Prkaca

Summary

Gene Symbol: Prkaca
Description: protein kinase cAMP-activated catalytic subunit alpha
Alias: Cs-PKA, PKCA1, cAMP-dependent protein kinase catalytic subunit alpha, PKA C-alpha, cAMP-dependent protein kinase catalytic subunit C alpha, protein kinase A, protein kinase, cAMP-dependent, alpha catalytic subunit, protein kinase, cAMP-dependent, catalytic, alpha
Species: rat
Products:     Prkaca

Top Publications

  1. Tumati S, Yamamura H, St John P, Vanderah T, Roeske W, Varga E. Sustained cannabinoid agonist treatment augments CGRP release in a PKA-dependent manner. Neuroreport. 2009;20:815-9 pubmed publisher
    ..neonatal rat dorsal root ganglion neurons significantly augments basal CGRP release from these cells in a protein kinase A-dependent manner...
  2. Yoon C, Korade Z, Carter B. Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype. J Neurosci. 2008;28:3738-46 pubmed publisher
  3. Moore C, Nelson P, Parelkar N, Rusch N, Rhee S. Protein kinase A-phosphorylated KV1 channels in PSD95 signaling complex contribute to the resting membrane potential and diameter of cerebral arteries. Circ Res. 2014;114:1258-67 pubmed publisher
    ..We explored whether a specific interaction between PSD95 and KV1 channels enables protein kinase A phosphorylation of KV1 channels in cVSMCs to promote vasodilation...
  4. Yang Y, Shi Y, Guo S, Zhang S, Cui N, Shi W, et al. PKA-dependent activation of the vascular smooth muscle isoform of KATP channels by vasoactive intestinal polypeptide and its effect on relaxation of the mesenteric resistance artery. Biochim Biophys Acta. 2008;1778:88-96 pubmed
    ..These results therefore indicate that the vascular isoform (Kir6.1/SUR2B) of KATP channels is a target of VIP. The channel activation relies on the PKA pathway and produces mesenteric arterial relaxation...
  5. Bird G, Lash L, Han J, Zou X, Willis W, Neugebauer V. Protein kinase A-dependent enhanced NMDA receptor function in pain-related synaptic plasticity in rat amygdala neurones. J Physiol. 2005;564:907-21 pubmed
    ..This study shows that pain-related synaptic plasticity is accompanied by protein kinase A (PKA)-mediated enhanced NMDA-receptor function and increased phosphorylation of NMDA-receptor 1 (NR1) ..
  6. Sampson L, Hayabuchi Y, Standen N, Dart C. Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels. Circ Res. 2004;95:1012-8 pubmed
    ..This reduces the cAMP-dependent protein kinase A-sensitive component of whole-cell K(ATP) current, indicating that the integrity of caveolae is important for ..
  7. Vermeulen L, De Wilde G, Van Damme P, Vanden Berghe W, Haegeman G. Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). EMBO J. 2003;22:1313-24 pubmed
    ..This effect represents, together with phosphorylation of nucleosome components such as histone H3, an essential step leading to selective transcriptional activation of NF-kappaB-dependent gene expression. ..
  8. Reinton N, Orstavik S, Haugen T, Jahnsen T, Tasken K, Skalhegg B. A novel isoform of human cyclic 3',5'-adenosine monophosphate-dependent protein kinase, c alpha-s, localizes to sperm midpiece. Biol Reprod. 2000;63:607-11 pubmed
    ..This novel C alpha-s splice variant appeared to have an independent anchor in the human sperm midpiece as it could not be completely solubilized even in the presence of both detergent and cAMP. ..
  9. Crawford A, Desai D, Gokina P, Basak S, Kim H. E-cadherin expression in postnatal Schwann cells is regulated by the cAMP-dependent protein kinase a pathway. Glia. 2008;56:1637-47 pubmed publisher
    ..We also show that the axonal effect is mediated through cAMP-dependent protein kinase A (cAMP-PKA) activation in the Schwann cell: (1) inhibition of cAMP-PKA blocks axon-induced E-cadherin ..

More Information

Publications62

  1. Murray A, Tucker S, Shewan D. cAMP-dependent axon guidance is distinctly regulated by Epac and protein kinase A. J Neurosci. 2009;29:15434-44 pubmed publisher
    ..Conversely, the repulsion conferred by MAG or netrin-1 on adult growth cones is mediated by protein kinase A (PKA)...
