placental growth factor

Summary

Gene Symbol: placental growth factor
Description: placental growth factor
Alias: Plgf, placenta growth factor
Species: rat
Products:     placental growth factor

Top Publications

  1. Yoo S, Yoon H, Kim H, Chae C, De Falco S, Cho C, et al. Role of placenta growth factor and its receptor flt-1 in rheumatoid inflammation: a link between angiogenesis and inflammation. Arthritis Rheum. 2009;60:345-54 pubmed publisher
    To investigate the direct effects of placenta growth factor (PlGF) and its specific receptor, flt-1, which are known to mediate angiogenesis, on the inflammatory process of rheumatoid arthritis (RA)...
  2. DiSalvo J, Bayne M, Conn G, Kwok P, Trivedi P, Soderman D, et al. Purification and characterization of a naturally occurring vascular endothelial growth factor.placenta growth factor heterodimer. J Biol Chem. 1995;270:7717-23 pubmed
    ..A homologous protein, placenta growth factor (PlGF), is also reported to be mitogenic for endothelial cells in culture...
  3. Van Steenkiste C, Ribera J, Geerts A, Pauta M, Tugues S, Casteleyn C, et al. Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice. Hepatology. 2011;53:1629-40 pubmed publisher
    b>Placental growth factor (PlGF) is associated selectively with pathological angiogenesis, and PlGF blockade does not affect the healthy vasculature...
  4. Kanellakis P, Pomilio G, Agrotis A, Gao X, Du X, Curtis D, et al. Darbepoetin-mediated cardioprotection after myocardial infarction involves multiple mechanisms independent of erythropoietin receptor-common beta-chain heteroreceptor. Br J Pharmacol. 2010;160:2085-96 pubmed publisher
    ..Darbepoetin also elevated mRNAs encoding angiogenic factors: placental growth factor, monocyte chemoattractant protein-1 and interleukin-1beta...
  5. Xu Y, Luo J, Yue Z, Wu L, Zhang X, Zhou C, et al. Increased expression of placental growth factor in patients with temporal lobe epilepsy and a rat model. Brain Res. 2012;1429:124-33 pubmed publisher
    b>Placental growth factor (PIGF) plays a role in angiogenesis and neuroprotection. It has been suggested that angiogenesis and blood-brain barrier damage are involved in the pathophysiology of epilepsy...
  6. Pilarczyk K, Sattler K, Galili O, Versari D, Olson M, Meyer F, et al. Placenta growth factor expression in human atherosclerotic carotid plaques is related to plaque destabilization. Atherosclerosis. 2008;196:333-40 pubmed
    b>Placenta growth factor (PlGF) mediates angiogenesis and inflammation, but its role in human atherosclerosis is unknown...
  7. Herlan L, Schulz A, Schulte L, Schulz H, Hübner N, Kreutz R. Novel candidate genes for impaired nephron development in a rat model with inherited nephron deficit and albuminuria. Clin Exp Pharmacol Physiol. 2015;42:1051-8 pubmed publisher
    ..Thus, we identified several genes that may act as crucial players in nephron development and are responsible for the nephron deficit in the MWF model. ..
  8. Ma C, Wang Y, Shen T, Zhang C, Ma J, Zhang L, et al. Placenta growth factor mediates angiogenesis in hypoxic pulmonary hypertension. Prostaglandins Leukot Essent Fatty Acids. 2013;89:159-68 pubmed publisher
    ..As placenta growth factor (PlGF) promotes pathological angiogenesis by acting on the growth, migration and survival of endothelial ..
  9. Binsalamah Z, Paul A, Khan A, Prakash S, Shum Tim D. Intramyocardial sustained delivery of placental growth factor using nanoparticles as a vehicle for delivery in the rat infarct model. Int J Nanomedicine. 2011;6:2667-78 pubmed publisher
    ..b>Placental growth factor (PlGF) is reported to stimulate angiogenesis and improve cardiac function...

More Information

Publications72

  1. Yano K, Liaw P, Mullington J, Shih S, Okada H, Bodyak N, et al. Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. J Exp Med. 2006;203:1447-58 pubmed
    ..with a time-dependent increase in circulating levels of vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) in animal and human models of sepsis...
  2. Wu Q, Du Y, Yang N, Liang Y, Li Y. Microvasculature change and placenta growth factor expression in the early stage of a rat remnant kidney model. Am J Nephrol. 2006;26:97-104 pubmed
    There is significant loss of microvasculature and impaired angiogenesis in rat remnant kidney (RK). Placenta growth factor (PlGF) is a potential angiogenic growth factor...
