PKC

Summary

Gene Symbol: PKC
Description: protein kinase C, alpha
Alias: Pkca, protein kinase C alpha type, PKC-A, PKC-alpha
Species: rat
Products:     PKC

Top Publications

  1. Powner D, Hodgkin M, Wakelam M. Antigen-stimulated activation of phospholipase D1b by Rac1, ARF6, and PKCalpha in RBL-2H3 cells. Mol Biol Cell. 2002;13:1252-62 pubmed
    ..is phosphatidylinositol 4,5-bisphosphate dependent via an N-terminal PH domain and is stimulated by Rho, ARF, and PKC family proteins, combinations of which cooperatively increase this activity...
  2. Ochoa W, Corbalan Garcia S, Eritja R, Rodríguez Alfaro J, Gomez Fernandez J, Fita I, et al. Additional binding sites for anionic phospholipids and calcium ions in the crystal structures of complexes of the C2 domain of protein kinase calpha. J Mol Biol. 2002;320:277-91 pubmed
    ..Implications for PKCalpha activity of these structural results, in particular at the level of the binding affinity of the C2 domain to membranes, are discussed. ..
  3. Corbalan Garcia S, García García J, Rodríguez Alfaro J, Gomez Fernandez J. A new phosphatidylinositol 4,5-bisphosphate-binding site located in the C2 domain of protein kinase Calpha. J Biol Chem. 2003;278:4972-80 pubmed
    ..The results obtained in this work point to a sequential activation model, in which protein kinase Calpha needs Ca(2+) before the PtdIns(4,5)P(2)-dependent activation of the enzyme can occur. ..
  4. Partovian C, Simons M. Regulation of protein kinase B/Akt activity and Ser473 phosphorylation by protein kinase Calpha in endothelial cells. Cell Signal. 2004;16:951-7 pubmed
    ..We conclude, therefore, that PKCalpha regulates Akt-1 activity via Ser473 phosphorylation and may function as PDK2 in endothelial cells. ..
  5. Lampe P, TenBroek E, Burt J, Kurata W, Johnson R, Lau A. Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication. J Cell Biol. 2000;149:1503-12 pubmed
    Phorbol esters (e.g., TPA) activate protein kinase C (PKC), increase connexin43 (Cx43) phosphorylation, and decrease cell-cell communication via gap junctions in many cell types...
  6. Marin Vicente C, Gomez Fernandez J, Corbalan Garcia S. The ATP-dependent membrane localization of protein kinase Calpha is regulated by Ca2+ influx and phosphatidylinositol 4,5-bisphosphate in differentiated PC12 cells. Mol Biol Cell. 2005;16:2848-61 pubmed
  7. Zara S, Bosco D, Di Giulio C, Antonucci A, Cataldi A. Protein kinase Calpha early activates splicing factor SC-35 during post-natal rat heart development. J Biol Regul Homeost Agents. 2009;23:45-54 pubmed
    ..Since the presence of Protein Kinase C (PKC) inside the nucleus could allow the enzyme to phosphorylate also proteins located on chromatin, on nuclear matrix ..
  8. Nishizuka Y. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature. 1988;334:661-5 pubmed
  9. Alpini G, Baiocchi L, Glaser S, Ueno Y, Marzioni M, Francis H, et al. Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha. Hepatology. 2002;35:1041-52 pubmed
    ..In vitro UDCA and TUDCA inhibition of cholangiocyte growth and secretion required increased [Ca(2+)](i) and PKC alpha. In conclusion, activation of Ca(2+)-dependent PKC alpha is required for UDCA and TUDCA inhibition of ..
  10. Bolsover S, Gomez Fernandez J, Corbalan Garcia S. Role of the Ca2+/phosphatidylserine binding region of the C2 domain in the translocation of protein kinase Calpha to the plasma membrane. J Biol Chem. 2003;278:10282-90 pubmed
    Signal transduction via protein kinase C (PKC) is closely regulated by its subcellular localization...

Detail Information

Publications102 found, 100 shown here

  1. Powner D, Hodgkin M, Wakelam M. Antigen-stimulated activation of phospholipase D1b by Rac1, ARF6, and PKCalpha in RBL-2H3 cells. Mol Biol Cell. 2002;13:1252-62 pubmed
    ..is phosphatidylinositol 4,5-bisphosphate dependent via an N-terminal PH domain and is stimulated by Rho, ARF, and PKC family proteins, combinations of which cooperatively increase this activity...
