Gene Symbol: Prex1
Description: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Alias: RGD1306534, phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Yoshizawa M, Kawauchi T, Sone M, Nishimura Y, Terao M, Chihama K, et al
. Involvement of a Rac activator,P-Rex1, in neurotrophin-derived signaling and neuronal migration. J Neurosci. 2005;25:4406-19 pubmed
..These findings suggest that P-Rex1, which is expressed in a variety of cell types, is activated by extracellular cues such as neurotrophins and contributes to neuronal migration in the developing nervous system. ..
Welch H, Coadwell W, Ellson C, Ferguson G, Andrews S, Erdjument Bromage H, et al
. P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell. 2002;108:809-21 pubmed
..P-Rex1 appears to be a coincidence detector in PtdIns(3,4,5)P3 and Gbetagamma signaling pathways that is particularly adapted to function downstream of heterotrimeric G proteins in neutrophils. ..
Schneider M, Dahlhoff M, Horst D, Hirschi B, Trulzsch K, Müller Höcker J, et al
. A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation. PLoS ONE. 2010;5:e14325 pubmed publisher
Qin J, Xie Y, Wang B, Hoshino M, Wolff D, Zhao J, et al
. Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis. Oncogene. 2009;28:1853-63 pubmed publisher
..Thus, by functioning as a coincidence detector of chemotactic signals from both GPCRs and RTKs, P-Rex1-dependent activation of Rac promotes prostate cancer metastasis. ..
Lawson C, Donald S, Anderson K, Patton D, Welch H. P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses. J Immunol. 2011;186:1467-76 pubmed publisher
..We conclude that P-Rex1 and Vav1 together are the major fMLFR-dependent Dbl family Rac-GEFs in neutrophils and cooperate in the control of fMLF-stimulated neutrophil responses. ..
Satoh T. Rho GTPases in insulin-stimulated glucose uptake. Small Gtpases. 2014;5:e28102 pubmed publisher
..In addition, the role for another Rho family member TC10 and its regulatory mechanism in adipocyte insulin signaling are described. ..
Waters J, Astle M, Ooms L, Balamatsias D, Gurung R, Mitchell C. P-Rex1 - a multidomain protein that regulates neurite differentiation. J Cell Sci. 2008;121:2892-903 pubmed publisher
..This study has identified P-Rex1 as a Rac3-GEF in neuronal cells that localises to, and regulates, actin cytoskeletal dynamics at the axonal growth cone to in turn regulate neurite differentiation. ..