Gene Symbol: Ppargc1a
Description: PPARG coactivator 1 alpha
Alias: Ppargc1, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PGC-1-alpha, PGC-1alpha, PPAR-gamma coactivator 1-alpha, PPARGC-1-alpha, peroxisome proliferative activated receptor gamma coactivator 1, peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Species: rat
Products:     Ppargc1a

Top Publications

  1. Louet J, Hayhurst G, Gonzalez F, Girard J, Decaux J. The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein (CREB). J Biol Chem. 2002;277:37991-8000 pubmed
    ..Taken together these observations suggest that PGC-1 acts to coordinate the process of metabolic adaptation in the liver. ..
  2. Liang H, Ward W, Jang Y, Bhattacharya A, Bokov A, Li Y, et al. PGC-1? protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model. Muscle Nerve. 2011;44:947-56 pubmed publisher
    ..A sustained level of excitatory amino acid transporter protein 2 (EAAT2) in astrocytes of the PGC-1?/G93A DL mice may contribute to neuronal protection. ..
  3. Taherzadeh Fard E, Saft C, Akkad D, Wieczorek S, Haghikia A, Chan A, et al. PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease. Mol Neurodegener. 2011;6:32 pubmed publisher
    ..for involvement of PGC-1alpha in HD pathogenesis was generated by the findings that sequence variations in the PPARGC1A gene encoding PGC-1alpha exert modifying effects on the AO in HD...
  4. Irrcher I, Adhihetty P, Sheehan T, Joseph A, Hood D. PPARgamma coactivator-1alpha expression during thyroid hormone- and contractile activity-induced mitochondrial adaptations. Am J Physiol Cell Physiol. 2003;284:C1669-77 pubmed
  5. Amengual Cladera E, Lladó I, Gianotti M, Proenza A. Sex differences in the effect of high-fat diet feeding on rat white adipose tissue mitochondrial function and insulin sensitivity. Metabolism. 2012;61:1108-17 pubmed publisher
    ..This sexual dimorphism suggests that there are different strategies for retroperitoneal WAT to maintain the energetic and metabolic homeostasis in response to HFD feeding. ..
  6. Lai C, Tucker K, Parnell L, Adiconis X, Garcia Bailo B, Griffith J, et al. PPARGC1A variation associated with DNA damage, diabetes, and cardiovascular diseases: the Boston Puerto Rican Health Study. Diabetes. 2008;57:809-16 pubmed
    ..We sought to link peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PPARGC1A), a master transcriptional regulator of mitochondrial oxidative phosphorylation and cellular energy metabolism, ..
  7. Weydt P, Soyal S, Gellera C, DiDonato S, Weidinger C, Oberkofler H, et al. The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease. Mol Neurodegener. 2009;4:3 pubmed publisher
    ..for modifier genes of HD age-of-onset had suggested linkage at chromosomal region 4p16-4p15, near the locus of PPARGC1A, the gene coding for PGC-1alpha...
  8. Che H, Metzger S, Portal E, Deyle C, Riess O, Nguyen H. Localization of sequence variations in PGC-1? influence their modifying effect in Huntington disease. Mol Neurodegener. 2011;6:1 pubmed publisher
    ..Until now, among others, the gene encoding PCG-1? (PPARGC1A) was shown to modify the AAO in two independent, however small, populations...
  9. SanGiovanni J, Chen J, Sapieha P, Aderman C, Stahl A, Clemons T, et al. DNA sequence variants in PPARGC1A, a gene encoding a coactivator of the ?-3 LCPUFA sensing PPAR-RXR transcription complex, are associated with NV AMD and AMD-associated loci in genes of complement and VEGF signaling pathways. PLoS ONE. 2013;8:e53155 pubmed publisher
    ..We postulated that DNA sequence variation in PPAR gamma (PPARG) co-activator 1 alpha (PPARGC1A), a gene encoding a co-activator of the LCPUFA-sensing PPARG-retinoid X receptor (RXR) transcription complex, may ..