  2. Ochoa W, Corbalan Garcia S, Eritja R, Rodríguez Alfaro J, Gomez Fernandez J, Fita I, et al. Additional binding sites for anionic phospholipids and calcium ions in the crystal structures of complexes of the C2 domain of protein kinase calpha. J Mol Biol. 2002;320:277-91 pubmed
    ..Implications for PKCalpha activity of these structural results, in particular at the level of the binding affinity of the C2 domain to membranes, are discussed. ..
  3. Corbalan Garcia S, García García J, Rodríguez Alfaro J, Gomez Fernandez J. A new phosphatidylinositol 4,5-bisphosphate-binding site located in the C2 domain of protein kinase Calpha. J Biol Chem. 2003;278:4972-80 pubmed
    ..The results obtained in this work point to a sequential activation model, in which protein kinase Calpha needs Ca(2+) before the PtdIns(4,5)P(2)-dependent activation of the enzyme can occur. ..
  4. Partovian C, Simons M. Regulation of protein kinase B/Akt activity and Ser473 phosphorylation by protein kinase Calpha in endothelial cells. Cell Signal. 2004;16:951-7 pubmed
    ..We conclude, therefore, that PKCalpha regulates Akt-1 activity via Ser473 phosphorylation and may function as PDK2 in endothelial cells. ..
  5. Lampe P, TenBroek E, Burt J, Kurata W, Johnson R, Lau A. Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication. J Cell Biol. 2000;149:1503-12 pubmed
    Phorbol esters (e.g., TPA) activate protein kinase C (PKC), increase connexin43 (Cx43) phosphorylation, and decrease cell-cell communication via gap junctions in many cell types...
  6. Marin Vicente C, Gomez Fernandez J, Corbalan Garcia S. The ATP-dependent membrane localization of protein kinase Calpha is regulated by Ca2+ influx and phosphatidylinositol 4,5-bisphosphate in differentiated PC12 cells. Mol Biol Cell. 2005;16:2848-61 pubmed
  7. Zara S, Bosco D, Di Giulio C, Antonucci A, Cataldi A. Protein kinase Calpha early activates splicing factor SC-35 during post-natal rat heart development. J Biol Regul Homeost Agents. 2009;23:45-54 pubmed
    ..Since the presence of Protein Kinase C (PKC) inside the nucleus could allow the enzyme to phosphorylate also proteins located on chromatin, on nuclear matrix ..
  8. Nishizuka Y. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature. 1988;334:661-5 pubmed
  9. Alpini G, Baiocchi L, Glaser S, Ueno Y, Marzioni M, Francis H, et al. Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha. Hepatology. 2002;35:1041-52 pubmed
    ..In vitro UDCA and TUDCA inhibition of cholangiocyte growth and secretion required increased [Ca(2+)](i) and PKC alpha. In conclusion, activation of Ca(2+)-dependent PKC alpha is required for UDCA and TUDCA inhibition of ..
  10. Bolsover S, Gomez Fernandez J, Corbalan Garcia S. Role of the Ca2+/phosphatidylserine binding region of the C2 domain in the translocation of protein kinase Calpha to the plasma membrane. J Biol Chem. 2003;278:10282-90 pubmed
    Signal transduction via protein kinase C (PKC) is closely regulated by its subcellular localization...
  11. Lesage G, Marucci L, Alvaro D, Glaser S, Benedetti A, Marzioni M, et al. Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity. Hepatology. 2002;36:641-51 pubmed
    ..We evaluated (1) if insulin effects are associated with activation of PKC alpha and (2) if activation of PKC causes inhibition of secretin-stimulated cAMP levels and PKA activity...
  12. Gonzalez M, Susarla B, Robinson M. Evidence that protein kinase Calpha interacts with and regulates the glial glutamate transporter GLT-1. J Neurochem. 2005;94:1180-8 pubmed
    ..of the sodium-dependent neurotransmitter transporters are rapidly (within minutes) regulated by protein kinase C (PKC), with changes in activity being correlated with changes in transporter trafficking to or from the plasma membrane...
