Plat

Summary

Gene Symbol: Plat
Description: plasminogen activator, tissue type
Alias: PATISS, tPA, tissue-type plasminogen activator, t-PA, t-plasminogen activator, tissue plasminogen activator
Species: rat

Top Publications

  1. doi Mitogen-activated protein kinase regulates FSH-induced expression of tissue-type plasminogen activator through an activator protein 1 response element
    Wei Yang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Da Tun Lu, Chao Yang District, Beijing, 100101, China
    Endocrine 34:101-7. 2008
  2. ncbi Temporal profile of tissue plasminogen activator (tPA) and inhibitor expression after transient focal cerebral ischemia
    Gang Zhao
    Department of Pediatrics, Queen s University, Rm 6 303, Doran 3, Kingston General Hospital, Kingston, Ontario K7L 2V7, Canada
    Neuroreport 14:1689-92. 2003
  3. doi Chemical sympathectomy attenuates inflammation, glycocalyx shedding and coagulation disorders in rats with acute traumatic coagulopathy
    Lin Xu
    Research Institute of General Surgery, Jinling Hospital, Clinical School of Nanjing, Second Military Medical University, Nanjing, China Lin Xu and Wen Kui Yu contributed equally to this article
    Blood Coagul Fibrinolysis 26:152-60. 2015
  4. doi Regulation of tissue plasminogen activator/plasminogen activator inhibitor-1 by hydrocortisone in rat primary astrocytes
    Kyoung Ja Kwon
    Department of Neurology and Institute of Biomedical Science and Technology, Konkuk University, Seoul, Korea
    J Neurosci Res 89:1059-69. 2011
  5. ncbi Tissue plasminogen activator for the treatment of intraventricular hematoma: the dose-effect relationship
    Yeou Chih Wang
    Department of Neurosurgery, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    J Neurol Sci 202:35-41. 2002
  6. ncbi Long-term administration of highly purified eicosapentaenoic acid ethyl ester improves blood coagulation abnormalities and dysfunction of vascular endothelial cells in Otsuka Long-Evans Tokushima fatty rats
    Yutaka Mori
    Department of Internal Medicine, National Higashi Utsunomiya Hospital, Tochigi, Japan
    Endocr J 50:603-11. 2003
  7. ncbi Expression of type-1 plasminogen activator inhibitor in the kidney of diabetic rat models
    Hiromi Hagiwara
    Department of Nutrition and Physiology, Nihon University Graduate School of Applied Life Sciences, Kameino 1866, Fujisawa, Kanagawa 252 8516, Japan
    Thromb Res 111:301-9. 2003
  8. pmc Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signaling
    Kebin Hu
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Clin Invest 117:3821-32. 2007
  9. pmc Neurodegeneration induced by PVC-211 murine leukemia virus is associated with increased levels of vascular endothelial growth factor and macrophage inflammatory protein 1 alpha and is inhibited by blocking activation of microglia
    Xiujie Li
    Laboratory of Cancer Prevention, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    J Virol 83:4912-22. 2009
  10. doi Biphasic regulation of tissue plasminogen activator activity in ischemic rat brain and in cultured neural cells: essential role of astrocyte-derived plasminogen activator inhibitor-1
    Ji Woon Kim
    Department of Pharmacology, Research Institute of Medical Sciences and Institute of Functional Genomics, Konkuk University, Seoul, Republic of Korea
    Neurochem Int 58:423-33. 2011

Research Grants

  1. TREATMENT OF TRAUMATIC BRAIN INJURY WITH SIMVASTATIN
    Asim Mahmood; Fiscal Year: 2009
  2. TRAUMATIC BRAIN INJURY AND MARROW STROMAL CELLS
    Asim Mahmood; Fiscal Year: 2009
  3. ENDOTHELIAL DYSFUNCTION IN HUMAN DIABETIC NEUROPATHY
    CHARLENE HAFER MACKO; Fiscal Year: 2002

Scientific Experts

Detail Information

Publications96

  1. doi Mitogen-activated protein kinase regulates FSH-induced expression of tissue-type plasminogen activator through an activator protein 1 response element
    Wei Yang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Da Tun Lu, Chao Yang District, Beijing, 100101, China
    Endocrine 34:101-7. 2008
    ..protein kinase (MAPK) and activator protein-1 (AP-1) in the regulation of FSH-induced tissue type plasminogen activator (tPA) production in granulosa cells (GCs) prepared from DES-treated immature rats; Treatment of the ..
  2. ncbi Temporal profile of tissue plasminogen activator (tPA) and inhibitor expression after transient focal cerebral ischemia
    Gang Zhao
    Department of Pediatrics, Queen s University, Rm 6 303, Doran 3, Kingston General Hospital, Kingston, Ontario K7L 2V7, Canada
    Neuroreport 14:1689-92. 2003
    Altered tPA expression may influence the fate of neurons after cerebral ischemia...
  3. doi Chemical sympathectomy attenuates inflammation, glycocalyx shedding and coagulation disorders in rats with acute traumatic coagulopathy
    Lin Xu
    Research Institute of General Surgery, Jinling Hospital, Clinical School of Nanjing, Second Military Medical University, Nanjing, China Lin Xu and Wen Kui Yu contributed equally to this article
    Blood Coagul Fibrinolysis 26:152-60. 2015
    ..Moreover, sympathectomy yielded anti-inflammatory, antifibrinolysis and endothelial protective effects in rats with ATC. The role of autonomic neuropathy in ATC should be explored further. ..
  4. doi Regulation of tissue plasminogen activator/plasminogen activator inhibitor-1 by hydrocortisone in rat primary astrocytes
    Kyoung Ja Kwon
    Department of Neurology and Institute of Biomedical Science and Technology, Konkuk University, Seoul, Korea
    J Neurosci Res 89:1059-69. 2011
    Although originally known as a plasma serine protease involved in clot dissolution, tPA and its primary inhibitor, PAI-1, play crucial roles in synaptic reorganization and plasticity in the central nervous system...
