Prkcb

Summary

Gene Symbol: Prkcb
Description: protein kinase C, beta
Alias: Pkcb, Prkcb1, PKC-beta, protein kinase C beta I, protein kinase C beta II, protein kinase C beta type, protein kinase C, beta 1
Species: rat

Top Publications

  1. pmc Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity
    Akira Mima
    Section of Vascular Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Kidney Int 79:883-96. 2011
  2. pmc PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses
    Suresh Selvaraj Palaniyandi
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA
    J Cell Mol Med 15:1769-77. 2011
  3. pmc Exercise-induced cardiac performance in autoimmune (type 1) diabetes is associated with a decrease in myocardial diacylglycerol
    Rajprasad Loganathan
    Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, Kansas 66160 7601, USA
    J Appl Physiol (1985) 113:817-26. 2012
  4. ncbi Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein
    Kevin C Corbit
    Department of Neurobiology, Pharmacology and Physiology, and Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 278:13061-8. 2003
  5. pmc Protein kinase C upregulates intercellular adhesion molecule-1 and leukocyte-endothelium interactions in hyperglycemia via activation of endothelial expressed calpain
    Amanda R Smolock
    Department of Physiology and the Cardiovascular Research Center, School of Medicine, Temple University, 3500 N Broad St, Philadelphia, PA 19041, USA
    Arterioscler Thromb Vasc Biol 31:289-96. 2011
  6. ncbi The hexosamine pathway regulates the plasminogen activator inhibitor-1 gene promoter and Sp1 transcriptional activation through protein kinase C-beta I and -delta
    Howard J Goldberg
    Department of Medicine, Mount Sinai Hospital and University Health Network, 600 University Avenue, Suite 780, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 277:33833-41. 2002
  7. ncbi RBCK1, a protein kinase CbetaI (PKCbetaI)-interacting protein, regulates PKCbeta-dependent function
    Alice Vallentin
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 282:1650-7. 2007
  8. ncbi Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart
    N Bowling
    Cardiovascular Research, Eli Lilly and Co, Indianapolis, Ind 46285 0520, USA
    Circulation 99:384-91. 1999
  9. doi Skin immunosenescence: decreased receptor for activated C kinase-1 expression correlates with defective tumour necrosis factor-alpha production in epidermal cells
    E Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    Br J Dermatol 160:16-25. 2009
  10. ncbi Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway
    Jie Zhang
    Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 279:22118-23. 2004

Research Grants

  1. PHOSPHORYLATION OF GAP JUNCTION PROTEINS
    Paul Lampe; Fiscal Year: 2009
  2. PHOSPHORYLATION OF GAP JUNCTION PROTEINS
    Paul Lampe; Fiscal Year: 2005
  3. Proteomic Biomarkers of Health Behaviors
    Paul Lampe; Fiscal Year: 2005
  4. PHOSPHORYLATION OF GAP JUNCTION PROTEINS
    Paul Lampe; Fiscal Year: 2000
  5. PHOSPHORYLATION OF GAP JUNCTION PROTEINS
    Paul Lampe; Fiscal Year: 2007
  6. PHOSPHORYLATION OF GAP JUNCTION PROTEINS
    Paul D Lampe; Fiscal Year: 2010
  7. MICROVASCULAR CHARACTERISTICS OF DIABETES MELLITUS
    HAROLD BOHLEN; Fiscal Year: 1991
  8. MICROVASCULAR CHARACTERISTIC OF DIABETES MELLITUS
    HAROLD BOHLEN; Fiscal Year: 1993
  9. MICROVASCULAR CHARACTERISTICS OF DIABETES MELLITUS
    HAROLD BOHLEN; Fiscal Year: 1980
  10. PROTEIN KINASE C AND PHOTORECEPTORS
    ALEXANDRA NEWTON; Fiscal Year: 2002

Scientific Experts

  • Paul Lampe
  • ALEXANDRA NEWTON
  • Takuya Chiba
  • M C Sugden
  • Li Zhang
  • JACK YOUNGREN
  • Jiro Nakamura
  • Emmanuela Corsini
  • S Kuroda
  • HAROLD BOHLEN
  • Francois Lallemend
  • Darren J Kelly
  • Nobuaki Ozaki
  • Hai chang Wang
  • F R Tang
  • Orisa J Igwe
  • Mattias Gäreskog
  • Daria Mochly-Rosen
  • S Kumar
  • Yu fang Huang
  • Emilie Boncoeur
  • Zhen Li
  • Julio C B Ferreira
  • Rajprasad Loganathan
  • Joanna E Kowalczyk
  • Patricia Chakur Brum
  • Suresh Selvaraj Palaniyandi
  • Amanda R Smolock
  • Hong Mei Zhang
  • Yan Liu
  • Akira Mima
  • Howard J Goldberg
  • Robert R Rigor
  • M Amadio
  • Young Ae Kim
  • Li Hua Zhu
  • Yoshiyuki Natsume
  • P Borowski
  • Zhi Yong Yin
  • Christine M Gould
  • George L King
  • D Wu
  • Prabhakara Reddy Nagareddy
  • Yasunori Kawai
  • John H McNeill
  • Toshihide Kashihara
  • Alena Rudkouskaya
  • H Ghanim
  • A K Goestemeyer
  • Alice Vallentin
  • Emma L Morgan
  • Ling Xia
  • Emi Arikawa
  • R Orman
  • A L Johnson
  • Aditya Goel
  • Hyun Gyo Lee
  • Zhengyuan Xia
  • S Ladrech
  • L Xia
  • Emmanuelle Sentex
  • Didi Omiyi
  • George L Kellett
  • Sridevi Devaraj
  • L aurelle A Johnson
  • Takahiro Amemiya
  • Gabriela Aleman
  • Ademi E Santiago-Walker
  • Catharine I Whiteside
  • I George Fantus
  • Dan Chen
  • Jie Zhang
  • Anoop Kumar Padival
  • Alan P Fields
  • Alessia Pascale
  • E Aubrey Thompson
  • Shaomian Yao
  • Yuichi Koide
  • Kevin C Corbit
  • Mohammad Asghar
  • D C Wright
  • Philip A Helliwell
  • Masayoshi Ishizawa
  • Tatsuo Ishizuka
  • Hiroyuki Morita
  • Yoshihiro Uno
  • Keigo Yasuda
  • Atsushi Miura
  • Kazuo Kajita
  • Hong Yang

Detail Information

Publications96

  1. pmc Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity
    Akira Mima
    Section of Vascular Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Kidney Int 79:883-96. 2011
    ..Thus, loss of insulin's effect on endothelial nitric oxide synthase and glycogen synthase kinase 3α activation may contribute to the glomerulopathy observed in diabetes and obesity...
