd Charlton Sacktor
  • Reut Shema
  • A Ivan Hernandez
  • Todd C Sacktor
  • Sreedharan Sajikumar
  • Yanhua Peng
  • Peter Serrano
  • Shiri Ron
  • Yadin Dudai
  • Angel Cogolludo
  • Laura Moreno
  • Sven R M Schuette
  • Wei Chen
  • Imène Jaadane
  • Ling Xia
  • John F Crary
  • Masanori Ito
  • Jun Wang
  • Jeremy M Barry
  • Jose A Crespo
  • Zhen Li
  • Juan Carlos Caraballo
  • Jing fang Zhang
  • Andre A Fenton
  • Li Li
  • Galina A Gusarova
  • K Sato
  • John R Ussher
  • Richard G Ruddell
  • Janine L Kwapis
  • Jihee Kim
  • Joshua P Thaler
  • Misato Saito
  • Marzena Grden
  • Francisco Perez-Vizcaino
  • Edward G Lynn
  • Jose P Palma-Nicolas
  • Giovanna Frazziano
  • Luciene Borges
  • Ji Il Kim
  • Diego Moncada
  • Michel M Murr
  • Todd E Fox
  • Celia A Sigua
  • Tatiana Ort
  • Alexandra Charruyer
  • Steven C Wu
  • Xian Zhang
  • Christina Moulakakis
  • Jae Il Park
  • Avia Herschkovitz
  • Camille Ehre
  • Bhupinder P S Vohra
  • Ben B Yaspelkis
  • Donato A Rivas
  • Donald W Reeder
  • Li Zhong Liu
  • Hong Wang
  • Howard J Goldberg
  • Souvik Sarkar
  • Snezana Munk
  • Emmanuelle Sentex
  • Catharine I Whiteside
  • M Sawkat Anwer
  • Yonjung Kim
  • Janice Kwan
  • Conrad P Hodgkinson
  • Michael Leitges
  • Henry J Herr
  • Takashi Nishimura
  • J Ann Le Good
  • Katrin Büther
  • Marie McConkey
  • Y Kim
  • Klaus Moeschel
  • Carles Canto
  • Mark R Sommerfeld

Detail Information

Publications107 found, 100 shown here

  1. pmc Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta
    E Berra
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Madrid, Spain
    EMBO J 14:6157-63. 1995
    ..The importance of MEK/MAPK in the signalling mechanisms activated by zeta PKC was addressed by using the activation of a kappa B-dependent promoter as a biological read-out of zeta PKC...
  2. ncbi Arachidonic acid binds 14-3-3zeta, releases 14-3-3zeta from phosphorylated BAD and induces aggregation of 14-3-3zeta
    Thomas G Brock
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Neurochem Res 33:801-7. 2008
    ..If so, then factors that mediate the release, metabolism and reacylation of arachidonic acid into membranes represent key points of regulation...
  3. ncbi Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa B
    Pierre Olivier Esteve
    INRS Institut Armand Frappier, Universite du Quebec, Laval, Quebec H7V 1B7, Canada
    J Biol Chem 277:35150-5. 2002
    ..Taken together, these results indicate that PKC-zeta plays a key role in the regulation of MMP-9 expression in C6 glioma cells through NF-kappaB...
  4. ncbi PKC zeta enhances insulin-like growth factor 1-dependent mitogenic activity in the rat clonal beta cell line RIN 1046-38
    Anita M Hennige
    Department of Internal Medicine IV, University of Tubingen, Otfried Mueller Strasse 10, D 72076 Tubingen, Germany
    Biochem Biophys Res Commun 290:85-90. 2002
    ..Our data suggest that PKC zeta is involved in basal as well as IGF-1-dependent mitogenesis in RIN 1046-38 cells, while none of the PKC isoforms tested seem to be related to glucose-stimulated insulin release...
  5. ncbi Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1
    Klaus Moeschel
    Department of Internal Medicine IV, Endocrinology, Metabolism, Pathobiochemistry and Clinical Chemistry, University Hospital Tubingen, D 72076 Tubingen, Germany
    J Biol Chem 279:25157-63. 2004
    ..These results, generated in BHK(IR) cells, suggest that phosphorylation of Ser(318) by PKC-zeta might contribute to the inhibitory effect of prolonged hyperinsulinemia on IRS-1 function...
  6. ncbi Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance
    Avia Herschkovitz
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Faculty of Agricultural, Food, and Environmental Quality, The Hebrew University of Jerusalem, Rehovot, Israel
    J Biol Chem 282:18018-27. 2007
    ..These findings suggest that insulin-stimulated IRS kinases such as PKCzeta overlap with IRS kinases triggered by inducers of insulin resistance, such as IKKbeta, to phosphorylate IRS-1 on common Ser sites...
  7. pmc Protein kinase Czeta and glycogen synthase kinase-3beta control neuronal polarity in developing rodent enteric neurons, whereas SMAD specific E3 ubiquitin protein ligase 1 promotes neurite growth but does not influence polarity
    Bhupinder P S Vohra
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 27:9458-68. 2007
    ....
  8. ncbi The structure, expression, and properties of additional members of the protein kinase C family
    Y Ono
    Biotechnology Laboratories, Takeda Chemical Industries, Osaka, Japan
    J Biol Chem 263:6927-32. 1988
    ..Northern blot analysis suggests that the new members of protein kinase C exist in the brain and some other tissues...
