Prkcg

Summary

Gene Symbol: Prkcg
Description: protein kinase C, gamma
Alias: PKC, PKCI, Prkc, Prkcc, RATPKCI, PKC-gamma, protein kinase C gamma type, protein kinase C type I (gamma type)
Species: rat

Top Publications

  1. ncbi In vivo expression of classic PKC isoforms in the rat dental follicle as related to tooth eruption
    Shaomian Yao
    Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University Baton Rouge, Louisiana 70803, USA
    Connect Tissue Res 45:216-21. 2004
  2. doi Dual regulation of the cardiac L-type calcium channel in L6 cells by protein kinase C
    Bashir A Tafti
    Stanford University School of Medicine, Stanford, CA 94305, United States
    Cell Calcium 44:545-53. 2008
  3. ncbi Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation
    Susana Santos Correia
    Center for Neuroscience and Cell Biology and Department of Biochemistry, University of Coimbra, 3004 517 Coimbra, Portugal
    J Biol Chem 278:6307-13. 2003
  4. ncbi Prolonged Alzheimer-like tau hyperphosphorylation induced by simultaneous inhibition of phosphoinositol-3 kinase and protein kinase C in N2a cells
    Guo Gang Xu
    Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Acta Biochim Biophys Sin (Shanghai) 37:349-54. 2005
  5. ncbi alpha-Synuclein shares physical and functional homology with 14-3-3 proteins
    N Ostrerova
    Department of Pharmacology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Neurosci 19:5782-91. 1999
  6. ncbi A synthetic peptide derived from the non-structural protein 3 of hepatitis C virus serves as a specific substrate for PKC
    P Borowski
    Bernhard Nocht Institut fur Tropenmedizin, Hamburg, Germany
    Biol Chem 381:19-27. 2000
  7. ncbi Activation of annexin 7 by protein kinase C in vitro and in vivo
    H Caohuy
    Department of Anatomy and Cell Biology, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Biol Chem 276:12813-21. 2001
  8. ncbi Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S, and gamma 2L subunits of the gamma-aminobutyric acid type A receptor
    S J Moss
    Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Biol Chem 267:14470-6. 1992
  9. ncbi Insulin receptor-protein kinase C-gamma signaling mediates inhibition of hypoxia-induced necrosis of cortical neurons
    Wakako Hamabe
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Japan
    J Pharmacol Exp Ther 313:1027-34. 2005
  10. ncbi Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein
    Kevin C Corbit
    Department of Neurobiology, Pharmacology and Physiology, and Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 278:13061-8. 2003

Research Grants

Scientific Experts

  • Jun Li Cao
  • Marie W Wooten
  • Chol Seung Lim
  • Qi Wei Zhu
  • Paul Lampe
  • JACK YOUNGREN
  • Jiro Nakamura
  • John H Tinsley
  • H J Krugers
  • Margaret Westfall
  • ALEXANDRA NEWTON
  • Paul J Colombo
  • Shohei Matsumoto
  • Simona Neumann
  • Zhong Hui Liu
  • Feng shan Wang
  • Wangyuan Zou
  • David F Werner
  • Hong Mei Zhang
  • Rafeeq P H Ahmed
  • Miguel Romero
  • C Penna
  • P Borowski
  • Bashir A Tafti
  • Fernando A Crocenzi
  • Elizabeth B Rex
  • Toshihide Kashihara
  • Jing shu Zhang
  • Bhuvana Balasubramanian
  • A S Hughes
  • Yasuto Yamaguchi
  • Mikhail A Sovershaev
  • Stephanie M Pontier
  • Franca Codazzi
  • Guo Gang Xu
  • B Hamplova
  • Wakako Hamabe
  • Jennifer A Shumilla
  • M Al-Fayez
  • Grewo Lim
  • Amos C Hung
  • Andrew J Boyle
  • Shaomian Yao
  • Kevin C Corbit
  • Susana Santos Correia
  • Dong Hui Chen
  • Anna Sedelnikova
  • Zongbin Song
  • Xianquan Zhan
  • Maoyu Li
  • J M Vila
  • Qulian Guo
  • H Caohuy
  • D M Boesch
  • Fang Peng
  • Chang Liu
  • G Y Liao
  • Ning Lin
  • Yan Dong
  • J Alex Fetzer
  • Sandeep Kumar
  • Min Luo
  • Hugh E Criswell
  • Asha Suryanarayanan
  • Chris E Comerford
  • A Leslie Morrow
  • Qing Su
  • Muhammad Rizwan Afzal
  • Jiang Shujia
  • I D Fraser
  • Khawaja Husnain Haider
  • Muhammad Ashraf
  • D M Xiao
  • F Moro
  • B Mognetti
  • D Mancardi
  • Maria José Zarzuelo
  • Antonio Zarzuelo
  • F Tullio
  • D Gattullo
  • Juan Duarte
  • Francisco Perez-Vizcaino
  • Rosario Jimenez
  • Manuel Sanchez
  • M Heiland
  • Francisco O'Valle
  • G Alloatti
  • Rocío López-Sepúlveda
  • P Pagliaro
  • Basil M Hantash

Detail Information

Publications63

  1. ncbi In vivo expression of classic PKC isoforms in the rat dental follicle as related to tooth eruption
    Shaomian Yao
    Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University Baton Rouge, Louisiana 70803, USA
    Connect Tissue Res 45:216-21. 2004
    Activation of protein kinase C (PKC) can upregulate tooth eruption molecules such as osteoprotegerin (OPG) and vascular endothelial growth factor (VEGF)...