  2. pmc PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses
    Suresh Selvaraj Palaniyandi
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA
    J Cell Mol Med 15:1769-77. 2011
    ..Therefore, sustained selective inhibition of PKCβII in a post-MI HF rat model improves cardiac function and is associated with inhibition of pathological myocardial remodelling...
  3. pmc Exercise-induced cardiac performance in autoimmune (type 1) diabetes is associated with a decrease in myocardial diacylglycerol
    Rajprasad Loganathan
    Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, Kansas 66160 7601, USA
    J Appl Physiol (1985) 113:817-26. 2012
    ..Exercise-induced benefits on cardiac performance in diabetes may be mediated by prevention of an increase in myocardial DAG levels...
  4. ncbi Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein
    Kevin C Corbit
    Department of Neurobiology, Pharmacology and Physiology, and Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 278:13061-8. 2003
    ..Taken together, these results constitute the first model showing how phosphorylation by PKC relieves a key inhibitor of the Raf/MAP kinase signaling cascade and may represent a general mechanism for the regulation of MAP kinase pathways...
  5. pmc Protein kinase C upregulates intercellular adhesion molecule-1 and leukocyte-endothelium interactions in hyperglycemia via activation of endothelial expressed calpain
    Amanda R Smolock
    Department of Physiology and the Cardiovascular Research Center, School of Medicine, Temple University, 3500 N Broad St, Philadelphia, PA 19041, USA
    Arterioscler Thromb Vasc Biol 31:289-96. 2011
    ..We tested the hypothesis of a role for the calcium-dependent protease calpain in the endothelial dysfunction induced by hyperglycemic activation of protein kinase C (PKC)...
  6. ncbi The hexosamine pathway regulates the plasminogen activator inhibitor-1 gene promoter and Sp1 transcriptional activation through protein kinase C-beta I and -delta
    Howard J Goldberg
    Department of Medicine, Mount Sinai Hospital and University Health Network, 600 University Avenue, Suite 780, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 277:33833-41. 2002
    ..These findings demonstrate a requirement for the PKC-betaI and -delta signal transduction pathways in HBP-induced transcription...
  7. ncbi RBCK1, a protein kinase CbetaI (PKCbetaI)-interacting protein, regulates PKCbeta-dependent function
    Alice Vallentin
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 282:1650-7. 2007
    ..Our results suggest that RBCK1 binds PKCbetaI and is a key regulator of PKCbetaI function in cells and that, together with PKCbetaII, the three proteins are essential for developmental hypertrophy of cardiac myocytes...
  8. ncbi Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart
    N Bowling
    Cardiovascular Research, Eli Lilly and Co, Indianapolis, Ind 46285 0520, USA
    Circulation 99:384-91. 1999
    ..Increased expression of Ca2+-sensitive protein kinase C (PKC) isoforms may be important markers of heart failure. Our aim was to determine the relative expression of PKC-beta1, -beta2, and -alpha in failed and nonfailed myocardium...
  9. doi Skin immunosenescence: decreased receptor for activated C kinase-1 expression correlates with defective tumour necrosis factor-alpha production in epidermal cells
    E Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    Br J Dermatol 160:16-25. 2009
    ..We have recently shown in immune cells that decreased expression of the receptor for activated C kinase (RACK)-1 underlies defective protein kinase C (PKC) activation and functional immune impairment with ageing...
  10. ncbi Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway
    Jie Zhang
    Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 279:22118-23. 2004
    ..This pathway provides a plausible mechanism by which PKCbetaII promotes colon carcinogenesis...
  11. ncbi Glutathione depletion induces apoptosis of rat hepatocytes through activation of protein kinase C novel isoforms and dependent increase in AP-1 nuclear binding
    C Domenicotti
    Department of Experimental Medicine, General Pathology Section, University of Genova, Genova, Italy
    Free Radic Biol Med 29:1280-90. 2000
    ..Taken together, these findings indicate the existence of an apoptotic pathway dependent on glutathione depletion, which occurs through the up-regulation of novel PKCs and AP-1...
  12. ncbi N-acetylcysteine attenuates PKCbeta2 overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats
    Zhengyuan Xia
    Faculty of Pharmaceutical Sciences, Division of Pharmacology, The University of British Columbia, 2146 East Mall, Vancouver, BC, Canada
    Cardiovasc Res 73:770-82. 2007
    ..We hypothesized that chronic treatment with the antioxidant N-acetylcysteine (NAC) would normalize oxidative stress-mediated overexpression of myocardial PKCbeta(2) and CTGF and attenuate the development of myocardial hypertrophy...
  13. ncbi Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats
    Emi Arikawa
    Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Diabetes 56:1410-20. 2007
    ..Thus, PKCbeta or ACE inhibitors may ameliorate cardiac metabolism and function in diabetes partly by normalization of fuel metabolic gene expression directly in the myocardium...
  14. ncbi Tissue angiotensin II during progression or ventricular hypertrophy to heart failure in hypertensive rats; differential effects on PKC epsilon and PKC beta
    Koichi Inagaki
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin, Sakyo, Kyoto 606 8507, Japan
    J Mol Cell Cardiol 34:1377-85. 2002
    ..At the LVF stage, however, PKC epsilon returned to the control level, whereas PKC beta I and beta II increased by 158% and 155%, respectively...
  15. ncbi Role of two conserved cytoplasmic threonine residues (T410 and T412) in CD5 signaling
    J M Vila
    Servei d Immunologia, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    J Immunol 166:396-402. 2001
    ..These results strongly argue in favor of a role for T410 and T412 in the signaling mediated by CD5...
