Prkag1

Summary

Gene Symbol: Prkag1
Description: protein kinase AMP-activated non-catalytic subunit gamma 1
Alias: Prkaac, Prkga1, 5'-AMP-activated protein kinase subunit gamma-1, AMP-activated protein kinase, noncatalytic gamma-1 subunit, AMPK gamma-1 chain, AMPK gamma1, AMPK subunit gamma-1, AMPKg, Protein kinase AMP-activated gamma, protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Species: rat
Products:     Prkag1

Top Publications

  1. Cheung P, Salt I, Davies S, Hardie D, Carling D. Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. Biochem J. 2000;346 Pt 3:659-69 pubmed
    ..Labelling studies, using the reactive AMP analogue 8-azido-[(32)P]AMP, indicate that the gamma subunit may participate directly in the binding of AMP within the complex. ..
  2. Xiao B, Heath R, Saiu P, Leiper F, Leone P, Jing C, et al. Structural basis for AMP binding to mammalian AMP-activated protein kinase. Nature. 2007;449:496-500 pubmed
    ..The structure also suggests a mechanism for propagating AMP/ATP signalling whereby a phosphorylated residue from the alpha and/or beta subunits binds to the gamma subunit in the presence of AMP but not when ATP is bound. ..
  3. Hardie D, Scott J, Pan D, Hudson E. Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett. 2003;546:113-20 pubmed
    ..A survey of the range of downstream targets for this important signalling pathway is presented. ..
  4. Woods A, Cheung P, Smith F, Davison M, Scott J, Beri R, et al. Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro. J Biol Chem. 1996;271:10282-90 pubmed
    ..These results suggest that AMPKbeta mediates the association of the heterotrimeric AMPK complex in vitro, and will facilitate future studies aimed at investigating the regulation of AMPK in vivo. ..
  5. Gao G, Fernandez C, Stapleton D, Auster A, Widmer J, Dyck J, et al. Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase. J Biol Chem. 1996;271:8675-81 pubmed
    ..The identification of isoform families for the AMPK subunits indicates the potential diversity of the roles of this highly conserved signaling system in nutrient regulation and utilization in mammalian cells. ..
  6. Xiao B, Sanders M, Underwood E, Heath R, Mayer F, Carmena D, et al. Structure of mammalian AMPK and its regulation by ADP. Nature. 2011;472:230-3 pubmed publisher
    ..From our biochemical and structural data we develop a model for how the energy status of a cell regulates AMPK activity. ..
  7. Jiang W, Zhu Z, Thompson H. Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver. Cancer Res. 2008;68:5492-9 pubmed publisher
  8. Baba M, Hong S, Sharma N, Warren M, Nickerson M, Iwamatsu A, et al. Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc Natl Acad Sci U S A. 2006;103:15552-7 pubmed
    ..Our data suggest that FLCN, mutated in Birt-Hogg-Dubé syndrome, and its interacting partner FNIP1 may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. ..
  9. Hardie D. The AMP-activated protein kinase pathway--new players upstream and downstream. J Cell Sci. 2004;117:5479-87 pubmed

More Information

Publications18

  1. Hawley S, Boudeau J, Reid J, Mustard K, Udd L, Makela T, et al. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol. 2003;2:28 pubmed publisher
    ..Our findings indicate that the tumors in Peutz-Jeghers syndrome could result from deficient activation of AMPK as a consequence of LKB1 inactivation. ..
  2. Turnley A, Stapleton D, Mann R, Witters L, Kemp B, Bartlett P. Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem. 1999;72:1707-16 pubmed
  3. Stapleton D, Gao G, Michell B, Widmer J, Mitchelhill K, Teh T, et al. Mammalian 5'-AMP-activated protein kinase non-catalytic subunits are homologs of proteins that interact with yeast Snf1 protein kinase. J Biol Chem. 1994;269:29343-6 pubmed
  4. Woods A, Johnstone S, Dickerson K, Leiper F, Fryer L, Neumann D, et al. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol. 2003;13:2004-8 pubmed
    ..These results identify a link between two protein kinases, previously thought to lie in unrelated, distinct pathways, that are associated with human diseases. ..
  5. Namkoong C, Kim M, Jang P, Han S, Park H, Koh E, et al. Enhanced hypothalamic AMP-activated protein kinase activity contributes to hyperphagia in diabetic rats. Diabetes. 2005;54:63-8 pubmed
    ..These data suggest that leptin and insulin deficiencies in diabetes lead to increased hypothalamic AMPK activity, which contributes to the development of diabetic hyperphagia. ..
  6. Li J, Coven D, Miller E, Hu X, Young M, Carling D, et al. Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart. Am J Physiol Heart Circ Physiol. 2006;291:H1927-34 pubmed
    ..Despite the pathophysiological importance of gamma(2)-isoform mutations, gamma(1)-isoform complexes account for most of the AMPK activity in the ischemic heart. ..
  7. Kawaguchi T, Osatomi K, Yamashita H, Kabashima T, Uyeda K. Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase. J Biol Chem. 2002;277:3829-35 pubmed
    ..AMPK was activated by the increased AMP that was generated by the fatty acid activation. ..
  8. Cai Y, Wang Q, Ling Z, Pipeleers D, McDermott P, Pende M, et al. Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR. Biochem Pharmacol. 2008;75:1981-93 pubmed publisher
  9. Zhu L, Chen L, Zhou X, Zhang Y, Zhang Y, Zhao J, et al. Structural insights into the architecture and allostery of full-length AMP-activated protein kinase. Structure. 2011;19:515-22 pubmed publisher
    ..These results not only make substantial revision to the current model of AMPK assembly, but also highlight a central role of the linker sequence of the ? subunit in mediating the allostery of AMPK. ..