  9. pmc Interaction of protein kinase C zeta with ZIP, a novel protein kinase C-binding protein
    A Puls
    Max Delbruck Laboratorium in der Max Planck Gesellschaft, Carl von Linne Weg 10, D 50829 Cologne, Germany
    Proc Natl Acad Sci U S A 94:6191-6. 1997
    ..Taking into account the recent isolation of ZIP by others in different contexts we propose that ZIP may function as a scaffold protein linking PKC-zeta to protein tyrosine kinases and cytokine receptors...
  10. ncbi Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta
    S Etienne-Manneville
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
    Cell 106:489-98. 2001
    ..Localized PKCzeta activity, acting through the microtubule motor protein dynein, is required for all aspects of induced polarity in these cells...
  11. ncbi Protein kinase Mzeta is necessary and sufficient for LTP maintenance
    Douglas S F Ling
    Department of Physiology, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, New York 11203, USA
    Nat Neurosci 5:295-6. 2002
  12. ncbi Protein kinase M zeta synthesis from a brain mRNA encoding an independent protein kinase C zeta catalytic domain. Implications for the molecular mechanism of memory
    A Ivan Hernandez
    Department of Physiology, State University of New York Downstate Medical Center, Brooklyn, 11203, USA
    J Biol Chem 278:40305-16. 2003
    ..Because PKM zeta is a kinase synthesized in an autonomously active form and is necessary and sufficient for maintaining LTP, it serves as an example of a link coupling gene expression directly to synaptic plasticity...
  13. ncbi Effect of hyperglycemia on signal transduction in skeletal muscle from diabetic Goto-Kakizaki rats
    Tatiana L Steiler
    Department of Physiology and Pharmacology, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
    Endocrinology 144:5259-67. 2003
    ..The long-term consequence of elevated PDK-1 and PKC phosphorylation/activity should be considered in the context of diabetes mellitus, as hyperglycemia is a clinical feature of this disease...
  14. ncbi KIBRA is a novel substrate for protein kinase Czeta
    Katrin Büther
    Department for Experimental Tumorbiology, University Muenster, Badestrasse 9, D 48149 Muenster, Germany
    Biochem Biophys Res Commun 317:703-7. 2004
    ..Our studies presented here revealed that KIBRA is a novel substrate for PKCzeta and suggest that PKCzeta phosphorylation may regulate the cellular function of KIBRA...
  15. ncbi Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term potentiation
    Peter Serrano
    Department of Physiology, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
    J Neurosci 25:1979-84. 2005
    ..An inactive scrambled version of the peptide had no effect on LTP. Thus, persistent, increased phosphorylation by PKMzeta specifically maintains the late phase of LTP...
  16. ncbi Role of protein kinase Czeta and its adaptor protein p62 in voltage-gated potassium channel modulation in pulmonary arteries
    Laura Moreno
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Mol Pharmacol 72:1301-9. 2007
    ..These observations identify PKCzeta and/or p62 as potential therapeutic targets for the treatment of pulmonary hypertension...
  17. ncbi Rapid erasure of long-term memory associations in the cortex by an inhibitor of PKM zeta
    Reut Shema
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Science 317:951-3. 2007
    ....
  18. pmc Protein kinase Mzeta maintains fear memory in the amygdala but not in the hippocampus
    Janine L Kwapis
    University of Wisconsin Milwaukee, Milwaukee, WI 53211, USA
    Behav Neurosci 123:844-50. 2009
    ..This suggests that PKMzeta may only maintain select forms of memory in specific brain structures and does not participate in a universal memory storage mechanism...
  19. doi PKMzeta maintains memories by regulating GluR2-dependent AMPA receptor trafficking
    Paola Virginia Migues
    Department of Psychology, McGill University, Montreal, Quebec, Canada
    Nat Neurosci 13:630-4. 2010
    ..Together, these findings indicate that PKMzeta maintains long-term memory by regulating the trafficking of GluR2-containing AMPA receptors, the postsynaptic expression of which directly predicts memory retention...
  20. doi Enhancement of consolidated long-term memory by overexpression of protein kinase Mzeta in the neocortex
    Reut Shema
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Science 331:1207-10. 2011
    ..Here, we report that overexpression in the rat neocortex of the protein kinase C isozyme protein kinase Mζ (PKMζ) enhances long-term memory, whereas a dominant negative PKMζ disrupts memory, even long after memory has been formed...
  21. pmc Specific involvement of atypical PKCζ/PKMζ in spinal persistent nociceptive processing following peripheral inflammation in rat
    Fabien Marchand
    Neurorestoration Group, Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London, SE1 1UL, UK
    Mol Pain 7:86. 2011
    ..Here we describe the role of a novel pathway involving atypical PKCζ/PKMζ in persistent spinal nociceptive processing, previously implicated in the maintenance of late-phase LTP...
  22. ncbi Synaptic tagging and cross-tagging: the role of protein kinase Mzeta in maintaining long-term potentiation but not long-term depression
    Sreedharan Sajikumar
    Department of Neurophysiology, Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
    J Neurosci 25:5750-6. 2005
    ..Thus, PKMzeta is the first LTP-specific PRP and is critical for the transformation of early into late LTP during both synaptic tagging and cross-tagging...
  23. pmc PKMzeta maintains spatial, instrumental, and classically conditioned long-term memories
    Peter Serrano
    Department of Physiology and Pharmacology, The Robert F Furchgott Center for Neural and Behavioral Science, State University of New York, Brooklyn, New York, USA
    PLoS Biol 6:2698-706. 2008
    ....