  16. ncbi Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current
    G Y Liao
    Laboratory of Integrative Neuroscience, Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA
    Mol Pharmacol 59:960-4. 2001
    ..The direct action of PKC on certain NMDA receptor subtypes may be important in any physiological or pathological process where PKC and NR2B/NR1 receptors interact...
  17. doi Induction of nitric oxide synthase expression by lipopolysaccharide is mediated by calcium-dependent PKCα-β1 in alveolar epithelial cells
    Emilie Boncoeur
    Centre de Recherche, Centre hospitalier de l Université de Montréal CR CHUM Hôtel Dieu, Montreal, Quebec, Canada
    Am J Physiol Lung Cell Mol Physiol 305:L175-84. 2013
    ..Altogether, these findings demonstrate that iNOS expression is highly modulated in alveolar epithelial cells by LPS via a Ca²⁺/PKCα-β1 pathway independent of ATP signaling...
  18. ncbi Molecular cloning and characterization of a novel protein kinase C-interacting protein with structural motifs related to RBCC family proteins
    C Tokunaga
    Biosignal Research Center, Faculty of Science, Kobe University, Japan
    Biochem Biophys Res Commun 244:353-9. 1998
    ..C (PKC)-interacting protein was identified by the yeast two-hybrid screening using the regulatory domain of PKC beta I as a bait...
  19. doi Antofine-induced connexin43 gap junction disassembly in rat astrocytes involves protein kinase Cβ
    Yu fang Huang
    Institute of Anatomy and Cell Biology, School of Medicine, National Yang Ming University, Taipei 11221, Taiwan
    Neurotoxicology 35:169-79. 2013
    ..Taken together, these findings indicate that antofine induces Cx43 gap junction disassembly by the PKCβ signaling pathway. Inhibition of GJIC by antofine may undermine the neuroprotective effect of astrocytes in CNS...
  20. doi Signal mechanisms underlying low-dose endothelial monocyte-activating polypeptide-II-induced opening of the blood-tumor barrier
    Zhen Li
    Department of Neurosurgery, Shengjing Hospital, China Medical University, Shenyang, Liaoning Province, 110004, People s Republic of China
    J Mol Neurosci 48:291-301. 2012
    ..However, PKC-ζ is involved in this process by other mechanisms...
  21. pmc Protein quality control disruption by PKCβII in heart failure; rescue by the selective PKCβII inhibitor, βIIV5-3
    Julio C B Ferreira
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 7:e33175. 2012
    ..PQC disruption by increased PKCβII activity in vivo appears to contribute to the pathophysiology of heart failure, suggesting that PKCβII inhibition may benefit patients with heart failure. (218 words)...
  22. doi Protein kinase C beta in postischemic brain mitochondria
    Joanna E Kowalczyk
    Molecular Biology Unit, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego St, 02 106 Warsaw, Poland
    Mitochondrion 12:138-43. 2012
    ..PKCβ acting through mitochondrial proteins could play a role in protecting the cells from death by e.g. influencing ROS and ATP production after ischemia in CA2-4,DG region of the hippocampus...
  23. ncbi Effects of blocking the renin-angiotensin system on expression and translocation of protein kinase C isoforms in the kidney of diabetic rats
    Li Zhang
    Department of Nephrology, First Affiliated Hospital of Nanjing Medical University, Jiangsu, China
    Nephron Exp Nephrol 104:e103-11. 2006
    ....
  24. ncbi RasGRP3 mediates phorbol ester-induced, protein kinase C-independent exocytosis
    Nobuaki Ozaki
    Department of Metabolic Disease, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Biochem Biophys Res Commun 329:765-71. 2005
    ..These results indicate that RasGRP3 is implicated in phorbol ester-induced, PKC-independent exocytosis...
  25. ncbi Role of inflammatory mediators in the suppression of insulin receptor phosphorylation in circulating mononuclear cells of obese subjects
    H Ghanim
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, Buffalo, NY, USA
    Diabetologia 50:278-85. 2007
    ....
  26. pmc Hemispheric differences in protein kinase C betaII levels in the rat amygdala: baseline asymmetry and lateralized changes associated with cue and context in a classical fear conditioning paradigm
    R Orman
    Program in Neural and Behavioral Science, Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Box 31, Brooklyn, NY 11203, USA
    Neuroscience 144:797-807. 2007
    ..We conclude that fear conditioning causes hemisphere and input specific increases in PKC betaII in the rat LA/BLA...
  27. ncbi Differential effects of systemic ethanol administration on protein kinase cepsilon, gamma, and beta isoform expression, membrane translocation, and target phosphorylation: reversal by chronic ethanol exposure
    S Kumar
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7178, USA
    J Pharmacol Exp Ther 319:1366-75. 2006
    ..Furthermore, chronic ethanol administration prevents ethanol-induced alterations in PKC expression in the P2 fraction, where PKC interacts with ethanol-responsive ion channels...
  28. ncbi Regulation by glucagon of the rat histidase gene promoter in cultured rat hepatocytes and human hepatoblastoma cells
    Gabriela Aleman
    Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Departamento Fisiología de la Nutrición, Universidad Nacional Autonomica de México, Mexico City, Mexico
    Am J Physiol Endocrinol Metab 289:E172-9. 2005
    ..9-fold), forskolin (0.9-fold), PMA (2.0-fold), and dexamethasone (2.9-fold). This evidence supports that the Hal gene is turned on by glucocorticoids and by glucagon either via PKC or PKA, but prefers the PKA pathway...
  29. ncbi Role of protein kinase C beta in phorbol ester-induced c-fos gene expression in neurons of normotensive and spontaneously hypertensive rat brains
    Takahiro Amemiya
    Department of Pharmacology, Showa Pharmaceutical University, Machida, Tokyo 194 8543, Japan
    Brain Res 1040:129-36. 2005
    ..In neuronal cultures of SHR brain, it appears that the PMA-induced c-fos gene expression is also enhanced via PKCbeta...