  5. ncbi Tissue plasminogen activator for the treatment of intraventricular hematoma: the dose-effect relationship
    Yeou Chih Wang
    Department of Neurosurgery, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    J Neurol Sci 202:35-41. 2002
    In this study, we investigated the dose-effect relationship and safety of tissue plasminogen activator (tPA) for the treatment of intraventricular hemorrhage/hematoma (IVH) in rats...
  6. ncbi Long-term administration of highly purified eicosapentaenoic acid ethyl ester improves blood coagulation abnormalities and dysfunction of vascular endothelial cells in Otsuka Long-Evans Tokushima fatty rats
    Yutaka Mori
    Department of Internal Medicine, National Higashi Utsunomiya Hospital, Tochigi, Japan
    Endocr J 50:603-11. 2003
    ..These data demonstrate that EPA-E beneficially altered certain factors known to promote thrombosis and atherosclerosis in this animal model...
  7. ncbi Expression of type-1 plasminogen activator inhibitor in the kidney of diabetic rat models
    Hiromi Hagiwara
    Department of Nutrition and Physiology, Nihon University Graduate School of Applied Life Sciences, Kameino 1866, Fujisawa, Kanagawa 252 8516, Japan
    Thromb Res 111:301-9. 2003
    ..However, gene expression of fibrinolytic factors in diabetic nephropathy has not been clearly defined. Therefore we determined the gene expression of fibrinolytic factors in the kidneys of diabetic rats...
  8. pmc Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signaling
    Kebin Hu
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Clin Invest 117:3821-32. 2007
    ..Here we describe a signaling pathway that leads to this activation. Tissue-type plasminogen activator (tPA) promoted TGF-beta1-mediated alpha-SMA and type I collagen expression in rat kidney interstitial fibroblasts...
  9. pmc Neurodegeneration induced by PVC-211 murine leukemia virus is associated with increased levels of vascular endothelial growth factor and macrophage inflammatory protein 1 alpha and is inhibited by blocking activation of microglia
    Xiujie Li
    Laboratory of Cancer Prevention, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    J Virol 83:4912-22. 2009
    ..accumulation of activated microglia in the spongiform areas of the brain accompanied by an increase in tissue plasminogen activator, a product of microglia implicated in neurodegeneration...
  10. doi Biphasic regulation of tissue plasminogen activator activity in ischemic rat brain and in cultured neural cells: essential role of astrocyte-derived plasminogen activator inhibitor-1
    Ji Woon Kim
    Department of Pharmacology, Research Institute of Medical Sciences and Institute of Functional Genomics, Konkuk University, Seoul, Republic of Korea
    Neurochem Int 58:423-33. 2011
    In brain, the serine protease tissue plasminogen activator (tPA) and its endogenous inhibitor plasminogen activator inhibitor-1 (PAI-1) have been implicated in the regulation of various neurophysiological and pathological responses...
  11. ncbi Thrombin activation and increased fibrinolysis in patients with chronic liver disease
    J A Paramo
    Haematology Service, University Clinic, University of Navarra, Pamplona, Spain
    Blood Coagul Fibrinolysis 2:227-30. 1991
    ..liver disease by measuring thrombin-antithrombin (TAT) complexes, tissue-type plasminogen activator antigen (tPA Ag) and fibrinogen and fibrin degradation products (FgDP and FbDP respectively) in 66 patients with liver disease ..
  12. pmc Plasminogen activator inhibitor-1 mitigates brain injury in a rat model of infection-sensitized neonatal hypoxia-ischemia
    Dianer Yang
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Cereb Cortex 23:1218-29. 2013
    ..We found that LPS pre-exposure blocked the HI-induced proteolytic activity of tissue-type plasminogen activator (tPA), but significantly enhanced NF-κB signaling, microglia activation, and the production of pro-inflammatory ..
  13. doi Coagulofibrinolytic changes in patients with disseminated intravascular coagulation associated with post-cardiac arrest syndrome--fibrinolytic shutdown and insufficient activation of fibrinolysis lead to organ dysfunction
    Takeshi Wada
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Thromb Res 132:e64-9. 2013
    ..markers, including soluble fibrin, thrombin-activatable fibrinolysis inhibitor (TAFI), tissue plasminogen activator-plasminogen activator inhibitor-1 complex (tPAIC), plasmin-alpha2 plasmin inhibitor complex (PPIC), ..
  14. pmc Prevalence of genetic risk factors related with thrombophilia and hypofibrinolysis in patients with osteonecrosis of the femoral head in Poland
    Jacek Gagala
    Orthopaedic and Traumatology Department, Medical University of Lublin, ul, Dr K Jaczewskiego 8, 20 954 Lublin, Poland
    BMC Musculoskelet Disord 14:264. 2013
    ..The aim of our study was to evaluate the relationship between genetic mutations leading to coagulation disorders and ONFH in Polish patients...
  15. pmc LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein
    Elisabetta Mantuano
    From the Department of Pathology, University of California San Diego School of Medicine, La Jolla, California 92093
    J Biol Chem 288:34009-18. 2013
    In addition to functioning as an activator of fibrinolysis, tissue-type plasminogen activator (tPA) interacts with neurons and regulates multiple aspects of neuronal cell physiology...
