Prkce

Summary

Gene Symbol: Prkce
Description: protein kinase C, epsilon
Alias: Pkce, protein kinase C epsilon type, nPKC-epsilon
Species: rat

Top Publications

  1. doi Activation of epsilon protein kinase C-mediated anti-apoptosis is involved in rapid tolerance induced by electroacupuncture pretreatment through cannabinoid receptor type 1
    Qiang Wang
    Department of Anesthesiology, Fourth Military Medical University, Shaanxi Province, China
    Stroke 42:389-96. 2011
  2. ncbi Glutathione depletion induces apoptosis of rat hepatocytes through activation of protein kinase C novel isoforms and dependent increase in AP-1 nuclear binding
    C Domenicotti
    Department of Experimental Medicine, General Pathology Section, University of Genova, Genova, Italy
    Free Radic Biol Med 29:1280-90. 2000
  3. doi Skin immunosenescence: decreased receptor for activated C kinase-1 expression correlates with defective tumour necrosis factor-alpha production in epidermal cells
    E Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    Br J Dermatol 160:16-25. 2009
  4. ncbi Glucagon-like peptide 1 activates protein kinase C through Ca2+-dependent activation of phospholipase C in insulin-secreting cells
    Yuko Suzuki
    Department of Physiology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    J Biol Chem 281:28499-507. 2006
  5. ncbi The structure, expression, and properties of additional members of the protein kinase C family
    Y Ono
    Biotechnology Laboratories, Takeda Chemical Industries, Osaka, Japan
    J Biol Chem 263:6927-32. 1988
  6. ncbi State-dependent phosphorylation of epsilon-isozyme of protein kinase C in adult rat dorsal root ganglia after inflammation and nerve injury
    Yu Zhou
    Institute of Neurobiology, Fu Dan University, Shanghai, China
    J Neurochem 85:571-80. 2003
  7. pmc Cytochrome c oxidase subunit IV as a marker of protein kinase Cepsilon function in neonatal cardiac myocytes: implications for cytochrome c oxidase activity
    Mourad Ogbi
    Department of Pharmacology and Toxicology, School of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912 2300, USA
    Biochem J 382:923-32. 2004
  8. ncbi Cardioprotection mediated by urocortin is dependent on PKCepsilon activation
    K M Lawrence
    Medical Molecular Biology Unit, Institute of Child Health, University College, London, UK
    FASEB J 19:831-3. 2005
  9. ncbi Mitochondrial PKC epsilon and mitochondrial ATP-sensitive K+ channel copurify and coreconstitute to form a functioning signaling module in proteoliposomes
    Martin Jaburek
    Department of Biology, Portland State University, PO Box 751, Portland, Oregon 97207, USA
    Circ Res 99:878-83. 2006
  10. pmc Ischemic preconditioning via epsilon protein kinase C activation requires cyclooxygenase-2 activation in vitro
    E Kim
    Cerebral Vascular Disease Research Center, Department of Neurology and Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Neuroscience 145:931-41. 2007

Research Grants

Scientific Experts

Detail Information

Publications119 found, 100 shown here

  1. doi Activation of epsilon protein kinase C-mediated anti-apoptosis is involved in rapid tolerance induced by electroacupuncture pretreatment through cannabinoid receptor type 1
    Qiang Wang
    Department of Anesthesiology, Fourth Military Medical University, Shaanxi Province, China
    Stroke 42:389-96. 2011
    ....
  2. ncbi Glutathione depletion induces apoptosis of rat hepatocytes through activation of protein kinase C novel isoforms and dependent increase in AP-1 nuclear binding
    C Domenicotti
    Department of Experimental Medicine, General Pathology Section, University of Genova, Genova, Italy
    Free Radic Biol Med 29:1280-90. 2000
    ..Taken together, these findings indicate the existence of an apoptotic pathway dependent on glutathione depletion, which occurs through the up-regulation of novel PKCs and AP-1...
  3. doi Skin immunosenescence: decreased receptor for activated C kinase-1 expression correlates with defective tumour necrosis factor-alpha production in epidermal cells
    E Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    Br J Dermatol 160:16-25. 2009
    ..We have recently shown in immune cells that decreased expression of the receptor for activated C kinase (RACK)-1 underlies defective protein kinase C (PKC) activation and functional immune impairment with ageing...
  4. ncbi Glucagon-like peptide 1 activates protein kinase C through Ca2+-dependent activation of phospholipase C in insulin-secreting cells
    Yuko Suzuki
    Department of Physiology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    J Biol Chem 281:28499-507. 2006
    ..Thus, GLP-1 can activate PKCalpha and PKCepsilon, and these GLP-1-activated PKCs may contribute considerably to insulin secretion at a substimulatory concentration of glucose...
  5. ncbi The structure, expression, and properties of additional members of the protein kinase C family
    Y Ono
    Biotechnology Laboratories, Takeda Chemical Industries, Osaka, Japan
    J Biol Chem 263:6927-32. 1988
    ..Northern blot analysis suggests that the new members of protein kinase C exist in the brain and some other tissues...
  6. ncbi State-dependent phosphorylation of epsilon-isozyme of protein kinase C in adult rat dorsal root ganglia after inflammation and nerve injury
    Yu Zhou
    Institute of Neurobiology, Fu Dan University, Shanghai, China
    J Neurochem 85:571-80. 2003
    ..Inflammatory mediator-induced activation of PKCepsilon and subsequent sensitization of VR1 to noxious stimuli by PKCepsilon may be involved in nociceptor sensitization...
  7. pmc Cytochrome c oxidase subunit IV as a marker of protein kinase Cepsilon function in neonatal cardiac myocytes: implications for cytochrome c oxidase activity
    Mourad Ogbi
    Department of Pharmacology and Toxicology, School of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912 2300, USA
    Biochem J 382:923-32. 2004
    ..The in vitro phosphorylation of COIV reflects a novel approach for monitoring PKCepsilon function in NCMs. Furthermore, PKCepsilon probably interacts with COIV in NCM mitochondria to enhance electron-transport chain complex IV activity...