  30. ncbi Protein kinase C betaII peptide inhibitor exerts cardioprotective effects in rat cardiac ischemia/reperfusion injury
    Didi Omiyi
    Department of Pathology, Microbiology, and Immunology, Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA 19131, USA
    J Pharmacol Exp Ther 314:542-51. 2005
    ..01). These results suggest that the PKC betaII peptide inhibitor attenuates PMN-induced post-I/R cardiac contractile dysfunction by increasing endothelial NO release and by inhibiting superoxide release from PMNs...
  31. ncbi Expression of protein kinase C isoforms in cardiac hypertrophy and heart failure due to volume overload
    Emmanuelle Sentex
    Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre and Department of Physiology, Faculty of Medicine University of Manitoba, 351 Tache Avenue, Winnipeg, MB R2H 2A6, Canada
    Can J Physiol Pharmacol 84:227-38. 2006
    ..Our data suggest that an increase in PKC isoform content neither plays an important role during the development of cardiac hypertrophy nor participates in the phase leading to heart failure owing to volume overload...
  32. ncbi Activation of protein kinase CbetaI constitutes a new neurotrophic pathway for deafferented spiral ganglion neurons
    Francois Lallemend
    Research Centre for Cellular and Molecular Neurobiology, Developmental Neurobiology Unit, University of Liege, Av de l Hopital 1 B36, 4000 Liege, Belgium
    J Cell Sci 118:4511-25. 2005
    ..Taken together, the data indicate that PKCbetaI activation represents a key factor for the protection of the integrity of neural elements in the cochlea...
  33. ncbi Translocation of PKC-betaII is mediated via RACK-1 in the neuronal cells following dioxin exposure
    Hyun Gyo Lee
    Department of Pharmacology and Toxicology, School of Medicine, Catholic University of Daegu, 3056 6 Daemyong 4 dong, Namgu, Daegu 705 718, Republic of Korea
    Neurotoxicology 28:408-14. 2007
    ..These results suggest that identification of target molecules may contribute to improve our understanding of TCDD-mediated signaling pathway and the risk assessment of TCDD-induced neurotoxicities...
  34. pmc Apical GLUT2 and Cav1.3: regulation of rat intestinal glucose and calcium absorption
    Emma L Morgan
    Department of Biology, The University of York, York YO10 5YW, UK
    J Physiol 580:593-604. 2007
    ..The integration of glucose and Ca(2+) absorption represents a complex nutrient-sensing system, which allows both absorptive pathways to be regulated rapidly and precisely to match dietary intake...
  35. ncbi Regulation of insulin receptor function
    J F Youngren
    Mount Zion Medical Center, Diabetes and Endocrine Research, University of California at San Francisco, San Francisco, CA 94143 1616, USA
    Cell Mol Life Sci 64:873-91. 2007
    ..The impact of these processes on the conformational changes and phosphorylation events required for full signaling activity, as well as the role of these mechanisms in human disease, is reviewed in this article...
  36. doi Effect of perinatal thyroid hormone deficiency on expression of rat hippocampal conventional protein kinase C isozymes
    Hong Mei Zhang
    Department of Endocrinology, Xin Hua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, People s Republic of China
    Mol Cell Biochem 353:65-71. 2011
    ..Since there are other PKC isoforms in the rat brain, whether these change is related to impaired learning and memory of perinatal hypothyroid rats requires further researches...
  37. doi The PKCbeta/HuR/VEGF pathway in diabetic retinopathy
    M Amadio
    Department of Experimental and Applied Pharmacology, Centre of Excellence in Applied Biology, University of Pavia, Pavia, Italy
    Biochem Pharmacol 80:1230-7. 2010
    ....
  38. pmc Activation of PKC isoform beta(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain
    Robert R Rigor
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Cereb Blood Flow Metab 30:1373-83. 2010
    ..Targeting PKCbeta(I) at the BBB may prove to be an effective strategy for enhancing the delivery of small molecule therapeutics to the brain...
  39. doi Puerarin attenuates high-glucose-and diabetes-induced vascular smooth muscle cell proliferation by blocking PKCbeta2/Rac1-dependent signaling
    Li Hua Zhu
    Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan 430060, PR China
    Free Radic Biol Med 48:471-82. 2010
    ....
  40. doi EGFR-PLCgamma1 signaling mediates high glucose-induced PKCbeta1-Akt activation and collagen I upregulation in mesangial cells
    D Wu
    Division of Nephrology, McMaster University, Hamilton, Ontario, Canada
    Am J Physiol Renal Physiol 297:F822-34. 2009
    ..Inhibition of EGFR or PLCgamma1 may provide attractive therapeutic targets for the treatment of diabetic nephropathy...
  41. ncbi [Antagonism of LY333531 on high glucose induced permeability upregulation of cardiac microvascular endothelial cells]
    Zhi Yong Yin
    Cardiovascular Department, Xijing Hospital, The Fourth Military Medical University, Xi an 710032, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 25:303-5. 2009
    ..To investigate the antagonism of LY333531 on the increased permeability of cardiac microvascular endothelial cells (CMECs) induced by high glucose...
  42. pmc The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail
    Christine M Gould
    Pharmacology Department, University of California, San Diego, La Jolla, California 92039 0721, USA
    J Biol Chem 284:4921-35. 2009
    ....
  43. pmc Two conventional protein kinase C isoforms, alpha and beta I, are involved in the ATP-induced activation of volume-regulated anion channel and glutamate release in cultured astrocytes
    Alena Rudkouskaya
    Center of Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Neurochem 105:2260-70. 2008
    ..These data suggest that ATP regulates VRAC activity and volume-sensitive excitatory amino acid release via cooperative activation of PKCalpha and betaI...
  44. ncbi Identification of fasting-induced genes in the rat hypothalamus: relationship with neuroprotection
    Takuya Chiba
    Department of Investigative Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Ann N Y Acad Sci 1119:216-26. 2007
    ..Thus, the increased expressions of the genes identified in the present study may have protective effects against neural damage that could otherwise result in cell death...
  45. ncbi Differential expression of PKC beta II in the rat organ of Corti
    S Ladrech
    INSERM U583, Montpellier, France
    Eur J Neurosci 26:2922-30. 2007
    ..protein kinase C (PKC) in cochlear efferent neurotransmission, we studied the expression of the calcium-dependent PKC beta II isoform in the rat organ of Corti at different postnatal ages using immunofluorescence and immunoelectron ..