  2. doi Dual regulation of the cardiac L-type calcium channel in L6 cells by protein kinase C
    Bashir A Tafti
    Stanford University School of Medicine, Stanford, CA 94305, United States
    Cell Calcium 44:545-53. 2008
    The role of protein kinase C (PKC) in the regulation of cardiac L-type Ca(2+) channel activity (LCC) was investigated in L6 rat neonatal myoblasts...
  3. ncbi Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation
    Susana Santos Correia
    Center for Neuroscience and Cell Biology and Department of Biochemistry, University of Coimbra, 3004 517 Coimbra, Portugal
    J Biol Chem 278:6307-13. 2003
    ..b>PKC gamma was co-immunoprecipitated with GluR4 AMPA receptor subunit in rat cerebellum and in cultured chick retina cell ..
  4. ncbi Prolonged Alzheimer-like tau hyperphosphorylation induced by simultaneous inhibition of phosphoinositol-3 kinase and protein kinase C in N2a cells
    Guo Gang Xu
    Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Acta Biochim Biophys Sin (Shanghai) 37:349-54. 2005
    ..of wortmannin (inhibitor of phosphatidylinositol-3 kinase, PI3K) and GF109203X (inhibitor of protein kinase C, PKC) into the rat brain was found to induce spatial memory deficiency and enhance tau hyperphosphorylation in the ..
  5. ncbi alpha-Synuclein shares physical and functional homology with 14-3-3 proteins
    N Ostrerova
    Department of Pharmacology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Neurosci 19:5782-91. 1999
    ..The activity and binding profile of alpha-synuclein suggests that it might act as a protein chaperone and that accumulation of alpha-synuclein could contribute to cell death in neurodegenerative diseases...
  6. ncbi A synthetic peptide derived from the non-structural protein 3 of hepatitis C virus serves as a specific substrate for PKC
    P Borowski
    Bernhard Nocht Institut fur Tropenmedizin, Hamburg, Germany
    Biol Chem 381:19-27. 2000
    ..of the hepatitis C virus (HCV) polyprotein was found to be a selective substrate for protein kinase C (PKC)...
  7. ncbi Activation of annexin 7 by protein kinase C in vitro and in vivo
    H Caohuy
    Department of Anatomy and Cell Biology, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Biol Chem 276:12813-21. 2001
    ..These results thus lead us to hypothesize that annexin 7 may be a positive mediator for protein kinase C action in the exocytotic membrane fusion reaction in chromaffin cells...
  8. ncbi Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S, and gamma 2L subunits of the gamma-aminobutyric acid type A receptor
    S J Moss
    Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Biol Chem 267:14470-6. 1992
    ..coli to examine the phosphorylation of these subunits by cAMP-dependent protein kinase (PKA) and protein kinase C (PKC)...
  9. ncbi Insulin receptor-protein kinase C-gamma signaling mediates inhibition of hypoxia-induced necrosis of cortical neurons
    Wakako Hamabe
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Japan
    J Pharmacol Exp Ther 313:1027-34. 2005
    ..Furthermore, an inhibitor of protein kinase C (PKC) eliminated the insulin-induced antinecrotic effect...