  2. Kvissel A, Ørstavik S, Eikvar S, Brede G, Jahnsen T, Collas P, et al. Involvement of the catalytic subunit of protein kinase A and of HA95 in pre-mRNA splicing. Exp Cell Res. 2007;313:2795-809 pubmed
    b>Protein kinase A (PKA) is a holoenzyme consisting of two catalytic (C) subunits bound to a regulatory (R) subunit dimer. Stimulation by cAMP dissociates the holoenzyme and causes translocation to the nucleus of a fraction of the C subunit...
  3. Pan Y, Wang C, Wang B. Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development. Dev Biol. 2009;326:177-89 pubmed publisher
    ..Gli3 processing is dependent on phosphorylation of the first four of the six protein kinase A (PKA) sites at its C-terminus...
  4. Ullas K, Rao M. Phosphorylation of rat spermatidal protein TP2 by sperm-specific protein kinase A and modulation of its transport into the haploid nucleus. J Biol Chem. 2003;278:52673-80 pubmed
    ..elongating and elongated) spermatid nuclei and the protein kinase phosphorylating TP2 was identified to be protein kinase A (PKA)...
  5. Marx S, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, et al. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell. 2000;101:365-76 pubmed
    ..6). We show that protein kinase A (PKA) phosphorylation of RyR2 dissociates FKBP12.6 and regulates the channel open probability (Po)...
  6. Gui P, Wu X, Ling S, Stotz S, Winkfein R, Wilson E, et al. Integrin receptor activation triggers converging regulation of Cav1.2 calcium channels by c-Src and protein kinase A pathways. J Biol Chem. 2006;281:14015-25 pubmed
    ..These sites are known to be phosphorylated by protein kinase A (PKA) and c-Src, respectively, and are conserved between rat neuronal (Cav1.2c) and smooth muscle (Cav1...
  7. Burmeister B, Wang L, Gold M, Skidgel R, O Bryan J, Carnegie G. Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity. J Biol Chem. 2015;290:12058-67 pubmed publisher
    ..We demonstrate that Shp2 is a component of the protein kinase A anchoring protein (AKAP)-Lbc complex...
  8. Needle E, Piparo K, Cole D, Worrall C, Whitehead I, Mahon G, et al. Protein kinase A-independent cAMP stimulation of progesterone in a luteal cell model is tyrosine kinase dependent but phosphatidylinositol-3-kinase and mitogen-activated protein kinase independent. Biol Reprod. 2007;77:147-55 pubmed
    ..Classically, increased intracellular concentrations of cAMP result in activation of protein kinase A (PKA), which in turn phosphorylates gene regulatory transcription factors...
  9. Lygren B, Carlson C, Santamaria K, Lissandron V, McSorley T, Litzenberg J, et al. AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum. EMBO Rep. 2007;8:1061-7 pubmed
    The beta-adrenergic receptor/cyclic AMP/protein kinase A (PKA) signalling pathway regulates heart rate and contractility...
  10. Sato Y, Maekawa S, Ishii R, Sanada M, Morikawa T, Shiraishi Y, et al. Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome. Science. 2014;344:917-20 pubmed publisher
    ..We report a hotspot mutation (L206R) in PRKACA, which encodes the catalytic subunit of cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA), in ..
  11. Murphy J, Stein I, Lau C, Peixoto R, Aman T, Kaneko N, et al. Phosphorylation of Ser1166 on GluN2B by PKA is critical to synaptic NMDA receptor function and Ca2+ signaling in spines. J Neurosci. 2014;34:869-79 pubmed publisher
    ..Emerging evidence indicates that NMDAR Ca(2+) permeability is under the control of cAMP/protein kinase A (PKA) signaling...
  12. Kim C, Xuong N, Taylor S. Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA. Science. 2005;307:690-6 pubmed
    ..The beta barrel of cAMP binding domain A, which is the docking site for cAMP, remains largely intact in the complex, whereas the helical subdomain undergoes major reorganization. ..
