Research Topics
Genomes and Genes
| Prkaa2SummaryGene Symbol: Prkaa2 Description: protein kinase, AMP-activated, alpha 2 catalytic subunit Summary: protein kinase that phosphorylates and inhibits acetyl-CoA carboxylase (ACC); rate-limiting enzyme in malonyl-CoA synthesis [RGD] Alias: AMPK, AMP-activated protein kinase, AMP-activated protein kinase alpha 2 catalytic subunit Species: rat Products: Prkaa2 antibody Prkaa2 cDNA Research Grants Regulation of Glucose Transport in the Ischemic HeartLawrence H Young; Fiscal Year: 2007 VisualSonics Vevo 770 Imaging SystemLawrence H Young; Fiscal Year: 2007 Regulation of Glucose Transport in the Ischemic HeartLawrence H Young; Fiscal Year: 2008 Publications Central exercise action increases the AMPK and mTOR response to leptinEduardo R Ropelle Department of Internal Medicine, FCM, State University of Campinas UNICAMP, Campinas, São Paulo, Brazil PLoS ONE 3:e3856 AMP-activated protein kinase mediates carotid body excitation by hypoxiaChristopher N Wyatt Division of Biomedical Sciences, School of Biology, Bute Building, University of St Andrews, St Andrews, Fife, KY16 9TS, UK J Biol Chem 282:8092-8 AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosisWon Ho Kim Division of Metabolic Diseases, Center for Biomedical Sciences, National Institutes of Health, 194 Tongillo, Eunpyeong gu, Seoul, South Korea Cell Signal 19:791-805 Ligand-regulated peptide aptamers that inhibit the 5'-AMP-activated protein kinaseRussell A Miller Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA J Mol Biol 365:945-57 Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinaseAndrew L Carey Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology RMIT University, Australia Diabetes 55:2688-97 Critical role of 5'-AMP-activated protein kinase in the stimulation of glucose transport in response to inhibition of oxidative phosphorylationMing Jing Clinical and Molecular Endocrinology, Department of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4951, USA Am J Physiol Cell Physiol 292:C477-87 AMPK and metabolic adaptation by the heart to pressure overloadMichael F Allard James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Rm 166, St Paul s Hospital, 1081 Burrard St, Vancouver, BC, Canada Am J Physiol Heart Circ Physiol 292:H140-8 Metformin increases the PGC-1alpha protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivoMasataka Suwa Institute of Health Science, Kyushu University, Kasuga, Fukuoka 816 8580, Japan J Appl Physiol 101:1685-92 Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heartJi Li Section of Cardiovascular Medicine, 3 FMP, Yale Univ School of Medicine, 333 Cedar St, New Haven, CT 06520 8017, USA Am J Physiol Heart Circ Physiol 291:H1927-34 Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubesMatthew J Watt Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, Victoria, Australia J Physiol 574:139-47 | Scientific Experts
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Detail Information
Research Grants
Regulation of Glucose Transport in the Ischemic HeartLawrence H Young; Fiscal Year: 2007
..This abstract is not available...
VisualSonics Vevo 770 Imaging SystemLawrence H Young; Fiscal Year: 2007
..Adult cardiovascular disease is the leading cause of death in this country and congenital heart disease a major cause of disability and death in children...
Regulation of Glucose Transport in the Ischemic HeartLawrence H Young; Fiscal Year: 2008
..The AMP-activated protein kinase (AMPK) is a serine-threonine protein kinase which is activated by energetic stress and is emerging as an important ..
Publications
Central exercise action increases the AMPK and mTOR response to leptinEduardo R Ropelle
Department of Internal Medicine, FCM, State University of Campinas UNICAMP, Campinas, São Paulo, Brazil
PLoS ONE 3:e3856
Department of Internal Medicine, FCM, State University of Campinas UNICAMP, Campinas, São Paulo, Brazil
PLoS ONE 3:e3856
AMP-activated protein kinase (AMPK) and mammalian Target of Rapamycin (mTOR) are key regulators of cellular energy balance and of the effects of leptin on food intake...