  3. Schreurs M, Houston E, May V, Cipolla M. The adaptation of the blood-brain barrier to vascular endothelial growth factor and placental growth factor during pregnancy. FASEB J. 2012;26:355-62 pubmed publisher
    Vascular endothelial growth factor (VEGF) and placental growth factor (PLGF) are increased in the maternal circulation during pregnancy...
  4. Viglietto G, Romano A, Manzo G, Chiappetta G, Paoletti I, Califano D, et al. Upregulation of the angiogenic factors PlGF, VEGF and their receptors (Flt-1, Flk-1/KDR) by TSH in cultured thyrocytes and in the thyroid gland of thiouracil-fed rats suggest a TSH-dependent paracrine mechanism for goiter hypervascularization. Oncogene. 1997;15:2687-98 pubmed
    b>Placenta growth factor (PlGF) and vascular endothelial growth factor (VEGF) represent two closely related angiogenic growth factors active as homodimers or heterodimers...
  5. Nakamura T, Funayama H, Kubo N, Yasu T, Kawakami M, Momomura S, et al. Elevation of plasma placental growth factor in the patients with ischemic cardiomyopathy. Int J Cardiol. 2009;131:186-91 pubmed publisher
    b>Placental growth factor (PlGF), which is a member of the vascular endothelial growth factor family, stimulates angiogenesis and collateral growth in ischemic tissues...
  6. Bobic S, Seys S, De Vooght V, Callebaut I, Hox V, Dooms C, et al. Placental growth factor contributes to bronchial neutrophilic inflammation and edema in allergic asthma. Am J Respir Cell Mol Biol. 2012;46:781-9 pubmed publisher
    b>Placental growth factor (PlGF) and its receptor vascular endothelial growth factor receptor 1 (VEGFR1) play an important role in pathological conditions related to angiogenesis, vascular leakage, and inflammation...
  7. Cho G, Roh G, Kim H, Kim Y, Cho S, Choi W, et al. Differential expression of placenta growth factors and their receptors in the normal and pregnancy-induced hypertensive human placentas. J Korean Med Sci. 2003;18:402-8 pubmed
    ..Adequate and organized interaction of vascular endothelial growth factors (VEGF), placenta growth factors (PlGF), and their receptors are essential for a normal development and function of the placenta...
  8. Matsumoto K, Suzuki K, Koike H, Okamura K, Tsuchiya K, Uchida T, et al. Prognostic significance of plasma placental growth factor levels in renal cell cancer: an association with clinical characteristics and vascular endothelial growth factor levels. Anticancer Res. 2003;23:4953-8 pubmed
    ..We assessed the relationship between clinical features of renal cell cancer (RCC) and PlGF levels in relation to VEGF. Plasma PlGF and VEGF levels were measured in patients with renal cell cancer...
  9. Brittain J, Hulkower B, Jones S, Strayhorn D, De Castro L, Telen M, et al. Placenta growth factor in sickle cell disease: association with hemolysis and inflammation. Blood. 2010;115:2014-20 pubmed publisher
    b>Placenta growth factor (PlGF) is released by immature erythrocytes and is elevated in sickle cell disease (SCD)...
  10. Ritz M, Graumann U, Gutierrez B, Hausmann O. Traumatic spinal cord injury alters angiogenic factors and TGF-beta1 that may affect vascular recovery. Curr Neurovasc Res. 2010;7:301-10 pubmed
    ..transient decreases of angiopoietin-1 (Ang-1), platelet-derived growth factor-BB (PDGF-BB), as well as placental growth factor (PlGF), with the lowest values obtained 3 days after injury, when compared to the expression levels ..
  11. Zimpfer D, Aharinejad S, Holfeld J, Thomas A, Dumfarth J, Rosenhek R, et al. Direct epicardial shock wave therapy improves ventricular function and induces angiogenesis in ischemic heart failure. J Thorac Cardiovasc Surg. 2009;137:963-70 pubmed publisher
    ..Vascular endothelial growth factor, Fms-related tyrosine kinase 1, and placental growth factor levels were upregulated after 24 and 48 hours and 7 days in the treatment group...