  10. ncbi Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein
    Kevin C Corbit
    Department of Neurobiology, Pharmacology and Physiology, and Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 278:13061-8. 2003
    Protein kinase C (PKC) regulates activation of the Raf-1 signaling cascade by growth factors, but the mechanism by which this occurs has not been elucidated...
  11. doi Protein kinase C stimulates HuD-mediated mRNA stability and protein expression of neurotrophic factors and enhances dendritic maturation of hippocampal neurons in culture
    Chol Seung Lim
    Blanchette Rockefeller Neurosciences Institute at West Virginia University, Morgantown, WV 26505, USA
    Hippocampus 22:2303-19. 2012
    ..neuronal differentiation, and learning and memory, and is up-regulated and redistributed by a protein kinase C (PKC)-dependent pathway in neurons...
  12. ncbi Phosphorylation of the recombinant rho1 GABA receptor
    Anna Sedelnikova
    Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0021, USA
    Int J Dev Neurosci 20:237-46. 2002
    ..sites on the human rho1 GABA receptor for six protein kinases widely expressed in the brain: protein kinase C (PKC); cAMP-dependent protein kinase (PKA); calmodulin-dependent kinase (CaMKII); casein kinase (CKII); mitogen-..
  13. ncbi [Effects of lead exposure on protein kinase C and calmodulin expression in hippocampus and neurobehavioral function of baby rats]
    Feng shan Wang
    Department of Toxicology, Centers for Disease Control and Prevention, Tianjin 300011, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 26:139-42. 2008
    To observe the effect of chronic lead contaminant on mRNA expression of protein kinase C (PKC) and calmodulin (CaM) in hippocampus of baby rats.
  14. ncbi Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current
    G Y Liao
    Laboratory of Integrative Neuroscience, Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA
    Mol Pharmacol 59:960-4. 2001
    Protein kinase-C (PKC) activation differentially affects currents from N-methyl-D-aspartate (NMDA) type glutamate receptors depending upon their subunit composition...
  15. ncbi [Different roles of the spinal protein kinase C alpha and gamma in morphine dependence and naloxone-precipitated withdrawal]
    Jun Li Cao
    Department of Anesthesiology, Affiliated Hospital of First Clinical College, China Medical University, Shenyang 110001, China
    Sheng Li Xue Bao 57:161-8. 2005
    ..During morphine dependence, but not naloxone-precipitated withdrawal, PKC gamma in the spinal cord translocated from cytosol to membrane fraction, and intrathecal administration of CHE did not ..
  16. ncbi The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination
    Marie W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Alabama 36849, USA
    J Biol Chem 280:35625-9. 2005
    ..growth factor treatment of PC12 cells induced TRAF6 polyubiquitination along with formation of a p62-TRAF6-IKKbeta-PKC iota signal complex, while inhibition of the p62/TRAF6 interaction had an opposite effect...
  17. ncbi Role of two conserved cytoplasmic threonine residues (T410 and T412) in CD5 signaling
    J M Vila
    Servei d Immunologia, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    J Immunol 166:396-402. 2001
    ..These results strongly argue in favor of a role for T410 and T412 in the signaling mediated by CD5...
  18. pmc Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication
    P D Lampe
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Cell Biol 149:1503-12. 2000
    Phorbol esters (e.g., TPA) activate protein kinase C (PKC), increase connexin43 (Cx43) phosphorylation, and decrease cell-cell communication via gap junctions in many cell types...
  19. doi Identification of differentially expressed proteins in the spinal cord of neuropathic pain models with PKCgamma silence by proteomic analysis
    Wangyuan Zou
    Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
    Brain Res 1440:34-46. 2012
    In order to elucidate the mechanisms that PKCγ regulates neuropathic pain (NP), and detect proteins that are associated with the function of PKCγ in NP, we exploited a chronic constriction injury (CCI)-induced neuropathic pain rat (CCI-..
  20. ncbi [Effects of lead exposure on protein kinase C and calmodulin expression in hippocampus of baby-rats]
    Zhong Hui Liu
    School of Public Health, Tianjin Medical University, Tianjin 300070, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 26:465-7. 2008
    To observe the effect of chronic lead contaminant on protein expression of protein kinase (PKC) and calmodulin (CaM) in hippocampus of baby-rats.
  21. ncbi [Effect of pioglitazone on hypoxia/reoxygenation injury and protein kinase C expression in neonatal rat cardiomyocytes]
    Qi Wei Zhu
    Second Department of Geriatric Cardiology, General Hospital of PLA, Beijing 100853, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:1819-23. 2011
    To observe the effect of pioglitazone on hypoxia/reoxygenation injury and the expression of protein kinase C (PKC) in neonatal rat cardiomyocytes.