  16. doi Clinical experience with recombinant tissue plasminogen activator in the management of intracardiac and arterial thrombosis in children
    Hasim Olgun
    aDepartment of Pediatrics, Division of Pediatric Cardiology bDepartment of Pediatrics Division of Pediatric Hematology and Oncology cDepartment of Cardiovascular Surgery dDepartment of Pediatrics, Division of Neonatology, Ataturk University Faculty of Medicine, Erzurum, Turkey
    Blood Coagul Fibrinolysis 25:726-30. 2014
    ..Drugs for therapeutic thrombolysis include streptokinase, urokinase and tissue plasminogen activator (t-PA). There is less experience with recombinant t-PA (rt-PA) in children...
  17. doi Noble-Collip Drum Trauma Induces Disseminated Intravascular Coagulation But Not Acute Coagulopathy of Trauma-Shock
    Mineji Hayakawa
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo and Department of Internal Medicine, School of Dentistry, Health Sciences University of Hokkaido, Ishikari gun, Japan
    Shock 43:261-7. 2015
    ..There are two opposing possibilities for the main pathogenesis of trauma-induced coagulopathy: an acute coagulopathy of trauma shock and disseminated intravascular coagulation with the fibrinolytic phenotype...
  18. pmc Granulocyte colony-stimulating factor attenuates delayed tPA-induced hemorrhagic transformation in ischemic stroke rats by enhancing angiogenesis and vasculogenesis
    Ike C Dela Peña
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, Florida, USA
    J Cereb Blood Flow Metab 35:338-46. 2015
    Treatment with tissue plasminogen activator (tPA) beyond the therapeutic time window (>4.5 hours post stroke) may produce hemorrhagic transformation (HT)...
  19. ncbi Effect of activated protein C on impaired fibrinolysis in rats with obstructive jaundice
    R Uchino
    Department of Surgery, Kumamoto Rosai Hospital, Yatsushiro, Japan
    Eur Surg Res 24:298-301. 1992
    ..Thus, DIC in obstructive jaundice may be due to impairment of fibrinolysis and an increased susceptibility of endothelial cells to endotoxin. APC may be effective as a treatment for patients with obstructive jaundice associated with DIC...
  20. ncbi Decreased tissue factor and tissue-plasminogen activator antigen in relapsed acute promyelocytic leukemia
    T Nakasaki
    Second Department of Internal Medicine, Mie University School of Medicine, Mie Ken, Japan
    Am J Hematol 64:145-50. 2000
    ..TF and tissue type plasminogen activator (t-PA) antigen levels in leukemic cell lysate were significantly increased in both groups, and they ..
  21. ncbi Thrombomodulin, tissue plasminogen activator and plasminogen activator inhibitor-1 in Henoch-Schönlein purpura
    N Besbas
    Department of Pediatric Nephrology and Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Clin Exp Rheumatol 16:95-8. 1998
    ....
  22. ncbi Role of endogenous platelet-derived growth factor in arterial smooth muscle cell migration after balloon catheter injury
    C L Jackson
    Department of Pathology, University of Washington, Seattle
    Arterioscler Thromb 13:1218-26. 1993
    ....
  23. ncbi Influence of white blood cells on the fibrinolytic response to sepsis: studies of septic patients with or without severe leucopenia
    M A Haj
    Department of Medicine and Therapeutics, University of Aberdeen Medical School, Foresterhill
    Br J Haematol 90:541-7. 1995
    ..When shock supervened, levels of PAI-I were high in both leucopenic and non-leucopenic groups, indicating that a source of PAI-I outwith the leucocytes themselves contributes to the phenomena observed...
  24. ncbi Elevation of plasma free PAI-1 levels as an integrated endothelial response to severe burns
    K Aoki
    Department of Emergency and Critical Care Medicine, School of Medicine, Keio University, 160 8582, Tokyo, Japan
    Burns 27:569-75. 2001
    ....
  25. pmc Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis
    Ines J Laudes
    Departments of Pathology and Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan
    Am J Pathol 160:1867-75. 2002
    ..of fibrinolysis was indicated by reduced plasma levels of plasminogen and increased levels of tissue plasminogen activator and plasminogen activator inhibitor...
  26. ncbi Increased plasma tissue-type plasminogen activator levels in patients with chronic thrombocytopenia
    M Hanss
    Laboratoire d Hémobiologie, INSERM U 331, Institut Pasteur, Lyon, France
    Haemostasis 20:341-6. 1990
    ..These results can justify antifibrinolytic therapy in bleeding thrombocytopenic patients...
  27. ncbi Urokinase redistribution from the secreted to the cell-bound fraction in granulosa cells of rat preovulatory follicles
    E Macchione
    Dipartimento di Istologia ed Embriologia Medica, University of Rome, La Sapienza, 00161 Rome, Italy
    Biol Reprod 62:895-903. 2000
    ..In fact, whereas in the rat, gonadotropins stimulate tissue-type PA (tPA) production, the same hormonal stimulation induces urokinase PA (uPA) secretion in mouse cells...
  28. doi Blood brain barrier (BBB) dysfunction associated with increased expression of tissue and urokinase plasminogen activators following peripheral thermal injury
    Tarak H Patel
    Plastic and Reconstructive Surgery, The University of Texas Health Science Center at San Antonio, United States
    Neurosci Lett 444:222-6. 2008
    Emerging data suggests the serine proteases, tissue plasminogen activator (tPA), and urokinase plasminogen activator (uPA), may play a detrimental role in traumatic states leading to compromise of the blood brain barrier (BBB)...
  29. ncbi Increased expression and activity of urokinase-type plasminogen activator during epileptogenesis
    Laura Lahtinen
    Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, University of Kuopio, and Departmentof Neurology, Kuopio University Hospital, Finland
    Eur J Neurosci 24:1935-45. 2006
    ..These data suggest that uPA is involved in the reorganization of neuronal tissue during the epileptogenic process...