  12. Choi W, Cho G, Won C, Koh P. Expression of placenta growth factor mRNA in the rat placenta during mid-late pregnancy. J Vet Sci. 2005;6:179-83 pubmed
    ..It is known that the placenta growth factor (PlGF)is a member of the vascular endothelial growth factor family and is critical for placental growth ..
  13. Bennuru S, Maldarelli G, Kumaraswami V, Klion A, Nutman T. Elevated levels of plasma angiogenic factors are associated with human lymphatic filarial infections. Am J Trop Med Hyg. 2010;83:884-90 pubmed publisher
    ..VEGF-D, and angiopoietins (Ang-1/Ang-2), with only levels of basic fibroblast growth factor (bFGF) and placental growth factor (PlGF) being elevated only if lymphedema was evident...
  14. Chang J, Sukhova G, Libby P, Schvartz E, Lichtenstein A, Field S, et al. Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. Proc Natl Acad Sci U S A. 2007;104:8077-82 pubmed
  15. Zheng M, Dai M, Lin L. [Increased expression of placenta growth factor in lung tissue of paraquat-induced rat pulmonary fibrosis model]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2007;25:527-31 pubmed
    To investigate the dynamic expression of placenta growth factor (PLGF) in the lungs with paraquat (PQ)-induced pulmonary fibrosis...
  16. Batchelor T, Duda D, di Tomaso E, Ancukiewicz M, Plotkin S, Gerstner E, et al. Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J Clin Oncol. 2010;28:2817-23 pubmed publisher
    ..Drug interruptions were not associated with outcome. Changes in plasma placental growth factor, basic fibroblast growth factor, matrix metalloproteinase (MMP) -2, soluble VEGF receptor 1, stromal cell-..
  17. Beck H, Acker T, Püschel A, Fujisawa H, Carmeliet P, Plate K. Cell type-specific expression of neuropilins in an MCA-occlusion model in mice suggests a potential role in post-ischemic brain remodeling. J Neuropathol Exp Neurol. 2002;61:339-50 pubmed
    ..semaphorins, and in angiogenesis by binding of the vascular endothelial growth factor isoform VEGF165 and placenta growth factor (PLGF)...
  18. Suenaga K, Kitahara S, Suzuki Y, Kobayashi M, Horie S, Sugawara J, et al. Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation. PLoS ONE. 2014;9:e104728 pubmed publisher
    ..Moreover, our study shows for the first time that VASH2 expressed in trophoblasts is involved in the regulation of cell fusion for syncytiotrophoblast formation. ..
  19. Maes C, Coenegrachts L, Stockmans I, Daci E, Luttun A, Petryk A, et al. Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair. J Clin Invest. 2006;116:1230-42 pubmed
    ..Previous studies indicated that the VEGF homolog placental growth factor (PlGF) has a more significant role in disease than in health...
  20. Vanheule E, Fan Y, Van Huysse J, Meester D, Olievier K, Praet M, et al. Expression of placental growth factor in regenerating livers after partial hepatectomy in the rat. Eur J Gastroenterol Hepatol. 2011;23:66-75 pubmed publisher
    b>Placental growth factor (PlGF) is known for its role in pathological conditions to protect parenchymal cells of different organs from injury, whereas its presence in the liver and its potential importance in stimulating liver ..
  21. Iwasaki H, Kawamoto A, Tjwa M, Horii M, Hayashi S, Oyamada A, et al. PlGF repairs myocardial ischemia through mechanisms of angiogenesis, cardioprotection and recruitment of myo-angiogenic competent marrow progenitors. PLoS ONE. 2011;6:e24872 pubmed publisher
    ..We explored the therapeutic potential of myocardial gene therapy of placental growth factor (PlGF), a VEGF-related angiogenic growth factor, with progenitor-mobilizing activity...
  22. Cheng L, Jia H, Löhr M, Bagherzadeh A, Holmes D, Selwood D, et al. Anti-chemorepulsive effects of vascular endothelial growth factor and placental growth factor-2 in dorsal root ganglion neurons are mediated via neuropilin-1 and cyclooxygenase-derived prostanoid production. J Biol Chem. 2004;279:30654-61 pubmed
    ..Neuropilin-1 (NP-1) is a receptor for VEGF165 and placental growth factor-2 (PlGF-2), but the role of NP-1 in VEGF-dependent neurotrophic actions is unclear...