  24. ncbi Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin
    L V Ravichandran
    Cardiology Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:3543-9. 2001
    ....
  25. ncbi Modulation of delayed rectifier potassium channels by alpha1-adrenergic activation via protein kinase C zeta and p62 in PC12 cells
    Yonjung Kim
    Department of Physiology, Sungkyunkwan University School of Medicine, Suwon 440 746, South Korea
    Neurosci Lett 387:43-8. 2005
    ..These results suggest that locally secreted NE induces an increase in p62 expression, and also exerts a modulatory effect on Kv channels via the PKCzeta-p62-Kvbeta channel modulating complex...
  26. ncbi In high glucose protein kinase C-zeta activation is required for mesangial cell generation of reactive oxygen species
    Janice Kwan
    Banting and Best Diabetes Centre, University of Toronto, Toronto, Canada
    Kidney Int 68:2526-41. 2005
    ..To identify signaling mechanisms relevant to PKC-zeta activation and ROS generation, including phosphoinositide 3 kinase (PI3 kinase), we examined mesangial cell stimulation with platelet-derived growth factor (PDGF)...
  27. doi PKMzeta maintains 1-day- and 6-day-old long-term object location but not object identity memory in dorsal hippocampus
    Oliver Hardt
    Department of Psychology, McGill University, Montreal, Quebec, Canada
    Hippocampus 20:691-5. 2010
    ..These results suggest that the dorsal hippocampus mediates long-term memory for where, but not what things have been encountered, and that PKMzeta maintains this type of spatial knowledge as long as the memory exists...
  28. pmc Metaplasticity governs compartmentalization of synaptic tagging and capture through brain-derived neurotrophic factor (BDNF) and protein kinase Mzeta (PKMzeta)
    Sreedharan Sajikumar
    Division of Cellular Neurobiology, Zoological Institute, TU Braunschweig, D 38106 Braunschweig, Germany
    Proc Natl Acad Sci U S A 108:2551-6. 2011
    ..These clusters will then prepare the synaptic network to form long-term memories...
  29. pmc Hypoxia increases transepithelial electrical conductance and reduces occludin at the plasma membrane in alveolar epithelial cells via PKC-ζ and PP2A pathway
    Juan Carlos Caraballo
    University of Iowa, Internal Medicine Department, Division of Pulmonary, Critical Care and Occupation Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Lung Cell Mol Physiol 300:L569-78. 2011
    ..In summary, we show that superoxide, PKC-ζ, and PP2A are involved in the hypoxia-induced increase in G(t) and occludin reduction at the plasma membrane in AEC...
  30. pmc Activation of PKCzeta and PKMzeta in the nucleus accumbens core is necessary for the retrieval, consolidation and reconsolidation of drug memory
    Jose A Crespo
    Experimental Psychiatry Unit, Department of General Psychiatry and Social Psychiatry, Innsbruck Medical University, Innsbruck, Austria
    PLoS ONE 7:e30502. 2012
    ..Acquisition or extinction of drug-associated memory remained unaffected by PKCzeta- and PKMzeta inhibition...
  31. pmc The activation of the atypical PKC zeta in light-induced retinal degeneration and its involvement in L-DNase II control
    Imène Jaadane
    INSERM U1138, Centre de Recherches des Cordeliers, Universite Paris Descartes, Universite Pierre et Marie Curie, Paris, France
    J Cell Mol Med 19:1646-55. 2015
    ..These results highlight the role of PKC zeta in retinal physiology and show that this kinase can control caspase-independent pathways. ..
  32. pmc Higher protein kinase C ζ in fatty rat liver and its effect on insulin actions in primary hepatocytes
    Wei Chen
    Department of Nutrition, University of Tennessee at Knoxville, Knoxville, Tennessee, United States of America
    PLoS ONE 10:e0121890. 2015
    ..These data suggest that elevation of aPKC expression may contribute to the hepatic insulin resistance at gene expression level. ..
  33. pmc Overexpression of Protein Kinase Mζ in the Hippocampus Enhances Long-Term Potentiation and Long-Term Contextual But Not Cued Fear Memory in Rats
    Sven R M Schuette
    CNS Research and
    J Neurosci 36:4313-24. 2016
    ..In this study, using an overexpression strategy as opposed to an inhibitor-based approach, we demonstrate an important modulatory role of PKMζ in synaptic plasticity and selective memory processing...
  34. pmc zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro
    M T Diaz-Meco
    Centro de Biologia Molecular, CSIC UAM, Madrid, Spain
    EMBO J 13:2842-8. 1994
    ..However, neither MKK nor MAPK is responsible for the putative I kappa B phosphorylating activity. These data provide a decisive step towards understanding the functions of zeta PKC...
  35. ncbi Regulation of protein kinase C zeta by PI 3-kinase and PDK-1
    M M Chou
    University of Pennsylvania School of Medicine, Department of Cell and Developmental Biology, Philadelphia 19104, USA
    Curr Biol 8:1069-77. 1998
    ..We therefore investigated whether PDK-1 is the kinase that activates PKC zeta...
  36. ncbi Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein
    Kevin C Corbit
    Department of Neurobiology, Pharmacology and Physiology, and Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 278:13061-8. 2003
    ..Taken together, these results constitute the first model showing how phosphorylation by PKC relieves a key inhibitor of the Raf/MAP kinase signaling cascade and may represent a general mechanism for the regulation of MAP kinase pathways...
