Plau

Summary

Gene Symbol: Plau
Description: plasminogen activator, urokinase
Alias: UPAM, urokinase-type plasminogen activator, U-plasminogen activator, Urinary plasminogen activator, urokinase, uPA, urokinase plasminogen activator
Species: rat
Products:     Plau

Top Publications

  1. Burk J, Burggraf D, Vosko M, Dichgans M, Hamann G. Protection of cerebral microvasculature after moderate hypothermia following experimental focal cerebral ischemia in mice. Brain Res. 2008;1226:248-55 pubmed publisher
    ..01). In the hypothermia group the urokinase plasminogen-activator (uPA) activity (P=0.01) was significantly decreased compared to the normothermia group...
  2. Thornton P, Pinteaux E, Allan S, Rothwell N. Matrix metalloproteinase-9 and urokinase plasminogen activator mediate interleukin-1-induced neurotoxicity. Mol Cell Neurosci. 2008;37:135-42 pubmed
    ..b>Urokinase plasminogen activator (uPA) was constitutively expressed on neuronal membrane fractions, and amiloride (an antagonist of ..
  3. Bueno M, Salgado S, Beas Zarate C, Armendariz Borunda J. Urokinase-type plasminogen activator gene therapy in liver cirrhosis is mediated by collagens gene expression down-regulation and up-regulation of MMPs, HGF and VEGF. J Gene Med. 2006;8:1291-9 pubmed
    Human urokinase-type plasminogen activator (uPA) gene administration via an adenoviral (Ad)-vector induced cirrhosis regression and ameliorated hepatic dysfunction in a model of experimental liver cirrhosis...
  4. Peng W, Tien Y, Huang C, Huang T, Liao J, Kuo C, et al. Fraxinus rhynchophylla ethanol extract attenuates carbon tetrachloride-induced liver fibrosis in rats via down-regulating the expressions of uPA, MMP-2, MMP-9 and TIMP-1. J Ethnopharmacol. 2010;127:606-13 pubmed publisher
    ..serum GOT and GPT levels), activities of liver anti-oxidant enzymes (such as catalase, SOD, GPx) and expressions of uPA, tPA, MMP-2, MMP-9 and TIMP-1, -2, -3, -4 in the liver fibrosis pathway were detected...
  5. Ozturk M, Kordan Y, Cangul H, Dogan H, Kilicarslan H, Vuruskan H, et al. Association of urokinase gene 3'-UTR T/C polymorphism with calcium oxalate urolithiasis in children. Int Urol Nephrol. 2008;40:563-8 pubmed publisher
    ..These results suggest that the urokinase gene might play a role in childhood recurrent calcium oxalate stone disease. ..
  6. Han X, Xiao W, Liu C, Xu X, Wang H, Xing Y. [Effect of amiloride on the pathology of a rat model of chronic obstructive pulmonary disease]. Zhonghua Jie He He Hu Xi Za Zhi. 2007;30:363-7 pubmed
    ..changes of chronic obstructive pulmonary disease (COPD) model, and to investigate the role of urokinase plasminogen activator system components in the pathogenesis of COPD...
  7. Catizone A, Ricci G, Tufano M, Perfetto B, Canipari R, Galdieri M. Hepatocyte growth factor (HGF) modulates Leydig cell extracellular matrix components. J Androl. 2010;31:306-13 pubmed publisher
    ..HGF increases the metabolic activity of isolated Leydig cells; in particular, the factor increases urokinase plasminogen activator and matrix metalloproteinase 2 secretion...
  8. Sejima T, Holtappels G, Bachert C. The expression of fibrinolytic components in chronic paranasal sinus disease. Am J Rhinol Allergy. 2011;25:1-6 pubmed publisher
    ..To clarify the relationship between these components and the pathology of CRS, we analyzed fibrinolytic components in sinonasal mucosa of CRS...
  9. Diaz J, Ballard Lipka N, Farris D, Hawley A, Wrobleski S, Myers D, et al. Impaired fibrinolytic system in ApoE gene-deleted mice with hyperlipidemia augments deep vein thrombosis. J Vasc Surg. 2012;55:815-22 pubmed publisher
    ..The undetectable levels of u-PA in ApoE-/-mice correlated to a decrease in vein wall MMP-2, MMP-9, MCP-1, and a decrease in monocyte recruitment diminishing thrombus resolution. ..
