Plg

Summary

Gene Symbol: Plg
Description: plasminogen
Alias: Ab1-346, plasminogen
Species: rat
Products:     Plg

Top Publications

  1. Candela M, Biagi E, Centanni M, Turroni S, Vici M, Musiani F, et al. Bifidobacterial enolase, a cell surface receptor for human plasminogen involved in the interaction with the host. Microbiology. 2009;155:3294-303 pubmed publisher
    The interaction with the host plasminogen/plasmin system represents a novel component in the molecular cross-talk between bifidobacteria and human host. Here, we demonstrated that the plasminogen-binding bifidobacterial species B...
  2. Xolalpa W, Vallecillo A, Lara M, Mendoza Hernandez G, Comini M, Spallek R, et al. Identification of novel bacterial plasminogen-binding proteins in the human pathogen Mycobacterium tuberculosis. Proteomics. 2007;7:3332-41 pubmed
    Binding and activation of human plasminogen (Plg) to generate the proteolytic enzyme plasmin (Plm) have been associated with the invasive potential of certain bacteria...
  3. Knaust A, Weber M, Hammerschmidt S, Bergmann S, Frosch M, Kurzai O. Cytosolic proteins contribute to surface plasminogen recruitment of Neisseria meningitidis. J Bacteriol. 2007;189:3246-55 pubmed
    b>Plasminogen recruitment is a common strategy of pathogenic bacteria and results in a broad-spectrum surface-associated protease activity. Neisseria meningitidis has previously been shown to bind plasminogen...
  4. Sha J, Erova T, Alyea R, Wang S, Olano J, Pancholi V, et al. Surface-expressed enolase contributes to the pathogenesis of clinical isolate SSU of Aeromonas hydrophila. J Bacteriol. 2009;191:3095-107 pubmed publisher
    ..that the surface-expressed enolase from diarrheal isolate SSU of Aeromonas hydrophila bound to human plasminogen and facilitated the latter's tissue-type plasminogen activator-mediated activation to plasmin...
  5. Pancholi V, Fischetti V. alpha-enolase, a novel strong plasmin(ogen) binding protein on the surface of pathogenic streptococci. J Biol Chem. 1998;273:14503-15 pubmed
    ..and showed significantly greater plasmin(ogen) binding affinity compared with previously reported streptococcal plasminogen binding proteins...
  6. Min K, Jou I, Joe E. Plasminogen-induced IL-1beta and TNF-alpha production in microglia is regulated by reactive oxygen species. Biochem Biophys Res Commun. 2003;312:969-74 pubmed
    ..In this study we showed that the blood component plasminogen/plasmin activates microglia...
  7. Floden A, Watt J, Brissette C. Borrelia burgdorferi enolase is a surface-exposed plasminogen binding protein. PLoS ONE. 2011;6:e27502 pubmed publisher
    ..In order to aid in its dissemination, B. burgdorferi binds plasminogen, a component of the hosts' fibrinolytic system. Plasminogen bound to the surface of B...
  8. Bohnsack R, Patel M, Olson L, Twining S, Dahms N. Residues essential for plasminogen binding by the cation-independent mannose 6-phosphate receptor. Biochemistry. 2010;49:635-44 pubmed publisher
    ..The CI-MPR is a receptor for plasminogen, and this interaction can be inhibited by lysine analogues...
  9. Jobin M, Brassard J, Quessy S, Gottschalk M, Grenier D. Acquisition of host plasmin activity by the Swine pathogen Streptococcus suis serotype 2. Infect Immun. 2004;72:606-10 pubmed
    In this study, the plasminogen-binding activity of Streptococcus suis serotype 2 was investigated. Bound human plasminogen was activated by purified streptokinase, urokinase, or Streptococcus dysgalactiae subsp...