  13. Qin L, Partridge N. Stimulation of amphiregulin expression in osteoblastic cells by parathyroid hormone requires the protein kinase A and cAMP response element-binding protein signaling pathway. J Cell Biochem. 2005;96:632-40 pubmed
    ..protein kinase activators, and inhibitors, we have demonstrated that PTH regulates amphiregulin in a cAMP-protein kinase A (PKA)-dependent manner both in vitro and in vivo...
  14. Karlsson A, Maizels E, Flynn M, Jones J, Shelden E, Bamburg J, et al. Luteinizing hormone receptor-stimulated progesterone production by preovulatory granulosa cells requires protein kinase A-dependent activation/dephosphorylation of the actin dynamizing protein cofilin. Mol Endocrinol. 2010;24:1765-81 pubmed publisher
    Activation of the LH receptor (LHR) on preovulatory granulosa cells stimulates the cAMP/protein kinase A (PKA) pathway to regulate expression of genes required for ovulation and luteinization...
  15. Kawashima H, Satoh H, Saotome M, Urushida T, Katoh H, Hayashi H. Protein phosphatase inhibitor-1 augments a protein kinase A-dependent increase in the Ca2+ loading of the sarcoplasmic reticulum without changing its Ca2+ release. Circ J. 2009;73:1133-40 pubmed
    ..The protein kinase A catalytic subunit (PKA(cat)) increased the peak of CaffCaTs between 5 and 50 U/ml, and the addition of ..
  16. Tawfeek H, Abou Samra A. Negative regulation of parathyroid hormone (PTH)-activated phospholipase C by PTH/PTH-related peptide receptor phosphorylation and protein kinase A. Endocrinology. 2008;149:4016-23 pubmed publisher
    PTH binding to the PTH/PTHrP receptor activates adenylate cyclase/protein kinase A (PKA) and phospholipase C (PLC) pathways and increases receptor phosphorylation...
  17. Wang C, Huang Q, Wang C, Zhu X, Duan Y, Yuan S, et al. Hydroxysafflor yellow A suppresses oleic acid-induced acute lung injury via protein kinase A. Toxicol Appl Pharmacol. 2013;272:895-904 pubmed publisher
    ..Activation of the cAMP/protein kinase A (PKA) signaling pathway may attenuate ALI by suppressing immune responses and inhibiting the generation of ..
  18. Baggaley E, McLarnon S, Demeter I, Varga G, Bruce J. Differential regulation of the apical plasma membrane Ca(2+) -ATPase by protein kinase A in parotid acinar cells. J Biol Chem. 2007;282:37678-93 pubmed
    ..Previous studies showed that protein kinase A (PKA) potentiates and phosphorylates the plasma membrane Ca(2+)-ATPase (PMCA) in a Ca(2+)-dependent manner in ..
  19. Xiao B, Tian X, Xie W, Jones P, Cai S, Wang X, et al. Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: sensitization of store overload-induced Ca2+ release. J Biol Chem. 2007;282:30256-64 pubmed
    The phosphorylation of the cardiac Ca(2+)-release channel (ryanodine receptor, RyR2) by protein kinase A (PKA) has been extensively characterized, but its functional consequence remains poorly defined and controversial...
  20. Hall D, Feekes J, Arachchige Don A, Shi M, Hamid J, Chen L, et al. Binding of protein phosphatase 2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation. Biochemistry. 2006;45:3448-59 pubmed
    ..2 is required for effective reversal of PKA-mediated channel phosphorylation. Accordingly, PKA as well as PP2A are constitutively associated with Ca(v)1.2 for its proper regulation by phosphorylation and dephosphorylation of serine 1928. ..
  21. Wang W, Zhang X, Zheng J, Yang J. High glucose stimulates adipogenic and inhibits osteogenic differentiation in MG-63 cells through cAMP/protein kinase A/extracellular signal-regulated kinase pathway. Mol Cell Biochem. 2010;338:115-22 pubmed publisher
  22. Wang S, Li Z, Shen H, Zhang Z, Yin Y, Wang Q, et al. Quantitative Phosphoproteomic Study Reveals that Protein Kinase A Regulates Neural Stem Cell Differentiation Through Phosphorylation of Catenin Beta-1 and Glycogen Synthase Kinase 3?. Stem Cells. 2016;34:2090-101 pubmed publisher
    ..Our data provides a valuable resource for studying the self-renewal and differentiation of NSCs. Stem Cells 2016;34:2090-2101. ..