  8. ncbi Cardioprotection mediated by urocortin is dependent on PKCepsilon activation
    K M Lawrence
    Medical Molecular Biology Unit, Institute of Child Health, University College, London, UK
    FASEB J 19:831-3. 2005
    ..This loss of cardioprotection by Ucn was also seen in whole hearts from PKCepsilon knockout mice. These findings indicate that the cardioprotective effect of Ucn is dependent upon PKCepsilon...
  9. ncbi Mitochondrial PKC epsilon and mitochondrial ATP-sensitive K+ channel copurify and coreconstitute to form a functioning signaling module in proteoliposomes
    Martin Jaburek
    Department of Biology, Portland State University, PO Box 751, Portland, Oregon 97207, USA
    Circ Res 99:878-83. 2006
    ..In addition, the activating effect of PKC agonists was reversed by exogenous protein phosphatase 2A. These results demonstrate persistent, functional association of mitochondrial PKC epsilon and mitoK(ATP)...
  10. pmc Ischemic preconditioning via epsilon protein kinase C activation requires cyclooxygenase-2 activation in vitro
    E Kim
    Cerebral Vascular Disease Research Center, Department of Neurology and Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Neuroscience 145:931-41. 2007
    ..These results demonstrate a crucial role for the epsilonPKC-->ERK1/2-->COX-2 pathway in the induction of neuroprotection via ischemic preconditioning...
  11. pmc Ischemic preconditioning targets the respiration of synaptic mitochondria via protein kinase C epsilon
    Kunjan R Dave
    The Cerebral Vascular Disease Research Center, and The John T MacDonald Center for Medical Genetics, Leonard M Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Neurosci 28:4172-82. 2008
    ..We propose that, at 48 h of reperfusion after ischemic preconditioning, epsilonPKC is poised at synaptic mitochondria to respond to ischemia either by direct phosphorylation or activation of the epsilonPKC signaling pathway...
  12. pmc Intramitochondrial signaling: interactions among mitoKATP, PKCepsilon, ROS, and MPT
    Alexandre D T Costa
    Dept of Biology, Portland State Univ, PO Box 751, Portland, OR 97201 0751, USA
    Am J Physiol Heart Circ Physiol 295:H874-82. 2008
    ..This feedback pathway may be responsible for the lasting protective effect of preconditioning, colloquially known as the memory effect...
  13. pmc PKCepsilon-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons
    Chun Lei Cang
    Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, PR China
    Mol Pain 5:33. 2009
    ..Our previous results have proved the expression of SP receptor neurokinin-1 (NK-1) on DRG neurons and its interaction with transient receptor potential vanilloid 1 (TRPV1) receptor...
  14. pmc Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury
    Grant R Budas
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Cardiovasc Res 88:83-92. 2010
    ..Heat shock protein 90 (HSP90) is a cytoprotective protein chaperone that participates in mitochondrial import of a number of proteins. Here, we investigated the role of HSP90 in mitochondrial import of PKCepsilon...
  15. doi Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting
    Tobias Deuse
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Circulation 122:S170-8. 2010
    ..protein kinase C (εPKC) is involved in vascular smooth muscle cell (VSMC) activation, but little is known about its function in vascular pathology. We aimed at assessing the role of εPKC in the development of restenosis...
  16. pmc Post-ischemic activation of protein kinase C ε protects the hippocampus from cerebral ischemic injury via alterations in cerebral blood flow
    D Della-Morte
    Department of Neurology, University of Miami, Miami, FL 33101, USA
    Neurosci Lett 487:158-62. 2011
    ..Our results suggest that ɛPKC can protect the rat brain against ischemic damage by regulating CBF. Thus, ɛPKC may be one of the treatment modalities against ischemic injury...
  17. ncbi Protein-protein interaction of zinc finger LIM domains with protein kinase C
    S Kuroda
    Biosignal Research Center, Kobe University, Kobe 657, Japan
    J Biol Chem 271:31029-32. 1996
    ..These results suggest that the LIM domain is one of the targets of PKC and that the LIM-PKC interaction may shed light on undefined roles of LIM domain-containing proteins...
  18. ncbi Cross-regulation of novel protein kinase C (PKC) isoform function in cardiomyocytes. Role of PKC epsilon in activation loop phosphorylations and PKC delta in hydrophobic motif phosphorylations
    Vitalyi O Rybin
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:14555-64. 2003
    ....
  19. pmc Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy
    Ranjana Arya
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599, USA
    J Cell Biol 167:1147-59. 2004
    ..These findings establish that MURF1 is a key regulator of the PKC-dependent hypertrophic response and can blunt cardiomyocyte hypertrophy, which may have important implications in the pathophysiology of clinical cardiac hypertrophy...
  20. pmc Protein kinase Cepsilon interacts with cytochrome c oxidase subunit IV and enhances cytochrome c oxidase activity in neonatal cardiac myocyte preconditioning
    Mourad Ogbi
    Department of Pharmacology and Toxicology, School of Medicine and the Program in Regenerative Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912 2300, USA
    Biochem J 393:191-9. 2006
    ..We therefore propose novel mechanisms of PKCepsilon-mediated PC involving enhanced energetics, decreased mitochondrial reactive oxygen species production and the preservation of COIV levels...
  21. ncbi Activation of focal adhesion kinase by protein kinase C epsilon in neonatal rat ventricular myocytes
    Maria C Heidkamp
    The Cardiovascular Institute, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA
    Am J Physiol Heart Circ Physiol 285:H1684-96. 2003
    ..We conclude that the ET-induced signal transduction pathway resulting in downstream Y397pFAK is partially dependent on PKC epsilon, ROCK, cofilin, and assembled actin filaments, but not ERK1/2 or Src...