More Information


  1. Herzog B, Hall R, Wang X, Waltner Law M, Granner D. Peroxisome proliferator-activated receptor gamma coactivator-1alpha, as a transcription amplifier, is not essential for basal and hormone-induced phosphoenolpyruvate carboxykinase gene expression. Mol Endocrinol. 2004;18:807-19 pubmed
    ..Taken together, these data suggest that, under chronic fasting conditions, i.e. when high levels of cAMP and glucocorticoids induce PGC-1alpha expression, this coactivator markedly amplifies PEPCK gene expression and gluconeogenesis. ..
  2. Wareski P, Vaarmann A, Choubey V, Safiulina D, Liiv J, Kuum M, et al. PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons. J Biol Chem. 2009;284:21379-85 pubmed publisher
  3. Russell L, Mansfield C, Lehman J, Kovacs A, Courtois M, Saffitz J, et al. Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner. Circ Res. 2004;94:525-33 pubmed
  4. Zhang P, Liu C, Zhang C, Zhang Y, Shen P, Zhang J, et al. Free fatty acids increase PGC-1alpha expression in isolated rat islets. FEBS Lett. 2005;579:1446-52 pubmed
    ..These data suggest that hyperlipidemia and hyperglycemia regulate PGC-1alpha expression in islets differently, and elevated PGC-1alpha by FFA plays an important role in chronic hyperlipidemia-induced beta-cell dysfunction. ..
  5. Ling C, Del Guerra S, Lupi R, Rönn T, Granhall C, Luthman H, et al. Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion. Diabetologia. 2008;51:615-22 pubmed publisher
    ..coactivator peroxisome proliferator activated receptor gamma coactivator-1 alpha (protein PGC-1alpha; gene PPARGC1A) is a master regulator of mitochondrial genes and its expression is decreased and related to impaired oxidative ..
  6. Rasbach K, Gupta R, Ruas J, Wu J, Naseri E, Estall J, et al. PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. Proc Natl Acad Sci U S A. 2010;107:21866-71 pubmed publisher
    ..These data indicate that HIF2? acts downstream of PGC-1? as a key regulator of a muscle fiber-type program and the adaptive response to exercise. ..
  7. Cowell R, Blake K, Russell J. Localization of the transcriptional coactivator PGC-1alpha to GABAergic neurons during maturation of the rat brain. J Comp Neurol. 2007;502:1-18 pubmed
  8. Terada S, Goto M, Kato M, Kawanaka K, Shimokawa T, Tabata I. Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle. Biochem Biophys Res Commun. 2002;296:350-4 pubmed
  9. Qin W, Haroutunian V, Katsel P, Cardozo C, Ho L, Buxbaum J, et al. PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia. Arch Neurol. 2009;66:352-61 pubmed publisher
    ..Therapeutic preservation of neuronal PGC-1alpha expression promotes the nonamyloidogenic processing of amyloid precursor protein precluding the generation of amyloidogenic Abeta peptides. ..
  10. O Hagan K, Cocchiglia S, Zhdanov A, Tambuwala M, Tambawala M, Cummins E, et al. PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells. Proc Natl Acad Sci U S A. 2009;106:2188-93 pubmed publisher
  11. Cui L, Jeong H, Borovecki F, Parkhurst C, Tanese N, Krainc D. Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. Cell. 2006;127:59-69 pubmed
    ..These studies suggest a key role for PGC-1alpha in the control of energy metabolism in the early stages of HD pathogenesis. ..
  12. Shin J, Ko H, Kang H, Lee Y, Lee Y, Pletinkova O, et al. PARIS (ZNF746) repression of PGC-1? contributes to neurodegeneration in Parkinson's disease. Cell. 2011;144:689-702 pubmed publisher
    ..The identification of PARIS provides a molecular mechanism for neurodegeneration due to parkin inactivation. ..
  13. Soyal S, Felder T, Auer S, Hahne P, Oberkofler H, Witting A, et al. A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset. Hum Mol Genet. 2012;21:3461-73 pubmed publisher
    ..Several single-nucleotide polymorphisms (SNPs) located in two separate haplotype blocks of PPARGC1A have shown associations with Huntington's disease (HD) and Parkinson's disease, but causative SNPs have not been ..