  22. ncbi Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C
    J Baudier
    Biochemistry 26:2886-93. 1987
    ..abstract truncated at 250 words)..
  23. doi Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC
    Miguel Romero
    Department of Pharmacology, School of Pharmacy, University of Granada, 18071 Granada, Spain
    Atherosclerosis 202:58-67. 2009
    ..and these effects were prevented by co-incubation with quercetin, isorhamnetin or chelerythrine (protein kinase C (PKC) inhibitor)...
  24. doi Neurochemical characterization of neuronal populations expressing protein kinase C gamma isoform in the spinal cord and gracile nucleus of the rat
    A S Hughes
    Department of Neuroscience, Institute of Molecular and Cellular Science, Bart s and The London School of Medicine and Dentistry, 4 Newark Street, London, UK
    Neuroscience 153:507-17. 2008
    ..As dorsal column nuclei cells may contribute to allodynia after peripheral nerve injury, pharmacological modulation of PKCgamma activity may therefore be a possible way to ameliorate neuropathic pain after peripheral nerve injury...
  25. doi Ethanol regulation of D(1) dopamine receptor signaling is mediated by protein kinase C in an isozyme-specific manner
    Elizabeth B Rex
    Molecular Neuropharmacology Section, National Institute on Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Neuropsychopharmacology 33:2900-11. 2008
    ..Protein kinase C (PKC) inhibitors mimic the effects of ethanol on D(1) receptor phosphorylation and dopamine-stimulated cAMP levels in a ..
  26. pmc Nonclassical mechanisms of progesterone action in the brain: I. Protein kinase C activation in the hypothalamus of female rats
    Bhuvana Balasubramanian
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Endocrinology 149:5509-17. 2008
    ..We explored the involvement of protein kinase C (PKC) in P-induced rapid signaling in the ventromedial nucleus of the hypothalamus (VMN) and preoptic area (POA) of the ..
  27. ncbi Regulation of insulin receptor function
    J F Youngren
    Mount Zion Medical Center, Diabetes and Endocrine Research, University of California at San Francisco, San Francisco, CA 94143 1616, USA
    Cell Mol Life Sci 64:873-91. 2007
    ..The impact of these processes on the conformational changes and phosphorylation events required for full signaling activity, as well as the role of these mechanisms in human disease, is reviewed in this article...
  28. ncbi Phosphorylation and up-regulation of diacylglycerol kinase gamma via its interaction with protein kinase C gamma
    Yasuto Yamaguchi
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    J Biol Chem 281:31627-37. 2006
    Diacylglycerol (DAG) acts as an allosteric activator of protein kinase C (PKC) and is converted to phosphatidic acid by DAG kinase (DGK). Therefore, DGK is thought to be a negative regulator of PKC activation...
  29. pmc Coordinated action of NSF and PKC regulates GABAB receptor signaling efficacy
    Stephanie M Pontier
    Département de Biochimie and Groupe de Recherche Universitaire sur le Médicament, Institut de Recherche en Immunologie et Cancérologie, Universite de Montreal, Montreal, QC, Canada
    EMBO J 25:2698-709. 2006
    ..Taken with the role of PKC in the desensitization process, our observation that TAT-Pep-27 prevented both agonist-promoted recruitment of PKC ..
  30. ncbi Preconditioning by 17beta-estradiol in isolated rat heart depends on PI3-K/PKB pathway, PKC, and ROS
    Mikhail A Sovershaev
    Dept of Biochemistry, Institute of Medical Biology, Faculty of Medicine, Univ of Tromsø, N 9037 Tromsø, Norway
    Am J Physiol Heart Circ Physiol 291:H1554-62. 2006
    ..To test the importance of phosphoinositide 3-kinase (PI3-K), protein kinase C (PKC), or reactive oxygen species (ROS) in E(2)-induced protection, we combined wortmannin (1 microM), chelerythrine (2 ..
  31. pmc Ca(2+)-dependent protein kinase C isoforms are critical to estradiol 17beta-D-glucuronide-induced cholestasis in the rat
    Fernando A Crocenzi
    Institute of Experimental Physiology, National University of Rosario, Rosario, Argentina
    Hepatology 48:1885-95. 2008
    ..The cPKC isoform PKCalpha, but not the Ca(2+)-independent PKC isoform, PKCepsilon, translocated to the plasma membrane after E(2)17G administration in primary cultured rat ..