  37. pmc Differential effects of shear stress and cyclic strain on Sp1 phosphorylation by protein kinase Czeta modulates membrane type 1-matrix metalloproteinase in endothelial cells
    Ji Il Kim
    Department of Vascular Surgery, Yale University School of Medicine, New Haven, Connecticut, USA
    Endothelium 15:33-42. 2008
    ....
  38. doi Involvement of phosphatidylinositol-3 kinase/AKT/PKCzeta/lambda pathway in the effect of palmitate on glucose-induced insulin secretion
    Tatiane C A Nogueira
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo USP, Sao Paulo, Brazil
    Pancreas 37:309-15. 2008
    ..In the present study, a novel pathway by which palmitate potentiates glucose-induced insulin secretion by pancreatic beta cells was investigated...
  39. doi PKMzeta inactivation induces spatial familiarity
    Diego Moncada
    Facultad de Medicina, Instituto de Biologia Celular y Neurociencias, Universidad de Buenos Aires, Buenos Aires, Argentina
    Learn Mem 15:810-4. 2008
    ....
  40. pmc Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta
    Galina A Gusarova
    Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, 240 E Huron, McGaw M 300, Chicago, IL 60611, USA
    Mol Cell Biol 29:3455-64. 2009
    ..Accordingly, we provide the first evidence that hypoxia-generated mitochondrial ROS lead to the activation of the AMPK alpha1 isoform, which binds and directly phosphorylates PKC zeta at Thr410, thereby promoting Na,K-ATPase endocytosis...
  41. doi Role of PKCzeta translocation in the development of type 2 diabetes in rats following continuous glucose infusion
    Jing fang Zhang
    Department of Pathophysiology, Medical College, Wuhan University, Wuhan, Hubei, China
    Diabetes Metab Res Rev 26:59-70. 2010
    ..We investigated the molecular mechanisms of hyperglycaemia-induced insulin resistance and type 2 diabetes in rats receiving a continuous glucose infusion (GI)...
  42. doi The progesterone-responsive gene 14-3-3τ enhances the transcriptional activity of progesterone receptor in uterine cells
    Masanori Ito
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Mol Endocrinol 49:193-202. 2012
    ..Moreover, by luciferase reporter assay, we demonstrated that 14-3-3τ enhances the transcriptional activity of PR-B. Taken together, we propose that 14-3-3τ is a P(4)-responsive gene in uterine cells that modulates P(4) signaling...
  43. pmc Cellular and subcellular localization of PKMζ
    A Ivan Hernandez
    Department of Pathology, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
    Philos Trans R Soc Lond B Biol Sci 369:20130140. 2014
    ..The localization of PKMζ within postsynaptic densities and spines suggests sites where the kinase stores information during LTP maintenance and long-term memory. ..
  44. pmc Overexpression of PKMζ alters morphology and function of dendritic spines in cultured cortical neurons
    Shiri Ron
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Cereb Cortex 22:2519-28. 2012
    ..These results suggest that PKMζ is involved in regulation of dendritic spine structure and function, which may underlie its role in long-term synaptic and behavioral plasticity...
  45. doi Signal mechanisms underlying low-dose endothelial monocyte-activating polypeptide-II-induced opening of the blood-tumor barrier
    Zhen Li
    Department of Neurosurgery, Shengjing Hospital, China Medical University, Shenyang, Liaoning Province, 110004, People s Republic of China
    J Mol Neurosci 48:291-301. 2012
    ..However, PKC-ζ is involved in this process by other mechanisms...
  46. pmc Metabotropic actions of the volatile anaesthetic sevoflurane increase protein kinase M synthesis and induce immediate preconditioning protection of rat hippocampal slices
    Jun Wang
    Department of Anesthesiology, Box 6, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    J Physiol 590:4093-107. 2012
    ..This hyperpolarization delays and attenuates the hypoxic depolarization, improving the recovery of neurons following hypoxia. Thus, sevoflurane acts via a metabotropic pathway to improve recovery following hypoxia...
  47. pmc Inhibition of protein kinase Mζ disrupts the stable spatial discharge of hippocampal place cells in a familiar environment
    Jeremy M Barry
    Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, USA
    J Neurosci 32:13753-62. 2012
    ....
  48. ncbi Identification of three additional members of rat protein kinase C family: delta-, epsilon- and zeta-subspecies
    Y Ono
    Biotechnology Laboratories, Takeda Chemical Industries, Osaka, Japan
    FEBS Lett 226:125-8. 1987
    ..The diverse heterogeneity of the enzyme seems to be an important factor in determining the mode of response of many tissues and cell types to a variety of external stimuli...
  49. pmc Identification of a brain-specific protein kinase C zeta pseudogene (psi PKC zeta) transcript
    J E Andrea
    MRC Group in Signal Transduction, University of Calgary, Alberta, Canada
    Biochem J 310:835-43. 1995
    ..75 kb mRNA in brain and heart, suggesting the existence of an additional PKC zeta-related species. This work, therefore, also emphasizes the importance of careful choice of oligonucleotide and cDNA probes to study PKC zeta mRNA...
  50. ncbi Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport
    M L Standaert
    J A Haley Veterans Hospital Research Service and Departments of Internal Medicine and Biochemistry Molecular Biology, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    J Biol Chem 272:30075-82. 1997
    ..Our findings suggest that insulin activates PKC-zeta through PI 3-kinase, and PKC-zeta may act as a downstream effector of PI 3-kinase and contribute to the activation of GLUT4 translocation...