  14. Sriwijitkamol A, Ivy J, Christ Roberts C, DeFronzo R, Mandarino L, Musi N. LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training. Am J Physiol Endocrinol Metab. 2006;290:E925-32 pubmed
    ..54, P = 0.02), and PGC-1alpha protein content (r = 0.81, P < 0.001). In summary, obese insulin-resistant rodents have abnormalities in the LKB1-AMPK-PGC-1 pathway in muscle, and these abnormalities can be restored by training. ..
  15. Muller Y, Bogardus C, Pedersen O, Baier L. A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians. Diabetes. 2003;52:895-8 pubmed
    ..These data indicate that the Gly482Ser missense polymorphism in PGC-1 has metabolic consequences on lipid metabolism that could influence insulin secretion. ..
  16. Baker D, Betik A, Krause D, Hepple R. No decline in skeletal muscle oxidative capacity with aging in long-term calorically restricted rats: effects are independent of mitochondrial DNA integrity. J Gerontol A Biol Sci Med Sci. 2006;61:675-84 pubmed
    ..However, there was a slower decline in PGC-1alpha gene expression with aging in CR versus AL animals, suggesting a better maintenance of mitochondrial biogenesis with aging in CR animals. ..
  17. Caton P, Nayuni N, Khan N, Wood E, Corder R. Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism. J Endocrinol. 2011;208:273-83 pubmed publisher
    ..These results highlight the need for a greater understanding of the role of SIRT1 in metabolic regulation and indicate the potential for adverse effects of SIRT1 activators if used therapeutically. ..
  18. Villeneuve C, Guilbeau Frugier C, Sicard P, Lairez O, Ordener C, Duparc T, et al. p53-PGC-1? pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: role in chronic left ventricular dysfunction in mice. Antioxid Redox Signal. 2013;18:5-18 pubmed publisher
    ..In the present study, we evaluated the consequences of cardiac MAO-A augmentation on chronic oxidative damage, cardiomyocyte survival, and heart function, and identified the intracellular pathways involved...
  19. Nedumaran B, Hong S, Xie Y, Kim Y, Seo W, Lee M, et al. DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression. J Biol Chem. 2009;284:27511-23 pubmed publisher
    ..Overall, this study demonstrates that DAX-1 acts as a corepressor of HNF4alpha to negatively regulate hepatic gluconeogenic gene expression in liver. ..
  20. Grimstad T, Bjørndal B, Cacabelos D, Aasprong O, Janssen E, Omdal R, et al. Dietary supplementation of krill oil attenuates inflammation and oxidative stress in experimental ulcerative colitis in rats. Scand J Gastroenterol. 2012;47:49-58 pubmed publisher
    ..To evaluate the effects of krill oil (KO) on inflammation and redox status in dextran sulfate sodium (DSS)-induced colitis in rats...
  21. Li F, Yu H, Xiao L, Liu Y. Response of BAX, Bcl-2 Proteins, and SIRT1/PGC-1? mRNA Expression to 8-Week Treadmill Running in the Aging Rat Skeletal Muscle. Adv Exp Med Biol. 2016;923:283-289 pubmed publisher
    ..Exercise training may inhibit age-induced myonuclear apoptosis by stimulating SIRT1/PGC-1? mRNA expression, thereby preventing sarcopenia in aging rat. ..
  22. Zhao X, Sun J, Hu Y, Yang Y, Zhang W, Hu Y, et al. The effect of overexpression of PGC-1? on the mtDNA4834 common deletion in a rat cochlear marginal cell senescence model. Hear Res. 2013;296:13-24 pubmed publisher
    ..Our study may shed light on the pathogenesis of presbycusis and provide a new therapeutic target for presbycusis. ..
  23. Schlagowski A, Singh F, Charles A, Gali Ramamoorthy T, Favret F, Piquard F, et al. Mitochondrial uncoupling reduces exercise capacity despite several skeletal muscle metabolic adaptations. J Appl Physiol (1985). 2014;116:364-75 pubmed publisher
    ..These results emphasize the importance of investigating the qualitative aspects of mitochondrial function in addition to the amount of mitochondria. ..