  32. ncbi Distinct roles of protein kinase C isoforms in myogenic constriction of rat posterior cerebral arteries
    Toshihide Kashihara
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Japan
    J Pharmacol Sci 108:446-54. 2008
    The involvement of protein kinase C (PKC) in myogenic constriction at physiological intraluminal pressure was investigated in rat posterior cerebral arteries...
  33. doi Post-ischaemic activation of kinases in the pre-conditioning-like cardioprotective effect of the platelet-activating factor
    C Penna
    Laboratories of Physiology and Pharmacology, Department of Clinical and Biological Sciences, University of Torino, Torino, Italy
    Acta Physiol (Oxf) 197:175-85. 2009
    ..The actual protection of ischaemic pre-conditioning occurs in the reperfusion phase. Therefore, we studied in this phase the kinases involved in PAF-induced pre-conditioning...
  34. pmc Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers
    Simona Neumann
    Department of Anatomy and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 28:7936-44. 2008
    ....
  35. pmc Protein kinase C: poised to signal
    Alexandra C Newton
    Dept of Pharmacology, Univ of California at San Diego, La Jolla, 92093, USA
    Am J Physiol Endocrinol Metab 298:E395-402. 2010
    Nestled at the tip of a branch of the kinome, protein kinase C (PKC) family members are poised to transduce signals emanating from the cell surface...
  36. pmc Sonic Hedgehog gene delivery to the rodent heart promotes angiogenesis via iNOS/netrin-1/PKC pathway
    Rafeeq P H Ahmed
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 5:e8576. 2010
    ..stem cells (MSCs) with Sonic Hedgehog (Shh) transgene, a morphogen during embryonic development and embryonic and adult stem cell growth, improved their survival and angiogenic potential in the ischemic heart via iNOS/netrin/PKC pathway.
  37. pmc PKCγ is required for ethanol-induced increases in GABA(A) receptor α4 subunit expression in cultured cerebral cortical neurons
    David F Werner
    Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    J Neurochem 116:554-63. 2011
    ..Ethanol is known to increase both GABA(A) receptor α4 subunits and protein kinase C (PKC) isozymes in vivo and in vitro...
  38. doi PKC and MLCK-dependent, cytokine-induced rat coronary endothelial dysfunction
    John H Tinsley
    Department of Internal Medicine, Scott and White Hospital, Temple, Texas 76504, USA
    J Surg Res 152:76-83. 2009
    ..the most important, propagate the activation of a multitude of signaling pathways, such as the protein kinase C (PKC) and myosin light chain kinase (MLCK) pathways, which lead to deleterious changes in the structure and function of ..
  39. doi Effect of perinatal thyroid hormone deficiency on expression of rat hippocampal conventional protein kinase C isozymes
    Hong Mei Zhang
    Department of Endocrinology, Xin Hua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, People s Republic of China
    Mol Cell Biochem 353:65-71. 2011
    ..Protein kinase C (PKC) isoforms play an important role in many types of learning and memory, and deletion of specific PKC genes results ..
  40. ncbi Synergistic control of protein kinase Cgamma activity by ionotropic and metabotropic glutamate receptor inputs in hippocampal neurons
    Franca Codazzi
    Department of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, I 20132 Milano, Italy
    J Neurosci 26:3404-11. 2006
    Conventional protein kinase C (PKC) isoforms are abundant neuronal signaling proteins with important roles in regulating synaptic plasticity and other neuronal processes...
  41. ncbi Protein kinase C attenuates beta-adrenergic receptor-mediated lipolysis, probably through inhibition of the beta1-adrenergic receptor system
    Jiro Nakamura
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba shi, Ibaraki ken 305 8575, Japan
    Arch Biochem Biophys 447:1-10. 2006
    ..CGP 20712A abolished the lipolysis-attenuating effect of PMA, but ICI 118551 did not. The protein kinase C (PKC) inhibitors, GF 109203X or Gö 6976, suppressed the effect of PMA...
  42. ncbi Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling
    I D Fraser
    Howard Hughes Medical Institute, Vollum Institute L 474, Oregon Health Sciences University, Portland, 97201, USA
    Curr Biol 10:409-12. 2000
    ..the beta(2)-AR in cell and tissue extracts, nucleating a signaling complex that includes PKA, protein kinase C (PKC) and protein phosphatase PP2B...