  13. Marin Vicente C, Nicolas F, Gomez Fernandez J, Corbalan Garcia S. The PtdIns(4,5)P2 ligand itself influences the localization of PKCalpha in the plasma membrane of intact living cells. J Mol Biol. 2008;377:1038-52 pubmed publisher
    ..In this work, we studied the effect of modulation of the PtdIns(4,5)P2 concentration on protein kinase C (PKC) alpha membrane localization in intact living cells...
  14. Hirano A, Hack I, Wassle H, Duvoisin R. Cloning and immunocytochemical localization of a cyclic nucleotide-gated channel alpha-subunit to all cone photoreceptors in the mouse retina. J Comp Neurol. 2000;421:80-94 pubmed
    ..Therefore, defects in this channel would be predicted to severely impair photopic vision. ..
  15. Lim S, Longley R, Couchman J, Woods A. Direct binding of syndecan-4 cytoplasmic domain to the catalytic domain of protein kinase C alpha (PKC alpha) increases focal adhesion localization of PKC alpha. J Biol Chem. 2003;278:13795-802 pubmed
    ..4V; LGKKPIYKK) binds phosphatidylinositol 4,5-bisphosphate, and together they regulate protein kinase C alpha (PKC alpha) activity...
  16. Wang W, Yeh S, Chang Y, Hsiao S, Lian W, Lin C, et al. PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells. J Biol Chem. 2003;278:37705-12 pubmed
    ..We have previously shown that PICK1 modulates the catalytic activity of PKC selectively toward the antiproliferative gene TIS21...
  17. Frazier D, Wilson A, Dougherty C, Li H, Bishopric N, Webster K. PKC-alpha and TAK-1 are intermediates in the activation of c-Jun NH2-terminal kinase by hypoxia-reoxygenation. Am J Physiol Heart Circ Physiol. 2007;292:H1675-84 pubmed
    ..Here we present evidence that protein kinase C (PKC) and transforming growth factor-beta-activated kinase-1 (TAK-1) are also components of this pathway...
  18. Pan T, Neo K, Hu L, Yong Q, Bian J. H2S preconditioning-induced PKC activation regulates intracellular calcium handling in rat cardiomyocytes. Am J Physiol Cell Physiol. 2008;294:C169-77 pubmed
    The present study was aimed to investigate the regulatory effect of protein kinase C (PKC) on intracellular Ca(2+) handling in hydrogen sulfide (H(2)S)-preconditioned cardiomyocytes and its consequent effects on ischemia challenge...
  19. Morioka N, Abdin J, Morita K, Kitayama T, Nakata Y, Dohi T. The regulation of glycine transporter GLYT1 is mainly mediated by protein kinase Calpha in C6 glioma cells. Neurochem Int. 2008;53:248-54 pubmed publisher
    ..It has been recently demonstrated that protein kinase C (PKC) mediates the downregulation of GLYT1 activity in several cell systems...
  20. Avalos A, Valdivia A, Muñoz N, Herrera Molina R, Tapia J, Lavandero S, et al. Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alphavbeta3 integrin that activates PKCalpha and RhoA. J Cell Sci. 2009;122:3462-71 pubmed publisher
    ..Furthermore, lack of RhoA activation and astrocyte responses in the presence of a PKC inhibitor or a dominant-negative form of PKCalpha implicated PKCalpha and RhoA activation in these events...
  21. Sakuma M, Shirai Y, Yoshino K, Kuramasu M, Nakamura T, Yanagita T, et al. Novel PKC?-mediated phosphorylation site(s) on cofilin and their potential role in terminating histamine release. Mol Biol Cell. 2012;23:3707-21 pubmed
    Using specific inhibitors, kinase-negative mutants, and small interfering RNA against protein kinase C? (PKC?) or PKC?I, we find that PKC?I positively regulates degranulation in rat basophilic leukemia-2H3 cells, whereas PKC? negatively ..
  22. Tain Y, Chen C, Lee C, Kao Y, Sheen J, Yu H, et al. Melatonin regulates L-arginine transport and NADPH oxidase in young rats with bile duct ligation: role of protein kinase C. Pediatr Res. 2013;73:395-401 pubmed publisher
    ..We hypothesized that protein kinase C-? (PKC-?) is involved in the increases of L-arginine in melatonin-treated BDL rats...