  24. Khader A, Yang W, Kuncewitch M, Jacob A, Prince J, Asirvatham J, et al. Sirtuin 1 activation stimulates mitochondrial biogenesis and attenuates renal injury after ischemia-reperfusion. Transplantation. 2014;98:148-56 pubmed publisher
    ..SRT1720 treatment enhanced energy metabolism by stimulating mitochondrial biogenesis as well as decreasing nitrosative stress and inflammation, thereby attenuating I/R-induced renal injury. ..
  25. Huang C, Wang T, Tung Y, Lin W. Effect of Exercise Training on Skeletal Muscle SIRT1 and PGC-1? Expression Levels in Rats of Different Age. Int J Med Sci. 2016;13:260-70 pubmed publisher
    ..Our result suggests that swimming training can regulate the SIRT1/PGC-1?, AMPK and FOXO3a proteins expression of the soleus muscles in aged rats. ..
  26. Kim H, Kumar A, Wang L, Liu G, Keller S, Lawrence J, et al. Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. Mol Cell Biol. 2010;30:3126-39 pubmed publisher
    ..These observations place lipin 1 as a potentially important link between triacylglycerol synthesis and adipose tissue inflammation. ..
  27. Song K, Li T, Chiang J. A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene. J Biol Chem. 2006;281:10081-8 pubmed
    ..These results suggest that Prox1 is a novel co-regulator of HNF4alpha that may play a key role in the regulation of bile acid synthesis and gluconeogenesis in the liver. ..
  28. Adachi T, Kikuchi N, Yasuda K, Anahara R, Gu N, Matsunaga T, et al. Fibre type distribution and gene expression levels of both succinate dehydrogenase and peroxisome proliferator-activated receptor-gamma coactivator-1alpha of fibres in the soleus muscle of Zucker diabetic fatty rats. Exp Physiol. 2007;92:449-55 pubmed
    ..We have also discovered that the expression levels of the oxidative metabolism-related genes, PGC-1alpha and SDH, decreased in type I and type II fibres, respectively, of ZDF rats...
  29. Dietrich C, Martin I, Porn A, Voigt S, Gartung C, Trautwein C, et al. Fasting induces basolateral uptake transporters of the SLC family in the liver via HNF4alpha and PGC1alpha. Am J Physiol Gastrointest Liver Physiol. 2007;293:G585-90 pubmed
    ..We conclude that upregulation of the basolateral bile acid transporters Ntcp, Oatp1, and Oatp2 in fasted rats is mediated via the HNF4alpha/PGC-1alpha pathway. ..
  30. Hasumi H, Baba M, Hasumi Y, Huang Y, Oh H, Hughes R, et al. Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN. J Natl Cancer Inst. 2012;104:1750-64 pubmed publisher
    ..Genetic studies of BHD patients have uncovered the causative gene, FLCN, but its function is incompletely understood...
  31. Ciron C, Lengacher S, Dusonchet J, Aebischer P, Schneider B. Sustained expression of PGC-1? in the rat nigrostriatal system selectively impairs dopaminergic function. Hum Mol Genet. 2012;21:1861-76 pubmed publisher
    ..These results highlight the central role of PGC-1? in the function and survival of dopaminergic neurons and the critical need for maintaining physiological levels of PGC-1? activity. ..
  32. Wang C, Lung F. The role of PGC-1 and Apo?4 in insomnia. Psychiatr Genet. 2012;22:82-7 pubmed publisher
    ..In the future, when treating those with insomnia and high lipid profiles, health education with regard to how to control their lipid profile maybe used. ..
  33. Ashabi G, Ramin M, Azizi P, Taslimi Z, Alamdary S, Haghparast A, et al. ERK and p38 inhibitors attenuate memory deficits and increase CREB phosphorylation and PGC-1? levels in A?-injected rats. Behav Brain Res. 2012;232:165-73 pubmed publisher
    ..Surprisingly, these factors were returned to vehicle level, 20 days after A?-injection. Our findings reinforce the potential neuroprotective effect of these inhibitors against the A? toxicity. ..