  22. pmc Activation of protein kinase C triggers its ubiquitination and degradation
    Z Lu
    Department of Biological Sciences, Hunter College and the Graduate School of the City University of New York, New York 10021, USA
    Mol Cell Biol 18:839-45. 1998
    ..Moreover, a kinase-dead ATP-binding mutant of PKC alpha could not be depleted by TPA treatment. These data are consistent with a suicide model whereby activation of PKC triggers its own degradation via the ubiquitin-proteasome pathway...
  23. ncbi Selective changes in protein kinase C isoforms and phosphorylation of endogenous substrate proteins in rat cerebral cortex during pre- and postnatal ethanol exposure
    K Mahadev
    School of Life Sciences, University of Hyderabad, Hyderabad, 500 046, India
    Arch Biochem Biophys 356:249-57. 1998
    ....
  24. ncbi Ca2+-dependent protein kinase C isoforms induce cholestasis in rat liver
    Ralf Kubitz
    Department of Gastroenterology, Hepatology, and Infectiology, Heinrich Heine University, D 40225 Dusseldorf, Germany
    J Biol Chem 279:10323-30. 2004
    ..The data identify Ca(2+)-dependent PKC isoforms as inducers of cholestasis. This is mainly due to inhibition of taurocholate excretion involving transporter retrieval from the canalicular membrane...
  25. ncbi Restoration of resting sarcomere length after uniaxial static strain is regulated by protein kinase Cepsilon and focal adhesion kinase
    Haytham Mansour
    Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA
    Circ Res 94:642-9. 2004
    ..In conclusion, using our novel culture system, we provide evidence indicating that the length remodeling process requires new protein synthesis, PKCepsilon and FAK...
  26. ncbi Lipid raft disruption triggers protein kinase C and Src-dependent protein kinase D activation and Kidins220 phosphorylation in neuronal cells
    Noemi Cabrera-Poch
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid CSIC UAM, c Arturo Duperier 4, 28029 Madrid, Spain
    J Biol Chem 279:28592-602. 2004
    ..Collectively, these results reveal the importance of lipid rafts on PKD activation, translocation, and downstream signaling to its substrate Kidins220...
  27. ncbi Preconditioning by 17beta-estradiol in isolated rat heart depends on PI3-K/PKB pathway, PKC, and ROS
    Mikhail A Sovershaev
    Dept of Biochemistry, Institute of Medical Biology, Faculty of Medicine, Univ of Tromsø, N 9037 Tromsø, Norway
    Am J Physiol Heart Circ Physiol 291:H1554-62. 2006
    ..Therefore, our data demonstrate the ability of E(2) to induce preconditioning-like cardioprotection via cell signaling events shared by classic ischemic preconditioning...
  28. ncbi Protein kinase C-dependent enhancement of activity of rat brain NCKX2 heterologously expressed in HEK293 cells
    Ju Young Lee
    National Research Laboratory for Cell Physiology, Department of Physiology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Ku, Seoul 110 799, South Korea
    J Biol Chem 281:39205-16. 2006
    ..These findings suggest that PKC-mediated activation of NCKX2 is sensitive to mutation of multiple PKC consensus sites via a mechanism that may involve several phosphorylation events...
  29. ncbi Identification of a PKCepsilon-dependent regulation of myocardial contraction by epicatechin-3-gallate
    Daxiang Li
    Department of Physiology and Pharmacology, Health Science Campus, University of Toledo, 3000 Arlington Avenue, Toledo, OH 43614 2598, USA
    Am J Physiol Heart Circ Physiol 294:H345-53. 2008
    ..Together, these findings indicate that ECG can regulate myocardial contractility via a novel PKCepsilon-dependent signaling pathway...
  30. pmc Muscle inflammation induces a protein kinase Cepsilon-dependent chronic-latent muscle pain
    Olayinka A Dina
    Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, California 94143, USA
    J Pain 9:457-62. 2008
    ....
  31. doi Adenosine A(1) receptors selectively target protein kinase C isoforms to the caveolin-rich plasma membrane in cardiac myocytes
    Zhaogang Yang
    Division of Pharmacology, College of Pharmacy, The Ohio State University, 530 Parks Hall, 500 West 12th Avenue, Columbus, OH 43210, USA
    Biochim Biophys Acta 1793:1868-75. 2009
    ..In conclusion, we demonstrate that activation of adenosine A1 receptors promotes the selective translocation of PKCvarepsilon and PKCdelta to the caveolin-enriched plasma membrane microdomains in cardiac myocytes...
  32. ncbi [Effect of thyroid hormone on protein kinase C signal pathway in cardiac myocytes and fibroblasts of rats in vitro]
    Bao Hua Wang
    Department of Pathophysiology, Medical College of Wuhan University, Wuhan 430071, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 20:38-41. 2004
    ..To study the effect of thyroid hormone on protein kinase C activity and isoprotein expressions in cardiac myocytes and fibroblasts of rats in vitro...
  33. pmc Hypoxia-derived oxidative stress mediates epigenetic repression of PKCε gene in foetal rat hearts
    Andrew J Patterson
    Division of Pharmacology, Department of Basic Sciences, Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Cardiovasc Res 93:302-10. 2012
    ..We tested the hypothesis that hypoxia inducible factor 1 (HIF-1) and/or reactive oxygen species (ROS) mediate hypoxia-induced PKCε gene repression...
  34. doi Molecular mechanism underlying adenosine receptor-mediated mitochondrial targeting of protein kinase C
    Zhaogang Yang
    College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Biochim Biophys Acta 1823:950-8. 2012
    ..These results point out a novel mechanism in regulating PKC in mitochondria and suggest an important implication in ischemic preconditioning or postconditioning...