  23. Ostrerova N, Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J, et al. alpha-Synuclein shares physical and functional homology with 14-3-3 proteins. J Neurosci. 1999;19:5782-91 pubmed
    ..The activity and binding profile of alpha-synuclein suggests that it might act as a protein chaperone and that accumulation of alpha-synuclein could contribute to cell death in neurodegenerative diseases. ..
  24. Wang A, Nomura M, Patan S, Ware J. Inhibition of protein kinase Calpha prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo. Circ Res. 2002;90:609-16 pubmed
    Although protein kinase C (PKC) activation is required for endothelial cell (EC) growth, migration, adhesion, and vessel formation, the role of individual PKC isoenzymes in these events is not defined...
  25. Corbit K, Trakul N, Eves E, Diaz B, Marshall M, Rosner M. Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein. J Biol Chem. 2003;278:13061-8 pubmed
    Protein kinase C (PKC) regulates activation of the Raf-1 signaling cascade by growth factors, but the mechanism by which this occurs has not been elucidated...
  26. Schanberg S, Ingledue V, Lee J, Hannun Y, Bartolome J. PKC alpha mediates maternal touch regulation of growth-related gene expression in infant rats. Neuropsychopharmacology. 2003;28:1026-30 pubmed
    ..Also, it could provide a basis for developing therapeutic interventions to maximize growth potential in children failing-to-thrive despite normal maternal care. ..
  27. Kenessey A, Sullivan E, Ojamaa K. Nuclear localization of protein kinase C-alpha induces thyroid hormone receptor-alpha1 expression in the cardiomyocyte. Am J Physiol Heart Circ Physiol. 2006;290:H381-9 pubmed
    ..rat ventricular myocytes were transduced with adenovirus (Ad) expressing wild-type (wt) or kinase-inactive (dn) PKC alpha or constitutively active (ca) PKC delta and PKC epsilon...
  28. Zhang S, Liu Y, Huang G, Liu L. Aconitine alters connexin43 phosphorylation status and [Ca2+] oscillation patterns in cultured ventricular myocytes of neonatal rats. Toxicol In Vitro. 2007;21:1476-85 pubmed
    ..These observations suggest that aconitine not only induces dephosphorylation of Cx43 and PKCalpha, but also alters intracellular [Ca(2+)] oscillation patterns in cultured cardiomyocytes. ..
  29. Luo S, Chang C, Lee I, Lee C, Lin W, Lin C, et al. Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells. Toxicol Appl Pharmacol. 2009;237:8-21 pubmed publisher
    ..Blockade of these pathways may reduce monocyte adhesion via VCAM-1 suppression and attenuation of the inflammatory responses in airway diseases. ..
  30. Rainbow R, Norman R, Everitt D, Brignell J, Davies N, Standen N. Endothelin-I and angiotensin II inhibit arterial voltage-gated K+ channels through different protein kinase C isoenzymes. Cardiovasc Res. 2009;83:493-500 pubmed publisher
    ..arterial smooth muscle (ASM) modulate arterial tone and are inhibited by vasoconstrictors through protein kinase C (PKC)...
  31. Ozturk O, Cetin A, Tokay A, Uzuner F, Tanriover G, Yesilkaya A. PDGF-? receptor and PKC have no effect on angiotensin II-induced JAK2 and STAT1 phosphorylation in vascular smooth muscle cells under high glucose condition. J Recept Signal Transduct Res. 2011;31:340-9 pubmed publisher
    ..Evidences show that platelet-derived growth factor (PDGF) and protein kinase C (PKC) play a critical role in this effect...
  32. Mohammadi K, Kometiani P, Xie Z, Askari A. Role of protein kinase C in the signal pathways that link Na+/K+-ATPase to ERK1/2. J Biol Chem. 2001;276:42050-6 pubmed
    ..To determine the role of protein kinase C (PKC) in this pathway, neonatal rat cardiac myocytes were exposed to ouabain and assayed for translocation/activation of ..