  34. Kok B, Dyck J, Harris T, Brindley D. Differential regulation of the expressions of the PGC-1? splice variants, lipins, and PPAR? in heart compared to liver. J Lipid Res. 2013;54:1662-77 pubmed publisher
    ..Our results identify novel differences in the regulation of lipins, PPAR?, and PGC-1? splice variants during fasting in heart versus liver, even though the ultimate outcome in both tissues is to increase FA turnover and oxidation. ..
  35. Zhong Y, Hu Y, Peng W, Sun Y, Yang Y, Zhao X, et al. Age-related decline of the cytochrome c oxidase subunit expression in the auditory cortex of the mimetic aging rat model associated with the common deletion. Hear Res. 2012;294:40-8 pubmed publisher
    ..Therefore, CcO may be a specific intramitochondrial site of age-related deterioration in the auditory cortex, and CcO subunit III might be a target in the development of presbycusis. ..
  36. Sullo N, Roviezzo F, Matteis M, Spaziano G, Del Gaudio S, Lombardi A, et al. Skeletal muscle oxidative metabolism in an animal model of pulmonary emphysema: formoterol and skeletal muscle dysfunction. Am J Respir Cell Mol Biol. 2013;48:198-203 pubmed publisher
    ..In conclusion, in emphysematous mice that showed an increased mtDNA content, exposure to inhaled LABA can improve mitochondrial skeletal muscle oxidative processes. PGC-1? may serve as a possible mediator of this effect. ..
  37. Yang S, Choi J, Chae S, Kim W, Park S, Rhee E, et al. Activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats. PLoS ONE. 2011;6:e17057 pubmed publisher
    ..accumulation and increased expression of Sirt6, peroxisome proliferator-activated receptor gamma coactivtor-1-? (Ppargc1a/PGC1-?) and Forkhead box O1 (Foxo1) in rat livers...
  38. Frier B, Wan Z, Williams D, Stefanson A, Wright D. Epinephrine and AICAR-induced PGC-1? mRNA expression is intact in skeletal muscle from rats fed a high-fat diet. Am J Physiol Cell Physiol. 2012;302:C1772-9 pubmed publisher
    ..These results question the existence of reduced ?-adrenergic responsiveness in diet-induced obesity and demonstrate that increases in p38 phosphorylation are not required for induction of PGC-1? in muscle from obese rats. ..
  39. Shi J, Jiang B, Qiu Y, Guan J, Jain M, Cao X, et al. PGC1? plays a critical role in TWEAK-induced cardiac dysfunction. PLoS ONE. 2013;8:e54054 pubmed publisher
    ..Selective targeting of the FN14-TRAF2-NF?B-dependent signaling pathway or augmenting PGC1? levels may serve as novel therapeutic strategies for cardiomyopathy and heart failure. ..
  40. Zhang M, Lv X, Li J, Meng Z, Wang Q, Chang W, et al. Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis. Mol Cell Endocrinol. 2012;363:122-30 pubmed publisher
    ..BER could suppress hepatic gluconeogenesis in rat model of diabetes at least in part via stimulation of AMPK activity and this action of BER is augmented by sodium caprate. ..
  41. Chen M, Wang Y, Qu A. PGC-1 alpha accelerates cytosolic Ca2+ clearance without disturbing Ca2+ homeostasis in cardiac myocytes. Biochem Biophys Res Commun. 2010;396:894-900 pubmed publisher
    ..Unraveling the PGC-1 alpha-calcium handling pathway sheds new light on the role of PGC-1 alpha in the therapy of cardiac diseases...
  42. Festuccia W, Blanchard P, Oliveira T, Magdalon J, Paschoal V, Richard D, et al. PPAR? activation attenuates cold-induced upregulation of thyroid status and brown adipose tissue PGC-1? and D2. Am J Physiol Regul Integr Comp Physiol. 2012;303:R1277-85 pubmed publisher
    ..In conclusion, pharmacological PPAR? activation impairs short-term cold elicitation of BAT adrenergic and thyroid signaling, which may result in abnormal tissue recruitment and thermogenic activity. ..