  23. Suwaki N, Masuyama H, Nakatsukasa H, Masumoto A, Sumida Y, Takamoto N, et al. Hypoadiponectinemia and circulating angiogenic factors in overweight patients complicated with pre-eclampsia. Am J Obstet Gynecol. 2006;195:1687-92 pubmed
    ..measured serum concentrations of adiponectin and angiogenic factors, vascular endothelial growth factor, placental growth factor, and the soluble vascular endothelial growth factor receptors, soluble fms-like tyrosine Kinase 1 (sFlt-1)..
  24. Sands M, Howell K, Costello C, McLoughlin P. Placenta growth factor and vascular endothelial growth factor B expression in the hypoxic lung. Respir Res. 2011;12:17 pubmed publisher
    ..The aim of this study was to examine the expression of placenta growth factor (PlGF) and VEGFB during the development of hypoxic pulmonary angiogenesis and their functional effects on ..
  25. Zhang L, Zhao S, Yuan L, Wu H, Jiang H, Luo G, et al. Knockdown of placental growth factor (PLGF) mitigates hyperoxia-induced acute lung injury in neonatal rats: Suppressive effects on NF?B signaling pathway. Int Immunopharmacol. 2016;38:167-74 pubmed publisher
    ..Our prior work illustrated that hyperoxic exposure could enhance the release of placental growth factor (PLGF) in the lungs of neonatal rats...
  26. Maae E, Olsen D, Steffensen K, Jakobsen E, Brandslund I, Sørensen F, et al. Prognostic impact of placenta growth factor and vascular endothelial growth factor A in patients with breast cancer. Breast Cancer Res Treat. 2012;133:257-65 pubmed publisher
    b>Placenta growth factor (PlGF) and vascular endothelial growth factor A (VEGF-A) are angiogenic growth factors interacting competitively with the same receptors...
  27. Dunne J, Keen K, van Eeden S. Circulating angiopoietin and Tie-2 levels in systemic sclerosis. Rheumatol Int. 2013;33:475-84 pubmed publisher
    ..Plasma levels of soluble sAng-1, sAng-2, sTie-2, vascular endothelial growth factor (VEGF), placental growth factor (PlGF) and endostatin were measured...
  28. Bastek J, Brown A, Anton L, Srinivas S, D Addio A, Elovitz M. Biomarkers of inflammation and placental dysfunction are associated with subsequent preterm birth. J Matern Fetal Neonatal Med. 2011;24:600-5 pubmed publisher
    ..whether the analysis of high sensitivity C-Reactive Protein (hsCRP), a biomarker of inflammation, and placental growth factor (PlGF), a biomarker of placental dysfunction, could help identify patients at risk for preterm birth (PTB)..
  29. Miyamoto N, De Kozak Y, Normand N, Courtois Y, Jeanny J, BenEzra D, et al. PlGF-1 and VEGFR-1 pathway regulation of the external epithelial hemato-ocular barrier. A model for retinal edema. Ophthalmic Res. 2008;40:203-7 pubmed publisher
    ..The ARPE19 human junctions in culture are modulated by VEGF through VEGFR-1 but not through VEGFR-2. PlGF-1, that is a pure agonist of VEGFR-1, is produced in ARPE-19 cells under hypoxic conditions and mimics VEGF effects ..
  30. Khurana R, Moons L, Shafi S, Luttun A, Collen D, Martin J, et al. Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation. Circulation. 2005;111:2828-36 pubmed
    b>Placental growth factor (PlGF) has been implicated in the pathophysiological angiogenesis and monocyte recruitment that underlie chronic inflammatory disease, but its role in atherosclerosis has not been examined...
  31. Xu Y, Zhang Y, Guo Z, Yin H, Zeng K, Wang L, et al. Increased placental growth factor in cerebrospinal fluid of patients with epilepsy. Neurochem Res. 2012;37:665-70 pubmed publisher
    ..However, relatively little data are available linking placenta growth factor (PIGF) with epilepsy...
  32. Tugues S, Fernandez Varo G, Muñoz Luque J, Ros J, Arroyo V, Rodes J, et al. Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats. Hepatology. 2007;46:1919-26 pubmed
    ..density and expression of vascular endothelial growth factor-A, angiopoietin-1, angiopoietin-2, and placental growth factor in cirrhotic livers...
  33. Zhang H, Palmer R, Gao X, Kreidberg J, Gerald W, Hsiao L, et al. Transcriptional activation of placental growth factor by the forkhead/winged helix transcription factor FoxD1. Curr Biol. 2003;13:1625-9 pubmed
    ..Here, we used cells with inducible expression of BF-2, combined with microarray analysis, to identify Placental Growth Factor (PlGF), a Vascular Endothelial Growth Factor (VEGF) family member previously implicated in angiogenesis, ..
