Gene Symbol: Plaur
Description: plasminogen activator, urokinase receptor
Alias: Par, Plaur3, uPAR, uPAR-2, uPAR-3, urokinase plasminogen activator surface receptor, U-PAR, plasminogen activator urokinase receptor 3, urinary plasminogen activator receptor 2, urinary plasminogen activator receptor 3, urokinase plasminogen activator receptor
Species: rat
Products:     Plaur

Top Publications

  1. Kofoed K, Eugen Olsen J, Petersen J, Larsen K, Andersen O. Predicting mortality in patients with systemic inflammatory response syndrome: an evaluation of two prognostic models, two soluble receptors, and a macrophage migration inhibitory factor. Eur J Clin Microbiol Infect Dis. 2008;27:375-83 pubmed publisher
  2. Huttunen R, Syrjanen J, Vuento R, Hurme M, Huhtala H, Laine J, et al. Plasma level of soluble urokinase-type plasminogen activator receptor as a predictor of disease severity and case fatality in patients with bacteraemia: a prospective cohort study. J Intern Med. 2011;270:32-40 pubmed publisher
    Urokinase-type plasminogen activator receptor (uPAR) is expressed on a variety of different immune cells and vascular endothelial cells during inflammation...
  3. Tzanakaki G, Paparoupa M, Kyprianou M, Barbouni A, Eugen Olsen J, Kourea Kremastinou J. Elevated soluble urokinase receptor values in CSF, age and bacterial meningitis infection are independent and additive risk factors of fatal outcome. Eur J Clin Microbiol Infect Dis. 2012;31:1157-62 pubmed publisher
    ..7, 95% CI 10.6-690.2) with both sensitivity and specificity being equal to the value of 0.9. In conclusion, suPAR, age and type of infection have an additive effect in predicting mortality among patients suspected of meningitis. ..
  4. Weinmann M, Thews O, Schroeder T, Vaupel P. Expression pattern of the urokinase-plasminogen activator system in rat DS-sarcoma: role of oxygenation status and tumour size. Br J Cancer. 2002;86:1355-61 pubmed
    ..This may indicate that the serum level of plasminogen activator inhibitor type 1 is not a reliable surrogate marker of tumour hypoxia. ..
  5. May A, Schmidt R, Kanse S, Chavakis T, Stephens R, Schomig A, et al. Urokinase receptor surface expression regulates monocyte adhesion in acute myocardial infarction. Blood. 2002;100:3611-7 pubmed
    The urokinase receptor (urokinase plasminogen activator receptor; uPAR) regulates monocyte adhesion by direct binding to vitronectin and by forming complexes with integrins...
  6. Haugaard S, Andersen O, Hansen T, Eugen Olsen J, Linneberg A, Madsbad S, et al. The immune marker soluble urokinase plasminogen activator receptor is associated with new-onset diabetes in non-smoking women and men. Diabet Med. 2012;29:479-87 pubmed publisher
    To explore the putative association of new-onset diabetes and the soluble urokinase plasminogen activator receptor (suPAR), which is a new and stable plasma marker of immune function and low-grade inflammation...
  7. Kenichi M, Masanobu M, Takehiko K, Shoko T, Akira F, Katsushige A, et al. Renal synthesis of urokinase type-plasminogen activator, its receptor, and plasminogen activator inhibitor-1 in diabetic nephropathy in rats: modulation by angiotensin-converting-enzyme inhibitor. J Lab Clin Med. 2004;144:69-77 pubmed
    ..of plasminogen-activator inhibitor-1 (PAI-1), urokinase-type plasminogen activator (uPA), and uPA receptor (uPAR), as well as the relevance of such expression to the production of type IV collagen, a major component of ..
  8. Wu M, Chang C, Shu K, Ho H, Li J, Fu Y. Rapamycin promotes podocyte migration through the up-regulation of urokinase receptor. Transplant Proc. 2014;46:1226-8 pubmed publisher
    ..However, induction of urokinase receptor (uPAR) signaling in podocytes leads to foot process effacement and urinary protein...