  46. pmc Gender difference in rat aorta vasodilation after acute exposure to high glucose: involvement of protein kinase C beta and superoxide but not of Rho kinase
    Aditya Goel
    Department of Physiology and Pharmacology, Thomas J Long School of Pharmacy and Health Sciences, University of the Pacific, 3601 Pacific Avenue, Stockton, CA 95211, USA
    Cardiovasc Res 76:351-60. 2007
    ....
  47. ncbi Distinct roles of protein kinase C isoforms in myogenic constriction of rat posterior cerebral arteries
    Toshihide Kashihara
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Japan
    J Pharmacol Sci 108:446-54. 2008
    ....
  48. ncbi Reactive oxygen species, PKC-beta1, and PKC-zeta mediate high-glucose-induced vascular endothelial growth factor expression in mesangial cells
    Ling Xia
    University Health Network, University of Toronto, Toronto, ON, Canada
    Am J Physiol Endocrinol Metab 293:E1280-8. 2007
    ..Thus reactive oxygen species generated by NADPH oxidase, and both PKC-beta(1) and -zeta, play important roles in high-glucose-stimulated VEGF expression and secretion by mesangial cells...
  49. ncbi Regulation of amphetamine-stimulated dopamine efflux by protein kinase C beta
    L aurelle A Johnson
    Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109 0632, USA
    J Biol Chem 280:10914-9. 2005
    ..A highly specific PKC beta inhibitor, LY379196, blocked dopamine efflux that was stimulated by either amphetamine or the PKC activator, 12-O-..
  50. ncbi Overproduction of protein kinase C causes disordered growth control in rat fibroblasts
    G M Housey
    Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Cell 52:343-54. 1988
    ..They also suggest that the activation of PKC may be of central importance in the process of multistage carcinogenesis...
  51. ncbi Obligatory role of protein kinase Cbeta and MARCKS in vesicular trafficking in living neurons
    Hong Yang
    Department of Physiology and Functional Genomics, College of Medicine, and University of Florida McKnight Brain Institute, Gainesville 32610 0274, USA
    Hypertension 39:567-72. 2002
    ..These observations demonstrate that PKCbeta-MARCKS signaling may be a general mechanism for the stimulation of vesicular trafficking in brain neurons...
  52. ncbi Possible involvement of PKC isoforms in signalling placental apoptosis in intrauterine growth retardation
    M C Sugden
    Department of Diabetes and Metabolic Medicine, Division of General and Developmental Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary, University of London, London E1 4NS, UK
    Mol Cell Endocrinol 185:119-26. 2001
    ....
  53. ncbi A synthetic peptide derived from the non-structural protein 3 of hepatitis C virus serves as a specific substrate for PKC
    P Borowski
    Bernhard Nocht Institut fur Tropenmedizin, Hamburg, Germany
    Biol Chem 381:19-27. 2000
    ..The data presented here show that[Phe1499]HCV(1487-1500) can serve as a convenient tool for investigations of PKC activity also in the presence of other kinases in tissues or in crude cell extracts...
  54. ncbi Phosphorylation of HMG-I by protein kinase C attenuates its binding affinity to the promoter regions of protein kinase C gamma and neurogranin/RC3 genes
    D M Xiao
    Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    J Neurochem 74:392-9. 2000
    ..The current results suggest that phosphorylation of the mammalian HMG-I by PKC alone or in combination with cdc2 kinase provides an effective mechanism for the regulation of HMG-I function...
  55. ncbi Characterization of the binding and phosphorylation of cardiac calsequestrin by epsilon protein kinase C
    M M Rodriguez
    Department of Molecular Pharmacology, Stanford University School of Medicine, CA 94305 5332, USA
    FEBS Lett 454:240-6. 1999
    ..Finally, we show that calsequestrin is an epsilonprotein kinase C substrate in vitro and protein kinase C phosphorylation of calsequestrin leads to a decreased binding of epsilonprotein kinase C to calsequestrin...
  56. ncbi Characterisation of non-structural protein 3 of hepatitis C virus as modulator of protein phosphorylation mediated by PKA and PKC: evidences for action on the level of substrate and enzyme
    P Borowski
    Bernhard Nocht Institut fur Tropenmedizin, Abt Virologie, Hamburg, Federal Republic of Germany
    Arch Virol 144:687-701. 1999
    ..The results are discussed in view of similar activities displayed by matchmakers and some molecular chaperones...
  57. ncbi Effect of ageing on the expression of protein kinase C and its activation by 1,25(OH)2-vitamin D3 in rat skeletal muscle
    M M Facchinetti
    Departamento de Biologia, Bioquimica y Farmacia, Universidad Nacional del Sur, Bahia Blanca, Argentina
    Cell Signal 11:39-44. 1999
    ..The data indicate that, in rat muscle, ageing impairs calcium-dependent PKC (alpha and beta) and calcium-independent PKC (delta, epsilon, theta and zeta) signal transduction pathways under selective regulation by 1,25(OH)2D3...
  58. ncbi Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+
    R B Sutton
    Howard Hughes Medical Institute Department of Biochemistry The University of Texas Southwestern Medical Center 5323 Harry Hines Blvd Dallas, TX 75235 9050, USA
    Structure 6:1395-405. 1998
    ..Neither the structural basis for cooperativity between phosphatidylserine and Ca2+, nor the binding site for phosphatidylserine are known...
  59. ncbi Selective changes in protein kinase C isoforms and phosphorylation of endogenous substrate proteins in rat cerebral cortex during pre- and postnatal ethanol exposure
    K Mahadev
    School of Life Sciences, University of Hyderabad, Hyderabad, 500 046, India
    Arch Biochem Biophys 356:249-57. 1998
    ....
  60. doi Role of PKCbetaII and PKCdelta in blood-brain barrier permeability during aglycemic hypoxia
    Young Ae Kim
    Department of Physiology, School of Medicine, Ajou University, Suwon 443 749, Republic of Korea
    Neurosci Lett 468:254-8. 2010
    ..These results suggest that PKCbetaII and PKCdelta counter-regulate BBB permeability during aglycemic hypoxia...