  30. doi The role and mechanism of the up-regulation of fibrinolytic activity in painful peripheral nerve injury
    Nie Yong
    Department of Biological Science and Biotechnology, Tsinghua University, Beijing 100084, People s Republic of China
    Neurochem Res 34:587-92. 2009
    ..We tested fibrinolytic activities and the expression level of tPA and uPA levels in chronic constriction injury (CCI) model...
  31. doi Evaluation of plasma urokinase-type plasminogen activator and urokinase-type plasminogen-activator receptor in patients with acute and chronic hepatitis B
    Huanqin Zhou
    Department of Clinical Laboratory, Zhejiang Hospital, Hangzhou 310013, China
    Thromb Res 123:537-42. 2009
    ..We therefore analyzed their role and clinicopathological significance in patients with acute or chronic hepatitis B...
  32. doi Both tissue-type plasminogen activator and urokinase prevent intraabdominal abscess formation after surgical treatment of peritonitis in the rat
    O R Buyne
    Department of Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Surgery 144:66-73. 2008
    ..Fibrinolytic therapy may be effective in this respect. The efficacy of recombinant tissue plasminogen activator (rtPA) and urokinase is compared in a preclinical model for surgical treatment of peritonitis.
  33. doi Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia
    Xiangdong Deng
    Division of Human Molecular Genetics, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Am J Med Genet B Neuropsychiatr Genet 156:850-8. 2011
    ..4 × 10(-6) ), PDE4A (P = 1.4 × 10(-6) ), and PLAT (P = 1 × 10(-3) ), after false discovery rate (FDR) correction...
  34. doi Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates the expression and the release of tissue plasminogen activator (tPA) in neuronal cells: involvement of tPA in the neuroprotective effect of PACAP
    Emilie Raoult
    Inserm U982, DC2N, Mont Saint Aignan, France
    J Neurochem 119:920-31. 2011
    Pituitary adenylate cyclase-activating polypeptide (PACAP) and tissue plasminogen activator (tPA) play important roles in neuronal migration and survival...
  35. doi Physiological regulation of MMPs and tPA/PAI in the arterial wall of rats by noradrenergic tone and angiotensin II
    Houcine Dab
    Université de Carthage, Unité de Physiologie Intégrée, Laboratoire de Pathologies Vasculaires, Faculte des Sciences de Bizerte, Tunisia
    J Renin Angiotensin Aldosterone Syst 13:36-45. 2012
    ..mRNA, protein and activity of matrix metalloproteinase (MMP)-2 and MMP-9 and mRNA of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) were quantified in abdominal aorta (AA) and ..
  36. pmc Deleterious effects of plasminogen activators in neonatal cerebral hypoxia-ischemia
    Faisal Adhami
    Division of Developmental Biology and Division of Neurology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Am J Pathol 172:1704-16. 2008
    ..lt;4 hours) and were accompanied by acute induction of both tissue-type and urinary-type plasminogen activators (tPA and uPA), which was not observed in adult brains subjected to the same insult...
  37. pmc Tissue plasminogen activator prevents mortality from sulfur mustard analog-induced airway obstruction
    Livia A Veress
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO, USA
    Am J Respir Cell Mol Biol 48:439-47. 2013
    ..Adult rats exposed to SM analog were treated with intratracheal tissue plasminogen activator (tPA) (0.15-0.7 mg/kg, 5.5 and 6.5 h), compared with controls (no treatment, isoflurane, and placebo)...
  38. pmc Cleavage of the NR2B subunit amino terminus of N-methyl-D-aspartate (NMDA) receptor by tissue plasminogen activator: identification of the cleavage site and characterization of ifenprodil and glycine affinities on truncated NMDA receptor
    Kay Siong Ng
    Departments of Pharmacology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 287:25520-9. 2012
    Thrombolysis using tissue plasminogen activator (tPA) has been the key treatment for patients with acute ischemic stroke for the past decade...
  39. doi Fraxinus rhynchophylla ethanol extract attenuates carbon tetrachloride-induced liver fibrosis in rats via down-regulating the expressions of uPA, MMP-2, MMP-9 and TIMP-1
    Wen Huang Peng
    Graduate Institute of Chinese Pharmaceutical Sciences, College of Pharmacy, China Medical University, Taichung, Taiwan, ROC
    J Ethnopharmacol 127:606-13. 2010
    ..To investigate the effect of Fraxinus rhynchophylla ethanol extract (FR(EtOH)) on liver fibrosis induced by carbon tetrachloride (CCl(4)) in rats...
  40. doi Molecular requirements for safer generation of thrombolytics by bioengineering the tissue-type plasminogen activator A chain
    J Parcq
    INSERM, Inserm UMR S U919, University of Caen Basse Normandie, Serine Proteases and Pathophysiology of Neurovascular Unit, GIP Cyceron, Caen, France
    J Thromb Haemost 11:539-46. 2013
    ..Although t-PA is an efficient clot lysis enzyme, it also causes damage to the neurovascular unit, including hemorrhagic transformations and neurotoxicity...
  41. pmc Developmental profile of tissue plasminogen activator in postnatal Long Evans rat visual cortex
    Sha Zheng
    Southwest Eye Hospital, Southwest Hospital, Third Military Medical University, Chongqing, China
    Mol Vis 14:975-82. 2008
    To investigate the distribution, expression, and activity of tissue plasminogen activator (tPA) in the visual cortex of the Long Evans rat during postnatal development, and to explore the relationship between tPA levels and the critical ..
  42. ncbi Tissue-type plasminogen activator is a regulator of monocyte diapedesis through the brain endothelial barrier
    Arie Reijerkerk
    Neuroimmunology Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Immunol 181:3567-74. 2008
    ..Our studies in plasma of rats indicated that the extracellular protease tissue-type plasminogen activator (tPA) correlates with the clinical signs of experimental allergic encephalomyelitis, a rat model of multiple sclerosis...
