Ppp1r13b

Summary

Gene Symbol: Ppp1r13b
Description: protein phosphatase 1, regulatory subunit 13B
Alias: apoptosis-stimulating of p53 protein 1, protein phosphatase 1, regulatory (inhibitor) subunit 13B
Species: rat
Products:     Ppp1r13b

Top Publications

  1. Samuels Lev Y, O Connor D, Bergamaschi D, Trigiante G, Hsieh J, Zhong S, et al. ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell. 2001;8:781-94 pubmed
    ..The expression of ASPP is frequently downregulated in human breast carcinomas expressing wild-type p53 but not mutant p53. Therefore, ASPP regulate the tumor suppression function of p53 in vivo. ..
  2. Beckerman R, Prives C. Transcriptional regulation by p53. Cold Spring Harb Perspect Biol. 2010;2:a000935 pubmed publisher
    ..How p53 is able to discriminate between these different loci is the subject of intense research. Here, we describe key aspects of the fundamentals of p53-mediated transcriptional regulation and target gene promoter selectivity. ..
  3. Wilson A, Morquette B, Abdouh M, Unsain N, Barker P, Feinstein E, et al. ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo. J Neurosci. 2013;33:2205-16 pubmed publisher
    ..Our study demonstrates a novel role for ASPP1 and ASPP2 in the death of RGCs and provides evidence that blockade of the ASPP-p53 pathway is beneficial for central neuron survival after axonal injury. ..