AMP-activated protein kinase mediates carotid body excitation by hypoxiaChristopher N Wyatt
Division of Biomedical Sciences, School of Biology, Bute Building, University of St Andrews, St Andrews, Fife, KY16 9TS, UK
J Biol Chem 282:8092-8
Division of Biomedical Sciences, School of Biology, Bute Building, University of St Andrews, St Andrews, Fife, KY16 9TS, UK
J Biol Chem 282:8092-8
..We tested the hypothesis that AMP-activated protein kinase (AMPK) is the effector of hypoxic chemotransduction...
AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosisWon Ho Kim
Division of Metabolic Diseases, Center for Biomedical Sciences, National Institutes of Health, 194 Tongillo, Eunpyeong gu, Seoul, South Korea
Cell Signal 19:791-805
Division of Metabolic Diseases, Center for Biomedical Sciences, National Institutes of Health, 194 Tongillo, Eunpyeong gu, Seoul, South Korea
Cell Signal 19:791-805
..These events are potentiated in AMPK-overexpressing cells, but are prevented in cells transfected with mutant dominant-negative AMPK (AMPK-K45R)...
Ligand-regulated peptide aptamers that inhibit the 5'-AMP-activated protein kinaseRussell A Miller
Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
J Mol Biol 365:945-57
Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
J Mol Biol 365:945-57
..of ligand-regulated peptide aptamers that interact with and inhibit the 5'-AMP-activated protein kinase (AMPK)...
Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinaseAndrew L Carey
Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology RMIT University, Australia
Diabetes 55:2688-97
Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology RMIT University, Australia
Diabetes 55:2688-97
..Furthermore, IL-6 rapidly and markedly increased AMP-activated protein kinase (AMPK)...
Critical role of 5'-AMP-activated protein kinase in the stimulation of glucose transport in response to inhibition of oxidative phosphorylationMing Jing
Clinical and Molecular Endocrinology, Department of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4951, USA
Am J Physiol Cell Physiol 292:C477-87
Clinical and Molecular Endocrinology, Department of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4951, USA
Am J Physiol Cell Physiol 292:C477-87
5'-AMP-activated protein kinase (AMPK) functions as an energy sensor to provide metabolic adaptation under conditions of ATP depletion, such as hypoxia and inhibition of oxidative phosphorylation...
AMPK and metabolic adaptation by the heart to pressure overloadMichael F Allard
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Rm 166, St Paul s Hospital, 1081 Burrard St, Vancouver, BC, Canada
Am J Physiol Heart Circ Physiol 292:H140-8
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Rm 166, St Paul s Hospital, 1081 Burrard St, Vancouver, BC, Canada
Am J Physiol Heart Circ Physiol 292:H140-8
..response to reduced energy production from long-chain fatty acid oxidation with 5'-AMP-activated protein kinase (AMPK) functioning as a cellular signal...
Metformin increases the PGC-1alpha protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivoMasataka Suwa
Institute of Health Science, Kyushu University, Kasuga, Fukuoka 816 8580, Japan
J Appl Physiol 101:1685-92
Institute of Health Science, Kyushu University, Kasuga, Fukuoka 816 8580, Japan
J Appl Physiol 101:1685-92
AMP-activated protein kinase (AMPK), which was activated by an antihyperglycemic drug metformin, has been hypothesized to mediate metabolic adaptations...
Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heartJi Li
Section of Cardiovascular Medicine, 3 FMP, Yale Univ School of Medicine, 333 Cedar St, New Haven, CT 06520 8017, USA
Am J Physiol Heart Circ Physiol 291:H1927-34
Section of Cardiovascular Medicine, 3 FMP, Yale Univ School of Medicine, 333 Cedar St, New Haven, CT 06520 8017, USA
Am J Physiol Heart Circ Physiol 291:H1927-34
AMP-activated protein kinase (AMPK) plays a key role in modulating cellular metabolic processes...
Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubesMatthew J Watt
Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, Victoria, Australia
J Physiol 574:139-47
Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, Victoria, Australia
J Physiol 574:139-47
We investigated the role of fatty acid availability on AMPK signalling and fatty acid oxidation in skeletal muscle...
Glucose-induced repression of PPARalpha gene expression in pancreatic beta-cells involves PP2A activation and AMPK inactivationKim Ravnskjaer
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
J Mol Endocrinol 36:289-99
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
J Mol Endocrinol 36:289-99
..activation of protein phosphatase 2A in a process involving inactivation of the AMP-activated protein kinase (AMPK)...
Extracellular adenosine activates AMP-dependent protein kinase (AMPK)Ivette Aymerich
Departament de Bioquímica i Biologia Molecular, Universitat de Barcelona, 08071 Barcelona, Spain
J Cell Sci 119:1612-21
Departament de Bioquímica i Biologia Molecular, Universitat de Barcelona, 08071 Barcelona, Spain
J Cell Sci 119:1612-21
Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a heterotrimeric complex that senses intracellular energy status and exerts rapid regulation on energy-demanding and -consuming metabolic pathways...
AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase BLuc Bertrand
Division of Cardiology, School of Medicine, Université Catholique de Louvain, Brussels, Belgium
Am J Physiol Heart Circ Physiol 291:H239-50
Division of Cardiology, School of Medicine, Université Catholique de Louvain, Brussels, Belgium
Am J Physiol Heart Circ Physiol 291:H239-50
..Part of these metabolic effects is thought to be mediated by the activation of AMP-activated protein kinase (AMPK)...
LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of trainingApiradee Sriwijitkamol
Diabetes Division, University of Texas Health Science Center at San Antonio, TX, USA
Am J Physiol Endocrinol Metab 290:E925-32
Diabetes Division, University of Texas Health Science Center at San Antonio, TX, USA
Am J Physiol Endocrinol Metab 290:E925-32
b>AMPK is a key regulator of fat and carbohydrate metabolism. It has been postulated that defects in AMPK signaling could be responsible for some of the metabolic abnormalities of type 2 diabetes...
Adrenaline is a critical mediator of acute exercise-induced AMP-activated protein kinase activation in adipocytesHo Jin Koh
Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
Biochem J 403:473-81
Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
Biochem J 403:473-81
Exercise increases AMPK (AMP-activated protein kinase) activity in human and rat adipocytes, but the underlying molecular mechanisms and functional consequences of this activation are not known...
Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesisRichard M Reznick
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
Cell Metab 5:151-6
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
Cell Metab 5:151-6
..Given the important role of the AMP-activated protein kinase (AMPK) in the regulation of fat oxidation and mitochondrial biogenesis, we examined AMPK activity in young and old rats ..
AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA ribosideBruno Guigas
Université catholique de Louvain and Institute of Cellular Pathology, Hormone and Metabolic Research Unit, Brussels, Belgium
Biochem J 404:499-507
Université catholique de Louvain and Institute of Cellular Pathology, Hormone and Metabolic Research Unit, Brussels, Belgium
Biochem J 404:499-507
..5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside) has been extensively used in cells to activate the AMPK (AMP-activated protein kinase), a metabolic sensor involved in cell energy homoeostasis...
Inducible nitric oxide synthase and AMP-activated protein kinase in basal forebrain during prolonged wakingHenna Kaisa M Wigren
Institute of Biomedicine Physiology, University of Helsinki, Biomedicum Helsinki, Finland
Neuroreport 20:97-101
Institute of Biomedicine Physiology, University of Helsinki, Biomedicum Helsinki, Finland
Neuroreport 20:97-101
..In contrast, no changes were found in the cortex. These results further support the hypothesis that basal forebrain, as compared to cortex, is selectively sensitive to the effects of prolonged waking...
