Gene Symbol: Ppp1r13l
Description: protein phosphatase 1, regulatory subunit 13 like
Alias: relA-associated inhibitor
Robinson R, Lu X, Jones E, Siebold C. Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73. Structure. 2008;16:259-68 pubmed publisher
..These results suggest that the binding properties of iASPP render it a target for antitumor therapeutics and provide a peptide-based template for compound design. ..
Herron B, Rao C, Liu S, Laprade L, Richardson J, Olivieri E, et al
. A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice. Hum Mol Genet. 2005;14:667-77 pubmed
..A C-terminal fragment of this protein was previously identified as the RelA associated inhibitor (RAI)...
Lu M, Breyssens H, Salter V, Zhong S, Hu Y, Baer C, et al
. Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP. Cancer Cell. 2013;23:618-33 pubmed publisher
..Concurrent p53 reactivation and BRAFV600E inhibition achieved additive suppression in vivo, presenting an alternative for melanoma therapy. ..
Minekawa R, Sakata M, Okamoto Y, Hayashi M, Isobe A, Takeda T, et al
. Involvement of RelA-associated inhibitor in regulation of trophoblast differentiation via interaction with transcriptional factor specificity protein-1. Endocrinology. 2007;148:5803-10 pubmed
..Taken together, these findings suggest that RAI may be involved in the regulation of trophoblast differentiation via interaction with Sp1. ..
Beckerman R, Prives C. Transcriptional regulation by p53. Cold Spring Harb Perspect Biol. 2010;2:a000935 pubmed publisher
..How p53 is able to discriminate between these different loci is the subject of intense research. Here, we describe key aspects of the fundamentals of p53-mediated transcriptional regulation and target gene promoter selectivity. ..