  43. doi The impact of metabolic syndrome and CRP on vascular phenotype in type 2 diabetes mellitus
    Reza Alizadeh Dehnavi
    Vascular Medicine, Department of General Internal Medicine and Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Intern Med 19:115-21. 2008
    ..The burden of cardiovascular disease in diabetes mellitus type 2 (DM2) patients is variable. We hypothesize that metabolic syndrome (MS) and low-grade systemic inflammation modify the extent of atherosclerosis in DM2...
  44. doi Tissue plasminogen activator (tPA) activity is a novel and early marker of asymptomatic LEAD in type 2 diabetes
    David Sahli
    Department of Medicine, Umea University Hospital, Umea, Sweden
    Thromb Res 123:701-6. 2009
    ..Lower extremity arterial disease (LEAD) is often one of the first signs of a generalized atherosclerotic disease in type 1 and type 2 diabetic subjects...
  45. ncbi Testosterone upregulation of tissue type plasminogen activator expression in Sertoli cells : tPA expression in Sertoli cells
    Jian Guo
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100080, China
    Endocrine 32:83-9. 2007
    Our previous studies have demonstrated that tissue type plasminogen activator (tPA) might be involved in matrix degradation of blood-testis barrier in rat...
  46. ncbi [Changes and significance of endogenous tissue plasminogen activators in cerebral hypoxia-ischemia in neonatal rats]
    Dan Yu
    Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China
    Zhongguo Dang Dai Er Ke Za Zhi 10:651-5. 2008
    ..Many studies have shown that tissue-type plasminogen activator (tPA) plays an important role in nervous system. This study investigated the effect of tPA in HIBD in neonatal rats.
  47. doi Regulation of matrix metalloproteinase-9 and tissue plasminogen activator activity by alpha-synuclein in rat primary glial cells
    So Hyun Joo
    Department of Pharmacology, Institute of Biomedical Sciences and Technology, Konkuk University, Hwayang dong, Gwangjin gu, Seoul 143 701, Republic of Korea
    Neurosci Lett 469:352-6. 2010
    ..major components of Lewy body that has been implicated in the modulation of neuroinflammation, regulates MMP-9 and tPA activity, which plays important roles in neurodegeneration as well as regeneration processes, in cultured rat ..
  48. doi Stem cells downregulate the elevated levels of tissue plasminogen activator in rats after spinal cord injury
    Krishna Kumar Veeravalli
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, One Illini Drive, Peoria, IL 61605, USA
    Neurochem Res 34:1183-94. 2009
    We investigated the involvement of tPA after SCI in rats and effect of treatment with human umbilical cord blood derived stem cells...
  49. doi Differential control of MMP and t-PA/PAI-1 expressions by sympathetic and renin-angiotensin systems in rat left ventricle
    Houcine Dab
    Unité de Physiologie Intégrée, Laboratoire de Pathologies Vasculaires, Faculte des Sciences de Bizerte, Tunisia
    Auton Neurosci 150:27-32. 2009
    ..The enzymatic activity of MMPs does not seem to be influenced directly by Ang II but it could be stimulated indirectly (via sympathostimulator pathway)...
  50. doi A nonfibrin macromolecular cofactor for tPA-mediated plasmin generation following cellular injury
    Andre L Samson
    Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia
    Blood 114:1937-46. 2009
    Tissue-type plasminogen activator (tPA) is an extracellular protease that converts plasminogen into plasmin. For tPA to generate plasmin under biologic conditions, a cofactor must first bring tPA and plasminogen into physical proximity...
  51. pmc Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke
    Haihao Zhu
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 30:1137-46. 2010
    Recent studies showed that soluble annexin A2 dramatically increases tissue plasminogen activator (tPA)-mediated plasmin generation in vitro, and reduces thrombus formation in vivo...
  52. ncbi The Kringle-2 domain of tissue plasminogen activator significantly reduces mortality and brain infarction in middle cerebral artery occlusion rats
    Haitao Zhang
    Institute of Molecular Medicine and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P R China
    Int J Mol Med 26:225-30. 2010
    b>Tissue plasminogen activator (TPA) showed brain-protective activity within the first 15 min after cerebral ischemia in rats...
  53. ncbi The structure of the TATA-less rat tissue-type plasminogen activator gene. Species-specific sequence divergences in the promoter predict differences in regulation of gene expression
    P Feng
    Department of Applied Cell and Molecular Biology, University of Umea, Sweden
    J Biol Chem 265:2022-7. 1990
    The genomic region carrying the rat tissue-type plasminogen activator (tPA) gene including its 5'-flanking sequence has been isolated and characterized by restriction enzyme analysis, Southern blotting, and DNA sequencing of all coding ..
  54. ncbi [Effects of Erigeron breviscapus injection on TNF-alpha, PAI-1 and tPA in rats with acute myocardial infarction]
    Kai Wen Huang
    the First People s Hospital of Shunde, Foshan 528300, China
    Zhong Yao Cai 33:1592-5. 2010
    To research the effects of Erigeron breviscapus injection (EBI) on TNF-alpha, PAI-1 and tPA in rats with acute myocardial infarction.
  55. ncbi Cloning and characterization of a cDNA for rat tissue-type plasminogen activator
    T Ny
    Department of Applied Cell and Molecular Biology, University of Umea, Sweden
    DNA 7:671-7. 1988
    ..The site at Asn-187 is glycosylated in the human protein, revealing a different glycosylation pattern between the human and rat proteins...
  56. ncbi Dexamethasone inhibition of tissue-type plasminogen activator (tPA) activity: paradoxical induction of both tPA antigen and plasminogen activator inhibitor
    T D Gelehrter
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109 0618
    Mol Endocrinol 1:97-101. 1987
    ..HTC PA was determined to be entirely of the tissue type (tPA), and both free and complexed antigen was quantified by a RIA using rabbit antirat tPA, with rat insulinoma tPA as ..