  10. Nakagawa M, Fukuyama K, Epstein W, Hara A, Sawada H. Partial purification and characterization of epidermal plasminogen activator and their inhibitor. Chem Pharm Bull (Tokyo). 1989;37:1859-63 pubmed
    ..On the other hand, an inhibitor which preferentially acts against u-PA exists, but inhibitor to t-PA does not appear to operate under normal epidermal functions. ..

Scientific Experts

Detail Information

Publications62

  1. Burk J, Burggraf D, Vosko M, Dichgans M, Hamann G. Protection of cerebral microvasculature after moderate hypothermia following experimental focal cerebral ischemia in mice. Brain Res. 2008;1226:248-55 pubmed publisher
    ..01). In the hypothermia group the urokinase plasminogen-activator (uPA) activity (P=0.01) was significantly decreased compared to the normothermia group...
  2. Thornton P, Pinteaux E, Allan S, Rothwell N. Matrix metalloproteinase-9 and urokinase plasminogen activator mediate interleukin-1-induced neurotoxicity. Mol Cell Neurosci. 2008;37:135-42 pubmed
    ..b>Urokinase plasminogen activator (uPA) was constitutively expressed on neuronal membrane fractions, and amiloride (an antagonist of ..
  3. Bueno M, Salgado S, Beas Zarate C, Armendariz Borunda J. Urokinase-type plasminogen activator gene therapy in liver cirrhosis is mediated by collagens gene expression down-regulation and up-regulation of MMPs, HGF and VEGF. J Gene Med. 2006;8:1291-9 pubmed
    Human urokinase-type plasminogen activator (uPA) gene administration via an adenoviral (Ad)-vector induced cirrhosis regression and ameliorated hepatic dysfunction in a model of experimental liver cirrhosis...
  4. Peng W, Tien Y, Huang C, Huang T, Liao J, Kuo C, et al. Fraxinus rhynchophylla ethanol extract attenuates carbon tetrachloride-induced liver fibrosis in rats via down-regulating the expressions of uPA, MMP-2, MMP-9 and TIMP-1. J Ethnopharmacol. 2010;127:606-13 pubmed publisher
    ..serum GOT and GPT levels), activities of liver anti-oxidant enzymes (such as catalase, SOD, GPx) and expressions of uPA, tPA, MMP-2, MMP-9 and TIMP-1, -2, -3, -4 in the liver fibrosis pathway were detected...
  5. Ozturk M, Kordan Y, Cangul H, Dogan H, Kilicarslan H, Vuruskan H, et al. Association of urokinase gene 3'-UTR T/C polymorphism with calcium oxalate urolithiasis in children. Int Urol Nephrol. 2008;40:563-8 pubmed publisher
    ..These results suggest that the urokinase gene might play a role in childhood recurrent calcium oxalate stone disease. ..
  6. Han X, Xiao W, Liu C, Xu X, Wang H, Xing Y. [Effect of amiloride on the pathology of a rat model of chronic obstructive pulmonary disease]. Zhonghua Jie He He Hu Xi Za Zhi. 2007;30:363-7 pubmed
    ..changes of chronic obstructive pulmonary disease (COPD) model, and to investigate the role of urokinase plasminogen activator system components in the pathogenesis of COPD...
  7. Catizone A, Ricci G, Tufano M, Perfetto B, Canipari R, Galdieri M. Hepatocyte growth factor (HGF) modulates Leydig cell extracellular matrix components. J Androl. 2010;31:306-13 pubmed publisher
    ..HGF increases the metabolic activity of isolated Leydig cells; in particular, the factor increases urokinase plasminogen activator and matrix metalloproteinase 2 secretion...
  8. Sejima T, Holtappels G, Bachert C. The expression of fibrinolytic components in chronic paranasal sinus disease. Am J Rhinol Allergy. 2011;25:1-6 pubmed publisher
    ..To clarify the relationship between these components and the pathology of CRS, we analyzed fibrinolytic components in sinonasal mucosa of CRS...
  9. Diaz J, Ballard Lipka N, Farris D, Hawley A, Wrobleski S, Myers D, et al. Impaired fibrinolytic system in ApoE gene-deleted mice with hyperlipidemia augments deep vein thrombosis. J Vasc Surg. 2012;55:815-22 pubmed publisher
    ..The undetectable levels of u-PA in ApoE-/-mice correlated to a decrease in vein wall MMP-2, MMP-9, MCP-1, and a decrease in monocyte recruitment diminishing thrombus resolution. ..