More Information

Publications49

  1. Nezi L, Greco D, Nitsch L, Garbi C. The role of proteases in fibronectin matrix remodeling in thyroid epithelial cell monolayer cultures. Biol Chem. 2002;383:167-76 pubmed
    ..FRT cells secrete and expose on the plasma membrane the tissue-type plasminogen activator and, in serum-free cultures, plasminogen induces a rapid loss of FN fibrils...
  2. Das R, Burke T, Plow E. Histone H2B as a functionally important plasminogen receptor on macrophages. Blood. 2007;110:3763-72 pubmed
    b>Plasminogen (Plg) facilitates inflammatory cell recruitment, a function that depends upon its binding to Plg receptors (Plg-Rs). However, the Plg-Rs that are critical for cell migration are not well defined...
  3. Mundodi V, Kucknoor A, Alderete J. Immunogenic and plasminogen-binding surface-associated alpha-enolase of Trichomonas vaginalis. Infect Immun. 2008;76:523-31 pubmed
    ..with vaginal epithelial cells, and this is the first report demonstrating up-regulation by cytoadherence of a plasminogen-binding alpha-enolase in T. vaginalis...
  4. Schuster V, Mingers A, Seidenspinner S, Nüssgens Z, Pukrop T, Kreth H. Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis. Blood. 1997;90:958-66 pubmed
    ..Both children exhibited a severe plasminogen deficiency...
  5. Gutierrez Fernandez A, Parmer R, Miles L. Plasminogen gene expression is regulated by nerve growth factor. J Thromb Haemost. 2007;5:1715-25 pubmed
    Studies have documented a requirement for an intact plasminogen (Plg) activation system in neurite outgrowth induced by nerve growth factor (NGF)...
  6. Fulde M, Bernardo García N, Rohde M, Nachtigall N, Frank R, Preissner K, et al. Pneumococcal phosphoglycerate kinase interacts with plasminogen and its tissue activator. Thromb Haemost. 2014;111:401-16 pubmed publisher
    ..is localised on the pneumococcal surface of both capsulated and non-capsulated strains and colocalises with plasminogen. Since pneumococci may concentrate host plasminogen (PLG) together with its activators on the bacterial cell ..
  7. Ichinose A, Espling E, Takamatsu J, Saito H, Shinmyozu K, Maruyama I, et al. Two types of abnormal genes for plasminogen in families with a predisposition for thrombosis. Proc Natl Acad Sci U S A. 1991;88:115-9 pubmed
    The gene coding for plasminogen has been compared with several abnormal genes from Japanese patients by the polymerase chain reaction and DNA sequence analysis...
  8. Nakajima K, Hamanoue M, Takemoto N, Hattori T, Kato K, Kohsaka S. Plasminogen binds specifically to alpha-enolase on rat neuronal plasma membrane. J Neurochem. 1994;63:2048-57 pubmed
    b>Plasminogen (PGn) that we identified in microglial-conditioned medium has a neurotrophic factor-like effect on cultured neurons...
  9. Yasuda S, Atsumi T, Ieko M, Matsuura E, Kobayashi K, Inagaki J, et al. Nicked beta2-glycoprotein I: a marker of cerebral infarct and a novel role in the negative feedback pathway of extrinsic fibrinolysis. Blood. 2004;103:3766-72 pubmed
    ..We demonstrate that nicked beta(2)-GPI binds to Glu-plasminogen with K(D) of 0...
  10. Heinemann F, Korza G, Ozols J. A plasminogen-like protein selectively degrades stearoyl-CoA desaturase in liver microsomes. J Biol Chem. 2003;278:42966-75 pubmed
    ..Here we show that the 90-kDa protein is a microsomal form of plasminogen (Pg) and that the purified SCD protease contains a spectrum of plasmin-like derivatives...
  11. Jong A, Chen S, Stins M, Kim K, Tuan T, Huang S. Binding of Candida albicans enolase to plasmin(ogen) results in enhanced invasion of human brain microvascular endothelial cells. J Med Microbiol. 2003;52:615-22 pubmed
    ..albicans enolase to human plasminogen/plasmin was investigated. C...
