Gene Symbol: Prdx4
Description: peroxiredoxin 4
Alias: peroxiredoxin-4, antioxidant enzyme AOE372, peroxiredoxin IV, prx-IV, thioredoxin peroxidase AO372, thioredoxin-dependent peroxide reductase A0372
Species: rat
Products:     Prdx4

Top Publications

  1. Matsumoto A, Okado A, Fujii T, Fujii J, Egashira M, Niikawa N, et al. Cloning of the peroxiredoxin gene family in rats and characterization of the fourth member. FEBS Lett. 1999;443:246-50 pubmed
    ..two genes which have previously been isolated in rats, PRx I and PRx II, and two rat homologues of PRx III and PRx IV. We showed, for the first time, the simultaneous expression of all four genes in various rat tissues by Northern ..
  2. Iuchi Y, Okada F, Tsunoda S, Kibe N, Shirasawa N, Ikawa M, et al. Peroxiredoxin 4 knockout results in elevated spermatogenic cell death via oxidative stress. Biochem J. 2009;419:149-58 pubmed publisher
    ..Our results suggest that the presence of Prx4, most likely the membrane-bound form, is important for spermatogenesis, but not an absolute requisite. ..
  3. Zito E, Hansen H, Yeo G, Fujii J, Ron D. Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice. Mol Cell. 2012;48:39-51 pubmed publisher
    ..We found that combined loss-of-function mutations in genes encoding the ER thiol oxidases ERO1α, ERO1β, and PRDX4 compromised the extracellular matrix in mice and interfered with the intracellular maturation of procollagen...
  4. Wong C, Chun A, Kok K, Zhou Y, Fung P, Kung H, et al. Characterization of human and mouse peroxiredoxin IV: evidence for inhibition by Prx-IV of epidermal growth factor- and p53-induced reactive oxygen species. Antioxid Redox Signal. 2000;2:507-18 pubmed
    The aim of this study was to identify and characterize human and mouse Prx-IV. We identified mouse peroxiredoxin IV (Prx-IV) by virtue of sequence homology to its human ortholog previously called AOE372...
  5. Jansen G, Maattanen P, Denisov A, Scarffe L, Schade B, Balghi H, et al. An interaction map of endoplasmic reticulum chaperones and foldases. Mol Cell Proteomics. 2012;11:710-23 pubmed publisher
  6. Rao Z, Wang S, Wang J. Peroxiredoxin 4 inhibits IL-1β-induced chondrocyte apoptosis via PI3K/AKT signaling. Biomed Pharmacother. 2017;90:414-420 pubmed publisher
    ..b>Peroxiredoxin 4 (PRDX4), a member of the PRDX family, is essential for removing metabolic free radicals and reducing ..
  7. Yao W, Zhao H, Shi R, Li X, Li Y, Ke C, et al. Recombinant protein transduction domain-Cu/Zn superoxide dismutase alleviates bone cancer pain via peroxiredoxin 4 modulation and antioxidation. Biochem Biophys Res Commun. 2017;486:1143-1148 pubmed publisher
    ..peroxide (H2O2) and H2O2 is then naturalized to be water by peroxiredoxin 4. We reported previously that recombinant protein transduction domain (PTD)-Cu/Zn SOD effectively scavenged ..
  8. Ikeda Y, Ito R, Ihara H, Okada T, Fujii J. Expression of N-terminally truncated forms of rat peroxiredoxin-4 in insect cells. Protein Expr Purif. 2010;72:1-7 pubmed publisher
    ..The procedures described in this study permit recombinant Prx-4 to be prepared more efficiently and easily for purposes of crystallization and antibody preparation. ..
  9. Yim S, Kim Y, Oh S, Fujii J, Zhang Y, Gladyshev V, et al. Identification and characterization of alternatively transcribed form of peroxiredoxin IV gene that is specifically expressed in spermatids of postpubertal mouse testis. J Biol Chem. 2011;286:39002-12 pubmed publisher
    ..b>Prx IV was shown previously to be synthesized as a 31-kDa polypeptide with an NH(2)-terminal signal peptide that is ..

More Information


  1. Avezov E, Cross B, Kaminski Schierle G, Winters M, Harding H, Melo E, et al. Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox. J Cell Biol. 2013;201:337-49 pubmed publisher
    ..These findings recommend fluorescent lifetime imaging as a sensitive method to track ER redox homeostasis in mammalian cells. ..