  10. Nakagawa M, Fukuyama K, Epstein W, Hara A, Sawada H. Partial purification and characterization of epidermal plasminogen activator and their inhibitor. Chem Pharm Bull (Tokyo). 1989;37:1859-63 pubmed
    ..On the other hand, an inhibitor which preferentially acts against u-PA exists, but inhibitor to t-PA does not appear to operate under normal epidermal functions. ..
  11. Cho E, Lee K, Seo J, Byun C, Chung S, Suh D, et al. Neuroprotection by urokinase plasminogen activator in the hippocampus. Neurobiol Dis. 2012;46:215-24 pubmed publisher
    Tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), which are both used for thrombolytic treatment of acute ischemic stroke, are serine proteases that convert plasminogen to active plasmin...
  12. Pawlak K, Pawlak D, Mysliwiec M. Effects of long-term erythropoietin therapy on fibrinolytic system in haemodialyzed patients. Thromb Res. 2008;121:787-91 pubmed
    ..of fibrinolytic parameters: tissue-type plasminogen activator (tPA) antigen, urokinase-type plasminogen activator (uPA) and its soluble receptor (suPAR), plasminogen activator inhibitor 1 (PAI-1) and plasmin/antiplasmin (PAP) ..
  13. Lan K, Lai S. Angiostrongylus cantonensis: induction of urokinase-type PA and degradation of type IV collagen in rat lung granulomatous fibrosis. Exp Parasitol. 2008;118:472-7 pubmed
    ..Casein zymogram analysis demonstrated that urokinase-type plasminogen activator (uPA) activity was increased during lung inflammation and fibrosis...
  14. Zickler P, Küry P, Gliem M, Hartung H, Jander S. Differential patterns of local gene regulation in crush lesions of the rat optic and sciatic nerve: relevance to posttraumatic regeneration. Cell Physiol Biochem. 2010;26:483-94 pubmed publisher
    ..The differential orchestration of local gene regulation has implications for axonal regeneration in central nervous system lesions. ..
  15. Serrati S, Panzardi I, Margheri F, Chillà A, Torre E, Fibbi G, et al. Urokinase and its receptor in follicular and inflammatory cysts of the jaws. Oral Dis. 2010;16:753-9 pubmed publisher
    ..Inflammatory cysts fluid contained higher amounts of plasminogen activators of the urinary-type (uPA), and lower amounts of PAI-1, when compared to follicular cysts fluid...
  16. Jiang Y, Xiao W, Zhang Y, Xing Y. Urokinase-type plasminogen activator system and human cationic antimicrobial protein 18 in serum and induced sputum of patients with chronic obstructive pulmonary disease. Respirology. 2010;15:939-46 pubmed publisher
    ..Serum and induced sputum levels of urokinase-type plasminogen activator (uPA), urokinase-type plasminogen activator receptor (uPAR), urokinase-type plasminogen activator inhibitor (PAI-1) and ..
  17. Catizone A, Ricci G, Caruso M, Ferranti F, Canipari R, Galdieri M. Hepatocyte growth factor (HGF) regulates blood-testis barrier (BTB) in adult rats. Mol Cell Endocrinol. 2012;348:135-46 pubmed publisher
    ..we report that, at stages VII-VIII, HGF significantly increases the amount of active TGF-? and the amount of uPA present in the tubules...
  18. Yong N, Guoping C. The role and mechanism of the up-regulation of fibrinolytic activity in painful peripheral nerve injury. Neurochem Res. 2009;34:587-92 pubmed publisher
    ..We tested fibrinolytic activities and the expression level of tPA and uPA levels in chronic constriction injury (CCI) model...
  19. Xue Y, Dai H, Cui A, Niu S, Pang B. [Effects of aerosolized earthworm fibrinolytic enzyme on bleomycin induced pulmonary fibrosis in rats]. Zhonghua Yi Xue Za Zhi. 2012;92:3429-33 pubmed
    ..for transforming growth factor ?(1) (TGF-?(1)), lung hydroxyproline contents, levels of urokinase PA (uPA), tissue plasminogen activator (tPA) and PA inhibitor 1 (PAI-1) in lung and blood were observed at Days 7, 14 and ..