  51. ncbi Selective changes in protein kinase C isoforms and phosphorylation of endogenous substrate proteins in rat cerebral cortex during pre- and postnatal ethanol exposure
    K Mahadev
    School of Life Sciences, University of Hyderabad, Hyderabad, 500 046, India
    Arch Biochem Biophys 356:249-57. 1998
    ....
  52. pmc Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein
    S Kuroda
    Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, 567 0047, Japan
    J Cell Biol 144:403-11. 1999
    ....
  53. ncbi Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2
    J Gong
    Department of Physiology, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Science 285:1565-9. 1999
    ..Finally, ZIP1 and ZIP2 coexist in the same cell type and are elevated differentially by neurotrophic factors. These results provide a mechanism for specificity and regulation of PKCzeta-targeted phosphorylation...
  54. ncbi Alteration of protein kinase C isoforms in the liver of septic rat
    Chin Hsu
    Department of Physiology, Kaohsiung Medical University, Taiwan, ROC
    Shock 17:41-6. 2002
    ..These results suggest that inactivation and the suppression of PKC-alpha gene transcription might be involved in modulating hepatic failure during sepsis...
  55. ncbi 1alpha,25(OH)2D3 regulates chondrocyte matrix vesicle protein kinase C (PKC) directly via G-protein-dependent mechanisms and indirectly via incorporation of PKC during matrix vesicle biogenesis
    Zvi Schwartz
    Hebrew University, Jerusalem 91120, Israel
    J Biol Chem 277:11828-37. 2002
    ....
  56. ncbi Protein kinase C-zeta phosphorylates insulin-responsive aminopeptidase in vitro at Ser-80 and Ser-91
    Jiwon Ryu
    Department of Physiology and Biophysical Sciences, The Biophysics Laboratory, Veterans Administration Medical Center, State University of New York School of Medicine, Buffalo, NY 14215, USA
    Arch Biochem Biophys 403:71-82. 2002
    ..These findings are consistent with the possibility that the IRAP cytoplasmic domain phosphorylation by PKC-zeta plays a key role in insulin-induced IRAP or GLUT4 recruitment in adipocytes...
  57. ncbi Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3
    Young Bum Kim
    Diabetes Unit, Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 277:32915-22. 2002
    ....
  58. ncbi ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2
    Cristina Croci
    Emil Fischer Zentrum, Institut fur Biochemie, Friedrich Alexander Universitat Erlangen Nurnberg, Fahrstrasse 17, 91054 Erlangen, Germany
    J Biol Chem 278:6128-35. 2003
    ..Subcellular co-expression of ZIP3 binding partners in the retina supported the proposed protein interactions. Our results indicate the formation of a ternary postsynaptic complex containing PKC-zeta, ZIP3, and GABA(C) receptors...
  59. pmc Angiotensin II AT1 receptor stimulates Na+ -K+ATPase activity through a pathway involving PKC-zeta in rat thyroid cells
    S Marsigliante
    Laboratorio di Fisiologia, Dipartimento di Scienze e Tecnologie Biologiche e Ambientali, Universita di Lecce, Ecotekne, via Prov le per Monteroni, 73100 Lecce, Italy
    J Physiol 546:461-70. 2003
    ....
  60. ncbi Distinct protein kinase C isoforms mediate regulation of vascular endothelial growth factor expression by A2A adenosine receptor activation and phorbol esters in pheochromocytoma PC12 cells
    Alicia M Gardner
    Department of Pharmacology and Cell Biophysics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0575, USA
    J Biol Chem 278:15421-8. 2003
    ..Together, the findings suggest that phorbol ester-induced down-regulation of VEGF mRNA occurs as a result of a reduction of PKCepsilon activity, whereas that mediated by the A(2A)AR occurs following deactivation of PKCzeta...
  61. ncbi Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins
    Trond Lamark
    Biochemistry Department, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    J Biol Chem 278:34568-81. 2003
    ..An interaction between the cell polarity scaffold protein Par6 and MEK5 was found. Furthermore, p62 interacts both with MEK5 and NBR1 in addition to the aPKCs. Evidence for involvement of p62 in MEK5-ERK5 signaling is presented...
  62. ncbi Correlations between protein kinase C zeta signaling and morphological modifications during rat heart development and aging
    L Centurione
    Dipartimento di Biomorfologia, Universita G D Annunzio, Via dei Vestini, 6, 66100 Chieti, Italy
    Mech Ageing Dev 124:957-66. 2003
    ..Further, we underline that in the aged heart, where this pathway is not activated, such balance is not maintained...
  63. ncbi Osteopontin inhibits interleukin-1beta-stimulated increases in matrix metalloproteinase activity in adult rat cardiac fibroblasts: role of protein kinase C-zeta
    Zhonglin Xie
    Department of Physiology, James H Quillen College of Medicine, James H Quillen Veterans Affairs Medical Center, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Biol Chem 278:48546-52. 2003
    ..Thus, OPN may play a key role in collagen deposition during myocardial remodeling following MI by modulating cytokine-stimulated MMP activity...
  64. pmc Molecular mechanisms regulating protein kinase Czeta turnover and cellular transformation
    J Ann Le Good
    Signal Transduction Research Group and Department of Biochemistry, University of Alberta, 357 Heritage Medical Research Centre, Edmonton, Alberta T6G 2S2, Canada
    Biochem J 378:83-92. 2004
    ....