  9. Wiersinga W, Kager L, Hovius J, van der Windt G, de Vos A, Meijers J, et al. Urokinase receptor is necessary for bacterial defense against pneumonia-derived septic melioidosis by facilitating phagocytosis. J Immunol. 2010;184:3079-86 pubmed publisher
    Urokinase receptor (urokinase-type plasminogen activator receptor [uPAR], CD87), a GPI-anchored protein, is considered to play an important role in inflammation and fibrinolysis...

More Information


  1. Cunningham O, Campion S, Perry V, Murray C, Sidenius N, Docagne F, et al. Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation. Glia. 2009;57:1802-14 pubmed publisher
    The urokinase plasminogen activator (uPA) receptor (uPAR) is a GPI-linked cell surface protein that facilitates focused plasmin proteolytic activity at the cell surface...
  2. Persson M, Engstrom G, Bjorkbacka H, Hedblad B. Soluble urokinase plasminogen activator receptor in plasma is associated with incidence of CVD. Results from the Malmö Diet and Cancer Study. Atherosclerosis. 2012;220:502-5 pubmed publisher
    Soluble urokinase plasminogen activator receptor (suPAR) is a highly sensitive marker that reflects increased inflammation and is positively correlated with pro-inflammatory biomarkers...
  3. Gustafsson A, Ljunggren L, Bodelsson M, Berkestedt I. The Prognostic Value of suPAR Compared to Other Inflammatory Markers in Patients with Severe Sepsis. Biomark Insights. 2012;7:39-44 pubmed publisher
    ..The weak correlation between suPAR and other inflammatory markers might suggest that suPAR reflects general activation of the immune system rather than exerting inflammatory actions. ..
  4. Rabbani S, Rajwans N, Achbarou A, Murthy K, Goltzman D. Isolation and characterization of multiple isoforms of the rat urokinase receptor in osteoblasts. FEBS Lett. 1994;338:69-74 pubmed
    A rat urokinase receptor (uPAR) cDNA fragment was amplified by RT-PCR from RNA of the rat osteoblastic cell line CFK-1. Using this DNA species as a hybridization probe two rat uPAR cDNAs were isolated from a CFK-1 cDNA library...
  5. Stavropoulou A, Philippou A, Halapas A, Sourla A, Pissimissis N, Koutsilieris M. uPA, uPAR and TGF?? expression during early and late post myocardial infarction period in rat myocardium. In Vivo. 2010;24:647-52 pubmed
    ..patterns of transforming growth factor beta 1 (TGF??), urokinase-type plasminogen activator (uPA) and uPA receptor (uPAR) were analysed after artery ligation-induced myocardial infarction (MI) in the rat myocardium...
  6. Lönnkvist M, Theodorsson E, Holst M, Ljung T, Hellstrom P. Blood chemistry markers for evaluation of inflammatory activity in Crohn's disease during infliximab therapy. Scand J Gastroenterol. 2011;46:420-7 pubmed publisher
    ..markers (high sensitive C-reactive protein [hs-CRP], calprotectin, total nitrite, soluble urokinase Plasminogen Activator Receptor [suPAR], ghrelin and endothelin) are investigated to study inflammatory activity and correlation ..
  7. Cancello R, Rouault C, Guilhem G, Bedel J, Poitou C, Di Blasio A, et al. Urokinase plasminogen activator receptor in adipose tissue macrophages of morbidly obese subjects. Obes Facts. 2011;4:17-25 pubmed publisher
    ..We previously identified, by a pangenomic approach (microarrays), the urokinase plasminogen activator receptor (PLAUR or CD87) as a potential marker of subcutaneous adipose tissue macrophage infiltration (ATM)..