  20. Gopal K, Nagarajan P, Raj T, Jahan P, Ganapathy H, Mahesh Kumar M. Effect of dietary ? carotene on cerebral aneurysm and subarachnoid haemorrhage in the brain apo E-/- mice. J Thromb Thrombolysis. 2011;32:343-55 pubmed publisher
    ..Real time analysis showed down regulation of mRNA levels of MMP 2, uPA, PAI, PPAR-A, MCSF1 and up regulation of tPA and MCP-1 in the brain during the progression of cerebral aneurysm and ..
  21. Cunningham O, Campion S, Perry V, Murray C, Sidenius N, Docagne F, et al. Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation. Glia. 2009;57:1802-14 pubmed publisher
    The urokinase plasminogen activator (uPA) receptor (uPAR) is a GPI-linked cell surface protein that facilitates focused plasmin proteolytic activity at the cell surface...
  22. Aceves C, Garcia Solis P, Arroyo Helguera O, Vega Riveroll L, Delgado G, Anguiano B. Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR). Mol Cancer. 2009;8:33 pubmed publisher
    ..05) and the enzyme caspase-3 (trend), as well as significant induction of PPAR type gamma (PPARgamma). Together, these data demonstrate that the antineoplasic effect of iodine involves 6-IL formation and PPARgamma induction. ..
  23. Cheng Y, Chen L, Chang M, Chen W, Tsai F, Tsai C, et al. Lipopolysaccharide upregulates uPA, MMP-2 and MMP-9 via ERK1/2 signaling in H9c2 cardiomyoblast cells. Mol Cell Biochem. 2009;325:15-23 pubmed publisher
    Upregulation of urokinase plasminogen activator (uPA), tissue plasminogen activator (tPA), and matrix metallopeptidases (MMPs) is associated with the development of myocardial infarction (MI), dilated cardiomyopathy, cardiac fibrosis, ..
  24. Xiao W, Chen P, Dong J. Effects of overtraining on skeletal muscle growth and gene expression. Int J Sports Med. 2012;33:846-53 pubmed
    ..01) and the OTR group (69%, P<0.01) from the sedentary group. uPA mRNA in the OT group was significantly lower than that in the sedentary group (32%, P<0.01)...
  25. Stepanova V, Bobik A, Bibilashvily R, Belogurov A, Rybalkin I, Domogatsky S, et al. Urokinase plasminogen activator induces smooth muscle cell migration: key role of growth factor-like domain. FEBS Lett. 1997;414:471-4 pubmed
    We defined the role of urokinase plasminogen activator (uPA) and its growth factor-like domain (GFD) in stimulating smooth muscle cell (SMC) migration...
  26. Qin W, Gui G, Zhang K, Twelves D, Kliethermes B, Sauter E. Proteins and carbohydrates in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsy. BMC Cancer. 2012;12:52 pubmed publisher
    ..study determined if concentrations in breast nipple discharge (ND) of two proteins (urinary plasminogen activator, uPA and its inhibitor, PAI-1) predicted the presence of breast atypia and cancer in pre- and/or postmenopausal women ..
  27. Akhter H, Katre A, Li L, Liu X, Liu R. Therapeutic potential and anti-amyloidosis mechanisms of tert-butylhydroquinone for Alzheimer's disease. J Alzheimers Dis. 2011;26:767-78 pubmed publisher
    ..in AD, accompanied by increases in the activities of tissue type and urokinase type plasminogen activators (tPA and uPA) as well as plasmin...
  28. Patel T, Sprague S, Lai Q, Jimenez D, Barone C, Ding Y. Blood brain barrier (BBB) dysfunction associated with increased expression of tissue and urokinase plasminogen activators following peripheral thermal injury. Neurosci Lett. 2008;444:222-6 pubmed publisher
    Emerging data suggests the serine proteases, tissue plasminogen activator (tPA), and urokinase plasminogen activator (uPA), may play a detrimental role in traumatic states leading to compromise of the blood brain barrier (BBB)...
  29. Aflalo E, Sod Moriah U, Potashnik G, Har Vardi I. Differences in the implantation rates of rat embryos developed in vivo and in vitro: possible role for plasminogen activators. Fertil Steril. 2004;81 Suppl 1:780-5 pubmed
    To assess the participation of urokinase-type (uPA) and tissue-type (tPA) plasminogen activators in embryo development and implantation...