  57. ncbi Tissue-type plasminogen activator -7,351C/T enhancer polymorphism is associated with a first myocardial infarction
    Per Ladenvall
    Cardiovascular Institute, Clinical Experimental Research Laboratory, Sahlgrenska University Hospital Ostra, Goteborg University, Sweden
    Thromb Haemost 87:105-9. 2002
    We recently identified a polymorphic Sp1 binding site in an enhancer at the tissue-type plasminogen activator (tPA) locus (tPA -7,351C/T), which was associated with vascular tPA release...
  58. ncbi Plasminogen activator inhibitor-1 and tissue-plasminogen activator in minority adolescents with type 2 diabetes and obesity
    Vatcharapan Umpaichitra
    Department of Pediatrics, Brookdale University Hospital and Medical Center corrected Brooklyn, NY 11212, USA
    Pediatr Res 58:483-7. 2005
    ....
  59. ncbi Role of tissue plasminogen activator/plasmin cascade in delayed neuronal death after transient forebrain ischemia
    Hiroshi Takahashi
    Department of Neurosurgery, Fujinomiya City General Hospital, Fujinomiya shi, Shizuoka ken 418 0076, Japan
    Neurosci Lett 381:189-93. 2005
    We studied the possible involvement of the tissue plasminogen activator (t-PA)/plasmin system on both delayed neuronal death in the hippocampus and the associated enhancement of locomotor activity in rats, after transient forebrain ..
  60. ncbi Fibrin-modifying serine proteases thrombin, tPA, and plasmin in ischemic stroke: a review
    John J Sheehan
    Program in Molecular and Cellular Pharmacology and Department of Pharmacological Sciences, University Medical Center at Stony Brook, Stony Brook, New York 11794 8651, USA
    Glia 50:340-50. 2005
    ..Treatment of ischemic stroke with recombinant tissue plasminogen activator (tPA) can improve patient outcomes...
  61. ncbi Rapid, activity-induced increase in tissue plasminogen activator is mediated by metabotropic glutamate receptor-dependent mRNA translation
    Chan Y Shin
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520 8103, USA
    J Neurosci 24:9425-33. 2004
    ..b>Tissue plasminogen activator (tPA) is a secreted protease required for some forms of long-term synaptic plasticity...
  62. ncbi Reductions in mRNA of the neuroprotective agent, neuroserpin, after cerebral ischemia/reperfusion in diabetic rats
    Wang Liang
    Institute of Neurology, Fudan University, 12 Wulumuqi Zhong Road, 200040, Shanghai, China
    Brain Res 1015:175-80. 2004
    ..Cerebral ischemia/reperfusion in normal and diabetic rats was accompanied by increased expression of tissue plasminogen activator (t-PA), urokinase plasminogen activator (u-PA), plasminogen activator inhibitor 1 (PAI-1) and ..
  63. ncbi NF1 regulatory element functions as a repressor of tissue plasminogen activator expression
    Nhat Long Pham
    Division of Vascular Biology, La Jolla Institute for Molecular Medicine, San Diego Calif 92121, USA
    Arterioscler Thromb Vasc Biol 24:982-7. 2004
    Analysis of the distribution of endothelial cell tissue plasminogen activator (tPA) in the vasculature of rodents and primates demonstrated that tPA is constitutively expressed predominantly in small artery endothelial cells of brain and ..
  64. ncbi Differences in the implantation rates of rat embryos developed in vivo and in vitro: possible role for plasminogen activators
    Eliahu D Aflalo
    Department of Life Sciences, Ben Gurion University of the Negev, PO Box 653, Beer Sheva 84105, Israel
    Fertil Steril 81:780-5. 2004
    To assess the participation of urokinase-type (uPA) and tissue-type (tPA) plasminogen activators in embryo development and implantation.
  65. ncbi Tissue plasminogen activator in primary afferents induces dorsal horn excitability and pain response after peripheral nerve injury
    Hiroki Yamanaka
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Eur J Neurosci 19:93-102. 2004
    ..We found the induction of mRNAs for tissue type plasminogen activator (tPA) and urokinase plasminogen activator (uPA) in the rat dorsal root ganglia following sciatic ..
  66. ncbi Blood coagulation and fibrinolysis before and after exhaustive exercise in patients with IDDM
    Thomas Hilberg
    Department of Sports Medicine, Friedrich Schiller University Jena, Wöllnitzerstr 42, D 07749 Jena, Germany
    Thromb Haemost 90:1065-73. 2003
    ..The rest values (mean of the two rest samples) in extrinsic total thrombin potential (TTPex, P=0.049), tPA-activity (P=0.007) were significantly higher and in PAI-1-antigen (P=0.002) -activity (P=0...
  67. ncbi Is tissue-plasminogen activator gene polymorphism a risk factor for venous thromboembolism in every population?
    I Kivilcim Oguzulgen
    Department of Pulmonary Medicine, Gazi University School of Medicine, Turan Gunes Bulvari 92 2, Cankaya 06550, Ankara, Turkey
    J Thromb Thrombolysis 19:61-3. 2005
    ..The aim of this study is to investigate the role of t-PA gene polymorphism in Turkish venous thromboembolism (VTE) patients...
  68. ncbi The role of proteases in fibronectin matrix remodeling in thyroid epithelial cell monolayer cultures
    Luigi Nezi
    Centro di Endocrinologia ed Oncologia Sperimentale, CNR, Dpt Biologia e Patologia Cellulare e Molecolare, Napoli, Italy
    Biol Chem 383:167-76. 2002
    ..These results indicate that in the FN remodeling process, occurring during FRT epithelium maturation, both plasmin-dependent (tPA activated) and plasmin-independent proteolytic activities are involved.