  34. Chen H, Su S, Chien C, Lin W, Yu S, Chou C, et al. Titanium dioxide nanoparticles induce emphysema-like lung injury in mice. FASEB J. 2006;20:2393-5 pubmed
    ..In particular, nanoTiO2 up-regulates placenta growth factor (PlGF) and other chemokines (CXCL1, CXCL5, and CCL3) expressions that may cause pulmonary emphysema and ..
  35. Salim M, Al Matubsi H, El Sharaky A, Kamel M, Oriquat G, Helmy M, et al. The levels of vascular endothelial growth factor-A and placental growth factor-2 in embryopathy associated with experimental diabetic gestation. Growth Factors. 2009;27:32-9 pubmed publisher
    ..objective of this study was to investigate the role of vascular endothelial growth factor-A (VEGF-A) and placental growth factor-2 (PlGF-2) in fetal malformations associated with maternal diabetes. Diabetes was induced in female rats...
  36. Voros G, Maquoi E, Demeulemeester D, Clerx N, Collen D, Lijnen H. Modulation of angiogenesis during adipose tissue development in murine models of obesity. Endocrinology. 2005;146:4545-54 pubmed
    ..b>Placental growth factor and Ang-2 expression were increased in SC adipose tissue of ob/ob mice, and thrombospondin-2 was ..
  37. Dueñas Pousa I, Maté Jiménez J, Salcedo Mora X, Abreu M, Moreno Otero R, Gisbert J, et al. Analysis of soluble angiogenic factors in Crohn's disease: a preliminary study. Gastroenterol Hepatol. 2007;30:518-24 pubmed
    ..Vascular endothelial growth factor (VEGF), placental growth factor (PlGF), angiopoietins (Ang) and receptors (VEGFR1, VEGFR2 and Tie2) in sera were assayed by ELISA...
  38. Chaiworapongsa T, Romero R, Gotsch F, Kusanovic J, Mittal P, Kim S, et al. Acute pyelonephritis during pregnancy changes the balance of angiogenic and anti-angiogenic factors in maternal plasma. J Matern Fetal Neonatal Med. 2010;23:167-78 pubmed
    ..This study was conducted to determine if maternal plasma concentrations of placental growth factor (PlGF), sVEGFR-2, and soluble endoglin (sEng) change in pregnancies complicated by acute pyelonephritis (..
  39. Theilade S, Lajer M, Jorsal A, Tarnow L, Parving H, Rossing P. Evaluation of placental growth factor and soluble Fms-like tyrosine kinase 1 as predictors of all-cause and cardiovascular mortality in patients with Type 1 diabetes with and without diabetic nephropathy. Diabet Med. 2012;29:337-44 pubmed publisher
    b>Placental growth factor is a vascular endothelial growth factor involved in angiogenesis, vascular inflammation and plaque formation...
  40. Carnevale D, Cifelli G, Mascio G, Madonna M, Sbroggiò M, Perrino C, et al. Placental growth factor regulates cardiac inflammation through the tissue inhibitor of metalloproteinases-3/tumor necrosis factor-?-converting enzyme axis: crucial role for adaptive cardiac remodeling during cardiac pressure overload. Circulation. 2011;124:1337-50 pubmed publisher
    ..Interestingly, the dual properties of placental growth factor as an angiogenic factor and cytokine make it a candidate to participate in cardiac remodeling in response ..
  41. Gmeiner M, Zimpfer D, Holfeld J, Seebacher G, Abraham D, Grimm M, et al. Improvement of cardiac function in the failing rat heart after transfer of skeletal myoblasts engineered to overexpress placental growth factor. J Thorac Cardiovasc Surg. 2011;141:1238-45 pubmed publisher
    ..We investigated whether transplant of myoblasts overexpressing placental growth factor would stimulate angiogenesis and enhance myoblast survival in a rat heart failure model...
  42. Shaw J, Xiang L, Shah A, Yin W, Lloyd P. Placenta growth factor expression is regulated by hydrogen peroxide in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2011;300:C349-55 pubmed publisher
    ..b>Placenta growth factor (PLGF) is known to mediate certain aspects of arteriogenesis, such as recruitment of monocytes to the ..