  30. Zhu G, Tang Y, Liang X, Zheng M, Yang J, Zhou H, et al. Role of hypoxia-inducible factor-1 alpha in the regulation of plasminogen activator activity in rat knee joint chondrocytes. Osteoarthritis Cartilage. 2009;17:1494-502 pubmed publisher
    ..promoter, while the enhancement or silencing of HIF-1alpha did not affect the expression of urokinase type PA (uPA), tissue type PA (tPA) or uPA receptor (uPAR)...
  31. Liu R, Liu Q, He S, Simpkins J, Yang S. Combination therapy of 17beta-estradiol and recombinant tissue plasminogen activator for experimental ischemic stroke. J Pharmacol Exp Ther. 2010;332:1006-12 pubmed publisher
    ..The expression and activation of urokinase (uPA), MMP2, and MMP9 were significantly increased in ischemic hemisphere after transient cerebral ischemia...
  32. Hua H, Zhang R, Wang H, Zhao Y, Yu S, Li W. Tissue-type plasminogen activator depletion affects the nasal mucosa matrix reconstruction in allergic rhinitis mice. Allergol Immunopathol (Madr). 2011;39:206-11 pubmed publisher
    ..MMP-9 expression decreased greatly after ovalbumin challenge in t-PA(-/-) mice. t-PA affects the nasal mucosa matrix reconstruction process in allergic rhinitis, with which MMP-9 is involved. ..
  33. Miyake K, Shimada M, Nishioka M, Sugimoto K, Batmunkh E, Uto Y, et al. Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer. Cancer Chemother Pharmacol. 2009;64:885-92 pubmed publisher
    ..survival, expression of matrix metalloproteinase (MMP)-2, MMP-7, MMP-9 and urokinase-type plasminogen activator (uPA) and incidence of lymph node metastasis were evaluated in treatment versus control group...
  34. Rout U, Diamond M. Role of plasminogen activators during healing after uterine serosal lesioning in the rat. Fertil Steril. 2003;79:138-45 pubmed
    ..Altered levels of t-PA and u-PA transcripts and its expression in newly formed blood vessels during healing and adhesion development indicate involvement of these plasminogen activators in serosal healing and adhesion development. ..
  35. Menshikov M, Plekhanova O, Cai H, Chalupsky K, Parfyonova Y, Bashtrikov P, et al. Urokinase plasminogen activator stimulates vascular smooth muscle cell proliferation via redox-dependent pathways. Arterioscler Thromb Vasc Biol. 2006;26:801-7 pubmed
    We showed previously that increased urokinase plasminogen activator (uPA) expression contributes to vascular smooth muscle cell (VSMC) proliferation and neointima formation after injury...
  36. Paule B, Deslandes E, Le Mouel S, Bastien L, Podgorniak M, Allory Y, et al. Identification of a novel biomarker signature associated with risk for bone metastasis in patients with renal cell carcinoma. Int J Biol Markers. 2010;25:112-5 pubmed
    ..Among the transcripts of the genes studied, VEGFR-1, VEGFR-2, HIF-1alpha, uPA , and PA I-1 overexpression in tumor tissues was significantly associated with the presence of bone metastasis (p=0...
  37. Buyne O, van Goor H, Bleichrodt R, Verweij P, Hendriks T. Both tissue-type plasminogen activator and urokinase prevent intraabdominal abscess formation after surgical treatment of peritonitis in the rat. Surgery. 2008;144:66-73 pubmed publisher
    ..Both rtPA and urokinase effectively and safely reduce abscess formation in a rat model for treatment of secondary peritonitis. Fibrinolytic therapy should be further developed for clinical application. ..
  38. Wang Z, Yang B, Zhu X, Wu S. [Effect of inhalation of aerosolized unfractioned heparin on peri alveolar coagulability and inflammatory response in endotoxin induced acute lung injury rat model]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2011;23:239-42 pubmed
    ..used to measure the level of thrombin antithrombin (TAT), tissue type plasminogen activator (t-PA), urokinase type plasminogen activator (u-PA), plasminogen activator inhibitor 1 (PAI-1), tumor necrosis factor ? (TNF-?), interleukin 6 (..
  39. Akao M, Hasebe Y, Okumura N, Hagiwara H, Seki T, Ariga T. Plasminogen activator-plasmin system potentiates the proliferation of hepatocytes in primary culture. Thromb Res. 2002;107:169-74 pubmed
    ..e., tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), and their substrate, plasminogen, in the proliferation of hepatocytes in primary culture...