  23. Stanger S, Law E, Jamsai D, O Bryan M, Nixon B, McLaughlin E, et al. A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA/TCP11 complex that undergoes conformational and phosphorylation changes upon capacitation. FASEB J. 2016;30:2777-91 pubmed publisher
    ..The current study was designed to identify binding partners of the sperm-specific (C?2) catalytic subunit of PKA (PRKACA) by using it as the "bait" in a yeast 2-hybrid system...
  24. Yao L, Arolfo M, Dohrman D, Jiang Z, Fan P, Fuchs S, et al. betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption. Cell. 2002;109:733-43 pubmed
    ..We propose that synergy of D2 and A2 confers ethanol hypersensitivity and that betagamma dimers are required for voluntary drinking. ..
  25. Su W, Liu X. RAB13 regulates Sertoli cell permeability barrier dynamics through protein kinase A. J Mol Endocrinol. 2013;50:305-18 pubmed publisher
    ..shown to decrease during the testosterone-induced TJ integrity enhancement, accompanied with an increment in protein kinase A (PKA) activity...
  26. Cao W, Sohail M, Liu G, Koumbadinga G, Lobo V, Xie J. Differential effects of PKA-controlled CaMKK2 variants on neuronal differentiation. RNA Biol. 2011;8:1061-72 pubmed publisher
    ..Here we examined the effect of the protein kinase A (PKA) pathway on the alternative splicing and variant properties of the Ca²?/calmodulin-dependent protein ..
  27. Lomash R, Sheng N, Li Y, Nicoll R, Roche K. Phosphorylation of the kainate receptor (KAR) auxiliary subunit Neto2 at serine 409 regulates synaptic targeting of the KAR subunit GluK1. J Biol Chem. 2017;292:15369-15377 pubmed publisher
    ..phosphorylated at serine 409 (Ser-409) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and protein kinase A (PKA) both in vitro and in heterologous cells...
  28. Pirino G, Wescott M, Donovan P. Protein kinase A regulates resumption of meiosis by phosphorylation of Cdc25B in mammalian oocytes. Cell Cycle. 2009;8:665-70 pubmed
    ..Cyclic AMP (cAMP)-mediated Protein Kinase A (PKA) activity sustains prophase arrest by inhibiting Cdk1...
  29. Kawahata I, Ohtaku S, Tomioka Y, Ichinose H, Yamakuni T. Dopamine or biopterin deficiency potentiates phosphorylation at (40)Ser and ubiquitination of tyrosine hydroxylase to be degraded by the ubiquitin proteasome system. Biochem Biophys Res Commun. 2015;465:53-8 pubmed publisher
  30. Blirando K, Blaise R, Gorodnaya N, Rouxel C, Meilhac O, Vincent P, et al. The stellate vascular smooth muscle cell phenotype is induced by IL-1β via the secretion of PGE2 and subsequent cAMP-dependent protein kinase A activation. Biochim Biophys Acta. 2015;1853:3235-47 pubmed publisher
    ..Finally, by knocking down the expression of the regulatory subunit PKAR1α, thereby reproducing the effects of IL-1β and PGE₂ on VSMCs, we demonstrated the contribution of PKA activity to the observed behavior of VSMCs. ..
  31. Dong J, Gao C, Liu J, Cao Y, Tian L. TSH inhibits SERCA2a and the PKA/PLN pathway in rat cardiomyocytes. Oncotarget. 2016;7:39207-39215 pubmed publisher
    ..SERCA2a activity and expression by binding to TSH receptors in cardiomyocyte membranes and inhibiting the protein kinase A/phoshpolamban (PKA/PLN) signaling pathway...
  32. Radhakrishnan I, Pérez Alvarado G, Dyson H, Wright P. Conformational preferences in the Ser133-phosphorylated and non-phosphorylated forms of the kinase inducible transactivation domain of CREB. FEBS Lett. 1998;430:317-22 pubmed
  33. Du F, Qian C, Qian Z, Wu X, Xie H, Yung W, et al. Hepcidin directly inhibits transferrin receptor 1 expression in astrocytes via a cyclic AMP-protein kinase A pathway. Glia. 2011;59:936-45 pubmed publisher
    ..we found that the effect of hepcidin in reducing TfR1 expression, which is dependent on the cyclic AMP-protein kinase A pathway, was the primary and dominant event...
