Gene Symbol: Ppfia1
Description: PTPRF interacting protein alpha 1
Alias: liprin-alpha-1, protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1, protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein, alpha 1
Shin H, Wyszynski M, Huh K, Valtschanoff J, Lee J, Ko J, et al
. Association of the kinesin motor KIF1A with the multimodular protein liprin-alpha. J Biol Chem. 2003;278:11393-401 pubmed
..These results suggest that liprin-alpha functions as a KIF1A receptor, linking KIF1A to various liprin-alpha-associated proteins for their transport in neurons. ..
Yin H, Wang L, Xiao F, Huang Z, Huang Y, Zhou C, et al
. Upregulation of liprin-?1 protein in the temporal neocortex of intractable epileptic patients and experimental rats. Synapse. 2011;65:742-50 pubmed publisher
..These results suggest that an increased expression of Liprin-?1 in the brain may be associated with human IE. ..
Sakamoto S, Ishizaki T, Okawa K, Watanabe S, Arakawa T, Watanabe N, et al
. Liprin-? controls stress fiber formation by binding to mDia and regulating its membrane localization. J Cell Sci. 2012;125:108-20 pubmed publisher
..Thus, Liprin-? negatively regulates the activity of mDia in the cell by displacing it from the plasma membrane through binding to the DID-DD region. ..
Dickinson B, Jo J, Seok H, Son G, Whitcomb D, Davies C, et al
. A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-alpha. Mol Brain. 2009;2:18 pubmed publisher
..These data indicate a novel mechanism of synaptic plasticity in which activation of M1 receptors results in AMPAR endocytosis, via a mechanism involving interactions between GluA2, GRIP and liprin-alpha. ..
Nomura H, Tadokoro S, Hirashima N. Liprin-? is involved in exocytosis and cell spreading in mast cells. Immunol Lett. 2011;139:110-6 pubmed publisher
..These results suggest that liprin-?1 facilitates exocytosis and cell spreading, and these events might have correlated each other in mast cells. ..