  40. Coutard M, Touat Z, Houard X, Leclercq A, Michel J. Thrombus versus wall biological activities in experimental aortic aneurysms. J Vasc Res. 2010;47:355-66 pubmed publisher
    ..Levels of elastase and urokinase plasminogen activator, plasmin and MPs, determined, respectively, by casein zymography, substrate hydrolysis and flow ..
  41. Hou Y, Okamoto C, Okada K, Kawao N, Kawata S, Ueshima S, et al. c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells. Cardiovasc Res. 2007;75:186-94 pubmed
    The purpose of this study was to investigate whether c-Myc regulates expression of urokinase plasminogen activator (uPA) on hypoxia-induced vascular smooth muscle cells (VSMCs)...
  42. Kohga S, Harvey S, Weaver R, Markus G. Localization of plasminogen activators in human colon cancer by immunoperoxidase staining. Cancer Res. 1985;45:1787-96 pubmed
  43. Plekhanova O, Stepanova V, Ratner E, Bobik A, Tkachuk V, Parfyonova Y. Urokinase plasminogen activator in injured adventitia increases the number of myofibroblasts and augments early proliferation. J Vasc Res. 2006;43:437-46 pubmed
    ..We assessed the role of urokinase plasminogen activator (uPA) and its proteolytic activity in myofibroblast differentiation and the early proliferation ..
  44. Connolly B, Choi E, Gardsvoll H, Bey A, Currie B, Chavakis T, et al. Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. Blood. 2010;116:1593-603 pubmed publisher
    The urokinase plasminogen activator receptor (uPAR) has emerged as a potential regulator of cell adhesion, cell migration, proliferation, differentiation, and cell survival in multiple physiologic and pathologic contexts...
  45. Lahtinen L, Huusko N, Myöhänen H, Lehtivarjo A, Pellinen R, Turunen M, et al. Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus. Neuroscience. 2009;163:316-28 pubmed publisher
  46. Shih C, Kuo W, Lin C, Chen W, Cheng W, Chen S, et al. Association of polymorphisms in the genes of the urokinase plasminogen activation system with susceptibility to and severity of non-small cell lung cancer. Clin Chim Acta. 2011;412:194-8 pubmed publisher
    Urokinase plasminogen activating (uPA) system is implicated in neoplastic progression. High tissue levels of uPA system components correlate with a poor prognosis in lung cancer...
  47. Lugano R, Pena E, Casani L, Badimon L, Padro T. UPA promotes lipid-loaded vascular smooth muscle cell migration through LRP-1. Cardiovasc Res. 2013;100:262-71 pubmed publisher
    ..The urokinase-plasminogen activator (UPA)/UPA receptor (UPAR) system plays a relevant role in vascular remodelling...
  48. Teesalu T, Blasi F, Talarico D. Expression and function of the urokinase type plasminogen activator during mouse hemochorial placental development. Dev Dyn. 1998;213:27-38 pubmed
    ..We have performed in situ expression analysis of urokinase type plasminogen activator (uPA), as well as functionally related molecules (uPA receptor, low density lipoprotein receptor-..
  49. Joossens J, Ali O, El Sayed I, Surpateanu G, Van der Veken P, Lambeir A, et al. Small, potent, and selective diaryl phosphonate inhibitors for urokinase-type plasminogen activator with in vivo antimetastatic properties. J Med Chem. 2007;50:6638-46 pubmed
    ..Some of these inhibitors show potent and highly selective irreversible uPA inhibition...
  50. Yang D, Nemkul N, Shereen A, Jone A, Dunn R, Lawrence D, et al. Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns. J Neurosci. 2009;29:8669-74 pubmed publisher
    ..Together, these results suggest that the brain PA system plays a pivotal role in neonatal cerebral HI and may be a promising therapeutic target in infants suffering hypoxic-ischemic encephalopathy. ..