  61. ncbi Protein-protein interaction of zinc finger LIM domains with protein kinase C
    S Kuroda
    Biosignal Research Center, Kobe University, Kobe 657, Japan
    J Biol Chem 271:31029-32. 1996
    ..These results suggest that the LIM domain is one of the targets of PKC and that the LIM-PKC interaction may shed light on undefined roles of LIM domain-containing proteins...
  62. pmc Characterization of site-specific mutants altered at protein kinase C beta 1 isozyme autophosphorylation sites
    J Zhang
    Molecular Pharmacology Section, Schering Plough Research Institute, Kenilworth, NJ 07033 0539
    Proc Natl Acad Sci U S A 90:6130-4. 1993
    ..To define the role of autophosphorylation we constructed three site-directed mutants of PKC beta 1 isozyme in which each pair of phosphorylatable residues is changed to alanine...
  63. ncbi Requirement for negative charge on "activation loop" of protein kinase C
    J W Orr
    Department of Chemistry, Indiana University, Bloomington 47405
    J Biol Chem 269:27715-8. 1994
    ..These data suggest that signal processing by protein kinase C cannot occur until the enzyme is first phosphorylated by a protein kinase C kinase...
  64. ncbi Cloning and expression of multiple protein kinase C cDNAs
    J L Knopf
    Cell 46:491-502. 1986
    ..The physiological implications of the discovery of three protein-kinase-C-related cDNAs are discussed...
  65. pmc Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family
    G M Housey
    Proc Natl Acad Sci U S A 84:1065-9. 1987
    ..These and additional results provide evidence that the gene encoding protein kinase C is a member of a novel serine/threonine protein kinase multigene family...
  66. ncbi Changes in protein kinase C (PKC) activity, isozyme translocation, and GAP-43 phosphorylation in the rat hippocampal formation after a single-trial contextual fear conditioning paradigm
    Elizabeth Young
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque 87131 5223, USA
    Hippocampus 12:457-64. 2002
    ....
  67. ncbi Protein kinase betaII in Zucker obese rats compromises oxygen and flow-mediated regulation of nitric oxide formation
    H Glenn Bohlen
    Department of Cellular and Integrative Physiology, Indiana University Medical School, Indianapolis, IN 46202, USA
    Am J Physiol Heart Circ Physiol 286:H492-7. 2004
    ..Therefore, activation of PKC-betaII in endothelial cells during obesity suppressed NO regulation both at rest and in response to increased flow velocity and decreased oxygen availability...
  68. ncbi Resistance to acute silicosis in senescent rats: role of alveolar macrophages
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Chem Res Toxicol 16:1520-7. 2003
    ....
  69. ncbi Dominant negative protein kinase Cbeta improves 1alpha, 25-dihydroxy vitamin D3-induced insulin resistance
    Yoshiyuki Natsume
    Third Department of Internal Medicine, Gifu University School of Medicine, Tsukasamachi, Gifu, Japan
    Endocr Res 29:457-64. 2003
    ..These results suggest that 1,25D3 reduces insulin-induced glucose uptake via activation of PKC(beta) in rat adipocytes...
  70. ncbi Centrosomal anchoring of protein kinase C betaII by pericentrin controls microtubule organization, spindle function, and cytokinesis
    Dan Chen
    Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla, California 92093 0640, USA
    J Biol Chem 279:4829-39. 2004
    ..These results reveal a novel role for PKC betaII in cytokinesis and indicate that this function is mediated by an interaction with pericentrin at centrosomes...
  71. ncbi Overexpression of PKC-betaI and -delta contributes to higher PKC activity in the proximal tubules of old Fischer 344 rats
    Mohammad Asghar
    Heart and Kidney Institute, College of Pharmacy, University of Houston, Houston, TX 77204, USA
    Am J Physiol Renal Physiol 285:F1100-7. 2003
    ....
  72. ncbi Translocation of protein kinase C-betaII in astrocytes requires organized actin cytoskeleton and is not accompanied by synchronous RACK1 relocation
    Alessia Pascale
    Laboratory of Adaptive Systems, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Glia 46:169-82. 2004
    ....
  73. ncbi Differential induction of protein kinase C isoforms at the cardiac hypertrophy stage and congestive heart failure stage in Dahl salt-sensitive rats
    Yuichi Koide
    Department of Medicine II, Yokohama City University School of Medicine, Yokohama, Japan
    Hypertens Res 26:421-6. 2003
    ....
  74. ncbi Expression of different isoforms of protein kinase C in the rat hippocampus after pilocarpine-induced status epilepticus with special reference to CA1 area and the dentate gyrus
    F R Tang
    Epilepsy Research Laboratory, National Neuroscience Institute, Singapore
    Hippocampus 14:87-98. 2004
    ....
  75. ncbi Evidence for the involvement of a phospholipase C--protein kinase C signaling pathway in insulin stimulated glucose transport in skeletal muscle
    D C Wright
    Human Performance Laboratory, Ball State University, Muncie, IN 47306, USA
    Life Sci 73:61-71. 2003
    ..Western blot analysis revealed that insulin induced a redistribution of PKC beta II from the cytosol to the membrane that was reversed in the presence of GF109203X (1 microM) and U73122 (20 ..
  76. ncbi Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase c-{alpha} and -{beta}
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, The University of California Davis Medical Center, 4635, II Ave, Res 1 Bldg, Rm 3000, Sacramento, CA 95817, USA
    Diabetes 54:85-91. 2005
    ..Thus, inhibition of PKC-alpha and -beta can ameliorate the proinflammatory state of diabetes...
  77. ncbi Phosphorylation of Thr642 is an early event in the processing of newly synthesized protein kinase C beta 1 and is essential for its activation
    J Zhang
    Molecular Pharmacology Section, Schering Plough Research Institute, Kenilworth, New Jersey 07003
    J Biol Chem 269:19578-84. 1994
    Earlier studies of a site-specific mutant of protein kinase C beta 1 (PKC beta 1) altered at Thr635 and Thr642 indicated that these phosphorylation sites are critical for enzymatic function (Zhang, J., Wang, L., Petrin, J., Bishop, W. R...