  12. Passero C, Mueller G, Rondon Berrios H, Tofovic S, Hughey R, Kleyman T. Plasmin activates epithelial Na+ channels by cleaving the gamma subunit. J Biol Chem. 2008;283:36586-91 pubmed publisher
    ..of ENaC may have a role in extracellular volume expansion in human disorders associated with proteinuria, as filtered plasminogen may be processed by urokinase, released from renal tubular epithelium, to generate active plasmin.
  13. Solberg H, Rinkenberger J, Danø K, Werb Z, Lund L. A functional overlap of plasminogen and MMPs regulates vascularization during placental development. Development. 2003;130:4439-50 pubmed
    Both plasminogen activators and matrix metalloproteinases (MMPs) have been implicated in a variety of developmental processes in the mouse during embryo implantation and placentation...
  14. Jolodar A, Fischer P, Bergmann S, Büttner D, Hammerschmidt S, Brattig N. Molecular cloning of an alpha-enolase from the human filarial parasite Onchocerca volvulus that binds human plasminogen. Biochim Biophys Acta. 2003;1627:111-20 pubmed
    Enolase represents a multifunctional protein involved in basic energy metabolism and plasminogen binding and activation at the surface of prokaryotic pathogens...
  15. Lopez Alemany R, Longstaff C, Hawley S, Mirshahi M, Fábregas P, Jardi M, et al. Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against alpha-Enolase. Am J Hematol. 2003;72:234-42 pubmed
    ..The binding of plasminogen to leukocytic cell lines induces a 30- to 80-fold increase in the rate of plasminogen activation by tissue-type ..
  16. Zhu M, Bi X, Jia Q, Shangguan S. The possible mechanism for impaired angiogenesis after transient focal ischemia in type 2 diabetic GK rats: different expressions of angiostatin and vascular endothelial growth factor. Biomed Pharmacother. 2010;64:208-13 pubmed publisher
    ..And the possible mechanism is hyperglycemia attenuates neovascularization by downregulating proliferative properties of VEGF and upregulating of negative properties of angiostatin. ..
  17. Matta S, Agarwal S, Bhatnagar R. Surface localized and extracellular Glyceraldehyde-3-phosphate dehydrogenase of Bacillus anthracis is a plasminogen binding protein. Biochim Biophys Acta. 2010;1804:2111-20 pubmed publisher
    ..anthracis. Human plasminogen predominantly interacted with the rGapA isoform at physiological concentrations and the interaction was found ..
  18. Longstaff C, Kolev K. Basic mechanisms and regulation of fibrinolysis. J Thromb Haemost. 2015;13 Suppl 1:S98-105 pubmed publisher
    ..Suitable models are at an early stage of development, but may improve as model clots increase in complexity to incorporate the components and interactions listed above. ..
  19. Okumura N, Koh T, Hasebe Y, Seki T, Ariga T. A novel function of thrombin-activatable fibrinolysis inhibitor during rat liver regeneration and in growth-promoted hepatocytes in primary culture. J Biol Chem. 2009;284:16553-61 pubmed publisher
    ..inhibitor (TAFI) exhibits anti-fibrinolytic activity by removing C-terminal lysine residues from fibrin or plasminogen receptor proteins on the cellular surface, and plays an important role in the regulation of fibrinolysis...
  20. Gründel A, Pfeiffer M, Jacobs E, Dumke R. Network of Surface-Displayed Glycolytic Enzymes in Mycoplasma pneumoniae and Their Interactions with Human Plasminogen. Infect Immun. 2015;84:666-76 pubmed publisher
    ..The presence of surface-displayed glycolytic enzymes and their interaction with human plasminogen as an important host factor were investigated in the genome-reduced and cell wall-less microorganism Mycoplasma ..