  51. Matsuo S, Lopez Guisa J, Cai X, Okamura D, Alpers C, Bumgarner R, et al. Multifunctionality of PAI-1 in fibrogenesis: evidence from obstructive nephropathy in PAI-1-overexpressing mice. Kidney Int. 2005;67:2221-38 pubmed
  52. Wiersinga W, Kager L, Hovius J, van der Windt G, de Vos A, Meijers J, et al. Urokinase receptor is necessary for bacterial defense against pneumonia-derived septic melioidosis by facilitating phagocytosis. J Immunol. 2010;184:3079-86 pubmed publisher
    ..pseudomallei by facilitating the migration of neutrophils toward the primary site of infection and subsequently facilitating the phagocytosis of B. pseudomallei. ..
  53. Manchanda P, Bid H, Mittal R. Association of Urokinase Gene 3'-UTR T/C polymorphism with bladder cancer. Urol Int. 2006;77:81-4 pubmed
    ..Perhaps analysis of patients with superficial bladder TCC and mutated urokinase might help clarify this aspect in large cohort studies in different populations. ..
  54. Watanabe K, Togo S, Takahashi T, Matsuyama R, Yamamoto H, Shimizu T, et al. PAI-1 plays an important role in liver failure after excessive hepatectomy in the rat. J Surg Res. 2007;143:13-9 pubmed
    ..Hepatic PAI-1 protein and urokinase-type plasminogen activator (uPA) levels were determined by enzyme-linked immunosorbent assay...
  55. Ploplis V, Tipton H, Menchen H, Castellino F. A urokinase-type plasminogen activator deficiency diminishes the frequency of intestinal adenomas in ApcMin/+ mice. J Pathol. 2007;213:266-74 pubmed
    ..In the current study, a mouse model of colon cancer, Apc(Min/+), with an additional deficiency of uPA (Apc(Min/+)/Plau-/-) was used to determine the effects of uPA on tumour initiation and growth...
  56. Henderson B, Tansey W, Phillips S, Ramshaw I, Kefford R. Transcriptional and posttranscriptional activation of urokinase plasminogen activator gene expression in metastatic tumor cells. Cancer Res. 1992;52:2489-96 pubmed
    b>Urokinase plasminogen activator (uPA) is a serine protease which has frequently been implicated in the process of tumor cell invasion and metastasis...
  57. Calenda G, Strong T, Pavlovich C, Schaeffer E, Burnett A, Yu W, et al. Whole genome microarray of the major pelvic ganglion after cavernous nerve injury: new insights into molecular profile changes after nerve injury. BJU Int. 2012;109:1552-64 pubmed publisher
    ..evidence of the early mobilization of genes involved in repair and neuroprotection mechanisms (SERPINF1, IGF1, PLAU/PLAUR, ARG1)...
  58. Liu X, Xue X. [Changes of u-PA and PAI-1 expression in the lung tissue of neonatal rats after inhaling high concentration oxygen]. Zhonghua Er Ke Za Zhi. 2008;46:458-63 pubmed
  59. Tsai M, Chen W, Chen H, Tsai F. Urokinase gene 3'-UTR T/C polymorphism is associated with oral cancer. J Clin Lab Anal. 2004;18:276-9 pubmed
    ..Therefore, the urokinase gene 3'-UTR "T" allele is associated with oral cancer and may play a role in oral cancer formation. However, we did not find the relationship between tumor progression and this polymorphism. ..
  60. Xia W, de Bock C, Murrell G, Wang Y. Expression of urokinase-type plasminogen activator and its receptor is up-regulated during tendon healing. J Orthop Res. 2003;21:819-25 pubmed
    The urokinase-type plasminogen activator (uPA) system has been implicated in cell migration, angiogenesis, extracellular matrix synthesis and tissue remodelling. However, little is known about the role of the system in tendon healing...
  61. Pawlak K, Ulazka B, Mysliwiec M, Pawlak D. Vascular endothelial growth factor and uPA/suPAR system in early and advanced chronic kidney disease patients: a new link between angiogenesis and hyperfibrinolysis?. Transl Res. 2012;160:346-54 pubmed publisher
    ..tissue factor (TF), its inhibitor (TFPI), and fibrinolytic system: urokinase-type plasminogen activator (uPA), its soluble receptor (suPAR), tissue-type plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), ..
  62. Swamynathan S, Swamynathan S. SLURP-1 modulates corneal homeostasis by serving as a soluble scavenger of urokinase-type plasminogen activator. Invest Ophthalmol Vis Sci. 2014;55:6251-61 pubmed publisher
    ..of membrane-tethered uPAR by acting as a soluble scavenger of its ligand urokinase-type plasminogen activator (uPA)...