  35. pmc Apolipoprotein E3 (ApoE3) but not ApoE4 protects against synaptic loss through increased expression of protein kinase C epsilon
    Abhik Sen
    Blanchette Rockefeller Neurosciences Institute, Morgantown, West Virginia 26505, USA
    J Biol Chem 287:15947-58. 2012
    ..This apoE pathway may account for much of the protective effect of apoE and reduced risk for the age-dependent form of AD. This finding supports the potential efficacy of newly developed therapeutics for AD...
  36. pmc Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase C(epsilon) regulates Ras/mitogen-activated protein kinase signaling and neuronal differentiation
    Ana Lonic
    Cell Growth and Differentiation Laboratory, Division of Human Immunology, South Australian Pathology, Adelaide, South Australia 5000, Australia
    J Biol Chem 288:14874-85. 2013
    ..Our findings show that in addition to FGFR tyrosine phosphorylation, the phosphorylation of a conserved serine residue, Ser(779), can quantitatively control Ras/MAPK signaling to promote specific cellular responses...
  37. pmc Protein kinase C epsilon regulates mitochondrial pools of Nampt and NAD following resveratrol and ischemic preconditioning in the rat cortex
    Kahlilia C Morris-Blanco
    1 Cerebral Vascular Disease Research Laboratories, University of Miami Miller School of Medicine, Miami, Florida, USA 2 Neuroscience Program, University of Miami Miller School of Medicine, Miami, Florida, USA 3 Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Cereb Blood Flow Metab 34:1024-32. 2014
    ..These findings indicate that PKCɛ is critical to increase or maintain mitochondrial Nampt and NAD after pathways of ischemic neuroprotection in the brain. ..
  38. doi Novel functional role of heat shock protein 90 in protein kinase C-mediated ischemic postconditioning
    Guo Qiang Zhong
    Department of Geriatric Cardiology, First Affiliated Hospital, Guang Xi Medical University, Nanning, China Department of Cardiology, First Affiliated Hospital, Guang Xi Medical University, Nanning, China Electronic address
    J Surg Res 189:198-206. 2014
    ..The present study was designed to explore whether HSP90 might be responsible for cardioprotection in ischemic postconditioning (PostC)...
  39. pmc Orexin A inhibits propofol-induced neurite retraction by a phospholipase D/protein kinase Cε-dependent mechanism in neurons
    Karin Björnström
    Department of Medical and Health Sciences, Division of Anaesthesiology, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden Clinic of Anaesthesiology, Östergötland County Council UHL, Linkoping, Sweden
    PLoS ONE 9:e97129. 2014
    ..Orexin A (OA) is an endogenous neuropeptide regulating wakefulness and may counterbalance anaesthesia. We aim to investigate if OA interacts with anaesthetics by inhibition of the propofol-induced neurite retraction...
  40. doi Cyclosporine-A mimicked the ischemic pre- and postconditioning-mediated cardioprotection in hypertensive rats: Role of PKCε
    Luisa Fernanda González Arbeláez
    Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Argentina Electronic address
    Exp Mol Pathol 100:266-75. 2016
    ..These data show that, in SHR, the CsA treatment mimicked and reinforced the cardioprotective action afforded by IP and IPC in which PKCε-mediated attenuation of mitochondrial permeability appears as the main mechanism involved...
  41. doi Role of FAT/CD36 in novel PKC isoform activation in heart of spontaneously hypertensive rats
    Martina J Klevstig
    Department of Cell Biology, Charles University, Vinicna 7, 12843 Prague, Czech Republic
    Mol Cell Biochem 357:163-9. 2011
    ..These results demonstrate that reduced insulin resistance in SHR-4 rats with wild-type FAT/CD36 is associated with the insulin signaling pathway involving nPKCs...
  42. doi Danshen-Gegen decoction protects against hypoxia/reoxygenation-induced apoptosis by inhibiting mitochondrial permeability transition via the redox-sensitive ERK/Nrf2 and PKCε/mKATP pathways in H9c2 cardiomyocytes
    Po Yee Chiu
    Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, China
    Phytomedicine 19:99-110. 2012
    ....
  43. pmc Aldehyde dehydrogenase type 2 activation by adenosine and histamine inhibits ischemic norepinephrine release in cardiac sympathetic neurons: mediation by protein kinase Cε
    Pablo A Robador
    Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA
    J Pharmacol Exp Ther 343:97-105. 2012
    ....
  44. pmc Promoter methylation of Egr-1 site contributes to fetal hypoxia-mediated PKCε gene repression in the developing heart
    Man Chen
    Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Regul Integr Comp Physiol 304:R683-9. 2013
    ....
  45. pmc Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family
    G M Housey
    Proc Natl Acad Sci U S A 84:1065-9. 1987
    ..These and additional results provide evidence that the gene encoding protein kinase C is a member of a novel serine/threonine protein kinase multigene family...
  46. ncbi Identification of three additional members of rat protein kinase C family: delta-, epsilon- and zeta-subspecies
    Y Ono
    Biotechnology Laboratories, Takeda Chemical Industries, Osaka, Japan
    FEBS Lett 226:125-8. 1987
    ..The diverse heterogeneity of the enzyme seems to be an important factor in determining the mode of response of many tissues and cell types to a variety of external stimuli...
  47. ncbi Molecular cloning and characterization of a novel protein kinase C-interacting protein with structural motifs related to RBCC family proteins
    C Tokunaga
    Biosignal Research Center, Faculty of Science, Kobe University, Japan
    Biochem Biophys Res Commun 244:353-9. 1998
    ..These results suggest that RBCK1 protein might be a transcription factor that has a role in the signaling pathway through PKC...
  48. pmc Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein
    S Kuroda
    Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, 567 0047, Japan
    J Cell Biol 144:403-11. 1999
    ....