  21. Kanalas J, Makker S. Identification of the rat Heymann nephritis autoantigen (GP330) as a receptor site for plasminogen. J Biol Chem. 1991;266:10825-9 pubmed
    ..Sequence analysis of an isolated clone identified the serum protein as plasminogen. Plasminogen was isolated from rat serum by standard techniques, and the binding of plasminogen to gp330 was ..
  22. Jones M, Holt R. Cloning and characterization of an alpha-enolase of the oral pathogen Streptococcus mutans that binds human plasminogen. Biochem Biophys Res Commun. 2007;364:924-9 pubmed
    ..Previously, we have demonstrated that S. mutans cells have the capacity to bind and activate plasminogen to plasmin. Here we report the first cloning and characterization of an alpha-enolase of S...
  23. Fujimoto S, Katsuki H, Ohnishi M, Takagi M, Kume T, Akaike A. Plasminogen potentiates thrombin cytotoxicity and contributes to pathology of intracerebral hemorrhage in rats. J Cereb Blood Flow Metab. 2008;28:506-15 pubmed
    ..Here, we investigated potential cytotoxic actions of plasminogen, a precursor protein of plasmin, using slice cultures prepared from neonatal rat brain and intracortical ..
  24. Kanalas J. Characterization of plasminogen system on rat yolk sac carcinoma (L2) cells. Am J Physiol. 1995;268:C442-8 pubmed
    The plasminogen (Plg) system on rat yolk sac carcinoma (L2) cells was characterized by zymography, Western and immunoprecipitation analysis, reverse-transcriptase polymerase chain reaction, binding, and activity assays...
  25. Lopez Lira F, Rosales León L, Martínez V, Ruiz Ordaz B. The role of beta2-glycoprotein I (beta2GPI) in the activation of plasminogen. Biochim Biophys Acta. 2006;1764:815-23 pubmed
    ..beta2GPI binds with high affinity to the atherogenic lipoprotein Lp(a) which shares structural homology with plasminogen, a key molecule in the fibrinolytic system. Impaired fibrinolysis has been described in APS...
  26. Graversen J, Lorentsen R, Jacobsen C, Moestrup S, Sigurskjold B, Thogersen H, et al. The plasminogen binding site of the C-type lectin tetranectin is located in the carbohydrate recognition domain, and binding is sensitive to both calcium and lysine. J Biol Chem. 1998;273:29241-6 pubmed
    ..highly related to corresponding regions of the mannose-binding proteins, is known specifically to bind the plasminogen kringle 4 protein domain, an interaction sensitive to lysine...
  27. Antikainen J, Kuparinen V, Lähteenmäki K, Korhonen T. Enolases from Gram-positive bacterial pathogens and commensal lactobacilli share functional similarity in virulence-associated traits. FEMS Immunol Med Microbiol. 2007;51:526-34 pubmed
    ..The fusion proteins were compared for putative virulence-associated functions, i.e., binding of human plasminogen, enhancement of plasminogen activation by human plasminogen activators, as well as binding to immobilized ..
  28. Silverstein R, Leung L, Harpel P, Nachman R. Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator. J Clin Invest. 1984;74:1625-33 pubmed
    ..In this study we have demonstrated that purified human platelet TSP formed a complex with purified human plasminogen (Plg)...
  29. Kim K, Choi Y, Park J, Lee J, Kim D, Lee S, et al. Proteolytic cleavage of extracellular ?-synuclein by plasmin: implications for Parkinson disease. J Biol Chem. 2012;287:24862-72 pubmed publisher
    ..Further, extracellular ?-syn regulated the plasmin system through up-regulation of plasminogen activator inhibitor-1 (PAI-1) expression...
  30. Rossignol P, Ho Tin Noe B, Vranckx R, Bouton M, Meilhac O, Lijnen H, et al. Protease nexin-1 inhibits plasminogen activation-induced apoptosis of adherent cells. J Biol Chem. 2004;279:10346-56 pubmed
    ..In this study, we further explored the role of plasminogen activation in cell adhesion and survival and show that uncontrolled plasminogen activation at the cell surface ..