  34. deSouza N, Reiken S, Ondrias K, Yang Y, Matkovich S, Marks A. Protein kinase A and two phosphatases are components of the inositol 1,4,5-trisphosphate receptor macromolecular signaling complex. J Biol Chem. 2002;277:39397-400 pubmed
    ..PKA phosphorylation of IP3R1 increases channel activity in planar lipid bilayers. These studies indicate that regulation of IP3R1 function via PKA phosphorylation involves components of a macromolecular signaling complex. ..
  35. Fu Y, Han J, Ishola T, Scerbo M, Adwanikar H, Ramsey C, et al. PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior. Mol Pain. 2008;4:26 pubmed publisher
    ..The data suggest that in the amygdala PKA and ERK, but not PKC, contribute to pain-related synaptic facilitation and behavior by increasing NMDA receptor function through independent signaling pathways. ..
  36. Herr J, Chertihin O, Digilio L, Jha K, Vemuganti S, Flickinger C. Distribution of RNA binding protein MOEP19 in the oocyte cortex and early embryo indicates pre-patterning related to blastomere polarity and trophectoderm specification. Dev Biol. 2008;314:300-16 pubmed publisher
    ..Although the RNAs bound to MOEP19 are presently unknown, we predict that the MOEP19 domain directs RNAs essential for normal embryonic development to specific locations in the oocyte and early embryo. ..
  37. Bernard L, Zhang H. MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism. PLoS ONE. 2015;10:e0124816 pubmed publisher
    ..Further, we show that this activation is dependent on protein kinase A (PKA), through the phosphorylation of Ser431 of Par4/LKB1, the major upstream kinase of MARK/Par1...
  38. Jeon S, Kim S, Kim E, Lee J, Kim S, Juhnn Y, et al. Chloride conductance is required for the protein kinase A and Rac1-dependent phosphorylation of moesin at Thr-558 by KCl in PC12 cells. J Biol Chem. 2005;280:12181-9 pubmed
    ..The inhibition of protein kinase A (PKA), known as an upstream kinase of Rac1, abolished Rac1 activation and moesin phosphorylation by KCl...
  39. Leblais V, Jo S, Chakir K, Maltsev V, Zheng M, Crow M, et al. Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes. Circ Res. 2004;95:1183-90 pubmed
  40. Yger M, Girault J. DARPP-32, Jack of All Trades… Master of Which?. Front Behav Neurosci. 2011;5:56 pubmed publisher
    ..Thus, DARPP-32 is a non-essential but tightly regulated signaling hub molecule which may improve the general performance of the neuronal circuits in which it is expressed. ..
  41. Liu J, Zhao X, Cao J, Xue Q, Feng X, Liu X, et al. Differential roles of PKA and Epac on the production of cytokines in the endotoxin-stimulated primary cultured microglia. J Mol Neurosci. 2011;45:186-93 pubmed publisher
    ..the anti-inflammatory effect of adenosine cyclic 3',5'-monophosphate (cAMP), we examined the effect of protein kinase A (PKA) and cAMP-responsive guanine nucleotide exchange factor (Epac) on the transcription and production of ..
  42. Xu J, Yang G, Li T, Ming J, Chen W, Liu L. [The role of CPI-17 in vascular calcium sensitivity regulated by protein kinase Calpha and Cepsilon in rats with hemorrhagic shock]. Zhonghua Shao Shang Za Zhi. 2009;25:167-70 pubmed
    ..05), and those in PKCalpha agonist and PKC agonist groups (P < 0.05 or P < 0.01). PKCalpha and PKCepsilon may regulate vascular calcium sensitivity through change in protein expression and activity of CPI-17 in HS rats. ..
  43. Matsumoto J, Almeida M, Castilho Martins E, Costa M, Fior Chadi D. Protein kinase A mediates adenosine A2a receptor modulation of neurotransmitter release via synapsin I phosphorylation in cultured cells from medulla oblongata. Neurosci Res. 2014;85:1-11 pubmed publisher
    ..The adenosine A2a receptor modulates neurotransmitter release by activating two cAMP protein effectors, the protein kinase A and the exchange protein activated by cAMP...