  49. ncbi Possible involvement of PKC isoforms in signalling placental apoptosis in intrauterine growth retardation
    M C Sugden
    Department of Diabetes and Metabolic Medicine, Division of General and Developmental Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary, University of London, London E1 4NS, UK
    Mol Cell Endocrinol 185:119-26. 2001
    ....
  50. ncbi Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor
    Yuji Saito
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 277:23216-22. 2002
    ..Because PDGF-mediated ERK activation is enhanced in Chinese hamster ovary cells that overexpress Gab1, Gab1 serves as an important link between PKC and ERK activation by PDGFbeta receptors in VSMC...
  51. pmc Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-epsilon and -delta
    Karen M Ridge
    Pulmonary and Critical Care Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
    Mol Biol Cell 13:1381-9. 2002
    ....
  52. ncbi Cholecystokinin stimulates extracellular signal-regulated kinase through activation of the epidermal growth factor receptor, Yes, and protein kinase C. Signal amplification at the level of Raf by activation of protein kinase Cepsilon
    Albrecht Piiper
    Department of Internal Medicine II, University of the Saarland, D 66421 Homburg Saar, Germany
    J Biol Chem 278:7065-72. 2003
    ....
  53. ncbi Distinct protein kinase C isoforms mediate regulation of vascular endothelial growth factor expression by A2A adenosine receptor activation and phorbol esters in pheochromocytoma PC12 cells
    Alicia M Gardner
    Department of Pharmacology and Cell Biophysics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0575, USA
    J Biol Chem 278:15421-8. 2003
    ..Together, the findings suggest that phorbol ester-induced down-regulation of VEGF mRNA occurs as a result of a reduction of PKCepsilon activity, whereas that mediated by the A(2A)AR occurs following deactivation of PKCzeta...
  54. ncbi Role of PKC in autocrine regulation of rat ventricular K+ currents by angiotensin and endothelin
    Yakhin Shimoni
    Cardiovascular Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Heart Circ Physiol 284:H1168-81. 2003
    ....
  55. ncbi Eicosanoid activation of protein kinase C epsilon: involvement in growth cone repellent signaling
    Keith Mikule
    Department of Cellular and Structural Biology and University of Colorado Cancer Center, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    J Biol Chem 278:21168-77. 2003
    ....
  56. ncbi Acute expression of RET/PTC induces isozyme-specific activation and subsequent downregulation of PKCepsilon in PCCL3 thyroid cells
    Jeffrey A Knauf
    Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, Mail Location 0547, Cincinnati, OH 45267, USA
    Oncogene 22:6830-8. 2003
    ....
  57. ncbi Identification of the linker histone H1 as a protein kinase Cepsilon-binding protein in vascular smooth muscle
    Mingcai Zhao
    Smooth Muscle Research Group and Department of Biochemistry and Molecular Biology, University of Calgary Faculty of Medicine, 330 Hospital Drive N W, Calgary, AB T2N 4N1, Canada
    Biochem Cell Biol 82:538-46. 2004
    ..Since PKC isoenzymes have been implicated in regulation of gene expression, stable interaction with histone H1 may be an important step in this process...
  58. ncbi Regulation of protein kinase C isozymes in volume overload cardiac hypertrophy
    Martin U Braun
    Department of Cardiology, Medical Clinic II, University of Technology Dresden, Germany
    Mol Cell Biochem 262:135-43. 2004
    ..This study characterizes in the left and right ventricle a differential regulation of the dominant PKC-isozymes in volume-overload cardiac hypertrophy both at the protein and at the mRNA-level...
  59. pmc PKCepsilon-PKD1 signaling complex at Z-discs plays a pivotal role in the cardiac hypertrophy induced by G-protein coupling receptor agonists
    Miki Iwata
    Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
    Biochem Biophys Res Commun 327:1105-13. 2005
    ..Taken together, the PKCepsilon-PKD1 complex at Z-discs could play a pivotal role in the cardiac hypertrophy induced by GPCR agonists, at least alpha-adrenergic receptor agonist...
  60. ncbi Protein kinase C isozymes in hypertension and hypertrophy: insight from SHHF rat hearts
    Dustin D Johnsen
    Cardiovascular Research Institute, University of South Dakota and Sioux Valley Hospital and Health Systems, Sioux Falls, South Dakota 57105, USA
    Mol Cell Biochem 270:63-9. 2005
    ..Regression of hypertrophy elicited by an ARB in this model occurred independently of changes in the expression and activity of the PKC isoforms examined...
  61. ncbi Nutrient regulation of PKCepsilon is mediated by leucine, not insulin, in skeletal muscle
    Thomas C Vary
    Dept of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 289:E684-94. 2005
    ....
  62. ncbi Ethanol sensitizes NF-kappaB activation in pancreatic acinar cells through effects on protein kinase C-epsilon
    Akihiko Satoh
    VA Greater L A Healthcare System, West L A Healthcare Center, Bldg 258, RM 340, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 291:G432-8. 2006
    ..These results suggest that ethanol enhances the CCK-8-induced NF-kappaB activation at least in part through its effects on PKC-epsilon...
  63. ncbi PKCepsilon induces astrocytic differentiation of multipotential neural precursor cells
    Rivka Steinhart
    Gonda Goldschmied Medical Diagnosis Research Center, The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Glia 55:224-32. 2007
    ..Our data suggest an important role of PKCepsilon in astrocytic differentiation and implicate Notch1 as a possible mediator of this effect...
  64. ncbi Interaction of the C2 domain from protein kinase C(epsilon) with model membranes
    Sonia Sánchez-Bautista
    Departamento de Bioquimica y Biologia Molecular A, Facultad de Veterinaria, Universidad de Murcia, Apartado de Correos 4021, E 30080 Murcia, Spain
    Biochemistry 46:3183-92. 2007
    ..All these results clearly illustrate the electrostatic interaction that takes place between this C2 domain and membranes which contain POPA in the absence of Ca2+...