  65. ncbi Modulation of delayed rectifier potassium channel by protein kinase C zeta-containing signaling complex in pheochromocytoma cells
    Y Kim
    Department of Physiology, Sungkyunkwan University School of Medicine, Suwon 440 746, South Korea
    Neuroscience 125:359-68. 2004
    ..These results suggest that the increased p62 protein induces the formation of the signaling complexes, enabling PKC zeta to modulate Kv channels. Thus, this may constitute a new way of modulating Kv channel activities...
  66. pmc Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking
    Conrad P Hodgkinson
    School of Biological Sciences, University of Southampton, Biomedical Sciences Building, Bassett Crescent East, Southampton SO16 7PX, UK
    Biochem J 388:785-93. 2005
    ..The results suggest a model whereby insulin triggers the formation of a PKCzeta-80K-H-munc18c complex that enhances GLUT4 translocation to the plasma membrane...
  67. ncbi PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1
    Takashi Nishimura
    Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa, Nagoya, Aichi 466 8550, Japan
    Nat Cell Biol 7:270-7. 2005
    ..We propose that the PAR-6-PAR-3 complex mediates Cdc42-induced Rac activation by means of STEF/Tiam1, and that this process seems to be required for the establishment of neuronal polarity...
  68. pmc Protein kinase Czeta mediates insulin-induced glucose transport through actin remodeling in L6 muscle cells
    Li Zhong Liu
    Department of Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 100005 Beijing, China
    Mol Biol Cell 17:2322-30. 2006
    ..Together, these results suggest that PKCzeta mediates insulin effect on glucose transport through actin remodeling in muscle cells...
  69. ncbi Essential role of PKC-zeta in normal and angiotensin II-accelerated neointimal growth after vascular injury
    Jean Hugues Parmentier
    Dept of Pharmacology, Crowe Bldg, Rm 211, Univ of Tennessee, 874 Union Ave, Memphis, TN 38163, USA
    Am J Physiol Heart Circ Physiol 291:H1602-13. 2006
    ....
  70. ncbi Alterations in soleus muscle gene expression associated with a metabolic endpoint following exercise training by lean and obese Zucker rats
    Tatiana Ort
    CuraGen Corporation, Branford, Connecticut, USA
    Physiol Genomics 29:302-11. 2007
    ..These findings could guide the development of pharmaceutical "exercise mimetics" in the treatment of insulin-resistant, prediabetic, or Type 2 diabetic individuals...
  71. ncbi Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains
    Todd E Fox
    Department of Pharmacology College of Medicine, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    J Biol Chem 282:12450-7. 2007
    ..Taken together, these data demonstrate that structured membrane microdomains are necessary for ceramide-induced activation of PKC zeta and resultant diminished Akt activity, leading to vascular smooth muscle cell growth arrest...
  72. ncbi Activation of protein kinase Czeta mediates luteinizing hormone- or forskolin-induced NGFI-B expression in preovulatory granulosa cells of rat ovary
    Jae Il Park
    Hormone Research Center and School of Biological Sciences and Technology, Chonnam National University, Republic of Korea
    Mol Cell Endocrinol 270:79-86. 2007
    ..Our findings demonstrate that PKCzeta, which is activated by LH or forskolin, contributes to the induction of NGFI-B in granulosa cells of preovulatory follicles...
  73. ncbi Dishevelled promotes axon differentiation by regulating atypical protein kinase C
    Xian Zhang
    Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Nat Cell Biol 9:743-54. 2007
    ..The Wnt5a effect on axon differentiation was attenuated by downregulating Dvl or inhibiting aPKC. Thus, Dvl-aPKC interaction can promote axon differentiation mediated by the PAR3-PAR6-aPKC complex...
  74. ncbi Protein kinase C-zeta is critical in pancreatitis-induced apoptosis of Kupffer cells
    Yanhua Peng
    Department of Surgery, James A Haley Veterans Affairs Medical Center, University of South Florida Health Sciences Center, Tampa, FL, USA
    J Gastrointest Surg 11:1253-61. 2007
    ..The ability of Kupffer cells to autoregulate their stress response by upregulating their death receptor/ligand and key proapoptotic cell signaling systems warrants further investigation...
  75. pmc Protein kinase C zeta. A novel regulator of both phosphorylation and de-phosphorylation of cardiac sarcomeric proteins
    Steven C Wu
    Center for Cardiovascular Research, Department of Physiology and Biophysics, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60612, USA
    J Biol Chem 282:30691-8. 2007
    ..Our data demonstrate that PKCzeta is a novel regulator of myofilament protein phosphorylation...
  76. ncbi nPKCepsilon, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells
    Camille Ehre
    CCystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599 7248, USA
    Am J Physiol Cell Physiol 293:C1445-54. 2007
    ..The translocation of nPKCdelta observed in activated cells is likely not related to mucin secretion but to some other aspect of goblet cell biology...
  77. ncbi In vitro evidence of the role of hemoglobin during vasospasm on the modifications of the expression of PKCalpha and zeta
    Florence Lefranc
    Department of Neurosurgery, Erasme University Hospital, Brussels, Belgium
    Int J Mol Med 20:415-9. 2007
    ..Our results encourage the prophylactic use of specific PKC isoform antagonists associated with calcium channel blockers early after SAH to prevent cerebral vasospasm...
  78. ncbi Surfactant protein A activation of atypical protein kinase C zeta in IkappaB-alpha-dependent anti-inflammatory immune regulation
    Christina Moulakakis
    Department of Immunochemistry and Biochemical Microbiology, Division of Cellular Pneumology, Research Center Borstel, Leibniz Center for Medicine and Bioscience, Borstel, Germany
    J Immunol 179:4480-91. 2007
    ....