  33. Leontieva O, Black J. Identification of two distinct pathways of protein kinase Calpha down-regulation in intestinal epithelial cells. J Biol Chem. 2004;279:5788-801 pubmed
    ..It has long been recognized that members of the protein kinase C (PKC) family of signal transduction molecules undergo down-regulation in response to activation...
  34. Yutsudo Y, Kido Y, Okabayashi Y, Matsumoto M, Ogawa W, Ohba M, et al. Protein kinase Calpha is implicated in cholecystokinin-induced activation of 70-kd S6 kinase in AR42J cells. Pancreas. 2005;30:50-3 pubmed
    ..previously that cholecystokinin (CCK)-induced 70-kd S6 kinase activation is partly mediated by protein kinase C (PKC) in pancreatic acinar AR42J cells. Here, we examined which isoform of PKC is involved in this process...
  35. Rucci N, DiGiacinto C, Orrù L, Millimaggi D, Baron R, Teti A. A novel protein kinase C alpha-dependent signal to ERK1/2 activated by alphaVbeta3 integrin in osteoclasts and in Chinese hamster ovary (CHO) cells. J Cell Sci. 2005;118:3263-75 pubmed
    We identified a novel protein kinase C (PKC)alpha-dependent signal to extracellular signal-regulated kinase (ERK)1/2 in mouse osteoclasts and Chinese hamster ovary (CHO) cells, specifically activated by the alphaVbeta3 integrin...
  36. Belin R, Sumandea M, Allen E, Schoenfelt K, Wang H, Solaro R, et al. Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure. Circ Res. 2007;101:195-204 pubmed
    It is becoming clear that upregulated protein kinase C (PKC) signaling plays a role in reduced ventricular myofilament contractility observed in congestive heart failure. However, data are scant regarding which PKC isozymes are involved...
  37. Braz J, Gregory K, Pathak A, Zhao W, Sahin B, Klevitsky R, et al. PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nat Med. 2004;10:248-54 pubmed
    The protein kinase C (PKC) family of serine/threonine kinases functions downstream of nearly all membrane-associated signal transduction pathways...
  38. Schwartz I, Ingbir M, Chernichovski T, Reshef R, Chernin G, Litvak A, et al. Arginine uptake is attenuated, through post-translational regulation of cationic amino acid transporter-1, in hyperlipidemic rats. Atherosclerosis. 2007;194:357-63 pubmed
    ..We studied aortic arginine uptake, CAT-1 and CAT-2 mRNA expression, and CAT-1, and PKC alpha protein in: (a) control, untreated animals (CTL), (b) rats fed with 4% cholesterol+1% cholate and 2% corn oil ..
  39. Kashihara T, Nakayama K, Ishikawa T. Distinct roles of protein kinase C isoforms in myogenic constriction of rat posterior cerebral arteries. J Pharmacol Sci. 2008;108:446-54 pubmed
    The involvement of protein kinase C (PKC) in myogenic constriction at physiological intraluminal pressure was investigated in rat posterior cerebral arteries...
  40. Newton A. Protein kinase C: poised to signal. Am J Physiol Endocrinol Metab. 2010;298:E395-402 pubmed publisher
    Nestled at the tip of a branch of the kinome, protein kinase C (PKC) family members are poised to transduce signals emanating from the cell surface...
  41. Lum M, Pundt K, Paluch B, Black A, Black J. Agonist-induced down-regulation of endogenous protein kinase c ? through an endolysosomal mechanism. J Biol Chem. 2013;288:13093-109 pubmed publisher
    Protein kinase C (PKC) isozymes undergo down-regulation upon sustained stimulation. Previous studies have pointed to the existence of both proteasome-dependent and -independent pathways of PKC? processing...
  42. Lu Z, Liu D, Hornia A, Devonish W, Pagano M, Foster D. Activation of protein kinase C triggers its ubiquitination and degradation. Mol Cell Biol. 1998;18:839-45 pubmed
    ..with the involvement of the ubiquitin-proteasome pathway in the degradation of PKC isoforms, ubiquitinated PKC alpha, delta, and epsilon were detected within 30 min of TPA treatment...
  43. Sugden M, Langdown M. Possible involvement of PKC isoforms in signalling placental apoptosis in intrauterine growth retardation. Mol Cell Endocrinol. 2001;185:119-26 pubmed
    ..Specific protein kinase C (PKC) isoforms regulate apoptosis in other cell types...