  69. ncbi New atherosclerosis risk factors in obese, hypertensive and diabetic children and adolescents
    Barbara Glowinska
    IInd Department of Children s Diseases, Medical University, Bialystok, Poland
    Atherosclerosis 167:275-86. 2003
    ..Lp(a)), apolipoprotein A-I (Apo A-I), apolipoprotein B (Apo B), homocysteine (Hcy), fibrinogen (FB), tissue plasminogen activator (t-PA) and tissue plasminogen activator inhibitor type 1 (PAI-1)) in children and adolescents with ..
  70. ncbi Recombinant human tissue plasminogen activator protects the basal lamina in experimental focal cerebral ischemia
    Dorothe Burggraf
    Department of Neurology, Ludwig Maximilians University Munich, Klinikum Grossadern, Germany
    Thromb Haemost 89:1072-80. 2003
    While recombinant tissue plasminogen activator (rt-PA) is successfully used in human ischemic stroke, it may also cause hemorrhagic complications...
  71. ncbi Enhanced tissue plasminogen activator synthesis by the sympathetic neurons that innervate aging vessels
    Xi Jiang
    Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Neurosci Res 71:567-74. 2003
    We investigated the source of the increased release of tissue plasminogen activator (t-PA) into the circulation that occurs during natural aging...
  72. ncbi Role of plasminogen activators during healing after uterine serosal lesioning in the rat
    Ujjwal Kumar Rout
    C S Mott Center for Human Growth and Development, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Fertil Steril 79:138-45. 2003
    ..Study the expression pattern of tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activators during uterine serosal healing after lesioning in a rat model...
  73. ncbi Plasminogen activator-plasmin system potentiates the proliferation of hepatocytes in primary culture
    Makoto Akao
    Department of Nutrition and Physiology, Nihon University Graduate School of Applied Life Sciences, Kameino 1866, Fujisawa, Kanagawa 252 8510, Japan
    Thromb Res 107:169-74. 2002
    ..We have examined the role of fibrinolytic factors, i.e., tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), and their substrate, plasminogen, in the proliferation of ..
  74. ncbi Reciprocal actions of NCAM and tPA via a Ras-dependent MAPK activation in rat hippocampal neurons
    Hyeon Son
    Department of Biochemistry, Hanyang University College of Medicine, 17 Haengdang dong, Sungdong gu, Seoul 133 791, South Korea
    Biochem Biophys Res Commun 298:262-8. 2002
    In an attempt to identify the functions of neural cell adhesion molecule (NCAM) and tissue plasminogen activator (tPA) in hippocampal synaptic plasticity, we investigated the relationship between the two molecules by focusing on mitogen-..
  75. ncbi Additional evidence that the sympathetic nervous system regulates the vessel wall release of tissue plasminogen activator
    Y Wang
    Department of Pathology, University of Connecticut Health Center, Farmington 06030, USA
    Blood Coagul Fibrinolysis 13:471-81. 2002
    It is established that sympathetic neurons can synthesize, transport and store tissue plasminogen activator (t-PA) within axon terminals in the smooth muscle of vessel walls. Moreover, sympathetic excitations (e.g...
  76. ncbi Impaired fibrinolytic activity in type II diabetes: correlation with urinary albumin excretion and progression of renal disease
    M Kamgar
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Denver, 80262, USA
    Kidney Int 69:1899-903. 2006
    ..5 vs 72.3%, P < 0.07) in the diabetic patients with more impaired fibrinolysis and greater UAE. Thus a prospective, randomized clinical trial in type II diabetes with PAI-1 inhibitors is needed...
  77. pmc Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent
    Manuel Yepes
    Department of Vascular Biology, American Red Cross Holland Laboratory, Rockville, Maryland 20855, USA
    J Clin Invest 109:1571-8. 2002
    Tissue-type plasminogen activator (tPA) is a highly specific serine proteinase expressed in the CNS during events that require neuronal plasticity...
  78. ncbi [Effects of losartan on expressions of plasminogen activator and plasminogen activator inhibitor-1 of rat proximal tubular epithelial cells cultured with high glucose]
    Li Jun Pu
    Department of Nephrology, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 38:813-5. 2007
    ..To investigate the effects of high glucose on expressions of plasminogen activator (PA) and plasminogen activator inhibitor-1 (PAI-1) of rat proximal tubular epithelial cells, and the role of angiotensin II receptor antagonist Losartan...
  79. ncbi Association of PAI-1 4G/5G and -844G/A gene polymorphism and changes in PAI-1/tPA levels in stroke: a case-control study
    Sarra Saidi
    Research Unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia
    J Stroke Cerebrovasc Dis 16:153-9. 2007
    ..the plasminogen activator inhibitor-1 (PAI-1) gene, along with altered PAI-1 and tissue-type plasminogen activator (tPA) levels, have been implicated in stroke pathogenesis...
  80. ncbi Microvascular tissue plasminogen activator is reduced in diabetic neuropathy
    Charlene E Hafer-Macko
    Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201 1595, USA
    Neurology 69:268-74. 2007
    ..linked to diabetic macrovascular disease; whether key vascular endothelial regulatory proteins, such as tissue plasminogen activator (tPA), are altered in diabetic neuropathy microvasculature is unknown...
  81. ncbi Tissue type plasminogen activator induced in rat dorsal horn astrocytes contributes to mechanical hypersensitivity following dorsal root injury
    Toyoko Kozai
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Glia 55:595-603. 2007
    ..b>Tissue type plasminogen activator (tPA) is a well-known extracellular serine protease and is involved in the modification of the ..