  78. ncbi Mesangial cell NADPH oxidase upregulation in high glucose is protein kinase C dependent and required for collagen IV expression
    L Xia
    Medical Sciences Building, Rm 7302, 1 King s College Circle, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Renal Physiol 290:F345-56. 2006
    ..We conclude that in HG, mesangial cell ROS generation by upregulated NADPH oxidase is dependent on conventional PKC isozymes and also required for collagen IV expression...
  79. ncbi Protein kinase CbetaII regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo
    Yan Liu
    Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 279:45556-63. 2004
    ....
  80. ncbi Protein kinase C is regulated in vivo by three functionally distinct phosphorylations
    L M Keranen
    Department of Pharmacology, University of California at San Diego, La Jolla 92093 0640, USA
    Curr Biol 5:1394-1403. 1995
    ..Here, we show that protein kinase C must first be processed by three distinct phosphorylations before it is competent to respond to second messengers...
  81. ncbi Expression and properties of two types of protein kinase C: alternative splicing from a single gene
    Y Ono
    Science 236:1116-20. 1987
    ..Partial analysis of the genomic structure confirmed that these two subspecies of protein kinase C resulted indeed from alternative splicing of a single gene...
  82. ncbi Cloning of rat brain protein kinase C complementary DNA
    Y Ono
    FEBS Lett 203:111-5. 1986
    ..The nucleotide sequence of this cDNA clone revealed the primary structure of the carboxyl-terminal region as having 224 amino acids, with significant sequence homology with cyclic AMP-dependent and cyclic GMP-dependent protein kinases...
  83. ncbi [Continuing education--cross-professional offer not sufficient]
    M Gass
    Sygeplejersken 92:20-1. 1992
  84. ncbi High glucose-induced membrane translocation of PKC betaI is associated with Arf6 in glomerular mesangial cells
    Anoop Kumar Padival
    Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Mol Cell Biochem 258:129-35. 2004
    ....
  85. ncbi Inhibition of PKCbeta improves glucocorticoid-induced insulin resistance in rat adipocytes
    Yasunori Kawai
    The Third Department of Internal Medicine, Gifu University School of Medicine, Tsukasa machi 40, Gifu 500, Japan
    IUBMB Life 54:365-70. 2002
    ..These results indicate that PKCbeta may play an important role in glucocorticoid-induced insulin resistance...
  86. ncbi Protein Kinase C- alpha/betaII, delta, and zeta/lambda involvement in ethanol-induced MAPK expression in vascular smooth muscle cells
    A L Johnson
    Department of Biological Sciences, Tennessee State University, Nashville, TN 37209, USA
    Cell Mol Biol (Noisy-le-grand) 53:38-44. 2007
    ..These results demonstrate also that classical, novel, and atypical PKCs respond to ethanol during the initial phase of activation of ERK 1 & 2...
  87. ncbi Phosphoinositide 3-kinase mediates protein kinase C beta II mRNA destabilization in rat A10 smooth muscle cell cultures exposed to high glucose
    Niketa A Patel
    Department of Biochemistry, College of Medicine, University of South Florida, Tampa, USA
    Arch Biochem Biophys 403:111-20. 2002
    ..High-glucose-induced mRNA destabilization is specific for PKC beta II mRNA, while PKC beta I and other PKC mRNA are not affected...
  88. ncbi Intestinal sugar absorption is regulated by phosphorylation and turnover of protein kinase C betaII mediated by phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent pathways
    Philip A Helliwell
    Department of Biology Area 3, University of York, York YO10 5YW, United Kingdom
    J Biol Chem 278:28644-50. 2003
    ..These findings suggest possible mechanisms for short term control of intestinal sugar absorption by insulin and amino acids...
  89. doi Protein kinase CbetaI interacts with the beta1-adrenergic signaling pathway to attenuate lipolysis in rat adipocytes
    Jiro Nakamura
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba shi, Ibaraki Ken, Japan
    Biochim Biophys Acta 1781:277-81. 2008
    ..These data suggest that PKCbetaI interacts with beta1-AR signaling and attenuates lipolysis in rat adipocytes...
  90. ncbi Protein kinase C delta stimulates apoptosis by initiating G1 phase cell cycle progression and S phase arrest
    Ademi E Santiago-Walker
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, 19104 6061, USA
    J Biol Chem 280:32107-14. 2005
    ..Importantly, they reveal the existence of a novel, cell cycle-dependent mechanism through which PKCdelta stimulates cell death...
  91. pmc Selective inhibition of protein kinase C beta(2) attenuates inducible nitric oxide synthase-mediated cardiovascular abnormalities in streptozotocin-induced diabetic rats
    Prabhakara Reddy Nagareddy
    Faculty of Pharmaceutical Sciences, The University of British Columbia, British Columbia, Canada
    Diabetes 58:2355-64. 2009
    ....
  92. ncbi Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension
    Darren J Kelly
    Department of Medicine, University of Melbourne, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Diabetes 52:512-8. 2003
    ..The present study thus sought to determine the in vivo effect of PKC beta inhibition in experimental diabetic nephropathy in the setting of continued hyperglycemia, hypertension, and ..
  93. ncbi Two types of complementary DNAs of rat brain protein kinase C. Heterogeneity determined by alternative splicing
    Y Ono
    FEBS Lett 206:347-52. 1986
    ..It is attractive to imagine that the heterogeneity of protein kinase C may reflect diverse pathways of signal transduction into the cell...
  94. ncbi Age-dependent activation of PKC isoforms by angiotensin II in the proximal nephron
    D M Boesch
    Division of Hypertension and Vascular Research, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202, USA
    Am J Physiol Regul Integr Comp Physiol 281:R861-7. 2001
    ..05). Maximum specific binding and affinity of ANG II receptors were not significantly different between young and adult rats. We concluded that the primary PKC isoform activated by ANG II changes during maturation...
  95. ncbi GLUT2 protein at the rat proximal tubule brush border membrane correlates with protein kinase C (PKC)-betal and plasma glucose concentration
    A K Goestemeyer
    Department of Physiology, Royal Free and University College Medical School, Hampstead Campus, Rowland Hill Street, London, NW3 2PF, UK
    Diabetologia 50:2209-17. 2007
    ....