  65. ncbi Protein kinase C epsilon phosphorylates keratin 8 at Ser8 and Ser23 in GH4C1 cells stimulated by thyrotropin-releasing hormone
    Yoshiko Akita
    Department of Laboratory Animal Science, The Tokyo Metropolitan Institute of Medical Science, Japan
    FEBS J 274:3270-85. 2007
    ..These results suggest that K8 is a physiological substrate for PKCepsilon, and the phosphorylation at Ser8 and Ser23 transduces, at least in part, TRH-PKCepsilon signaling in pituitary cells...
  66. pmc Protein kinase Cepsilon (PKCepsilon) and Src control PKCdelta activation loop phosphorylation in cardiomyocytes
    Vitalyi O Rybin
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 282:23631-8. 2007
    ..Collectively, these results identify a novel PKCdelta-Thr(505) autophosphorylation mechanism that is triggered by PKCepsilon overexpression and involves Src-dependent PKCdelta-Tyr(311)/Tyr(332) phosphorylation...
  67. ncbi Protein kinase C-epsilon coimmunoprecipitates with cytochrome oxidase subunit IV and is associated with improved cytochrome-c oxidase activity and cardioprotection
    Dehuang Guo
    Department of Pharmacology and Toxicology, School of Medicine, Medical College of Georgia, Augusta, Georgia 30912 2300, USA
    Am J Physiol Heart Circ Physiol 293:H2219-30. 2007
    ..Our results suggest that PKC-epsilon may interact with COIV as a component of the cardioprotection in PC. Induction of this interaction may provide a novel therapeutic target for protecting the heart from I/R damage...
  68. ncbi nPKCepsilon, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells
    Camille Ehre
    CCystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599 7248, USA
    Am J Physiol Cell Physiol 293:C1445-54. 2007
    ..The translocation of nPKCdelta observed in activated cells is likely not related to mucin secretion but to some other aspect of goblet cell biology...
  69. ncbi The epsilon-isoform of PKC mediates the hypertonic activation of cation channels in confluent monolayers of rat hepatocytes
    Katrin Bierhals
    Department of Systemic Cell Biology, Max Planck Institute for Molecular Physiology, Dortmund, Germany
    Cell Physiol Biochem 20:397-404. 2007
    ..Finally, by use of Rottlerin (as an inhibitor exhibiting a slight preference for PKC delta over epsilon) PKC epsilon could be identified as the most likely isoform responsible for the activation of the HICC...
  70. ncbi Regulation of protein kinase D activity in adult myocardium: novel counter-regulatory roles for protein kinase Cepsilon and protein kinase A
    Robert S Haworth
    Cardiovascular Division, King s College London, The Rayne Institute, St Thomas Hospital, Lambeth Palace Road, London, UK
    J Mol Cell Cardiol 43:686-95. 2007
    ..These results show that ET1-induced PKD activation in ARVM is mediated by PKC, primarily the PKCepsilon isoform, and is suppressed by PKA activation...
  71. ncbi H2S preconditioning-induced PKC activation regulates intracellular calcium handling in rat cardiomyocytes
    Ting Ting Pan
    Cardiovascular Biology Research Group, Department of Pharmacology, National University of Singapore, Singapore
    Am J Physiol Cell Physiol 294:C169-77. 2008
    ..Such PKC activation, in turn, protects the heart against ischemia-reperfusion insults at least partly by ameliorating intracellular Ca(2+) handling...
  72. doi Differential loss of cytochrome-c oxidase subunits in ischemia-reperfusion injury: exacerbation of COI subunit loss by PKC-epsilon inhibition
    Qilin Yu
    Department of Pharmacology and Toxicology, School of Medicine, Medical College of Georgia, Augusta, Georgia, USA
    Am J Physiol Heart Circ Physiol 294:H2637-45. 2008
    ..We propose that additional measures to protect CO subunits when coadministered with PC may improve its cardioprotection against I/R injury...
  73. ncbi Probable involvement of epsilon-isoform of protein kinase C in rat bronchial smooth muscle contraction induced by acetylcholine
    Hiroyasu Sakai
    Department of Pharmacology, School of Pharmacy, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    J Smooth Muscle Res 44:9-16. 2008
    ..Moreover, mRNA and protein of PKC epsilon were detected in rat bronchial smooth muscle. Taken together, PKC epsilon might be involved in the ACh-induced bronchial smooth muscle contraction in rats...
  74. doi Mechanisms related to the cardioprotective effects of protein kinase C epsilon (PKC epsilon) peptide activator or inhibitor in rat ischemia/reperfusion injury
    Jane Chun wen Teng
    Biomedical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, PA 19131 1694, USA
    Naunyn Schmiedebergs Arch Pharmacol 378:1-15. 2008
    ..By contrast, the cardioprotective effects of PKC epsilon activator PT may be mediated by enhancing vascular endothelial NO release before ischemia...
  75. doi Effects of 18-glycyrrhetinic acid on serine 368 phosphorylation of connexin43 in rat neonatal cardiomyocytes
    Jyun Yan Liang
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cell Biol Int 32:1371-9. 2008
    ..We conclude that 18beta-GA induces Ser368 phosphorylation of Cx43 via PKCepsilon...
  76. pmc GABA synapses mediate neuroprotection after ischemic and epsilonPKC preconditioning in rat hippocampal slice cultures
    R Anthony DeFazio
    Cerebral Vascular Disease Research Center, Department of Neurology, Leonard M Miller School of Medicine, University of Miami, Miami, Florida 33101, USA
    J Cereb Blood Flow Metab 29:375-84. 2009
    ..We conclude that neuroprotection conferred by preconditioning depends on functional modifications of GABA synapses...
