Gene Symbol: Prdx6
Description: peroxiredoxin 6
Alias: peroxiredoxin-6, 1-Cys PRX, 1-Cys peroxiredoxin, NSGPx, acidic calcium-independent phospholipase A2, aiPLA2, antioxidant protein 2, non-selenium glutathione peroxidase, thiol-specific antioxidant protein
Species: rat
Products:     Prdx6

Top Publications

  1. Paula F, Ferreira S, Boschero A, Souza K. Modulation of the peroxiredoxin system by cytokines in insulin-producing RINm5F cells: down-regulation of PRDX6 increases susceptibility of beta cells to oxidative stress. Mol Cell Endocrinol. 2013;374:56-64 pubmed publisher
    ..RINm5F cells expressed significant amounts of PRDX1, PRDX3 and PRDX6 enzymes...
  2. Sorokina E, Feinstein S, Zhou S, Fisher A. Intracellular targeting of peroxiredoxin 6 to lysosomal organelles requires MAPK activity and binding to 14-3-3?. Am J Physiol Cell Physiol. 2011;300:C1430-41 pubmed publisher
    b>Peroxiredoxin 6 (Prdx6), a bifunctional protein with GSH peroxidase and lysosomal-type phospholipase A(2) activities, has been localized to both cytosolic and acidic compartments (lamellar bodies and lysosomes) in lung alveolar ..
  3. Lee C, Kim H, Lee Y, So H, Park H, Won K, et al. Analysis of peroxiredoxin decreasing oxidative stress in hypertensive aortic smooth muscle. Biochim Biophys Acta. 2007;1774:848-55 pubmed
    ..These results suggest that Prxs play a crucial role against oxidative stress in vascular smooth muscles during hypertension. ..
  4. Shim S, Kim H, Kim E, Choi J. Expression of peroxiredoxin 1, 2, and 6 in the rat brain during perinatal development and in response to dexamethasone. Free Radic Res. 2012;46:231-9 pubmed publisher
    ..In conclusion, we reveal for the first time that Prdx 1, 2 and 6 are found in abundance in the perinatal rat brain and are differentially expressed during development. The expression of Prdx 6 was affected by dexamethasone treatment. ..
  5. Jia G, Tan B, Ma J, Zhang L, Jin X, Li C. Prdx6 Upregulation by Curcumin Attenuates Ischemic Oxidative Damage via SP1 in Rats after Stroke. Biomed Res Int. 2017;2017:6597401 pubmed publisher
    The role of Peroxiredoxin 6 (Prdx6) in brain ischemia remains unclear. Curcumin (Cur) treatment elicits neuroprotective effects against cerebral ischemic injury, and the associated mechanisms may involve Prdx6...
  6. Chen J, Dodia C, Feinstein S, Jain M, Fisher A. 1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. J Biol Chem. 2000;275:28421-7 pubmed
    ..The cDNA encoding aiPLA(2) was found to be identical to that of a non-selenium glutathione peroxidase (NSGPx). Protein expressed using a previously reported E...
  7. Rahaman H, Zhou S, Dodia C, Feinstein S, Huang S, Speicher D, et al. Increased phospholipase A2 activity with phosphorylation of peroxiredoxin 6 requires a conformational change in the protein. Biochemistry. 2012;51:5521-30 pubmed
    We have shown previously and confirmed in this study that the phospholipase A(2) (PLA(2)) activity of peroxiredoxin 6 (Prdx6) is markedly increased by phosphorylation...
  8. Kubo E, Singh D, Fatma N, Akagi Y. TAT-mediated peroxiredoxin 5 and 6 protein transduction protects against high-glucose-induced cytotoxicity in retinal pericytes. Life Sci. 2009;84:857-64 pubmed publisher
    ..Results suggest that delivery of PRDX5 and 6 might protect hyperglycemia-induced pericyte loss to inhibit oxidative stress. ..
  9. Vascotto C, Fantini D, Romanello M, Cesaratto L, Deganuto M, Leonardi A, et al. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. Mol Cell Biol. 2009;29:1834-54 pubmed publisher
    ..Our data demonstrate that APE1 affects cell growth by directly acting on RNA quality control mechanisms, thus affecting gene expression through posttranscriptional mechanisms. ..