  44. Haberman Y, Ziv I, Gorzalczany Y, Fukuda M, Sagi Eisenberg R. Classical protein kinase C(s) regulates targeting of synaptotagmin IX to the endocytic recycling compartment. J Cell Sci. 2005;118:1641-9 pubmed
    ..As such, correct targeting of Syt IX is facilitated by the phorbol ester TPA but prevented by the cPKC inhibitor Go 6976. ..
  45. Suzuki Y, Zhang H, Saito N, Kojima I, Urano T, Mogami H. Glucagon-like peptide 1 activates protein kinase C through Ca2+-dependent activation of phospholipase C in insulin-secreting cells. J Biol Chem. 2006;281:28499-507 pubmed
    ..We recently discovered that Ca(2+) influx alone can activate conventional protein kinase C (PKC) as well as novel PKC in insulin-secreting (INS-1) cells...
  46. Assender J, Gee J, Lewis I, Ellis I, Robertson J, Nicholson R. Protein kinase C isoform expression as a predictor of disease outcome on endocrine therapy in breast cancer. J Clin Pathol. 2007;60:1216-21 pubmed
    ..To define the pattern of PKC alpha and delta expression using breast cancer cell lines, with and without endocrine resistance, and also breast ..
  47. Sun S, Silver P, Caspi R, Du Y, Chan C, Wilder R, et al. Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats. Int Immunol. 1999;11:529-34 pubmed
    ..Further analysis of these genomic regions may lead to identification of the susceptibility genes and to characterization of their function. ..
  48. Elfenbein A, Rhodes J, Meller J, Schwartz M, Matsuda M, Simons M. Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway. J Cell Biol. 2009;186:75-83 pubmed publisher
    ..Thus, FGF2-induced Rac1 activation depends on the suppression of RhoG by a previously uncharacterized ternary S4-synectin-RhoGDI1 protein complex and activation via PKCalpha. ..
  49. Dykes A, Fultz M, Norton M, Wright G. Microtubule-dependent PKC-alpha localization in A7r5 smooth muscle cells. Am J Physiol Cell Physiol. 2003;285:C76-87 pubmed
    ..energy transfer (FRET), and atomic force (AFM) microscopy, we investigated association of protein kinase C (PKC)-alpha with microtubules during stimulus-induced relocalization in A7r5 smooth muscle cells...
  50. Thallas Bonke V, Thorpe S, Coughlan M, Fukami K, Yap F, Sourris K, et al. Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway. Diabetes. 2008;57:460-9 pubmed
    ..oxidase activation is closely linked to other putative pathways, its interaction with changes in protein kinase C (PKC) and increased advanced glycation was examined...
  51. Melling C, Thorp D, Milne K, Noble E. Myocardial Hsp70 phosphorylation and PKC-mediated cardioprotection following exercise. Cell Stress Chaperones. 2009;14:141-50 pubmed publisher
    Both protein kinase C (PKC) activation and Hsp70 expression have been shown to be key components for exercise-mediated myocardial protection during ischemia-reperfusion injury...
  52. Anfuso C, Lupo G, Romeo L, Giurdanella G, Motta C, Pascale A, et al. Endothelial cell-pericyte cocultures induce PLA2 protein expression through activation of PKCalpha and the MAPK/ERK cascade. J Lipid Res. 2007;48:782-93 pubmed
  53. Frasch S, Henson P, Kailey J, Richter D, Janes M, Fadok V, et al. Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta. J Biol Chem. 2000;275:23065-73 pubmed
    ..We report here that protein kinase C (PKC) delta plays an important role in activated transbilayer movement of phospholipids and surface PS exposure by ..
  54. Weichert W, Gekeler V, Denkert C, Dietel M, Hauptmann S. Protein kinase C isoform expression in ovarian carcinoma correlates with indicators of poor prognosis. Int J Oncol. 2003;23:633-9 pubmed
    ..The findings of this study, together with data from functional studies by other groups suggest that alteration of PKC isoform expression may be involved in progression of ovarian carcinomas.