  77. doi Adenosine triggers the nuclear translocation of protein kinase C epsilon in H9c2 cardiomyoblasts with the loss of phosphorylation at Ser729
    Tian Rui Xu
    Department of Biology Area 3, University of York, York, UK
    J Cell Biochem 106:633-42. 2009
    ....
  78. doi Protein kinase C-Fyn kinase cascade mediates the oleic acid-induced disassembly of neonatal rat cardiomyocyte adherens junctions
    Kwan Lih Hsu
    Department of Internal Medicine, E Da Hospital, Department of Nursing, I Shou University, Kaohsiung, Taiwan
    Int J Biochem Cell Biol 41:1536-46. 2009
    ..Therefore, inhibitors of PKC-alpha/-epsilon and Src family kinase are potential candidates as cardioprotection agents against OA-induced heart injury during ischemia-reperfusion...
  79. ncbi Transient upregulation of protein kinase C in pressure-overloaded neonatal rat myocardium
    B Hamplova
    Charles University, Faculty of Science, Department of Cell Biology, Prague, Czech Republic
    Physiol Res 59:25-33. 2010
    ..It is concluded that PKCalpha, PKCdelta and PKCepsilon undergo transient upregulation associated with the accelerated cardiac growth induced by pressure overload imposed in the very early postnatal period...
  80. pmc Prenatal cocaine exposure abolished ischemic preconditioning-induced protection in adult male rat hearts: role of PKCepsilon
    Kurt D Meyer
    Center for Perinatal Biology, Dept of Physiology and Pharmacology, Loma Linda Univ School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Heart Circ Physiol 296:H1566-76. 2009
    ....
  81. doi Time courses of subcellular signal transduction and cellular apoptosis in remote viable myocardium of rat left ventricles following acute myocardial infarction: role of pharmacomodulation
    Sarah Chua
    Division of Cardiology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien, Taiwan, ROC
    J Cardiovasc Pharmacol Ther 14:104-15. 2009
    ..05). Furthermore, 14-day left ventricular ejection fraction was higher and cellular apoptosis was lower in AMI-L1 group than in AMI-L0 group (P < .0001)...
  82. doi Involvement of Cpi-17 and zipper-interacting protein kinase in the regulation of protein kinase C-alpha, protein kinase C-epsilon on vascular calcium sensitivity after hemorrhagic shock
    Jing Xu
    State Key Laboratory of Trauma, Burns and Combined Injury, The 2nd Department of Research Institute of Surgery, Daping Hospital, People s Republic of China
    Shock 33:49-55. 2010
    ..Protein kinase C alpha and epsilon regulation of MLCP-MLC20 phosphorylation pathway in the process of VSMC contraction is mainly through ZIPK; CPI-17 may play an indirect modulating role...
  83. doi Endothelin-I and angiotensin II inhibit arterial voltage-gated K+ channels through different protein kinase C isoenzymes
    Richard D Rainbow
    Department of Cardiovascular Sciences, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Cardiovasc Res 83:493-500. 2009
    ....
  84. doi Reciprocal regulation between M3 muscarinic acetylcholine receptor and protein kinase C-epsilon in ventricular myocytes during myocardial ischemia in rats
    Peng Zhou Hang
    Institute of Clinical Pharmacology of Second Hospital, Harbin Medical University, Key Laboratory of Heilongjiang Province, Baojian Road 157, Nangang District, Harbin, Heilongjiang Province, 150081, People s Republic of China
    Naunyn Schmiedebergs Arch Pharmacol 380:443-50. 2009
    ..This reciprocal regulation is likely to play a role in heart signal transduction during ischemia between ventricular myocytes...
  85. ncbi [The role of CPI-17 in vascular calcium sensitivity regulated by protein kinase Calpha and Cepsilon in rats with hemorrhagic shock]
    Jing Xu
    Second Department of Research Institute of Surgery, Daping Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, The Third Military Medical University, Chongqing 400042, China
    Zhonghua Shao Shang Za Zhi 25:167-70. 2009
    ....
  86. ncbi Long-term pioglitazone treatment augments insulin sensitivity and PKC-epsilon and PKC-theta activation in skeletal muscles in sucrose fed rats
    I Markova
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Physiol Res 59:509-16. 2010
    ....
  87. doi The regulatory domain of protein kinase C delta positively regulates insulin receptor signaling
    Avraham I Jacob
    Mina and Everard Goodman Faculty of Life Sciences, Gonda Diagnostic Center, Bar Ilan University, Ramat Gan 52900, Israel
    J Mol Endocrinol 44:155-69. 2010
    ..Thus, the regulatory domain of PKCdelta via interaction with Src appears to determine the role of PKCdelta as a positive regulator of IR signaling in skeletal muscle...
  88. doi Protein kinase C epsilon-dependent extracellular signal-regulated kinase 5 phosphorylation and nuclear translocation involved in cardiomyocyte hypertrophy with angiotensin II stimulation
    Zhuo Zhao
    The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Shandong, PR China
    J Cell Biochem 109:653-62. 2010
    ..PKCepsilon and ERK5 may be potential targets in the treatment of pathological vascular hypertrophy associated with the enhanced renin-angiotensin system...
  89. doi Testis dysfunction by isoproterenol is mediated by upregulating endothelin receptor A, leptin and protein kinase Cvarepsilon and is attenuated by an endothelin receptor antagonist CPU0213
    Yu Si Cheng
    Research Division of Pharmacology, China Pharmaceutical University, Nanjing 210009, China
    Reprod Toxicol 29:421-6. 2010
    ..Over-expression of ET(A) and leptin accounting for the testis dysfunction is likely to be mediated by pPKCvarepsilon in the ISO treated rats. The upregulated ET pathway appears to be critical in pathologies of the testis...