Follicle-stimulating hormone inhibits adenosine 5'-monophosphate-activated protein kinase activation and promotes cell proliferation of primary granulosa cells in culture through an Akt-dependent pathwayPradeep P Kayampilly
Department of Obstetrics and Gynecology and Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Endocrinology 150:929-35
Department of Obstetrics and Gynecology and Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Endocrinology 150:929-35
..The present study investigated whether AMP-activated protein kinase (AMPK), which controls the energy balance of the cell, plays a role in FSH-mediated increase in granulosa cell ..
Metabolic switch and hypertrophy of cardiomyocytes following treatment with angiotensin II are prevented by AMP-activated protein kinaseBettina Johanna Stuck
Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg Saar, D 66421 Homburg Saar, Germany
J Biol Chem 283:32562-9
Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg Saar, D 66421 Homburg Saar, Germany
J Biol Chem 283:32562-9
..of angiotensin II on glucose and fatty acid utilization and the modifying role of AMP-activated protein kinase (AMPK), a key regulator of metabolism and proliferation...
Fructose-2,6-bisphosphate is lower in copper deficient rat cerebellum despite higher content of phosphorylated AMP-activated protein kinaseAnna A Gybina
Department of Biochemistry and Molecular Biology, University of Minnesota Medical School Duluth, Duluth, MN 55812, USA
Exp Biol Med (Maywood) 233:1262-70
Department of Biochemistry and Molecular Biology, University of Minnesota Medical School Duluth, Duluth, MN 55812, USA
Exp Biol Med (Maywood) 233:1262-70
..b>AMP activated protein kinase (AMPK) is a cellular energy "master-switch" that is thought to augment glycolysis through ..
Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphate-activated protein kinase signaling in the arcuate nucleus of ratsHiroshi Shimizu
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
Endocrinology 149:4544-53
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
Endocrinology 149:4544-53
Recent studies suggest that the AMP-activated protein kinase (AMPK) signaling in the hypothalamus is the master regulator of energy balance...
Chronic palmitate exposure inhibits AMPKalpha and decreases glucose-stimulated insulin secretion from beta-cells: modulation by fenofibrateYing Sun
Department of Endocrinology, Shandong University, Jinan 250021, China
Acta Pharmacol Sin 29:443-50
Department of Endocrinology, Shandong University, Jinan 250021, China
Acta Pharmacol Sin 29:443-50
AIM: Adenosine monophosphate-activated protein kinase (AMPK), a vital regulator of glucose metabolism, may affect insulin secretion in beta-cells. However, the role of AMPK in beta-cell lipotoxicity remains unclear...
Ilex paraguariensis extract ameliorates obesity induced by high-fat diet: potential role of AMPK in the visceral adipose tissueJisook Pang
Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, 134 Shinchon dong, Sudaemun Ku, Seoul 120 749, South Korea
Arch Biochem Biophys 476:178-85
Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, 134 Shinchon dong, Sudaemun Ku, Seoul 120 749, South Korea
Arch Biochem Biophys 476:178-85
..paraguariensis extract protected rats from the HFD-induced decreases in the phospho-AMP-activated protein kinase (AMPK)/AMPK and phospho-acetyl-CoA carboxylase (ACC)/ACC protein ratio related to fatty acid oxidation in the edipidymal ..
Downregulation of PPARs and SREBP by acyl-CoA-binding protein overexpression in transgenic ratsSanna Oikari
Department of Biotechnology and Molecular Medicine, A I Virtanen Institute, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
Pflugers Arch 456:369-77
Department of Biotechnology and Molecular Medicine, A I Virtanen Institute, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
Pflugers Arch 456:369-77
..in liver and adipose tissue of fed transgenic rats, whereas adenosine monophosphate-activated protein kinase (AMPK) protein levels were increased (by 60%)...
Chemical hypoxia-induced glucose transporter-4 translocation in neonatal rat cardiomyocytesFu Guan
Department of Cardiology, The First Affiliated Hospital, China Medical University, Shenyang, China
Arch Med Res 39:52-60
Department of Cardiology, The First Affiliated Hospital, China Medical University, Shenyang, China
Arch Med Res 39:52-60
BACKGROUND: AMP-activated protein kinase (AMPK) activation plays an essential role in glucose metabolism of the heart...