  43. ncbi Phosphorylation of HMG-I by protein kinase C attenuates its binding affinity to the promoter regions of protein kinase C gamma and neurogranin/RC3 genes
    D M Xiao
    Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    J Neurochem 74:392-9. 2000
    ..DNA-binding protein that binds the AT-rich sequences within the promoters of the brain-specific protein kinase C (PKC) gamma and neurogranin/RC3 genes has been characterized as chromosomal nonhistone high-mobility-group protein (HMG)-..
  44. ncbi Characterisation of non-structural protein 3 of hepatitis C virus as modulator of protein phosphorylation mediated by PKA and PKC: evidences for action on the level of substrate and enzyme
    P Borowski
    Bernhard Nocht Institut fur Tropenmedizin, Abt Virologie, Hamburg, Federal Republic of Germany
    Arch Virol 144:687-701. 1999
    Generally, the maximum activities of the protein kinases A (PKA) and C (PKC) show an optimum value for their substrate concentrations rather than a saturation curve; at high substrate concentrations, the kinase activity is completely ..
  45. ncbi Selective changes in protein kinase C isoforms and phosphorylation of endogenous substrate proteins in rat cerebral cortex during pre- and postnatal ethanol exposure
    K Mahadev
    School of Life Sciences, University of Hyderabad, Hyderabad, 500 046, India
    Arch Biochem Biophys 356:249-57. 1998
    The effect of pre- and postnatal ethanol exposure on protein kinase C (PKC) activity, immunochemical analysis of PKC alpha, betaI, betaII, gamma, delta, epsilon, eta, and zeta by isoform-specific antibodies, and in vitro phosphorylation ..
  46. pmc Segregation of a PRKCG mutation in two RP11 families
    M Al-Maghtheh
    Am J Hum Genet 62:1248-52. 1998
  47. ncbi Molecular cloning and characterization of a novel protein kinase C-interacting protein with structural motifs related to RBCC family proteins
    C Tokunaga
    Biosignal Research Center, Faculty of Science, Kobe University, Japan
    Biochem Biophys Res Commun 244:353-9. 1998
    A novel protein kinase C (PKC)-interacting protein was identified by the yeast two-hybrid screening using the regulatory domain of PKC beta I as a bait...
  48. ncbi Exposure to chronic psychosocial stress and corticosterone in the rat: effects on spatial discrimination learning and hippocampal protein kinase Cgamma immunoreactivity
    H J Krugers
    Department of Biological Psychiatry, Graduate School for Behavioral and Cognitive Neurosciences, University of Groningen, The Netherlands
    Hippocampus 7:427-36. 1997
    ..The spatial learning deficits following stress are reflected only in part in the redistribution of hippocampal PKCgamma-ir following training...
  49. ncbi NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions
    R X Xu
    Glaxo Wellcome Research and Development, Research Triangle Park, North Carolina 27709, USA
    Biochemistry 36:10709-17. 1997
    Classical protein kinase C (PKC) family members are activated by the binding of various ligands to one of several cysteine-rich domains of the enzyme...
  50. ncbi Cloning and expression of multiple protein kinase C cDNAs
    J L Knopf
    Cell 46:491-502. 1986
    Three different protein kinase C related cDNA clones were isolated from a rat brain cDNA library and designated PKC-I, PKC-II, and PKC-III...
  51. pmc Nucleotide sequences of cDNAs for alpha and gamma subspecies of rat brain protein kinase C
    Y Ono
    Central Research Division, Takeda Chemical Industries, Osaka, Japan
    Nucleic Acids Res 16:5199-200. 1988
  52. ncbi Age-dependent activation of PKC isoforms by angiotensin II in the proximal nephron
    D M Boesch
    Division of Hypertension and Vascular Research, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202, USA
    Am J Physiol Regul Integr Comp Physiol 281:R861-7. 2001
    ..ANG II increases fluid absorption in the proximal nephron, in part, via activation of protein kinase C (PKC)...
  53. ncbi Individual differences in spatial memory among aged rats are related to hippocampal PKCgamma immunoreactivity
    Paul J Colombo
    Department of Psychology, Tulane University, New Orleans, Louisiana 70118, USA
    Hippocampus 12:285-9. 2002
    ..1997). In the current study, immunocytochemistry was used to test whether the relationship between elevated PKC-gamma and memory impairment among aged rats could be localized further within regions of the hippocampus...
