Gene Symbol: Ppp5c
Description: protein phosphatase 5, catalytic subunit
Alias: serine/threonine-protein phosphatase 5, PP5, PPT, protein phosphatase T
Species: rat
Products:     Ppp5c

Top Publications

  1. Deana A, Pinna L. Identification of pseudo 'phosphothreonyl-specific' protein phosphatase T with a fraction of polycation-stimulated protein phosphatase 2A. Biochim Biophys Acta. 1988;968:179-85 pubmed
    b>Protein phosphatase T from rat liver, so termed due to its activity toward [32P-Thr]casein and its marked preference for the phosphopeptide Arg-Arg-Ala-Thr(P)-Val-Ala over its phosphoseryl derivative (Donella Deana, A., Marchiori, F...
  2. Becker W, Kentrup H, Klumpp S, Schultz J, Joost H. Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain. J Biol Chem. 1994;269:22586-92 pubmed
    ..The other novel cDNA encoded a protein phosphatase of 499 amino acids and was designated PPT. Its catalytic domain contains motifs typical for protein phosphatases but is only distantly related with PP1, PP2A,..
  3. Rahman A, Khan K, Al Khaledi G, Khan I, Attur S. Early postnatal lead exposure induces tau phosphorylation in the brain of young rats. Acta Biol Hung. 2012;63:411-25 pubmed publisher
    ..the expression of tau, phosphorylated tau and various serine/threonine protein phosphatases (PP1, PP2A, PP2B and PP5) in the brain was analyzed by Western blot...
  4. Zhao S, Sancar A. Human blue-light photoreceptor hCRY2 specifically interacts with protein serine/threonine phosphatase 5 and modulates its activity. Photochem Photobiol. 1997;66:727-31 pubmed
    ..We found that the tetratricopeptide repeat protein 1, Tpr1, and the protein serine/threonine phosphatase 5 (PP5) that contains the TPR motif specifically interacted with hCRY2...
  5. Rahman A, Khan K, Al Khaledi G, Khan I, Al Shemary T. Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats. Neurotoxicology. 2012;33:370-83 pubmed publisher
    ..Pb levels in blood, brain and hippocampus were measured and expression of PP1, PP2A, PP2B and PP5 in hippocampus was analyzed. Total phosphatase activity, and PP1 and PP2A activities were determined...
  6. Yoshinari K, Kobayashi K, Moore R, Kawamoto T, Negishi M. Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital. FEBS Lett. 2003;548:17-20 pubmed
    ..This recruitment may lead CAR to translocate into the nucleus, consistent with the inhibitions of nuclear CAR accumulation in PB-induced mouse primary hepatocytes by okadaic acid as well as by geldanamycin. ..
  7. Gong C, Liu F, Wu G, Rossie S, Wegiel J, Li L, et al. Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5. J Neurochem. 2004;88:298-310 pubmed
    Protein phosphatase 5 (PP5) is a 58-kDa novel phosphoseryl/phosphothreonyl protein phosphatase...
  8. Chatterjee A, Wang L, Armstrong D, Rossie S. Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro. J Biol Chem. 2010;285:3872-82 pubmed publisher
    Physiological studies of ion channel regulation have implicated the Ser/Thr protein phosphatase 5 (PP5) as an effector of Rac1 GTPase signaling, but direct biochemical evidence for PP5 regulation by Rac1 is lacking...
  9. Chinkers M. Targeting of a distinctive protein-serine phosphatase to the protein kinase-like domain of the atrial natriuretic peptide receptor. Proc Natl Acad Sci U S A. 1994;91:11075-9 pubmed
    ..This protein is a possible candidate for the phosphatase involved in desensitizing the ANP receptor. Targeting of regulatory proteins may be an important function of protein kinase-like domains. ..

