Gene Symbol: Plppr4
Description: phospholipid phosphatase related 4
Alias: Lppr4, Prg-1, Prg1, phospholipid phosphatase-related protein type 4, brain-specific phosphatidic acid phosphatase-like protein 1, lipid phosphate phosphatase-related protein type 4, plasticity related gene 1, plasticity-related gene 1 protein
Yamada M, Shida Y, Takahashi K, Tanioka T, Nakano Y, Tobe T, et al
. Prg1 is regulated by the basic helix-loop-helix transcription factor Math2. J Neurochem. 2008;106:2375-84 pubmed publisher
..Of the genes regulated by Math2, we focused on plasticity-related gene 1 (Prg1)...
Ni H, Jiang Y, Tao L, Jin M, Wu X. ZnT-1, ZnT-3, CaMK II, PRG-1 expressions in hippocampus following neonatal seizure-induced cognitive deficit in rats. Toxicol Lett. 2009;184:145-50 pubmed publisher
..Our results suggest that the long-term adverse effects of recurrent neonatal seizures on cognition and mossy fiber sprouting may be associated with the down-regulated expression of ZnT-1 and CaMK II in hippocampus. ..
Ni H, Jiang Y, Xiao Z, Tao L, Jin M, Wu X. Dynamic pattern of gene expression of ZnT-1, ZnT-3 and PRG-1 in rat brain following flurothyl-induced recurrent neonatal seizures. Toxicol Lett. 2010;194:86-93 pubmed publisher
Gaaya A, Poirier O, Mougenot N, Hery T, Atassi F, Marchand A, et al
. Plasticity-related gene-1 inhibits lysophosphatidic acid-induced vascular smooth muscle cell migration and proliferation and prevents neointima formation. Am J Physiol Cell Physiol. 2012;303:C1104-14 pubmed publisher
..Taken together, these findings provide the first evidence of a protective role of PRG-1 in the vascular media under pathophysiological conditions. ..
Hashimoto T, Yamada M, Iwai T, Saitoh A, Hashimoto E, Ukai W, et al
. Plasticity-related gene 1 is important for survival of neurons derived from rat neural stem cells. J Neurosci Res. 2013;91:1402-7 pubmed publisher
Plasticity-related gene 1 (Prg1) is a membrane-associated lipid phosphate phosphatase...
Bräuer A, Savaskan N, Kuhn H, Prehn S, Ninnemann O, Nitsch R. A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting. Nat Neurosci. 2003;6:572-8 pubmed
..Thus, we propose a novel mechanism by which axons are able to control phospholipid-mediated signaling and overcome the growth-inhibiting, phospholipid-rich environment of the extracellular space. ..