  8. SEEDS N, Mikesell S, Vest R, Bugge T, Schaller K, Minor K. Plasminogen activator promotes recovery following spinal cord injury. Cell Mol Neurobiol. 2011;31:961-7 pubmed publisher
    ..As shown here uPA acts in a cell signaling manner via binding to its receptor uPAR rather than as a protease, since uPAR knockout mice or knock-in mice possessing a modified uPA that is unable to ..
  9. Djoba Siawaya J, Bapela N, Ronacher K, Veenstra H, Kidd M, Gie R, et al. Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy response. J Infect. 2008;56:340-7 pubmed publisher
    ..C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1), soluble urokinase plasminogen activator receptor (suPAR), soluble lymphocyte activation gene-3 (sLAG-3), granzyme B, soluble tumour necrosis ..
  10. Jin H, Song Y, Boel G, Kochar J, Pancholi V. Group A streptococcal surface GAPDH, SDH, recognizes uPAR/CD87 as its receptor on the human pharyngeal cell and mediates bacterial adherence to host cells. J Mol Biol. 2005;350:27-41 pubmed
    ..identified this SDH-binding pharyngeal cell-surface-exposed membrane-bound protein as uPAR (urokinase plasminogen activator receptor)/CD87...
  11. Huang D, Zhao H, Tian Y, Li H, Ding X, Xiong C. Gene expression changes of urokinase plasminogen activator and urokinase receptor in rat testes at postnatal stages. Asian J Androl. 2007;9:679-83 pubmed
    To investigate the gene expression changes of urokinase plasminogen activator (uPA)/urokinase receptor (uPAR) in rat testes at postnatal stages and explore the effects of uPA/uPAR system on the rat spermatogenesis...
  12. Zhou H, Wu X, Lu X, Chen G, Ye X, Huang J. Evaluation of plasma urokinase-type plasminogen activator and urokinase-type plasminogen-activator receptor in patients with acute and chronic hepatitis B. Thromb Res. 2009;123:537-42 pubmed publisher
    Urokinase-type plasminogen activator (uPA) and urokinase-type plasminogen activator receptor (uPAR) are known to be important factors in the pathogenesis of tumors and certain non-viral inflammatory diseases...
  13. Lahtinen L, Huusko N, Myöhänen H, Lehtivarjo A, Pellinen R, Turunen M, et al. Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus. Neuroscience. 2009;163:316-28 pubmed publisher
    Urokinase-type plasminogen activator receptor (uPAR) is functionally a pleiotropic mediator involved in cell adhesion, proliferation, differentiation and migration as well as in matrix degradation, apoptosis, and angiogenesis in cancer ..
  14. Fourie C, van Rooyen J, Kruger A, Olsen M, Eugen Olsen J, Schutte R, et al. Soluble urokinase plasminogen activator receptor (suPAR) is associated with metabolic changes in HIV-1-infected Africans: a prospective study. Inflammation. 2012;35:221-9 pubmed publisher
    Soluble urokinase plasminogen activator receptor (suPAR) is associated with inflammation and may predict lipodystrophy and dysmetabolism in human immunodeficiency virus (HIV)-infected individuals on antiretroviral therapy...
  15. Xia W, de Bock C, Murrell G, Wang Y. Expression of urokinase-type plasminogen activator and its receptor is up-regulated during tendon healing. J Orthop Res. 2003;21:819-25 pubmed
    ..We used a rat Achilles tendon model to study mRNA and protein expression of uPA and its receptor (uPAR) during tendon healing using immunohistochemical, Northern and Western blot analyses...
  16. Rabna P, Andersen A, Wejse C, Oliveira I, Francisco Gomes V, Bonde Haaland M, et al. Urine suPAR levels compared with plasma suPAR levels as predictors of post-consultation mortality risk among individuals assumed to be TB-negative: a prospective cohort study. Inflammation. 2010;33:374-80 pubmed publisher
    ..75. For HIV-negative individuals, little or no prognostic effect was observed. However, in both HIV positives and negatives, the predictive effect of U-suPAR was found to be inferior to that of P-suPAR. ..