More Information


  1. Rapicavoli N, Poth E, Zhu H, Blackshaw S. The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity. Neural Dev. 2011;6:32 pubmed publisher
  2. Gergs U, Boknik P, Buchwalow I, Fabritz L, Gr√ľndker N, Kucerova D, et al. Modulation of cardiac contractility by serine/threonine protein phosphatase type 5. Int J Cardiol. 2012;154:116-21 pubmed publisher
    Protein phosphatase 5 (PP5) a serine/threonine phosphatase is ubiquitously expressed in mammalian tissues including the heart, but its physiological role in the heart is still unknown...
  3. Sanchez Ortiz E, Hahm B, Armstrong D, Rossie S. Protein phosphatase 5 protects neurons against amyloid-beta toxicity. J Neurochem. 2009;111:391-402 pubmed publisher
    ..Protein phosphatase 5 (PP5) is a ubiquitously expressed serine/threonine phosphatase which has been implicated in several cell stress response ..
  4. Maeda T, Hamabe W, Gao Y, Fukazawa Y, Kumamoto K, Ozaki M, et al. Morphine has an antinociceptive effect through activation of the okadaic-acid-sensitive Ser/Thr protein phosphatases PP 2 A and PP5 estimated by tail-pinch test in mice. Brain Res. 2005;1056:191-9 pubmed
    ..c.v. or i.t. injections of antisense oligodeoxynucleotide (AS-ODN) directed against either the PP 2 A or PP5 subtypes of PPs before assessment of morphine-induced antinociception...
  5. Conde R, Xavier J, McLoughlin C, Chinkers M, Ovsenek N. Protein phosphatase 5 is a negative modulator of heat shock factor 1. J Biol Chem. 2005;280:28989-96 pubmed
    ..Here we demonstrate that protein phosphatase 5 (PP5), a tetratricopeptide domain-containing component of Hsp90-steroid receptor complexes, functions as a negative ..
  6. Liu F, Iqbal K, Grundke Iqbal I, Rossie S, Gong C. Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease. J Biol Chem. 2005;280:1790-6 pubmed
    ..Here, we investigated the kinetics of dephosphoryation of phospho-tau by PP5 and found that PP5 had a K(m) of 8-13 microm toward tau, which is similar to that of PP2A, the major known tau ..
  7. Fukuda H, Shima H, Vesonder R, Tokuda H, Nishino H, Katoh S, et al. Inhibition of protein serine/threonine phosphatases by fumonisin B1, a mycotoxin. Biochem Biophys Res Commun. 1996;220:160-5 pubmed
    ..The effects of FB1 on the activity of protein serine/threonine phosphatases (PPs) (PP1, PP2A, PP2B, PP2C and PP5/T/K/H) were investigated in the present study...
  8. Gentile S, Darden T, Erxleben C, Romeo C, Russo A, Martin N, et al. Rac GTPase signaling through the PP5 protein phosphatase. Proc Natl Acad Sci U S A. 2006;103:5202-6 pubmed
    ..Here we present physiological evidence for the protein serine/threonine phosphatase, PP5, as an effector of Rac GTPase signaling...
  9. Rossie S, Jayachandran H, Meisel R. Cellular co-localization of protein phosphatase 5 and glucocorticoid receptors in rat brain. Brain Res. 2006;1111:1-11 pubmed
    ..In non-neuronal cells, protein phosphatase 5 (PP5) has been found in complexes with heat shock protein 90 and glucocorticoid receptors and may be a negative ..
  10. Chen L, Liu L, Huang S. Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5. Free Radic Biol Med. 2008;45:1035-44 pubmed publisher
    ..Furthermore, we found that Cd-induced ROS inhibited serine/threonine protein phosphatases 2A (PP2A) and 5 (PP5), leading to activation of Erk1/2 and JNK, which was abrogated by NAC...
  11. Chen L, Liu L, Yin J, Luo Y, Huang S. Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway. Int J Biochem Cell Biol. 2009;41:1284-95 pubmed publisher
    ..Furthermore, we found that H(2)O(2)-induced ROS inhibited serine/threonine protein phosphatases 2A (PP2A) and 5 (PP5), which was abrogated by NAC...
  12. Cliff M, Williams M, Brooke Smith J, Barford D, Ladbury J. Molecular recognition via coupled folding and binding in a TPR domain. J Mol Biol. 2005;346:717-32 pubmed
    ..This function is exemplified by the TPR domain of protein phosphatase 5 (PP5), which binds to the C terminus of the chaperone protein Hsp90...
  13. Shinoda S, Skradski S, Araki T, Schindler C, Meller R, Lan J, et al. Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. Eur J Neurosci. 2003;17:2065-76 pubmed
    ..These data suggest ASK1 may be involved in the mechanism of seizure-induced neuronal death downstream of a TNFR1 death-signalling complex. ..
  14. Bhatti S, Kozlov S, Farooqi A, Naqi A, Lavin M, Khanna K. ATM protein kinase: the linchpin of cellular defenses to stress. Cell Mol Life Sci. 2011;68:2977-3006 pubmed publisher
    ..In this review, we have tried to untangle the complex web of ATM signaling pathways with the purpose of pinpointing multiple roles of ATM underlying the complex phenotypes observed in AT patients...
  15. Hong T, Kim S, Wi A, Lee P, Kang M, Jeong J, et al. Dynamic nucleotide-dependent interactions of cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1 and melusin with cochaperones PP5 and Sgt1. J Biol Chem. 2013;288:215-22 pubmed publisher
    ..Here, we report that ADP and ATP can bind to Hsp90 cochaperones Chp-1 and PP5, inducing their conformational changes...
  16. von Kriegsheim A, Pitt A, Grindlay G, Kolch W, Dhillon A. Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5. Nat Cell Biol. 2006;8:1011-6 pubmed
    ..Protein phosphatase 5 (PP5) was identified as an inactivator that associates with Raf-1 on growth factor stimulation and selectively ..
  17. Yamaguchi Y, Katoh H, Mori K, Negishi M. Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity. Curr Biol. 2002;12:1353-8 pubmed
    ..a yeast two-hybrid screening of a rat brain cDNA library and revealed that Ser/Thr protein phosphatase type 5 (PP5) is a novel effector of Galpha(12) and Galpha(13)...
  18. Chen M, Silverstein A, Pratt W, Chinkers M. The tetratricopeptide repeat domain of protein phosphatase 5 mediates binding to glucocorticoid receptor heterocomplexes and acts as a dominant negative mutant. J Biol Chem. 1996;271:32315-20 pubmed
    We previously identified a protein-serine phosphatase designated PP5, based on the binding of its tetratricopeptide repeat (TPR) domain to the atrial natriuretic peptide receptor (Chinkers, M. (1994) Proc. Natl. Acad. Sci. U. S. A...