  43. Prior S, Clark A, Jones D, Bain S, Hurel S, Humphries S, et al. Association of the PGC-1? rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus. Dis Markers. 2012;32:363-9 pubmed publisher
    ..Furthermore, homozygosity for the A-allele is also associated with a preponderance of small dense-LDL particles. ..
  44. Misra J, Chanda D, Kim D, Li T, Koo S, Back S, et al. Curcumin differentially regulates endoplasmic reticulum stress through transcriptional corepressor SMILE (small heterodimer partner-interacting leucine zipper protein)-mediated inhibition of CREBH (cAMP responsive element-binding protein H). J Biol Chem. 2011;286:41972-84 pubmed publisher
    ..Overall, for the first time we suggest a novel phenomenon that the curcumin/LKB1/AMPK/SMILE/PGC1? pathway differentially regulates ER stress-mediated gene transcription. ..
  45. Chen Y, Lai Y, Lin S, Li X, Fu Y, Xu W. SIRT1 interacts with metabolic transcriptional factors in the pancreas of insulin-resistant and calorie-restricted rats. Mol Biol Rep. 2013;40:3373-80 pubmed publisher
    ..PPAR? was elevated in the HFa group, but dropped in the CR and HFr groups. These data suggest that SIRT1 and its regulators are involved in the development of insulin resistance. ..
  46. Hioki T, Suzuki S, Morimoto M, Masaki T, Tozawa R, Morita S, et al. Brain testosterone deficiency leads to down-regulation of mitochondrial gene expression in rat hippocampus accompanied by a decline in peroxisome proliferator-activated receptor-? coactivator 1? expression. J Mol Neurosci. 2014;52:531-7 pubmed publisher
    ..These findings indicate that androgen plays an important role in mitochondrial gene expression in the hippocampus. ..
  47. Terada S, Tabata I. Effects of acute bouts of running and swimming exercise on PGC-1alpha protein expression in rat epitrochlearis and soleus muscle. Am J Physiol Endocrinol Metab. 2004;286:E208-16 pubmed
    ..The number of factors involved (both AMPK and Ca2+, or Ca2+ only) in exercise-induced PGC-1alpha expression may differ among muscles. ..
  48. Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa Shindo Y, Kawate H, Iesato Y, et al. Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system. Hypertension. 2013;61:341-51 pubmed publisher
    ..These data demonstrate that the AM-RAMP2 system is essential for cardiac metabolism and homeostasis. The AM-RAMP2 system is a promising therapeutic target of heart failure. ..
  49. Marosi K, Bori Z, Hart N, Sarga L, Koltai E, Radak Z, et al. Long-term exercise treatment reduces oxidative stress in the hippocampus of aging rats. Neuroscience. 2012;226:21-8 pubmed publisher
    ..These results suggest that long-term physical exercise can comprises antioxidant properties and by this way protect neurons against oxidative stress at the early stage of aging. ..
  50. Thakran S, Sharma P, Attia R, Hori R, Deng X, Elam M, et al. Role of sirtuin 1 in the regulation of hepatic gene expression by thyroid hormone. J Biol Chem. 2013;288:807-18 pubmed publisher
    ..Our results indicate that SIRT1 contributes to the T(3) regulation of hepatic genes. ..
  51. Lee M, Choi R, Kim H, Cho E, Kim B, Choi Y, et al. Peroxisome proliferator-activated receptor ? agonist attenuates hepatic steatosis by anti-inflammatory mechanism. Exp Mol Med. 2012;44:578-85 pubmed publisher
    ..The PPAR-? agonist may attenuate hepatic fat accumulation through anti-inflammatory mechanism, reducing hepatic PGC-1? gene expression, and improvement of insulin signaling. ..