  90. doi Epac stimulation induces rapid increases in connexin43 phosphorylation and function without preconditioning effect
    Nicolas Duquesnes
    Signalisation et Physiopathologie Cardiaque, Chatenay Malabry, France
    Pflugers Arch 460:731-41. 2010
    ..In conclusion, Epac stimulation induces PKCepsilon activation and Cx43 phosphorylation with an increase in GJIC, but Epac activation does not induce preconditioning to ischemia in contrast with beta-adrenergic stimulation...
  91. doi Acute treatment with Danshen-Gegen decoction protects the myocardium against ischemia/reperfusion injury via the redox-sensitive PKCɛ/mK(ATP) pathway in rats
    Po Yee Chiu
    Section of Biochemistry and Cell Biology, Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Phytomedicine 18:916-25. 2011
    ..Our results suggest that clinical studies examining the effectiveness of DG extract given prophylactically in affording protection against myocardial I/R injury would be warranted...
  92. ncbi alpha-Synuclein shares physical and functional homology with 14-3-3 proteins
    N Ostrerova
    Department of Pharmacology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Neurosci 19:5782-91. 1999
    ..The activity and binding profile of alpha-synuclein suggests that it might act as a protein chaperone and that accumulation of alpha-synuclein could contribute to cell death in neurodegenerative diseases...
  93. ncbi Characterization of the binding and phosphorylation of cardiac calsequestrin by epsilon protein kinase C
    M M Rodriguez
    Department of Molecular Pharmacology, Stanford University School of Medicine, CA 94305 5332, USA
    FEBS Lett 454:240-6. 1999
    ..Finally, we show that calsequestrin is an epsilonprotein kinase C substrate in vitro and protein kinase C phosphorylation of calsequestrin leads to a decreased binding of epsilonprotein kinase C to calsequestrin...
  94. ncbi Role of protein kinase C in the signal pathways that link Na+/K+-ATPase to ERK1/2
    K Mohammadi
    Department of Pharmacology, Medical College of Ohio, Toledo, Ohio 43614, USA
    J Biol Chem 276:42050-6. 2001
    ....
  95. ncbi Protein kinase C-epsilon mediates phorbol ester-induced phosphorylation of connexin-43
    B W Doble
    Institute of Cardiovascular Sciences and Department of Human Anatomy, University of Manitoba, Winnipeg, Canada
    Cell Commun Adhes 8:253-6. 2001
    ..Selective inhibition of PKCE significantly decreased baseline levels of Cx43 phosphorylation and the PMA-induced accumulation of > or = 45 ..
  96. ncbi A PKC epsilon-ENH-channel complex specifically modulates N-type Ca2+ channels
    Yuka Maeno-Hikichi
    Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104, USA
    Nat Neurosci 6:468-75. 2003
    ....
  97. ncbi Protein kinase C epsilon-dependent activation of proline-rich tyrosine kinase 2 in neonatal rat ventricular myocytes
    Allison L Bayer
    The Cardiovascular Institute, Loyola University Chicago Stritch School of Medicine, Maywood, IL 60153, USA
    J Mol Cell Cardiol 35:1121-33. 2003
    ..These data demonstrate that ET-induced PYK2 activation is Gq, PKC epsilon, and Src dependent, describing a distinct signaling pathway leading to agonist-induced PYK2 activation in cardiomyocytes...
  98. ncbi Characterization of the membrane binding mode of the C2 domain of PKC epsilon
    Senena Corbalan-Garcia
    Department de Bioquímica y Biología Molecular A, Facultad de Veterinaria, Universidad de Murcia, Apdo 4021, E 30100 Murcia, Spain
    Biochemistry 42:11661-8. 2003
    ....
  99. ncbi Diacylglycerol-induced membrane targeting and activation of protein kinase Cepsilon: mechanistic differences between protein kinases Cdelta and Cepsilon
    Robert V Stahelin
    Department of Chemistry, University of Illinois, Chicago, 60607, USA
    J Biol Chem 280:19784-93. 2005
    ..Collectively, these results provide new insight into the differential activation mechanisms of PKCdelta and PKCepsilon based on different structural and functional properties of their C1 domains...
  100. ncbi Integrated pharmacological preconditioning and memory of cardioprotection: role of protein kinase C and phosphatidylinositol 3-kinase
    Takayuki Okada
    Cardiovascular Center, Kansai Medical Univ, 10 15 Fumizono cho, Moriguchi city 570 8507, Japan
    Am J Physiol Heart Circ Physiol 289:H761-7. 2005
    ..These results suggest that the combined-PPC protocol confers cardioprotective memory through sustained and interdependent activation of PKC and PI3-kinase...

Research Grants5

  1. DEFECTIVE ALPHA, ADRENERGIC SIGNALING IN SENESCENT RAT
    DONNA KORZICK; Fiscal Year: 2003
    ..Environment: The environment surrounding Dr. Korzick at the University of Missouri is one marked by a commitment to research and academic scholarship with major strengths in cardiovascular sciences. ..
  2. PROTEIN KINASE C AND PHOTORECEPTORS
    ALEXANDRA NEWTON; Fiscal Year: 2002
    ..Specifically, the effect of this phosphorylation on rhodopsin s macromolecular interactions (transducin coupling, arrestin binding) will be explored. ..
  3. Cardiomyocyte Signaling Through Focal Adhesion
    MARIA HEIDKAMP; Fiscal Year: 2003
    ..Therefore, experiments will be performed to determine the effects of overexpression of mutant forms of PKCe on FAF and SA in cultured neonatal rat myocytes...
  4. Pancreatic zymogen activation in a reconstituted system
    Edwin Thrower; Fiscal Year: 2006
    ..We plan to use this system to identify the compartment(s) responsible for zymogen processing and to examine the ATP and calcium-dependent mechanism of activation. [unreadable] [unreadable] [unreadable]..
  5. Alcohol-Induced Regulation of Hepatic Protein Synthesis
    THOMAS VARY; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..