A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight lossEduardo R Ropelle
Department of Internal Medicine, State University of Campinas UNICAMP, 13083 970, Campinas, São Paulo, Brazil
Diabetes 57:594-605
Department of Internal Medicine, State University of Campinas UNICAMP, 13083 970, Campinas, São Paulo, Brazil
Diabetes 57:594-605
..AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) function as majors regulators of cellular metabolism that respond to ..
AMPK activation with AICAR provokes an acute fall in plasma [K+]Dan Zheng
Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, CA 90089 9142, USA
Am J Physiol Cell Physiol 294:C126-35
Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, CA 90089 9142, USA
Am J Physiol Cell Physiol 294:C126-35
AMP-activated protein kinase (AMPK), activated by an increase in intracellular AMP-to-ATP ratio, stimulates pathways that can restore ATP levels...
Nitric oxide increases GLUT4 expression and regulates AMPK signaling in skeletal muscleVitor A Lira
Department of Applied Physiology and Kinesiology, Center for Exercise Science, Univ of Florida, Gainesville, FL 32611, USA
Am J Physiol Endocrinol Metab 293:E1062-8
Department of Applied Physiology and Kinesiology, Center for Exercise Science, Univ of Florida, Gainesville, FL 32611, USA
Am J Physiol Endocrinol Metab 293:E1062-8
Nitric oxide (NO) and 5'-AMP-activated protein kinase (AMPK) are involved in glucose transport and mitochondrial biogenesis in skeletal muscle...
Hypoxic stimulus alters hypothalamic AMP-activated protein kinase phosphorylation concomitant to hypophagiaN Simler
CRSSA, Department of Human Factors, BP 87, 38702 La Tronche Cedex, France
J Appl Physiol 102:2135-41
CRSSA, Department of Human Factors, BP 87, 38702 La Tronche Cedex, France
J Appl Physiol 102:2135-41
..We tested the hypothesis that hypothalamic AMP-activated protein kinase (AMPK) phosphorylation is affected by acute exposure to hypobaric hypoxia and thus would be involved in initial anorexia...
Bax translocates to mitochondria of heart cells during simulated ischaemia: involvement of AMP-activated and p38 mitogen-activated protein kinasesMichela Capano
Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
Biochem J 395:57-64
Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
Biochem J 395:57-64
..there was an increase in the active, phosphorylated forms of p38 MAPK (mitogen-activated protein kinase) and AMPK (AMP-activated protein kinase)...
Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinaseWoo Je Lee
Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea
Arterioscler Thromb Vasc Biol 25:2488-94
Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea
Arterioscler Thromb Vasc Biol 25:2488-94
..We showed previously that alpha-lipoic acid (ALA) activates AMP-activated protein kinase (AMPK) and reduces lipid accumulation in skeletal muscle of obese rats...
Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICARKei Sakamoto
MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Scotland, UK
Am J Physiol Endocrinol Metab 287:E310-7
MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Scotland, UK
Am J Physiol Endocrinol Metab 287:E310-7
Activation of AMP-activated protein kinase (AMPK) by exercise and metformin is beneficial for the treatment of type 2 diabetes...
Contractions induce phosphorylation of the AMPK site Ser565 in hormone-sensitive lipase in muscleMorten Donsmark
Copenhagen Muscle Research Centre, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Denmark
Biochem Biophys Res Commun 316:867-71
Copenhagen Muscle Research Centre, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Denmark
Biochem Biophys Res Commun 316:867-71
..5' AMP-activated protein kinase (AMPK) is an intracellular fuel gauge which regulates metabolism...
Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractionsDavid C Wright
Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Diabetes 53:330-5
Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Diabetes 53:330-5
It is now generally accepted that activation of AMP-activated protein kinase (AMPK) is involved in the stimulation of glucose transport by muscle contractions...
