Gene Symbol: Pou4f3
Description: POU class 4 homeobox 3
Alias: POU domain, class 4, transcription factor 3
Species: rat
Products:     Pou4f3

Top Publications

  1. Xiang M, Zhou L, Macke J, Yoshioka T, Hendry S, Eddy R, et al. The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. J Neurosci. 1995;15:4762-85 pubmed
  2. Erkman L, McEvilly R, Luo L, Ryan A, Hooshmand F, O Connell S, et al. Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature. 1996;381:603-6 pubmed
    ..Mutation of Brn-3.1 results in complete deafness, owing to a failure of hair cells to appear in the inner ear, with subsequent loss of cochlear and vestibular ganglia. ..
  3. Xiang M, Gan L, Li D, Chen Z, Zhou L, O Malley B, et al. Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development. Proc Natl Acad Sci U S A. 1997;94:9445-50 pubmed
  4. Vahava O, Morell R, Lynch E, Weiss S, Kagan M, Ahituv N, et al. Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans. Science. 1998;279:1950-4 pubmed
    ..Linkage analysis placed this deafness locus, DFNA15, on chromosome 5q31. The human homolog of mouse Pou4f3, a member of the POU-domain family of transcription factors whose targeted inactivation causes profound deafness ..
  5. Clough R, Sud R, Davis Silberman N, Hertzano R, Avraham K, Holley M, et al. Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity. Biochem Biophys Res Commun. 2004;324:372-81 pubmed
    ..Additionally, BDNF expression is reduced in the inner ear of a Brn-3c mutant mouse during embryogenesis. Our data suggest that Brn-3c may play a role in regulating neurotrophin gene expression in the inner ear. ..
  6. Xiang M, Gao W, Hasson T, Shin J. Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells. Development. 1998;125:3935-46 pubmed
    ..These data indicate a crucial role for Brn-3c in maturation, survival and migration of hair cells, but not in proliferation or commitment of hair cell progenitors. ..
  7. Wang S, Mu X, Bowers W, Kim D, Plas D, Crair M, et al. Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development. 2002;129:467-77 pubmed
    ..Our results reveal a complex genetic relationship between Brn3b and Brn3c in regulating the retinal ganglion cell axon outgrowth. ..
  8. Morris P, Theil T, Ring C, Lillycrop K, Moroy T, Latchman D. The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain. Mol Cell Biol. 1994;14:6907-14 pubmed
  9. Tornari C, Towers E, Gale J, Dawson S. Regulation of the orphan nuclear receptor Nr2f2 by the DFNA15 deafness gene Pou4f3. PLoS ONE. 2014;9:e112247 pubmed publisher
    Hair cells are the mechanotransducing cells of the inner ear that are essential for hearing and balance. POU4F3--a POU-domain transcription factor selectively expressed by these cells--has been shown to be essential for hair cell ..

More Information


  1. Lin Y, Lin Y, Lu Y, Liu T, Chen C, Hsu C, et al. A novel missense variant in the nuclear localization signal of POU4F3 causes autosomal dominant non-syndromic hearing loss. Sci Rep. 2017;7:7551 pubmed publisher
    ..a massively parallel sequencing panel targeting 159 deafness genes, we identified a novel missense variant of POU4F3 (c.982A>G, p...
  2. Xiang M, Maklad A, Pirvola U, Fritzsch B. Brn3c null mutant mice show long-term, incomplete retention of some afferent inner ear innervation. BMC Neurosci. 2003;4:2 pubmed
    ..The molecular nature of the long term survival of apical spiral neurons remains unclear. ..
  3. Zhang L, Wahlin K, Li Y, Masuda T, Yang Z, Zack D, et al. RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors. Mol Vis. 2013;19:1371-86 pubmed
  4. Theil T, McLean Hunter S, Zörnig M, Moroy T. Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a. Nucleic Acids Res. 1993;21:5921-9 pubmed
    ..In addition, our data indicate that Brn-3b acts as an inhibitor of Brn-3a(l) activity. ..