  44. Cieslak D, Lazou A. Regulation of BAD protein by PKA, PKCdelta and phosphatases in adult rat cardiac myocytes subjected to oxidative stress. Mol Cells. 2007;24:224-31 pubmed
    ..These data suggest that, during oxidative stress-induced cardiac myocyte apoptosis, there is a caspase-dependent down-regulation of BAD protein, which seems to be regulated by coordinated action of PKA, PKCdelta and phosphatases. ..
  45. Li Y, He W, Jha K, Klotz K, Kim Y, Mandal A, et al. FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis. J Biol Chem. 2007;282:34104-19 pubmed
    ..FSCB is phosphorylated by protein kinase A as shown by in vitro phosphorylation assay and also by determining phosphorylation sites in native FSCB from ..
  46. Wang W, Zhu W, Wang S, Yang D, Crow M, Xiao R, et al. Sustained beta1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway. Circ Res. 2004;95:798-806 pubmed
    ..receptor (beta1AR) signaling is that stimulation of the receptor activates the adenylate cyclase-cAMP-protein kinase A (PKA) pathway, resulting in positive inotropic and relaxant effects in the heart...
  47. Lefrançois Martinez A, Blondet Trichard A, Binart N, Val P, Chambon C, Sahut Barnola I, et al. Transcriptional control of adrenal steroidogenesis: novel connection between Janus kinase (JAK) 2 protein and protein kinase A (PKA) through stabilization of cAMP response element-binding protein (CREB) transcription factor. J Biol Chem. 2011;286:32976-85 pubmed publisher
    ..Hence, we describe a novel link between PKA and JAK2 by which nuclear JAK2 signaling controls adrenal steroidogenesis by increasing the stability of CREB. ..
  48. Jedrzejewski P, Girod A, Tholey A, Konig N, Thullner S, Kinzel V, et al. A conserved deamidation site at Asn 2 in the catalytic subunit of mammalian cAMP-dependent protein kinase detected by capillary LC-MS and tandem mass spectrometry. Protein Sci. 1998;7:457-69 pubmed
    The N-terminal sequence myr-Gly-Asn is conserved among the myristoylated cAPK (protein kinase A) catalytic subunit isozymes Calpha, Cbeta, and Cgamma...
  49. Datta S, Desarnaud F. Protein kinase A in the pedunculopontine tegmental nucleus of rat contributes to regulation of rapid eye movement sleep. J Neurosci. 2010;30:12263-73 pubmed publisher
    ..This study was designed to determine the role of PPT intracellular cAMP-dependent protein kinase A (cAMP-PKA) in the regulation of recovery REM sleep in freely moving rats...
  50. Kultgen P, Byrd S, Ostrowski L, Milgram S. Characterization of an A-kinase anchoring protein in human ciliary axonemes. Mol Biol Cell. 2002;13:4156-66 pubmed
    Although protein kinase A (PKA) activation is known to increase ciliary beat frequency in humans the molecular mechanisms involved are unknown...
  51. Di Giulio C, Rapino M, Zingariello M, Antonucci A, Cataldi A. PKC alpha-mediated CREB activation is oxygen and age-dependent in rat myocardial tissue. Histochem Cell Biol. 2007;127:327-33 pubmed
  52. Lee J, Shim S, Kim M, Myung J, Jang W, Bae C, et al. Pentoxifylline Regulates Plasminogen Activator Inhibitor-1 Expression and Protein Kinase A Phosphorylation in Radiation-Induced Lung Fibrosis. Biomed Res Int. 2017;2017:1279280 pubmed publisher
    ..inhibitor- (PAI-) 1 and fibronectin (FN) and PTX treatment reduced expression of PAI-1 and FN by restoring protein kinase A (PKA) phosphorylation but not TGF-?/Smad in both irradiated lung tissues and epithelial cells...
  53. Monterisi S, Lobo M, Livie C, Castle J, Weinberger M, Baillie G, et al. PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling. elife. 2017;6: pubmed publisher
    ..We further demonstrate that inhibition of PDE2A, by enhancing the hormone-dependent cAMP response locally, affects mitochondria dynamics and protects from apoptotic cell death. ..