  17. Ragno P, Cassano S, Degen J, Kessler C, Blasi F, Rossi G. The receptor for the plasminogen activator of urokinase type is up-regulated in transformed rat thyroid cells. FEBS Lett. 1992;306:193-8 pubmed
    ..membrane-bound uPA by treating the cells with phosphatidylinositol-specific phospholipase C, suggesting that rat uPAR, like its human counterpart, is linked to the membrane by a glucosyl-phosphatidylinositol anchor...
  18. Asuthkar S, Gondi C, Nalla A, Velpula K, Gorantla B, Rao J. Urokinase-type plasminogen activator receptor (uPAR)-mediated regulation of WNT/?-catenin signaling is enhanced in irradiated medulloblastoma cells. J Biol Chem. 2012;287:20576-89 pubmed publisher
    b>Urokinase plasminogen activator receptor (uPAR) is known to promote invasion, migration, and metastasis in cancer cells...
  19. Nagai N, Kawao N, Okada K, Ishida C, Okumoto K, Ueshima S, et al. Initial brain lesion size affects the extent of subsequent pathophysiological responses. Brain Res. 2010;1322:109-17 pubmed publisher
    ..Furthermore, we found that, smaller lesions in mice lacking gene of urokinase-receptor (uPAR(-/-)) than wild type (uPAR(+/+)) mice on day 3 showed less reduction until day 7 in MCA-O model, whereas lesions ..
  20. Hovius J, Bijlsma M, van der Windt G, Wiersinga W, Boukens B, Coumou J, et al. The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi. PLoS Pathog. 2009;5:e1000447 pubmed publisher
    ..borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated...
  21. Gueler F, Rong S, Mengel M, Park J, Kiyan J, Kirsch T, et al. Renal urokinase-type plasminogen activator (uPA) receptor but not uPA deficiency strongly attenuates ischemia reperfusion injury and acute kidney allograft rejection. J Immunol. 2008;181:1179-89 pubmed
    ..processes highly regulated by the urokinase-type plasminogen activator (uPA) and its specific receptor (uPAR). Recently, up-regulation of uPA and uPAR has been shown to correlate with allograft rejection in human biopsies...
  22. Kreiling J, Byrd J, Deisz R, Mizukami I, Todd R, MacDonald R. Binding of urokinase-type plasminogen activator receptor (uPAR) to the mannose 6-phosphate/insulin-like growth factor II receptor: contrasting interactions of full-length and soluble forms of uPAR. J Biol Chem. 2003;278:20628-37 pubmed
    Urokinase-type plasminogen activator receptor (uPAR) binding by the mannose 6-phosphate/insulin-like growth factor II receptor (Man-6-P/IGF2R) is considered important to Man-6-P/IGF2R tumor suppressor function via regulation of cell ..
  23. Han X, Xiao W, Liu C, Xu X, Wang H, Xing Y. [Effect of amiloride on the pathology of a rat model of chronic obstructive pulmonary disease]. Zhonghua Jie He He Hu Xi Za Zhi. 2007;30:363-7 pubmed
    ..The expressions of u-PA, u-PAR and PAI-1 in bronchial lung tissues were examined by immunohistochemical analysis...
  24. Schuler P, Bendszus M, Kuehnel S, Wagner S, Hoffmann T, Goldbrunner R, et al. Urokinase plasminogen activator, uPAR, MMP-2, and MMP-9 in the C6-glioblastoma rat model. In Vivo. 2012;26:571-6 pubmed
    ..In vitro, the GBM cell line C6 expresses high levels of uPA. In vivo, a continuous increase of uPA, uPA-receptor (uPAR), MMP-2, and MMP-9 expression was found in the infiltration zone...
  25. Andronicos N, Chen E, Baik N, Bai H, Parmer C, Kiosses W, et al. Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation. Blood. 2010;115:1319-30 pubmed publisher
    ..Plg-R(KT) was highly colocalized on the cell surface with the urokinase receptor, uPAR. Our data suggest that Plg-R(KT) also interacts directly with tissue plasminogen activator...