AMP-activated protein kinase plays a role in the control of food intakeUlrika Andersson
Medical Research Council Clinical Sciences Centre, Cellular Stress Group and Endocrine Unit, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 ONN, United Kingdom
J Biol Chem 279:12005-8
Medical Research Council Clinical Sciences Centre, Cellular Stress Group and Endocrine Unit, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 ONN, United Kingdom
J Biol Chem 279:12005-8
AMP-activated protein kinase (AMPK) is the downstream component of a protein kinase cascade that acts as an intracellular energy sensor maintaining the energy balance within the cell...
Contraction-induced fatty acid translocase/CD36 translocation in rat cardiac myocytes is mediated through AMP-activated protein kinase signalingJoost J F P Luiken
Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
Diabetes 52:1627-34
Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
Diabetes 52:1627-34
..We conclude that AMP kinase regulates cardiac FA use through mobilization of FAT/CD36 from a contraction-inducible intracellular storage compartment...
Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytesXiangdong Wu
Dorrance H Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
Diabetes 52:1355-63
Dorrance H Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
Diabetes 52:1355-63
....
AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatmentGregory R Steinberg
Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
Am J Physiol Endocrinol Metab 284:E648-54
Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
Am J Physiol Endocrinol Metab 284:E648-54
..Acute stimulation of AMP-activated protein kinase (AMPK) results in a repartitioning of FA toward oxidation and away from esterification in rodent soleus muscle and has ..
Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscleS H Park
Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah 84602, USA
J Appl Physiol 93:2081-8
Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah 84602, USA
J Appl Physiol 93:2081-8
AMP-activated protein kinase (AMPK) consists of three subunits: alpha, beta, and gamma...
Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exerciseHaejoe Park
Diabetes Unit, Section of Endocrinology and Department of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA
J Biol Chem 277:32571-7
Diabetes Unit, Section of Endocrinology and Department of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA
J Biol Chem 277:32571-7
..acyltransferase (GPAT), which like MCD and ACC can be regulated by AMP-activated protein kinase (AMPK), was assayed...
Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytesHideyuki Sakoda
Institute for Adult Disease, Asahi Life Foundation, Tokyo 116, Japan
Am J Physiol Endocrinol Metab 282:E1239-44
Institute for Adult Disease, Asahi Life Foundation, Tokyo 116, Japan
Am J Physiol Endocrinol Metab 282:E1239-44
5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR) reportedly activates AMP-activated protein kinase (AMPK) and stimulates glucose uptake by skeletal muscle cells...
AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signalingDouglas R Bolster
Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Biol Chem 277:23977-80
Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Biol Chem 277:23977-80
AMP-activated protein kinase (AMPK) is viewed as an energy sensor that acts to modulate glucose uptake and fatty acid oxidation in skeletal muscle...
Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca(2+)Edward O Ojuka
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Am J Physiol Endocrinol Metab 282:E1008-13
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Am J Physiol Endocrinol Metab 282:E1008-13
..5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR), which activates AMP-activated protein kinase (AMPK), also induced approximately twofold increases in GLUT4, MEF2A, and MEF2D in L6 myocytes...
Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrateJohn W Scott
Division of Molecular Physiology, School of Life Sciences and Wellcome Trust Biocentre, Dundee University, Scotland, UK
J Mol Biol 317:309-23
Division of Molecular Physiology, School of Life Sciences and Wellcome Trust Biocentre, Dundee University, Scotland, UK
J Mol Biol 317:309-23
We have expressed a truncated form of the alpha1 kinase domain of AMP-activated protein kinase (AMPK) in Escherichia coli as a glutathione-S-transferase fusion (GST-KD)...
Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyteAnita Y M Chan
Cardiovascular Research Group, Department of Pediatrics, Faculty of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
J Biol Chem 279:32771-9
Cardiovascular Research Group, Department of Pediatrics, Faculty of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
J Biol Chem 279:32771-9
..We have recently shown that eEF2 kinase is also controlled by phosphorylation by AMP-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis...
