Polq

Summary

Gene Symbol: Polq
Description: DNA polymerase theta
Alias: DNA polymerase theta, polymerase (DNA directed), theta, polymerase (DNA) theta
Species: rat
Products:     Polq

Top Publications

  1. Shima N, Hartford S, Duffy T, Wilson L, Schimenti K, Schimenti J. Phenotype-based identification of mouse chromosome instability mutants. Genetics. 2003;163:1031-40 pubmed
    ..3-Mb interval on chromosome 16 containing Polq, encoding DNA polymerase theta. We identified a nonconservative mutation in the ENU-derived allele, making it a strong candidate for ..
  2. Prasad R, Longley M, Sharief F, Hou E, Copeland W, Wilson S. Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro. Nucleic Acids Res. 2009;37:1868-77 pubmed publisher
    b>DNA polymerase theta (Pol theta) is a low-fidelity DNA polymerase that belongs to the family A polymerases and has been proposed to play a role in somatic hypermutation...
  3. Seki M, Marini F, Wood R. POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells. Nucleic Acids Res. 2003;31:6117-26 pubmed
    ..the isolation of the full-length human DNA POLQ gene, and an initial characterization of its gene product, DNA polymerase theta. POLQ is of particular interest as it is orthologous to Drosophila Mus308, a gene implicated in cellular ..
  4. Masuda K, Ouchida R, Takeuchi A, Saito T, Koseki H, Kawamura K, et al. DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes. Proc Natl Acad Sci U S A. 2005;102:13986-91 pubmed
    ..Compared with WT mice, Polq-inactive (Polq, the gene encoding Pol) mice exhibited a reduced level of serum IgM and IgG1...
  5. Zan H, Shima N, Xu Z, Al Qahtani A, Evinger Iii A, Zhong Y, et al. The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation. EMBO J. 2005;24:3757-69 pubmed
  6. Masuda K, Ouchida R, Hikida M, Nakayama M, Ohara O, Kurosaki T, et al. Absence of DNA polymerase theta results in decreased somatic hypermutation frequency and altered mutation patterns in Ig genes. DNA Repair (Amst). 2006;5:1384-91 pubmed
    ..We have previously shown that mice expressing a catalytically inactive POLQ (Polq-inactive) have a reduction in C/G mutations...
  7. Shima N, Munroe R, Schimenti J. The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm. Mol Cell Biol. 2004;24:10381-9 pubmed
    ..The chaos1 allele was genetically associated with a missense mutation in Polq, which encodes DNA polymerase theta;...
  8. Hogg M, Sauer Eriksson A, Johansson E. Promiscuous DNA synthesis by human DNA polymerase ?. Nucleic Acids Res. 2012;40:2611-22 pubmed publisher
    The biological role of human DNA polymerase ? (POLQ) is not yet clearly defined, but it has been proposed to participate in several cellular processes based on its translesion synthesis capabilities...
  9. Ceccaldi R, Liu J, Amunugama R, Hajdu I, Primack B, Petalcorin M, et al. Homologous-recombination-deficient tumours are dependent on Pol?-mediated repair. Nature. 2015;518:258-62 pubmed publisher
    ..Previous studies have implicated the DNA polymerase ? (Pol? also known as POLQ, encoded by POLQ) in a pathway required for the repair of DNA double-strand breaks, referred to as the error-prone ..

More Information

Publications12

  1. Mateos Gomez P, Gong F, Nair N, Miller K, Lazzerini Denchi E, Sfeir A. Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination. Nature. 2015;518:254-7 pubmed publisher
    ..activity responsible for the random insertions enabled us to identify polymerase theta (Polθ; encoded by Polq in mice) as a crucial alternative NHEJ factor in mammalian cells...
  2. Kent T, Chandramouly G, McDevitt S, Ozdemir A, Pomerantz R. Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ. Nat Struct Mol Biol. 2015;22:230-7 pubmed publisher
    ..Finally, we identify a conserved loop domain that is essential for MMEJ and higher-order structures of Polθ that probably promote DNA synapse formation. ..
  3. Newman J, Cooper C, Aitkenhead H, Gileadi O. Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway. Structure. 2015;23:2319-2330 pubmed publisher
    b>DNA polymerase theta (Polθ) has been identified as a crucial alternative non-homologous end-joining factor in mammalian cells...