  26. van Zoelen M, Florquin S, de Beer R, Pater J, Verstege M, Meijers J, et al. Urokinase plasminogen activator receptor-deficient mice demonstrate reduced hyperoxia-induced lung injury. Am J Pathol. 2009;174:2182-9 pubmed publisher
    ..Hyperoxia-induced lung injury is characterized by neutrophil infiltration into the lungs. The urokinase plasminogen activator receptor (uPAR) has been deemed important for leukocyte trafficking...
  27. Zhou D, Trauzold A, Roder C, Pan G, Zheng C, Kalthoff H. The potential molecular mechanism of overexpression of uPA, IL-8, MMP-7 and MMP-9 induced by TRAIL in pancreatic cancer cell. Hepatobiliary Pancreat Dis Int. 2008;7:201-9 pubmed
    ..It points to the necessity to carefully evaluate in vivo side effects of TRAIL. ..
  28. Kotipatruni R, Nalla A, Asuthkar S, Gondi C, Dinh D, Rao J. Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma. PLoS ONE. 2012;7:e44798 pubmed publisher
    ..Matrix metalloproteinase-9 (MMP-9) and urokinase plasminogen activator receptor (uPAR) are over expressed in several cancers and well established for their roles in tumor ..
  29. Donadio A, Remedi M, Frede S, Bonacci G, Chiabrando G, Pistoresi Palencia M. Decreased expression of intercellular adhesion molecule-1 (ICAM-1) and urokinase-type plasminogen activator receptor (uPAR) is associated with tumor cell spreading in vivo. Clin Exp Metastasis. 2002;19:437-44 pubmed
    ..1 +/- 8.7%) and urokinase-type plaminogen activator receptor (uPAR, 51.2 +/- 5.2%) positive cells, while a weak expression of MHC class II (IA, 2.2 +/- 0.2% and IE, 17.4 +/- 3...
  30. Al Hassan N, Behzadian A, Caldwell R, Ivanova V, Syed V, Motamed K, et al. Differential roles of uPAR in peritoneal ovarian carcinomatosis. Neoplasia. 2012;14:259-70 pubmed
    ..b>Urokinase plasminogen activator receptor (uPAR) is a multifunctional receptor involved in a myriad of tumor cell processes...
  31. Degryse B, Resnati M, Czekay R, Loskutoff D, Blasi F. Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor. J Biol Chem. 2005;280:24792-803 pubmed
    We investigated the interaction between the urokinase receptor (uPAR) and the integrin alphavbeta3. Vitronectin (VN) induces cell migration by binding to alphavbeta3, but expression of the uPAR boosts its efficacy...
  32. Larmann J, Frenzel T, Hahnenkamp A, Herzog C, Lorenz A, Steinbicker A, et al. In vivo fluorescence-mediated tomography for quantification of urokinase receptor-dependent leukocyte trafficking in inflammation. Anesthesiology. 2010;113:610-8 pubmed publisher
    ..Leukocyte recruitment critically depends on the urokinase-type plasminogen activator receptor (u-PAR). We here use a novel technique to longitudinally quantify cell trafficking in inflammatory models in live animals...
  33. Kindzelskii A, Amhad I, Keller D, Zhou M, Haugland R, Garni Wagner B, et al. Pericellular proteolysis by leukocytes and tumor cells on substrates: focal activation and the role of urokinase-type plasminogen activator. Histochem Cell Biol. 2004;121:299-310 pubmed
    Previous studies have shown that the urokinase-type plasminogen activator receptor (uPAR) is localized to the adherence sites of leukocytes and tumor cells suggesting that pericellular proteolysis may accompany focal activation of ..
