Prex2

Summary

Gene Symbol: Prex2
Description: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Alias: Depdc2, phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein, DEP domain containing 2
Species: rat
Products:     Prex2

Top Publications

  1. Donald S, Hill K, Lecureuil C, Barnouin R, Krugmann S, John Coadwell W, et al. P-Rex2, a new guanine-nucleotide exchange factor for Rac. FEBS Lett. 2004;572:172-6 pubmed
    ..Together, they form an enzyme family capable of mediating Rac signalling downstream of G protein-coupled receptors and phosphoinositide 3-kinase. ..
  2. Donald S, Humby T, Fyfe I, Segonds Pichon A, Walker S, Andrews S, et al. P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination. Proc Natl Acad Sci U S A. 2008;105:4483-8 pubmed publisher
    ..We conclude that P-Rex1 and P-Rex2 are important regulators of Purkinje cell morphology and cerebellar function. ..
  3. Hodakoski C, Hopkins B, Barrows D, Mense S, Keniry M, Anderson K, et al. Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis. Proc Natl Acad Sci U S A. 2014;111:155-60 pubmed publisher
    ..Consistent with its function as a PTEN inhibitor, deletion of Prex2 in fibroblasts and mice results in increased Pten activity and decreased insulin signaling in liver and adipose ..