  54. ncbi Deficits in the mid-brain raphe nuclei and striatum of the AS/AGU rat, a protein kinase C-gamma mutant
    M Al-Fayez
    Department of Anatomy, King Saud University, Kingdom of Saudi Arabia
    Eur J Neurosci 22:2792-8. 2005
    ..The median raphe appears to be unaffected. The results are seen in terms of an initial dysfunction in transmitter release leading to cell death, perhaps through the formation of free radicals or neurotoxins...
  55. ncbi Expression of spinal NMDA receptor and PKCgamma after chronic morphine is regulated by spinal glucocorticoid receptor
    Grewo Lim
    Pain Research Group, Division of Pain Medicine, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 25:11145-54. 2005
    Spinal NMDA receptor (NMDAR), protein kinase C (PKC), and glucocorticoid receptor (GR) have all been implicated in the mechanisms of morphine tolerance; however, how these cellular elements interact after chronic morphine exposure ..
  56. ncbi Differential contribution of troponin I phosphorylation sites to the endothelin-modulated contractile response
    Margaret V Westfall
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 280:41324-31. 2005
    ....
  57. ncbi Ethanol withdrawal-associated allodynia and hyperalgesia: age-dependent regulation by protein kinase C epsilon and gamma isoenzymes
    Jennifer A Shumilla
    Department of Anesthesiology, Stanford University School of Medicine, Stanford, CA, USA
    J Pain 6:535-49. 2005
    ..Protein kinase C (PKC) has been implicated in mediating pain responses...
  58. ncbi Protein kinase C activity and isoform expression during early postnatal development of rat myocardium
    B Hamplova
    Department of Animal Physiology, Faculty of Science, Charles University in Prague, Vinicna 7, 128 44 Prague 2, Czech Republic
    Cell Biochem Biophys 43:105-17. 2005
    Total protein kinase C (PKC) activity, its isoform expression, and concentration and fatty acid (FA) composition of diacylglycerol (DAG) were determined in the left ventricular myocardium of the rat during early postnatal development (d ..
  59. ncbi Roles of protein kinase C in regulation of P2X7 receptor-mediated calcium signalling of cultured type-2 astrocyte cell line, RBA-2
    Amos C Hung
    Institute of Neuroscience, College of Life Science, National Yang Ming University and Brain Research Center, Shi Pai, Taipei 112, Taiwan, ROC
    Cell Signal 17:1384-96. 2005
    The role of protein kinase C (PKC) on regulation of P2X(7) receptor-mediated Ca(2+) signalling was examined on RBA-2 astrocytes...
  60. ncbi Inhibition of protein kinase C reduces left ventricular fibrosis and dysfunction following myocardial infarction
    Andrew J Boyle
    Department of Medicine, St Vincent s Hospital, University of Melbourne, Melbourne, Princes Street, Fitzroy 3065, Vic, Australia
    J Mol Cell Cardiol 39:213-21. 2005
    ..One week post-MI, animals were randomized to receive the PKC-inhibitor, ruboxistaurin (LY333531) for 4 weeks, or no treatment...
  61. ncbi Protein kinase C-gamma and calcium/calmodulin-dependent protein kinase II-alpha are persistently translocated to cell membranes of the rat brain during and after middle cerebral artery occlusion
    Shohei Matsumoto
    Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, Lund University Hospital, Lund, Sweden
    J Cereb Blood Flow Metab 24:54-61. 2004
    The levels of protein kinase C-gamma (PKC-gamma ) and the calcium/calmodulin-dependent kinase II-alpha (CaMKII-alpha) were measured in crude synaptosomal (P2), particulate (P3), and cytosolic (S3) fractions of the neocortex of rats ..
  62. pmc Missense mutations in the regulatory domain of PKC gamma: a new mechanism for dominant nonepisodic cerebellar ataxia
    Dong Hui Chen
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA
    Am J Hum Genet 72:839-49. 2003
    ..4-qter. A particularly compelling candidate gene, PRKCG, encodes protein kinase C gamma (PKC gamma), a member of a family of serine/threonine kinases...
  63. ncbi Characterization of the 5'-flanking region of the rat protein kinase C gamma gene
    K H Chen
    Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 265:19961-5. 1990
    ..using HeLa cell nuclear extracts and chloramphenicol acetyltransferase assay by transfection of 293 cells with a PKC gamma-CAT fusion construct. Chloramphenicol acetyltransferase assay revealed that a fragment of about 0...