  52. Cheng A, Wan R, Yang J, Kamimura N, Son T, Ouyang X, et al. Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines. Nat Commun. 2012;3:1250 pubmed publisher
    ..Our findings suggest that proliferator-activated receptor γ co-activator-1α and mitochondrial biogenesis have important roles in the formation and maintenance of hippocampal dendritic spines and synapses. ..
  53. Reed C, Hutcheson J, Mayhew C, Witkiewicz A, Knudsen E. RB tumor suppressive function in response to xenobiotic hepatocarcinogens. Am J Pathol. 2014;184:1853-9 pubmed publisher
    ..These data demonstrate the context specificity of RB and the key role RB plays in the suppression of hepatocellular carcinoma driven by xenobiotic stress. ..
  54. Liu X, Gao H, Huang X, Chen Y, Feng X, He Y, et al. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha protects cardiomyocytes from hypertrophy by suppressing calcineurin-nuclear factor of activated T cells c4 signaling pathway. Transl Res. 2015;166:459-473.e3 pubmed publisher
    ..These findings provide novel insights into the role of PGC-1α in regulation of cardiac hypertrophy. ..
  55. Qu A, Jiang C, Xu M, Zhang Y, Zhu Y, Xu Q, et al. PGC-1alpha attenuates neointimal formation via inhibition of vascular smooth muscle cell migration in the injured rat carotid artery. Am J Physiol Cell Physiol. 2009;297:C645-53 pubmed publisher
    ..These data strongly suggest that PGC-1alpha inhibits VSMC migration and neointimal formation after vascular injury in rats, mainly by upregulating the expression of the mitochondrial antioxidant enzyme SOD-2. ..
  56. Lane R, Maclennan N, Hsu J, Janke S, Pham T. Increased hepatic peroxisome proliferator-activated receptor-gamma coactivator-1 gene expression in a rat model of intrauterine growth retardation and subsequent insulin resistance. Endocrinology. 2002;143:2486-90 pubmed
    ..These data suggest that increased PGC-1 expression and subsequent hepatic glucose production contribute to the insulin resistance observed in the IUGR juvenile rat. ..
  57. Aoi W, Naito Y, Mizushima K, Takanami Y, Kawai Y, Ichikawa H, et al. The microRNA miR-696 regulates PGC-1{alpha} in mouse skeletal muscle in response to physical activity. Am J Physiol Endocrinol Metab. 2010;298:E799-806 pubmed publisher
    ..These observations demonstrate that miR-696 is a physical activity-dependent miRNA involved in the translational regulation of PGC-1alpha and skeletal muscle metabolism in mice. ..
  58. Gundewar S, Calvert J, Jha S, Toedt Pingel I, Ji S, Nunez D, et al. Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure. Circ Res. 2009;104:403-11 pubmed publisher
    ..This study demonstrates that metformin significantly improves left ventricular function and survival via activation of AMPK and its downstream mediators, eNOS and PGC-1alpha, in a murine model of heart failure. ..
  59. Smith B, Mukai K, Lally J, Maher A, Gurd B, Heigenhauser G, et al. AMP-activated protein kinase is required for exercise-induced peroxisome proliferator-activated receptor co-activator 1 translocation to subsarcolemmal mitochondria in skeletal muscle. J Physiol. 2013;591:1551-61 pubmed publisher
    ..These data suggest that exercise causes translocation of PGC-1? preferentially to SS mitochondria in an AMPK-dependent manner. ..
  60. Han J, Wang H, Yan D, Wang Z, Han H, Zhu H, et al. Myocardial ischaemic and diazoxide preconditioning both increase PGC-1alpha and reduce mitochondrial damage. Acta Cardiol. 2010;65:639-44 pubmed
    ..05). IPC and DPC have a protective effect on myocardial mitochondria, and their mechanism of action may be related to activation and over-expression of PGC-1alpha. ..
  61. Hickey F, Corcoran J, Docherty N, Griffin B, Bhreathnach U, Furlong F, et al. IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1?. J Am Soc Nephrol. 2011;22:1475-85 pubmed publisher
    ..In summary, these data suggest that IHG-1 increases mitochondrial biogenesis by promoting PGC-1?-dependent processes, potentially contributing to the pathogenesis of renal fibrosis. ..