The metabolic "switch" AMPK regulates cardiac heparin-releasable lipoprotein lipaseDing An
Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada
Am J Physiol Endocrinol Metab 288:E246-53
Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada
Am J Physiol Endocrinol Metab 288:E246-53
The "fuel gauge" AMP-activated protein kinase (AMPK) facilitates ATP production to meet energy demands during metabolic stress...
Diminished overload-induced hypertrophy in aged fast-twitch skeletal muscle is associated with AMPK hyperphosphorylationDavid M Thomson
Human Performance Laboratory, 363 Ward Sports Medicine Bldg, East Carolina Univ, Greenville, NC 27858, USA
J Appl Physiol 98:557-64
Human Performance Laboratory, 363 Ward Sports Medicine Bldg, East Carolina Univ, Greenville, NC 27858, USA
J Appl Physiol 98:557-64
..Because 5'-AMP-activated protein kinase (AMPK) activity is thought to inhibit skeletal muscle protein synthesis and may therefore modulate muscle mass and ..
Chronic rosiglitazone treatment restores AMPKalpha2 activity in insulin-resistant rat skeletal muscleSarah J Lessard
School of Medical Sciences, RMIT University, Melbourne, Victoria, Australia
Am J Physiol Endocrinol Metab 290:E251-7
School of Medical Sciences, RMIT University, Melbourne, Victoria, Australia
Am J Physiol Endocrinol Metab 290:E251-7
..that part of the insulin-sensitizing effect of RSG is mediated through the action of AMP-activated protein kinase (AMPK)...
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinaseSimon A Hawley
Division of Molecular Physiology University of Dundee, Dundee, Scotland, United Kingdom
Cell Metab 2:9-19
Division of Molecular Physiology University of Dundee, Dundee, Scotland, United Kingdom
Cell Metab 2:9-19
The AMP-activated protein kinase (AMPK) is a critical regulator of energy balance at both the cellular and whole-body levels. Two upstream kinases have been reported to activate AMPK in cell-free assays, i.e...
AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed ratsMurwarid M Assifi
Diabetes and Metabolism Unit, Boston Univ Medical Center, Boston, MA 02118, USA
Am J Physiol Endocrinol Metab 289:E794-800
Diabetes and Metabolism Unit, Boston Univ Medical Center, Boston, MA 02118, USA
Am J Physiol Endocrinol Metab 289:E794-800
..relate temporally to alterations in the activities of the fuel-sensing enzyme AMP-activated protein kinase (AMPK). Rats starved for 48 h and refed a carbohydrate chow diet for 1, 3, 12, and 24 h were studied...
Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinaseBlerina Kola
Department of Endocrinology, William Harvey Research Institute, Barts and the London Medical School, London EC1M 6BQ, United Kingdom
J Biol Chem 280:25196-201
Department of Endocrinology, William Harvey Research Institute, Barts and the London Medical School, London EC1M 6BQ, United Kingdom
J Biol Chem 280:25196-201
..The AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme that functions as a fuel sensor to regulate energy balance at both cellular and whole ..
AMP kinase activation with AICAR simultaneously increases fatty acid and glucose oxidation in resting rat soleus muscleAngela C Smith
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
J Physiol 565:537-46
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
J Physiol 565:537-46
5-Amino-4-imidazolecarboxamide riboside (AICAR), a pharmacological activator of AMP-activated protein kinase (AMPK), acutely stimulates glucose uptake and fatty acid (FA) oxidation in skeletal muscle...
AMP kinase activation with AICAR further increases fatty acid oxidation and blunts triacylglycerol hydrolysis in contracting rat soleus muscleAngela C Smith
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
J Physiol 565:547-53
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
J Physiol 565:547-53
..metabolism in isolated rat skeletal muscle, due at least in part to an increase in AMP-activated kinase activity (AMPK)...
Exercise in rats does not alter hypothalamic AMP-activated protein kinase activityUlrika Andersson
Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, DuCane Road, London W12 0NN, UK
Biochem Biophys Res Commun 329:719-25
Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, DuCane Road, London W12 0NN, UK
Biochem Biophys Res Commun 329:719-25
Recent studies have demonstrated that AMP-activated protein kinase (AMPK) in the hypothalamus is involved in the regulation of food intake...
AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270)Tristan J Iseli
St Vincent s Institute, University of Melbourne, Victoria, Australia
J Biol Chem 280:13395-400
St Vincent s Institute, University of Melbourne, Victoria, Australia
J Biol Chem 280:13395-400
AMP-activated protein kinase (AMPK) is an important metabolic stress-sensing protein kinase responsible for regulating metabolism in response to changing energy demand and nutrient supply...
Hypoxia and AMP independently regulate AMP-activated protein kinase activity in heartMarkus Frederich
Nuclear Magnetic Resonance Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Physiol Heart Circ Physiol 288:H2412-21
Nuclear Magnetic Resonance Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Physiol Heart Circ Physiol 288:H2412-21
The hypothesis was tested that hypoxia increases AMP-activated protein kinase (AMPK) activity independently of AMP concentration ([AMP]) in heart. In isolated perfused rat hearts, cytosolic [AMP] was changed from 0...
Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in ratsGabriela Suchankova
Pennington Biomedical Research Center, Baton Rouge, LA, USA
Biochem Biophys Res Commun 326:851-8
Pennington Biomedical Research Center, Baton Rouge, LA, USA
Biochem Biophys Res Commun 326:851-8
..metformin, thiazolidinediones) and hormones (leptin, adiponectin) that activate AMP-activated protein kinase (AMPK) have been reported to improve insulin sensitivity...
Effect of phosphorylation by AMP-activated protein kinase on palmitoyl-CoA inhibition of skeletal muscle acetyl-CoA carboxylaseD S Rubink
Dept of Physiology and Developmental Biology, 545 WIDB, Brigham Young Univ, Provo, UT 84602, USA
J Appl Physiol 98:1221-7
Dept of Physiology and Developmental Biology, 545 WIDB, Brigham Young Univ, Provo, UT 84602, USA
J Appl Physiol 98:1221-7
AMP-activated protein kinase (AMPK) has previously been demonstrated to phosphorylate and inactivate skeletal muscle acetyl-CoA carboxylase (ACC), the enzyme responsible for synthesis of malonyl-CoA, an inhibitor of carnitine ..
AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell lineFranck Rencurel
Biomedical Research Centre and Cancer Research UK Molecular Pharmacology Unit, Level 5, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
J Biol Chem 280:4367-73
Biomedical Research Centre and Cancer Research UK Molecular Pharmacology Unit, Level 5, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
J Biol Chem 280:4367-73
..The AMP-activated protein kinase (AMPK) functions as an energy sensor and is activated when cells experience energy-depleting stresses...
Impact of adenoviral transduction with SREBP1c or AMPK on pancreatic islet gene expression profile: analysis with oligonucleotide microarraysFrederique Diraison
Henry Wellcome Signalling Laboratories and Department of Biochemistry, School of Medical Sciences, University Walk, University of Bristol, Bristol, BS8 ITD, UK
Diabetes 53:S84-91
Henry Wellcome Signalling Laboratories and Department of Biochemistry, School of Medical Sciences, University Walk, University of Bristol, Bristol, BS8 ITD, UK
Diabetes 53:S84-91
..3%) were upregulated. By contrast, overexpression of constitutively active AMP-activated protein kinase (AMPK), expected to promote lipolysis, altered the expression of 752 genes, of which 702 (93%) were upregulated...
Regulation of phosphatidylcholine and phosphatidylethanolamine synthesis in rat hepatocytes by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)Martin Houweling
Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, University of Utrecht, P O Box 80176, 3508 TD Utrecht, The Netherlands
Biochem J 362:97-104
Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, University of Utrecht, P O Box 80176, 3508 TD Utrecht, The Netherlands
Biochem J 362:97-104
The present study was undertaken to study the role of AMP-activated kinase (AMPK) in the biosynthesis of two major membrane phospholipids, phosphatidylcholine (PC) and phosphatidylethanolamine (PE)...