Research Grants55

  1. Proteomic Biomarkers of Health Behaviors
    Paul Lampe; Fiscal Year: 2005
    ..abstract_text> ..
  2. PHOSPHORYLATION OF GAP JUNCTION PROTEINS
    Paul Lampe; Fiscal Year: 2009
    ..We hypothesize that Cx43 phosphorylation changes are linked to these processes in a way that affects cellular function. ..
  3. PHOSPHORYLATION OF GAP JUNCTION PROTEINS
    Paul Lampe; Fiscal Year: 2000
    ....
  4. PHOSPHORYLATION OF GAP JUNCTION PROTEINS
    Paul Lampe; Fiscal Year: 2007
    ..We hypothesize that Cx43 phosphorylation changes are linked to these processes in a way that affects cellular function. ..
  5. PHOSPHORYLATION OF GAP JUNCTION PROTEINS
    Paul D Lampe; Fiscal Year: 2010
    ....
  6. PHOSPHORYLATION OF GAP JUNCTION PROTEINS
    Paul Lampe; Fiscal Year: 2005
    ..We plan to apply our knowledge of connexin phosphorylation and phosphorylation specific probes to the analysis of connexin status in wounded skin and the remodeling of gap junctions during heart disease. ..
  7. DAUs as IGF-1 Receptor Inhibitors in Breast Cancer
    JACK YOUNGREN; Fiscal Year: 2007
    ..other kinases, and characterize the biological effects of altering the specificity of DAUs for the IGF-1 R. Together these studies will result in the production of well-characterized DAU-based compounds for anti-cancer drug development. ..
  8. STRUCTURE, FUNCTION AND REGULATION OF PROTEIN KINASE C
    ALEXANDRA NEWTON; Fiscal Year: 2007
    ..of the proposed research is to understand the molecular mechanisms and biological function of protein kinase C (PKC)...
  9. Signal Termination by PHLPP, PH domain Leucine-rich repeat Protein Phosphatase
    ALEXANDRA NEWTON; Fiscal Year: 2007
    ....
  10. Phosphoinositide-dependent Kinase: Molecular mechanisms
    ALEXANDRA NEWTON; Fiscal Year: 2006
    ....
  11. Signal Termination by PHLPP, PH domain Leucine-rich repeat Protein Phosphatase
    Alexandra C Newton; Fiscal Year: 2010
    ....
  12. Signal Termination by PHLPP, PH domain Leucine-rich repeat Protein Phosphatase
    ALEXANDRA NEWTON; Fiscal Year: 2009
    ....
  13. Influence of Troponin I Phosphrylation by PKC on Contractile Function
    Margaret Westfall; Fiscal Year: 2009
    Protein kinase C (PKC) plays an important role in modulating cardiac contractile function...
  14. Influence of Troponin I Phosphrylation by PKC on Contractile Function
    Margaret V Westfall; Fiscal Year: 2010
    Protein kinase C (PKC) plays an important role in modulating cardiac contractile function...
  15. DAUs as IGF-1 Receptor Inhibitors in Breast Cancer
    Jack F Youngren; Fiscal Year: 2010
    ..Together these studies will result in the production of well-characterized DAU-based compounds for anti-cancer drug development. ..
  16. Signal Termination by PHLPP, PH domain Leucine-rich repeat Protein Phosphatase
    ALEXANDRA NEWTON; Fiscal Year: 2009
    ....
  17. STRUCTURE, FUNCTION AND REGULATION OF PROTEIN KINASE C
    ALEXANDRA NEWTON; Fiscal Year: 2007
    ..of the proposed research is to understand the molecular mechanisms and biological function of protein kinase C (PKC)...
  18. PKC Troponin I phosphorylation & contractile function
    Margaret Westfall; Fiscal Year: 2005
    ..isoform of troponin I (cTnI) in vitro is associated with enhanced contractile function during protein kinase C (PKC) activation in intact myocytes...
  19. STRUCTURE, FUNCTION AND REGULATION OF PROTEIN KINASE C
    ALEXANDRA NEWTON; Fiscal Year: 2002
    ....
  20. PROTEIN KINASE C AND PHOTORECEPTORS
    ALEXANDRA NEWTON; Fiscal Year: 2002
    ..Specifically, the effect of this phosphorylation on rhodopsin s macromolecular interactions (transducin coupling, arrestin binding) will be explored. ..