  62. Patki G, Lau Y. Impact of exercise on mitochondrial transcription factor expression and damage in the striatum of a chronic mouse model of Parkinson's disease. Neurosci Lett. 2011;505:268-72 pubmed publisher
  63. Napal L, Marrero P, Haro D. An intronic peroxisome proliferator-activated receptor-binding sequence mediates fatty acid induction of the human carnitine palmitoyltransferase 1A. J Mol Biol. 2005;354:751-9 pubmed
    ..These results corroborate the hypothesis that PPARalpha regulates the limiting step in the oxidation of fatty acids in liver mitochondria. ..
  64. Goodman C, Pol D, Zacharewicz E, Lee Young R, Snow R, Russell A, et al. Statin-Induced Increases in Atrophy Gene Expression Occur Independently of Changes in PGC1α Protein and Mitochondrial Content. PLoS ONE. 2015;10:e0128398 pubmed publisher
    ..Moreover, muscle-specific increases in NOS expression and possibly NO production, and decreases in fatty acid oxidation, could contribute to the previously reported development of overt statin-induced muscle damage in FT muscles. ..
  65. Budick Harmelin N, Anavi S, Madar Z, Tirosh O. Fatty acids-stress attenuates gluconeogenesis induction and glucose production in primary hepatocytes. Lipids Health Dis. 2012;11:66 pubmed publisher
    ..The present results demonstrate that free-FAs directly inhibit the induced gluconeogenic response in hepatocytes. Hence, high levels of free-FAs may attenuate hepatic gluconeogenesis, and liver glucose output. ..
  66. Chen M, Feng H, Gupta D, Kelleher J, Dickerson K, Wang J, et al. G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency. Am J Physiol Cell Physiol. 2009;296:C930-40 pubmed publisher
    ..MGsKO mice are a valuable model for future studies of the role of G(s)alpha signaling pathways in skeletal muscle adaptation and their effects on whole body metabolism. ..
  67. Ma K, Zhang Y, Elam M, Cook G, Park E. Cloning of the rat pyruvate dehydrogenase kinase 4 gene promoter: activation of pyruvate dehydrogenase kinase 4 by the peroxisome proliferator-activated receptor gamma coactivator. J Biol Chem. 2005;280:29525-32 pubmed
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    ..The increase in LKB1 and PGC-1alpha with endurance and interval training may function to maintain the training-induced increases in mitochondrial mass. ..
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    ..The rs7665116 SNP in PPARGC1A, encoding the mitochondrial regulator PGC-1?, has been reported to be a significant modifier of AO in three ..
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    ..Overall, long-term BPA exposure induces cardiomyopathy in male rats, and the underlying mechanism may involve the impairment of cardiac mitochondrial function and the disturbance of methylation of PGC-1α. ..
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    ..These results show that both PGC-1alpha and PGC-1beta are involved in the regulation of skeletal muscle fiber transition and metabolism and that they have both overlapping and differing effects. ..
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    The transcriptional coactivator PPAR gamma coactivator 1 alpha (PGC-1alpha) is a key regulator of metabolic processes such as mitochondrial biogenesis and respiration in muscle and gluconeogenesis in liver...
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    ..Induction of IL1Rn by PGC-1? and AMPK may be involved in the beneficial effects of exercise and caloric restriction and putative anti-inflammatory effects of metformin. ..
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    ..The activation of the PPARgamma/PGC-1alpha pathway may protect against COPD progression by upregulating gamma-GCS and relieving oxidative stress. ..
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    ..desaturase and fatty acid synthase (Fasn) together with a decrease in PPAR gamma, delta and PPAR gamma coactivator 1 alpha (PGC1 alpha) expression. In the heart, Fasn and PPAR delta expression were increased...
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    ..The link between mHtt, PGC-1α, and NMDAR activity was also confirmed in rat striatal neurons. Thus, targeting levels of PGC-1α expression may help reduce aberrant NMDAR(EX) activity in disorders where PGC-1α is underexpressed. ..
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