  34. Pawlak K, Buraczewska Buczko A, Mysliwiec M, Pawlak D. Hyperfibrinolysis, uPA/suPAR system, kynurenines, and the prevalence of cardiovascular disease in patients with chronic renal failure on conservative treatment. Am J Med Sci. 2010;339:5-9 pubmed publisher
    ..This cross-sectional study has demonstrated that hyperfibrinolysis was associated with uPA/suPAR system, KYNs, oxidative status, and CVD prevalence in patients with CRF. ..
  35. Toldi G, Bíró E, Szalay B, Stenczer B, Molvarec A, Rigo J, et al. Soluble urokinase plasminogen activator receptor (suPAR) levels in healthy pregnancy and preeclampsia. Clin Chem Lab Med. 2011;49:1873-6 pubmed publisher
    ..Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker increasingly used for the monitoring of systemic inflammation...
  36. Zimmermann H, Koch A, Seidler S, Trautwein C, Tacke F. Circulating soluble urokinase plasminogen activator is elevated in patients with chronic liver disease, discriminates stage and aetiology of cirrhosis and predicts prognosis. Liver Int. 2012;32:500-9 pubmed publisher
    ..Interactions between urokinase plasminogen activator (uPA) and its receptor (uPAR) have been functionally linked to hepatic inflammation and fibrosis in mice...
  37. Koga T, Okada A, Kawashiri S, Kita J, Suzuki T, Nakashima Y, et al. Soluble urokinase plasminogen activator receptor as a useful biomarker to predict the response to adalimumab in patients with rheumatoid arthritis in a Japanese population. Clin Exp Rheumatol. 2011;29:811-5 pubmed
    To determine whether soluble urokinase plasminogen activator receptor is a useful biomarker to predict the response to adalimumab (ADA) in Japanese patients with rheumatoid arthritis...
  38. Schnapp L, Geaghan S, Campagna A, Fahy J, Steiger D, Ng V, et al. Toxoplasma gondii pneumonitis in patients infected with the human immunodeficiency virus. Arch Intern Med. 1992;152:1073-7 pubmed
    ..Toxoplasma gondii must be considered a potential cause of pulmonary disease during the evaluation of human immunodeficiency virus-infected patients with respiratory symptoms. ..
  39. Beaufort N, Leduc D, Rousselle J, Magdolen V, Luther T, Namane A, et al. Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G. J Immunol. 2004;172:540-9 pubmed
    ..Secretable leukocyte serine-proteinases are thus endowed with high potential for the regulation of CD87 expression and function on inflammatory cells. ..
  40. Sejima T, Holtappels G, Bachert C. The expression of fibrinolytic components in chronic paranasal sinus disease. Am J Rhinol Allergy. 2011;25:1-6 pubmed publisher
    ..To clarify the relationship between these components and the pathology of CRS, we analyzed fibrinolytic components in sinonasal mucosa of CRS...
  41. Sener M, Karakus E, Halici Z, Akpinar E, Topcu A, Kok A. Can early myocardial infarction-related deaths be diagnosed using postmortem urotensin receptor expression levels?. Forensic Sci Med Pathol. 2014;10:395-400 pubmed publisher
    ..0001). The largest increases were observed at ambient temperature and 6 h postmortem. Based on our findings, increased postmortem UR expression could serve as a biomarker to aid diagnosis of early MI. ..
  42. de Bock C, Wang Y. Clinical significance of urokinase-type plasminogen activator receptor (uPAR) expression in cancer. Med Res Rev. 2004;24:13-39 pubmed
    ..The molecular role of the uPA receptor (uPAR) is well characterized with its participation in cell migration and extracellular matrix (ECM) degradation...
  43. Elfman F, Bok R, Conn M, Shuman M, Cunha G. Urokinase plasminogen activator amino-terminal peptides inhibit development of the rat ventral prostate. Differentiation. 2001;69:108-20 pubmed
    The plasma membrane urokinase plasminogen activator receptor (uPAR) localizes and enhances activation of pro-uPA. Active uPA, in turn, promotes increased degradation of the extracellular matrix (ECM) by activation of plasminogen...