  31. Dewyer N, Sood V, Lynch E, Luke C, Upchurch G, Wakefield T, et al. Plasmin inhibition increases MMP-9 activity and decreases vein wall stiffness during venous thrombosis resolution. J Surg Res. 2007;142:357-63 pubmed
    ..analysis included total collagen by colorimetric assay, cytokines, chemokines, and d-dimer by ELISA, urokinase-plasminogen activator (uPA), and plasminogen activator inhibitor-1 (PAI-1) by immuno-blotting, MMP-2 and -9 by zymography, ..
  32. Okumura N, Seki T, Ariga T. Cell surface-bound plasminogen regulates hepatocyte proliferation through a uPA-dependent mechanism. Biosci Biotechnol Biochem. 2007;71:1542-9 pubmed
    b>Plasminogen and plasminogen activators play important roles in liver regeneration. Previously, we found that plasminogen potentiates hepatocyte proliferation in the primary culture of rat hepatocytes...
  33. Suelves M, Lopez Alemany R, Lluis F, Aniorte G, Serrano E, Parra M, et al. Plasmin activity is required for myogenesis in vitro and skeletal muscle regeneration in vivo. Blood. 2002;99:2835-44 pubmed
    ..Active plasmin is generated from proteolytic cleavage of the zymogen plasminogen (Plg) by urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA)...
  34. Nogueira S, Smith A, Qin J, Pal U. A surface enolase participates in Borrelia burgdorferi-plasminogen interaction and contributes to pathogen survival within feeding ticks. Infect Immun. 2012;80:82-90 pubmed publisher
    ..However, the protein also interacts with host plasminogen, potentially leading to its activation and resulting in B. burgdorferi-induced fibrinolysis...
  35. Brower M, Harpel P. Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase. J Biol Chem. 1982;257:9849-54 pubmed
    ..The limited digestion of these inhibitory proteins by leukocyte elastase may prove useful in studies of their primary structure. ..
  36. Mu W, Long D, Ouyang X, Agarwal A, Cruz P, Roncal C, et al. Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism. Am J Physiol Renal Physiol. 2009;296:F145-52 pubmed publisher
    Angiostatin, a proteolytic fragment of plasminogen, is a potent anti-angiogenic factor recently shown also to have an inhibitory effect on leukocyte recruitment and macrophage migration...
  37. Obermajer N, Doljak B, Jamnik P, Fonović U, Kos J. Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells. Int J Biochem Cell Biol. 2009;41:1685-96 pubmed publisher
    ..On the other hand, the proliferation of cells is decreased, indicating induction of differentiation. Our study reveals enolase isozymes as crucial neurotrophic factors that are regulated by the proteolytic activity of cathepsin X. ..
  38. Azuma H, Uno Y, Shigekiyo T, Saito S. Congenital plasminogen deficiency caused by a Ser572 to Pro mutation. Blood. 1993;82:475-80 pubmed
    ..chain reaction (PCR) strategy and restriction fragment polymorphism analysis to evaluate all 19 exons of the plasminogen (PLG) gene in a Japanese patient with congenital PLG deficiency and her family members...
  39. Miyata T, Iwanaga S, Sakata Y, Aoki N. Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site. Proc Natl Acad Sci U S A. 1982;79:6132-6 pubmed
    Structural studies on a hereditarily abnormal plasminogen, plasminogen Tochigi, have been performed to identify the difference responsible for its lack of proteolytic activity...
  40. Mehta P, Parker R. Imbalance of plasminogen activator inhibitor type-1 (PAI-1) and tissue plasminogen activator (t-PA) activity in patients with Noonan syndrome. J Pediatr Hematol Oncol. 2010;32:532-6 pubmed publisher
    ..Fibrinolytic parameters including tissue plasminogen activator (t-PA; activity and antigen), plasminogen activator inhibitor type-1 (PAI-1; activity and antigen), ..