  43. Rolny C, Mazzone M, Tugues S, Laoui D, Johansson I, Coulon C, et al. HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. Cancer Cell. 2011;19:31-44 pubmed publisher
    ..Skewing of TAM polarization by HRG relies substantially on downregulation of placental growth factor (PlGF)...
  44. He M, Das K, Blacksin M, Benevenia J, Hameed M. A translocation involving the placental growth factor gene is identified in an epithelioid hemangioendothelioma. Cancer Genet Cytogenet. 2006;168:150-4 pubmed
    ..One of the genes at 14q24 encodes for placental growth factor [PlGF, also called vascular endothelial growth factor (VEGF)-related protein]...
  45. Koh S, Baik W, Noh M, Cho G, Kim H, Kim K, et al. The functional deficiency of bone marrow mesenchymal stromal cells in ALS patients is proportional to disease progression rate. Exp Neurol. 2012;233:472-80 pubmed publisher
    ..We therefore suggest that healthy allogeneic BM-MSCs might be a better option for cell therapy in ALS patients. ..
  46. Kowalczuk L, Touchard E, Omri S, Jonet L, Klein C, Valamanes F, et al. Placental growth factor contributes to micro-vascular abnormalization and blood-retinal barrier breakdown in diabetic retinopathy. PLoS ONE. 2011;6:e17462 pubmed publisher
    There are controversies regarding the pro-angiogenic activity of placental growth factor (PGF) in diabetic retinopathy (DR)...
  47. Zhang L, Yuan L, Zhao S, Shan Y, Wu H, Xue X. The role of placenta growth factor in the hyperoxia-induced acute lung injury in an animal model. Cell Biochem Funct. 2015;33:44-9 pubmed publisher
    ..However, the cellular and molecular mechanisms remain unknown. Here, we aimed to investigate the role of placental growth factor (PLGF) in hyperoxia-induced lung injury...
  48. Roncal C, Buysschaert I, Gerdes N, Georgiadou M, Ovchinnikova O, Fischer C, et al. Short-term delivery of anti-PlGF antibody delays progression of atherosclerotic plaques to vulnerable lesions. Cardiovasc Res. 2010;86:29-36 pubmed publisher
    b>Placental growth factor (PlGF), a homologue of vascular endothelial growth factor, is a pleiotropic cytokine with a pro-inflammatory activity...
  49. Liu H, Honmou O, Harada K, Nakamura K, Houkin K, Hamada H, et al. Neuroprotection by PlGF gene-modified human mesenchymal stem cells after cerebral ischaemia. Brain. 2006;129:2734-45 pubmed
    ..b>Placental growth factor (PlGF) is angiogenic to impaired non-neural tissue...
  50. Koh P, Sung J, Won C, Cho J, Moon J, Park O, et al. Streptozotocin-induced diabetes decreases placenta growth factor (PlGF) levels in rat placenta. J Vet Med Sci. 2007;69:877-80 pubmed
    The placenta produces several growth factors, including placenta growth factor (PlGF), which are essential for placenta growth and fetal growth. Diabetic pregnancy induces the abnormal placental growth and fetal development...
  51. Molvarec A, Szarka A, Walentin S, Beko G, Karadi I, Prohaszka Z, et al. Serum heat shock protein 70 levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in women with preeclampsia. Clin Chim Acta. 2011;412:1957-62 pubmed publisher
    ..Serum total soluble fms-like tyrosine kinase-1 (sFlt-1) and biologically active placental growth factor (PlGF) levels were measured by electrochemiluminescence immunoassay...
  52. Robak E, Kierstan M, Cebula B, Krawczynska A, Sysa Jedrzejowska A, Wierzbowska A, et al. Circulating endothelial cells and angiogenic proteins in patients with systemic lupus erythematosus. Lupus. 2009;18:332-41 pubmed publisher
    ..Serum concentrations of angiogenic proteins (vascular endothelial growth factor, placental growth factor (PIGF), soluble vascular cell adhesion molecule and endoglin) were evaluated by ELISA...
  53. Zheng Y, Watanabe M, Kuraishi T, Hattori S, Kai C, Shibuya M. Chimeric VEGF-ENZ7/PlGF specifically binding to VEGFR-2 accelerates skin wound healing via enhancement of neovascularization. Arterioscler Thromb Vasc Biol. 2007;27:503-11 pubmed
    VEGF-E(NZ7)/PlGF molecules composed of Orf virus-derived VEGF-E(NZ7) and human PlGF1 were previously proven to be potent angiogenic factors stimulating angiogenesis without significant enhancement of vascular leakage and inflammation in ..