  96. ncbi In vivo expression of classic PKC isoforms in the rat dental follicle as related to tooth eruption
    Shaomian Yao
    Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University Baton Rouge, Louisiana 70803, USA
    Connect Tissue Res 45:216-21. 2004
    ..Injection of a PKC activator, phorbol 12-myristate 13-acetate (PMA), at late postnatal days, slightly accelerated first mandibular molar eruption. This study suggests that PKC isoforms may be involved in the regulation of tooth eruption...

Research Grants80

  1. PHOSPHORYLATION OF GAP JUNCTION PROTEINS
    Paul Lampe; Fiscal Year: 2009
    ..We hypothesize that Cx43 phosphorylation changes are linked to these processes in a way that affects cellular function. ..
  2. PHOSPHORYLATION OF GAP JUNCTION PROTEINS
    Paul Lampe; Fiscal Year: 2005
    ..We plan to apply our knowledge of connexin phosphorylation and phosphorylation specific probes to the analysis of connexin status in wounded skin and the remodeling of gap junctions during heart disease. ..
  3. Proteomic Biomarkers of Health Behaviors
    Paul Lampe; Fiscal Year: 2005
    ..abstract_text> ..
  4. PHOSPHORYLATION OF GAP JUNCTION PROTEINS
    Paul Lampe; Fiscal Year: 2000
    ....
  5. PHOSPHORYLATION OF GAP JUNCTION PROTEINS
    Paul Lampe; Fiscal Year: 2007
    ..We hypothesize that Cx43 phosphorylation changes are linked to these processes in a way that affects cellular function. ..
  6. PHOSPHORYLATION OF GAP JUNCTION PROTEINS
    Paul D Lampe; Fiscal Year: 2010
    ....
  7. MICROVASCULAR CHARACTERISTICS OF DIABETES MELLITUS
    HAROLD BOHLEN; Fiscal Year: 1991
    ....
  8. MICROVASCULAR CHARACTERISTIC OF DIABETES MELLITUS
    HAROLD BOHLEN; Fiscal Year: 1993
    ..These results will be used to determine the time-dependent expression of aldose reductase, temporal correlation to disturbances in microvascular regulation, and whether the cause of hyperglycemia influences aldose reductase expression...
  9. MICROVASCULAR CHARACTERISTICS OF DIABETES MELLITUS
    HAROLD BOHLEN; Fiscal Year: 1980
    ..This will allow a quantitative evaluation of the sequence of microvascular changes in the same unanesthetized mammal during the development of diabetes...
  10. PROTEIN KINASE C AND PHOTORECEPTORS
    ALEXANDRA NEWTON; Fiscal Year: 2002
    ..Specifically, the effect of this phosphorylation on rhodopsin s macromolecular interactions (transducin coupling, arrestin binding) will be explored. ..
  11. DAUs as IGF-1 Receptor Inhibitors in Breast Cancer
    Jack F Youngren; Fiscal Year: 2010
    ..Together these studies will result in the production of well-characterized DAU-based compounds for anti-cancer drug development. ..
  12. Signal Termination by PHLPP, PH domain Leucine-rich repeat Protein Phosphatase
    ALEXANDRA NEWTON; Fiscal Year: 2009
    ....
  13. Signal Termination by PHLPP, PH domain Leucine-rich repeat Protein Phosphatase
    ALEXANDRA NEWTON; Fiscal Year: 2007
    ....
  14. DAUs as IGF-1 Receptor Inhibitors in Breast Cancer
    JACK YOUNGREN; Fiscal Year: 2007
    ..other kinases, and characterize the biological effects of altering the specificity of DAUs for the IGF-1 R. Together these studies will result in the production of well-characterized DAU-based compounds for anti-cancer drug development. ..
  15. Signal Termination by PHLPP, PH domain Leucine-rich repeat Protein Phosphatase
    ALEXANDRA NEWTON; Fiscal Year: 2009
    ....
  16. STRUCTURE, FUNCTION AND REGULATION OF PROTEIN KINASE C
    ALEXANDRA NEWTON; Fiscal Year: 2002
    ....
  17. MICROVASCULAR BEHAVIOR DURING INTESTINAL ABSORPTION
    HAROLD BOHLEN; Fiscal Year: 1993
    ..The studies will determine at what stage of hypertension the suppression of vascular branching development occurs and if prevention of hypertension can restore normal branching development...
  18. STRUCTURE, FUNCTION AND REGULATION OF PROTEIN KINASE C
    ALEXANDRA NEWTON; Fiscal Year: 2007
    ..Upregulation of phosphatase activity could account for the pleiotropic effects of PKC activation. ..
  19. MICROVASCULAR BEHAVIOR DURING INTESTINAL ABSORPTION
    HAROLD BOHLEN; Fiscal Year: 2004
    ....
  20. Microvascular Regulation During Intestinal Absorption
    HAROLD G BOHLEN; Fiscal Year: 2010
    ..A substantial fraction of the NO in blood may be from NO loading in the small arteries based on their very high wall NO concentration and represents a new form of vascular regulation. ..
  21. Microvascular Regulation During Intestinal Absorption
    HAROLD BOHLEN; Fiscal Year: 2007
    ..A substantial fraction of the NO in blood may be from NO loading in the small arteries based on their very high wall NO concentration and represents a new form of vascular regulation. ..
  22. MICROVASCULAR CHARACTERISTICS OF DIABETES MELLITUS
    HAROLD BOHLEN; Fiscal Year: 2002
    ..Positive results will confirm that chronic insulin resistance predisposes the microvasculature to abnormalities of endothelial function. However, antioxidants and inhibition of beta II isoenzymes of PKC may protect endothelial function. ..
  23. MICROVASCULAR BEHAVIOR DURING INTESTINAL ABSORPTION
    HAROLD BOHLEN; Fiscal Year: 1980
    ..These studies will be followed by an evaluation of intestinal absorptive hyperemia and skeletal muscle exercise hyperemia in innervated tissues of adult hypertens (Text Truncated - Exceeds Capacity)..