  79. ncbi Protein kinase C-zeta (PKC-zeta) regulates Kupffer cell apoptosis during experimental sepsis
    Yanhua Peng
    Department of Surgery, James A Haley Veterans Affairs Medical Center, University of South Florida Health Sciences Center, C O Tampa General Hospital, Tampa, FL 33601, USA
    J Gastrointest Surg 11:1712-21. 2007
    ..Kupffer cells play an important role in sepsis-mediated liver injury. We tested the hypothesis that PKC-zeta plays a critical role in Kupffer cell apoptosis during sepsis...
  80. doi PKC isoenzymes differentially modulate the effect of thrombin on MAPK-dependent RPE proliferation
    Jose P Palma-Nicolas
    Departamento de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico UNAM, Apartado Postal 70 253, Ciudad Universitaria, C P 04510, Mexico, D F, Mexico
    Biosci Rep 28:307-17. 2008
    ..The present study is the first report demonstrating directly thrombin-induced ERK phosphorylation in the RPE, and the involvement of atypical PKCzeta in this process...
  81. doi ARHGAP21 associates with FAK and PKCzeta and is redistributed after cardiac pressure overload
    Luciene Borges
    Department of Internal Medicine, Hematology and Hemotherapy Center, School of Medical Science, University of Campinas UNICAMP, Campinas, Sao Paulo 13083 970, Brazil
    Biochem Biophys Res Commun 374:641-6. 2008
    ..Additionally, PKCzeta is phosphorylated by mechanical stimuli. These results suggest that ARHGAP21 may act as a signaling or scaffold protein of FAK and PKCzeta signaling pathways, developing an important function during cardiac stress...
  82. pmc Activation of neutral sphingomyelinase is involved in acute hypoxic pulmonary vasoconstriction
    Angel Cogolludo
    Department of Pharmacology, School of Medicine, University Complutense of Madrid, 28040 Madrid, Spain
    Cardiovasc Res 82:296-302. 2009
    ..The mechanisms involved in hypoxic pulmonary vasoconstriction (HPV) are not yet fully defined. The aim of the study was to determine the role of protein kinase C zeta (PKCzeta) and neutral sphingomyelinase (nSMase) in HPV...
  83. pmc Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells
    Richard G Ruddell
    The Hepatic Fibrosis Group, Queensland Institute of Medical Research and the University of Queensland, P Royal Brisbane and Women s Hospital, Brisbane, Australia
    Hepatology 49:887-900. 2009
    ....
  84. doi Permissive action of protein kinase C-zeta in insulin-induced CD36- and GLUT4 translocation in cardiac myocytes
    Joost J F P Luiken
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, PO Box 616, NL 6200 MD Maastricht, The Netherlands
    J Endocrinol 201:199-209. 2009
    ..However, PKC-zeta is already fully active under basal conditions and not further activated by insulin, indicating that its role in insulin-stimulated uptake of both glucose and LCFA is permissive rather than regulatory...
  85. doi DHEA improves impaired activation of Akt and PKC zeta/lambda-GLUT4 pathway in skeletal muscle and improves hyperglycaemia in streptozotocin-induced diabetes rats
    K Sato
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Acta Physiol (Oxf) 197:217-25. 2009
    ..However, such an effect of DHEA in vivo remains unclear...
  86. doi Role of the atypical protein kinase Czeta in regulation of 5'-AMP-activated protein kinase in cardiac and skeletal muscle
    John R Ussher
    Cardiovascular Research Group, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    Am J Physiol Endocrinol Metab 297:E349-57. 2009
    ..We conclude that PKCzeta plays a very minor role in the regulation of AMPK in cardiac and skeletal muscle and may actually be a downstream target of AMPK in skeletal muscle...
  87. doi Src tyrosine kinase regulates angiotensin II-induced protein kinase Czeta activation and proliferation in vascular smooth muscle cells
    Li Li
    Department of Physiology and Pathophysiology, Peking University Health Science Center and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China
    Peptides 31:1159-64. 2010
    ..In conclusion, Src kinase plays an important role in AngII-elicited PKCzeta activation and the subsequent downstream signaling including ERK1/2 activation and VSMCs proliferation...
  88. pmc Temporary disruption of fear-potentiated startle following PKMζ inhibition in the amygdala
    Ryan G Parsons
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia, USA
    Nat Neurosci 14:295-6. 2011
    ..These results suggest that PKMζ inhibition does not erase memory, but temporarily disrupts expression of memory...
  89. pmc The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta
    Bertrand Cariou
    Departement d Endocrinologie, Institut Cochin, CNRS INSERM Université René Descartes 75674 Paris, France
    Mol Cell Biol 22:6959-70. 2002
    ..Together, these results suggest that Grb14, ZIP, and PKCzeta participate in a new feedback pathway of insulin signaling...
  90. ncbi Inhibitory effect of ceramide on insulin-induced protein kinase Czeta translocation in rat adipocytes
    Atsushi Miura
    Third Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Metabolism 52:19-24. 2003
    ..These results suggest that ceramide may induce insulin resistance via the suppression of IRS-1-PI3K signaling, and subsequent activation of PKCzeta...