More Information


  1. Buonora J, Mousseau M, Jacobowitz D, Lazarus R, Yarnell A, Olsen C, et al. Autoimmune Profiling Reveals Peroxiredoxin 6 as a Candidate Traumatic Brain Injury Biomarker. J Neurotrauma. 2015;32:1805-14 pubmed publisher
    Autoimmune profiling in rats revealed the antioxidant enzyme, peroxiredoxin 6 (PRDX6), as a target for autoantibodies evoked in response to traumatic brain injury (TBI)...
  2. Zhang S, Wang W, Gu Q, Xue J, Cao H, Tang Y, et al. Protein and miRNA profiling of radiation-induced skin injury in rats: the protective role of peroxiredoxin-6 against ionizing radiation. Free Radic Biol Med. 2014;69:96-107 pubmed publisher
    ..Our present findings illustrate the molecular changes during radiation-induced skin injury and the important role of PRDX-6 in ameliorating this damage in rats. ..
  3. Manevich Y, Reddy K, Shuvaeva T, Feinstein S, Fisher A. Structure and phospholipase function of peroxiredoxin 6: identification of the catalytic triad and its role in phospholipid substrate binding. J Lipid Res. 2007;48:2306-18 pubmed
    b>Peroxiredoxin 6 (Prdx6) is a bifunctional protein with glutathione peroxidase and phospholipase A(2) (PLA(2)) activities, and it alone among mammalian peroxiredoxins can hydrolyze phospholipids...
  4. Peshenko I, Novoselov V, Evdokimov V, Nikolaev YuV -, Shuvaeva T, Lipkin V, et al. Novel 28-kDa secretory protein from rat olfactory epithelium. FEBS Lett. 1996;381:12-14 pubmed
    ..The 28-kDa protein catalyzed decomposition of the hydrogen peroxide as well as organic hydroperoxides by reduced glutathione and seems to be a member of the glutathion peroxidase family. ..
  5. Wu Y, Feinstein S, Manevich Y, Chowdhury I, Pak J, Kazi A, et al. Mitogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A(2) activity. Biochem J. 2009;419:669-79 pubmed publisher
    Prdx6 (peroxiredoxin 6), a bifunctional protein with both GSH peroxidase and PLA(2) (phospholipase A(2)) [aiPLA(2) (acidic calcium-independent PLA(2))] activities, is responsible for the metabolism of lung surfactant phospholipids...
  6. Kubo E, Fatma N, Akagi Y, Beier D, Singh S, Singh D. TAT-mediated PRDX6 protein transduction protects against eye lens epithelial cell death and delays lens opacity. Am J Physiol Cell Physiol. 2008;294:C842-55 pubmed publisher
    ..b>Peroxiredoxin 6 (PRDX6), a protective molecule, regulates gene expression/function by controlling reactive oxygen species (..
  7. Tan L, Zhao Y, Jiang B, Yang B, Zhang H. [Knockdown of PRDX6 in microglia reduces neuron viability after OGD/R injury]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016;32:1014-20 pubmed
    Objective To observe the effects of peroxiredoxin 6 (PRDX6) knockdown in the microglia on neuron viability after oxygen-glucose deprivation and reoxygenation (OGD/R)...
  8. Fatma N, Kubo E, Sen M, Agarwal N, Thoreson W, Camras C, et al. Peroxiredoxin 6 delivery attenuates TNF-alpha-and glutamate-induced retinal ganglion cell death by limiting ROS levels and maintaining Ca2+ homeostasis. Brain Res. 2008;1233:63-78 pubmed publisher
    ..Herein we show that the transduction of Peroxiredoxin 6 (PRDX6) attenuates TNF-alpha- and glutamate-induced RGC death, by limiting ROS and maintaining Ca2+ ..
  9. Gao L, Tse S, Conrad C, Andreadis A. Saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6. J Biol Chem. 2005;280:39268-72 pubmed
    ..and glutathione S-transferase pull-down assays, we discovered and confirmed that Saitohin interacts with peroxiredoxin 6, a unique member of that family that is bifunctional and the levels of which increase in Pick disease...