  82. ncbi Beneficial effects of dalteparin on haemostatic function and local tissue oxygenation in patients with diabetes, severe vascular disease and foot ulcers
    Majid Kalani
    Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Stockholm, Sweden
    Thromb Res 120:653-61. 2007
    ..We have previously reported an improved outcome of chronic diabetic foot ulcers during treatment with dalteparin. In the present study we investigated the effects of dalteparin on skin microcirculation and haemostatic function...
  83. ncbi [Value of coagulation function and fibrinolytic system assessment in patients with gestational diabetes mellitus]
    Bao ying Liu
    Department of Obstetrics and Gynecology, Guangzhou Chest Hospital, Guangzhou 510095, China
    Nan Fang Yi Ke Da Xue Xue Bao 27:35-7. 2007
    ..To study the clinical implications of changes of coagulation function and fibrinolytic system in patients with gestational diabetes mellitus (GDM)...
  84. ncbi Effect of troglitazone on serum gamma-glutamyltransferase activity and plasma t-PA/PAI-1 complex in type 2 diabetic patients
    Hideki Koh
    Division of Diabetes and Metabolism, Department of Internal Medicine, Mita Hospital, International University of Health and Welfare, Tokyo, Japan
    Arzneimittelforschung 56:288-94. 2006
    ..This study was conducted to determine whether troglitazone (CAS 97322-87-7, Noscal), a thiazolidinedione with alpha-tocopherol in the side chain, had an antioxidant effect in patients with Type 2 diabetes...
  85. doi Tissue plasminogen activator, von Willebrand factor, and risk of type 2 diabetes in older men
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill St, London NW3 2PF, UK
    Diabetes Care 31:995-1000. 2008
    ..of this study was to assess the relationship between putative markers of endothelial dysfunction (tissue plasminogen activator [t-PA] antigen and von Willebrand factor [vWF] antigen) and development of type 2 diabetes, as well as ..
  86. ncbi Activity-dependent release of tissue plasminogen activator from the dendritic spines of hippocampal neurons revealed by live-cell imaging
    Janis E Lochner
    Department of Chemistry, Lewis and Clark College, Portland, OR 97219, USA
    J Neurobiol 66:564-77. 2006
    b>Tissue plasminogen activator (tPA) has been implicated in a variety of important cellular functions, including learning-related synaptic plasticity and potentiating N-methyl-D-aspartate (NMDA) receptor-dependent signaling...
  87. pmc Identification of polyclonal and monoclonal antibodies against tissue plasminogen activator in the antiphospholipid syndrome
    Cai Sheng Lu
    University of California, Los Angeles, CA 90095, USA
    Arthritis Rheum 52:4018-27. 2005
    To test the hypotheses that some plasmin-reactive anticardiolipin antibodies (aCL) may bind to tissue plasminogen activator (tPA) and that some of the tPA-reactive aCL may inhibit tPA activity.
  88. ncbi Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression
    Kebin Hu
    Department of Pathology, University of Pittsburgh School of Medicine, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    J Biol Chem 281:2120-7. 2006
    Tissue-type plasminogen activator (tPA), a serine protease well known for generating plasmin, has been demonstrated to induce matrix metalloproteinase-9 (MMP-9) gene expression and protein secretion in renal interstitial fibroblasts...
  89. ncbi Fibrinolytic gene polymorphism and ischemic stroke
    Katarina Jood
    Institute of Clinical Neuroscience, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Stroke 36:2077-81. 2005
    The tissue-type plasminogen activator (tPA) -7351C>T and the plasminogen activator inhibitor type 1 (PAI-1) -675 4G>5G polymorphisms influence transcriptional activity...
  90. ncbi Matrix-degrading enzymes tissue plasminogen activator and matrix metalloprotease-3 in the hypothalamo-neurohypophysial system
    Seiji Miyata
    Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Kyoto, Japan
    Brain Res 1058:1-9. 2005
    ..study localization and activity-dependent changes in the expression of matrix-degrading enzymes such as tissue plasminogen activator (tPA) and matrix metalloprotease-3 (MMP-3)...
  91. ncbi Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia
    Kiyoshi Tsuji
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Stroke 36:1954-9. 2005
    Thrombolytic therapy with tissue plasminogen activator (tPA) in ischemic stroke is limited by increased risks of cerebral hemorrhage and brain injury...
  92. ncbi [Expression of plasminogen activator inhibitor-1 and tissue plasminogen activator in the kidney of KKAy mice with type 2 diabetes]
    Li meng Chen
    Department of Nephrology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 27:344-8. 2005
    To study the role of plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) in the accumulation of extracellular matrix (ECM) in the kidney of KKAy mice with type 2 diabetes.
  93. ncbi Stimulated release of tissue plasminogen activator from artery wall sympathetic nerves: implications for stress-associated wall damage
    Zhifang Hao
    Department of Pathology, University of Connecticut Health Center, Farmington 06030 3105, USA
    Stress 8:141-9. 2005
    ..Stress stimulates acute regulated release of tissue plasminogen activator (t-PA) into the circulation, which is presently attributed to the vascular endothelium...

Research Grants3

  1. TREATMENT OF TRAUMATIC BRAIN INJURY WITH SIMVASTATIN
    Asim Mahmood; Fiscal Year: 2009
    ..abstract_text> ..
  2. TRAUMATIC BRAIN INJURY AND MARROW STROMAL CELLS
    Asim Mahmood; Fiscal Year: 2009
    ..If the treatment combining MSCs with simvastatin is found to be more effective than monotherapy, this will increase the clinical relevance of MSC treatment by allowing us to use smaller and safer doses. ..
  3. ENDOTHELIAL DYSFUNCTION IN HUMAN DIABETIC NEUROPATHY
    CHARLENE HAFER MACKO; Fiscal Year: 2002
    ..Our preliminary data shows that tissue plasminogen activator (tPA) is absent from a substantial proportion of endoneurial vessels in diabetic nerves, but not ..