  54. Wang C, Duan H, He L. Inhibitory effect of atractylenolide I on angiogenesis in chronic inflammation in vivo and in vitro. Eur J Pharmacol. 2009;612:143-52 pubmed publisher
    ..interleukin-1beta (IL-1beta), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF) activity in the flute of mouse air pouch and the peritoneal macrophages stimulated by ..
  55. Murakami T, Imada Y, Kawamura M, Takahashi T, Fujita Y, Sato E, et al. Placental growth factor-2 gene transfer by electroporation restores diabetic sensory neuropathy in mice. Exp Neurol. 2011;227:195-202 pubmed publisher
    b>Placental growth factor-2 (PlGF-2) exhibits neurotrophic activity in dorsal root ganglion (DRG) neurons through the neuropilin-1 (NP-1) receptor in vitro...
  56. Cisse O, Fajardy I, Dickes Coopman A, Moitrot E, Montel V, Deloof S, et al. Mild gestational hyperglycemia in rat induces fetal overgrowth and modulates placental growth factors and nutrient transporters expression. PLoS ONE. 2013;8:e64251 pubmed publisher
    ..N-STZ model offers the opportunity to determinate whether these neonatal outcomes may contribute to developmental programming of metabolic diseases in adulthood. ..
  57. Hindryckx P, Laukens D, Serry G, Van Praet L, Cuvelier C, Mielants H, et al. Subclinical gut inflammation in spondyloarthritis is associated with a pro-angiogenic intestinal mucosal phenotype. Ann Rheum Dis. 2011;70:2044-8 pubmed publisher
    Vascular endothelial growth factor (VEGF-A) and placental growth factor (PlGF) are major regulators of pathological angiogenesis, which is a prominent feature of both Crohn's disease (CD) and peripheral synovitis in spondyloarthritis...
  58. Hindryckx P, Waeytens A, Laukens D, Peeters H, Van Huysse J, Ferdinande L, et al. Absence of placental growth factor blocks dextran sodium sulfate-induced colonic mucosal angiogenesis, increases mucosal hypoxia and aggravates acute colonic injury. Lab Invest. 2010;90:566-76 pubmed publisher
    Angiogenesis has recently been described as a component of inflammatory bowel disease. Placental growth factor (PlGF), a vascular endothelial growth factor (VEGF) homologue, establishes its angiogenic capacity under pathophysiological ..
  59. Smadja D, Gaussem P, Mauge L, Lacroix R, Gandrille S, Remones V, et al. Comparison of endothelial biomarkers according to reversibility of pulmonary hypertension secondary to congenital heart disease. Pediatr Cardiol. 2010;31:657-62 pubmed publisher
    ..interleukin-6), and angiogenic cytokine levels [vascular endothelial growth factor (VEGF) and placental growth factor (PlGF)] in 26 patients with CHD, 16 with reversible PAH (median age, 2 years) and 10 with irreversible ..
  60. Agunanne E, Uddin M, Horvat D, Puschett J. Contribution of angiogenic factors in a rat model of pre-eclampsia. Am J Nephrol. 2010;32:332-9 pubmed publisher
    ..At the 7- to 10-day time point, plasma PlGF was greater in the NP rats than in the PDS group (p < 0.05)...
  61. Chaballe L, Close P, Sempels M, Delstanche S, Fanielle J, Moons L, et al. Involvement of placental growth factor in Wallerian degeneration. Glia. 2011;59:379-96 pubmed publisher
    ..Within this network, the role of placental growth factor (PlGF) remains totally unknown...
  62. Bahtiyar M, Buhimschi C, Ravishankar V, Copel J, Norwitz E, Julien S, et al. Contrasting effects of chronic hypoxia and nitric oxide synthase inhibition on circulating angiogenic factors in a rat model of growth restriction. Am J Obstet Gynecol. 2007;196:72.e1-6 pubmed
    ..levels of soluble fms-like tyrosine kinase 1 (sFlt-1), vascular endothelial growth factor (VEGF), and placental growth factor (PlGF)...
  63. Olsson A, Dimberg A, Kreuger J, Claesson Welsh L. VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol. 2006;7:359-71 pubmed
    ..Recent insights have shed light onto VEGFR signal transduction and the interplay between different VEGFRs and VEGF co-receptors in development, adult physiology and disease. ..