  91. ncbi Neuregulin signaling on glucose transport in muscle cells
    Carles Canto
    Departament de Bioquímica i Biologia Molecular and Parc Científic de Barcelona, Universitat de Barcelona, Avda Diagonal 645, E 08028 Barcelona, Spain
    J Biol Chem 279:12260-8. 2004
    ..The PI3K, PDK1, and PKCzeta pathway can be considered as an alternative mechanism, independent of insulin, to induce glucose uptake...
  92. ncbi In vitro phosphorylation of insulin receptor substrate 1 by protein kinase C-zeta: functional analysis and identification of novel phosphorylation sites
    Mark R Sommerfeld
    Department of Clinical Biochemistry and Pathobiochemistry, German Diabetes Research Institute, Germany
    Biochemistry 43:5888-901. 2004
    ..Whereas Ser(612) appears not to participate in the negative control of insulin signaling, Ser(570) may at least partly contribute to this process...
  93. ncbi Tumor necrosis factor alpha and ceramide depolarise the resting membrane potential of thyroid FRTL-5 cells via a protein kinase Czeta-dependent regulation of K+ channels
    Cia Ramström
    Department of Biology, Abo Akademi University, BioCity, Artillerigatan 6, 20520, Turku, Finland
    Cell Signal 16:1417-24. 2004
    ..We conclude that TNFalpha and ceramide depolarise the RMP of thyroid FRTL-5 cells by attenuating a Ba(2+)- and acid-sensitive potassium conductance via activation of PKCzeta...
  94. pmc Insulin-stimulated plasma membrane association and activation of Akt2, aPKC zeta and aPKC lambda in high fat fed rodent skeletal muscle
    Henry J Herr
    Department of Kinesiology, California State University Northridge, 18111 Nordhoff Street, Northridge, CA 91330 8287, USA
    J Physiol 565:627-36. 2005
    ..In addition, high fat feeding impairs insulin-stimulated activation of total aPKC zeta/lambda and Akt2, as well as PM association and activation of aPKC zeta and lambda...
  95. ncbi ANG II stimulates phospholipase D through PKCzeta activation in VSMC: implications in adhesion, spreading, and hypertrophy
    Jean Hugues Parmentier
    Dept of Pharmacology, Crowe Bldg, The Univ of Tennessee Health Science Center, Memphis, TN 38163, USA
    Am J Physiol Heart Circ Physiol 290:H46-54. 2006
    ....
  96. ncbi PKCzeta is required for microtubule-based motility of vesicles containing the ntcp transporter
    Souvik Sarkar
    Marion Bessin Liver Research Center, Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Traffic 7:1078-91. 2006
    ..These data indicate that PKCzeta is required specifically for the intracellular movement of vesicles that contain the ntcp transporter...
  97. ncbi Expression of protein kinase C isoforms in cardiac hypertrophy and heart failure due to volume overload
    Emmanuelle Sentex
    Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre and Department of Physiology, Faculty of Medicine University of Manitoba, 351 Tache Avenue, Winnipeg, MB R2H 2A6, Canada
    Can J Physiol Pharmacol 84:227-38. 2006
    ..Our data suggest that an increase in PKC isoform content neither plays an important role during the development of cardiac hypertrophy nor participates in the phase leading to heart failure owing to volume overload...
  98. pmc PKCzeta protects against UV-C-induced apoptosis by inhibiting acid sphingomyelinase-dependent ceramide production
    Alexandra Charruyer
    INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, F 31300, France
    Biochem J 405:77-83. 2007
    ..These findings may have important consequences for UV-induced carcinogenesis and resistance to phototherapy...
  99. ncbi Reactive oxygen species, PKC-beta1, and PKC-zeta mediate high-glucose-induced vascular endothelial growth factor expression in mesangial cells
    Ling Xia
    University Health Network, University of Toronto, Toronto, ON, Canada
    Am J Physiol Endocrinol Metab 293:E1280-8. 2007
    ..Thus reactive oxygen species generated by NADPH oxidase, and both PKC-beta(1) and -zeta, play important roles in high-glucose-stimulated VEGF expression and secretion by mesangial cells...
  100. ncbi High glucose suppresses expression of equilibrative nucleoside transporter 1 (ENT1) in rat cardiac fibroblasts through a mechanism dependent on PKC-zeta and MAP kinases
    Marzena Grden
    Department of Molecular Medicine, Medical University of Gdansk, Gdansk, Poland
    J Cell Physiol 215:151-60. 2008
    ..These findings indicate that high glucose suppresses the expression of ENT1 in CFs by NO independent manner involving the signaling through PKC-zeta, Raf-1, MEK, and p38 MAPK pathways...
  101. pmc Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responses
    Joshua P Thaler
    Division of Metabolism, University of Washington, Seattle, Washington 98109, USA
    Endocrinology 150:5362-72. 2009
    ..We conclude that although hypothalamic aPKC signaling is not required for food intake inhibition by insulin or leptin, it plays a key role in inflammatory anorexia and fever induced by LPS...

Research Grants2

  1. Regulation of Nuclear Import/Export of 5-Lipoxygenase
    Thomas Brock; Fiscal Year: 2006
    ..This foundation can then be used to elucidate the ways these factors can change and give rise to the disease states that arise from abnormal 5-LO localization and LT synthesis. ..
  2. PROTEIN KINASE C AND PHOTORECEPTORS
    ALEXANDRA NEWTON; Fiscal Year: 2002
    ..Specifically, the effect of this phosphorylation on rhodopsin s macromolecular interactions (transducin coupling, arrestin binding) will be explored. ..