  10. Andreeva S, Merkulova M, Shuvaeva T, Novoselov V, Peshenko I, Novoselov S, et al. [Study of structure of secretory 28 kDa protein from the rat olfactory epithelium]. Bioorg Khim. 1998;24:816-21 pubmed
    ..The 28-kDa protein belongs to the 1 Cys-subfamily of peroxiredoxines and is the first member of peroxiredoxines identified in the olfactory epithelium. ..
  11. Wu Y, Manevich Y, Baldwin J, Dodia C, Yu K, Feinstein S, et al. Interaction of surfactant protein A with peroxiredoxin 6 regulates phospholipase A2 activity. J Biol Chem. 2006;281:7515-25 pubmed
    b>Peroxiredoxin 6 (Prdx6) is a "moonlighting" protein with both GSH peroxidase and phospholipase A(2) (PLA(2)) activities...
  12. Wang X, Phelan S, Petros C, Taylor E, Ledinski G, Jurgens G, et al. Peroxiredoxin 6 deficiency and atherosclerosis susceptibility in mice: significance of genetic background for assessing atherosclerosis. Atherosclerosis. 2004;177:61-70 pubmed
    Peroxiredoxin 6 (Prdx6; also called antioxidant protein 2, or Aop2) is a candidate gene for Ath1, a locus responsible for the respective susceptibility and resistance of mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) to diet-induced ..
  13. Wang X, Phelan S, Forsman Semb K, Taylor E, Petros C, Brown A, et al. Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress. J Biol Chem. 2003;278:25179-90 pubmed
    ..Peroxiredoxin 6 (PRDX6) (also called antioxidant protein 2, or AOP2) is a novel peroxiredoxin family member whose function in vivo is unknown...
  14. Choi H, Kang S, Yang C, Rhee S, Ryu S. Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution. Nat Struct Biol. 1998;5:400-6 pubmed
    ..The positively charged environment surrounding Cys 47 accounts for the peroxidase activity of the enzyme, which contains no redox cofactors. ..
  15. Nilsson A, Sköld K, Sjögren B, Svensson M, Pierson J, Zhang X, et al. Increased striatal mRNA and protein levels of the immunophilin FKBP-12 in experimental Parkinson's disease and identification of FKBP-12-binding proteins. J Proteome Res. 2007;6:3952-61 pubmed
    ..In conclusion, these data strongly suggests that FKBP-12 is altered in an experimental model of PD. ..
  16. Bystrova M, Budanova E, Novoselov V, Fesenko E. [Study of the quaternary structure of rat 1-Cys peroxiredoxin]. Biofizika. 2007;52:436-42 pubmed
    ..The native 1-Cys Prx existed in the monomeric and dimeric forms in rat olfactory epithelium, with monomers being more common. The structural sensitivity of the recombinant 1-Cys Prx to imidazole was shown. ..
  17. Panupinthu N, Zhao L, Possmayer F, Ke H, Sims S, Dixon S. P2X7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic acid. J Biol Chem. 2007;282:3403-12 pubmed
    ..This pathway may contribute to P2X7-stimulated osteogenesis during skeletal development and mechanotransduction. ..
  18. Liu N, Xue L, Guan Y, Li Q, Cao F, Pang S, et al. Expression of Peroxiredoxins and Pulmonary Surfactant Protein A Induced by Silica in Rat Lung Tissue. Biomed Environ Sci. 2016;29:584-588 pubmed
    ..The results suggest that Prx proteins may be involved in pulmonary fibrosis induced by silica. Downregulation of SP-A expression caused due to silica is an important factor in the occurrence and development of silicosis. ..
  19. Kim T, Sundaresh C, Feinstein S, Dodia C, Skach W, Jain M, et al. Identification of a human cDNA clone for lysosomal type Ca2+-independent phospholipase A2 and properties of the expressed protein. J Biol Chem. 1997;272:2542-50 pubmed
    ..These results represent the first molecular cloning of a cDNA for the lysosomal type Ca2+-independent phospholipase A2 group of enzymes. ..