  55. Metzger E, Imhof A, Patel D, Kahl P, Hoffmeyer K, Friedrichs N, et al. Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. Nature. 2010;464:792-6 pubmed publisher
    ..Activation of PKCbeta(I) requires androgen-dependent recruitment of the gatekeeper kinase protein kinase C (PKC)-related kinase 1 (PRK1)...
  56. Geiger T, Muller M, Dean N, Fabbro D. Antitumor activity of a PKC-alpha antisense oligonucleotide in combination with standard chemotherapeutic agents against various human tumors transplanted into nude mice. Anticancer Drug Des. 1998;13:35-45 pubmed
  57. Schwartz I, Chernichovski T, Krishtol N, Grupper A, Laron I, Schwartz D. Sexual dimorphism in glomerular arginine transport affects nitric oxide generation in old male rats. Am J Physiol Renal Physiol. 2009;297:F80-4 pubmed publisher
    ..Phosphorylated PKCalpha was significantly increased in old rats from both genders. alphaTocopherol, a PKC inhibitor, produced a significant increase in arginine transport and restored NO generation in old males only...
  58. Petiti J, Gutierrez S, Mukdsi J, De Paul A, Torres A. Specific subcellular targeting of PKCalpha and PKCepsilon in normal and tumoral lactotroph cells by PMA-mitogenic stimulus. J Mol Histol. 2009;40:417-25 pubmed publisher
    The variations of the intracellular localization of the individual protein kinase C (PKC) isoforms are related with their different biological functions...
  59. Yang J, Pollock J, Carmines P. NADPH oxidase and PKC contribute to increased Na transport by the thick ascending limb during type 1 diabetes. Hypertension. 2012;59:431-6 pubmed publisher
    Type 1 diabetes triggers protein kinase C (PKC)-dependent NADPH oxidase activation in the renal medullary thick ascending limb (mTAL), resulting in accelerated superoxide production...
  60. Hongpaisan J, Alkon D. A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC. Proc Natl Acad Sci U S A. 2007;104:19571-6 pubmed
    ..This memory-specific increase of mushroom spine number was enhanced by the PKC activator and candidate Alzheimer's disease therapeutic bryostatin, blocked by the PKCalpha-isozyme blocker Ro 31-..
  61. Herrera M, Silva G, Garvin J. Angiotensin II stimulates thick ascending limb superoxide production via protein kinase C(?)-dependent NADPH oxidase activation. J Biol Chem. 2010;285:21323-8 pubmed publisher
    ..is generally attributed to the AT?receptor. In some cells, Ang II stimulates protein kinase C (PKC), whose ? isoform (PKC?) can activate NADPH oxidase. We hypothesized that in TALs, Ang II stimulates O?...
  62. Tillo S, Xiong W, Takahashi M, Miao S, Andrade A, Fortin D, et al. Liberated PKA Catalytic Subunits Associate with the Membrane via Myristoylation to Preferentially Phosphorylate Membrane Substrates. Cell Rep. 2017;19:617-629 pubmed publisher
    ..We propose that activation-dependent association of PKA-C renders the membrane a unique PKA-signaling compartment. Constrained mobility of PKA-C may synergize with AKAP anchoring to determine specific PKA function in neurons. ..
  63. Fournier D, Chisamore M, Lurain J, Rademaker A, Jordan V, Tonetti D. Protein kinase C alpha expression is inversely related to ER status in endometrial carcinoma: possible role in AP-1-mediated proliferation of ER-negative endometrial cancer. Gynecol Oncol. 2001;81:366-72 pubmed
    ..We hypothesize that alterations of the PKC isozyme profile of endometrial carcinomas are similar to that of hormone-independent breast cancer and determine ..
  64. Hinken A, Hanft L, Scruggs S, Sadayappan S, Robbins J, Solaro R, et al. Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase A. J Muscle Res Cell Motil. 2012;33:439-48 pubmed publisher
    Following activation by G-protein-coupled receptor agonists, protein kinase C (PKC) modulates cardiac myocyte function by phosphorylation of intracellular targets including myofilament proteins cardiac troponin I (cTnI) and cardiac ..
  65. Hsieh Y, Jao H, Yang R, Hsu H, Hsu C. Suppression of protein kinase Calpha triggers apoptosis through down-regulation of Bcl-xL in a rat hepatic epithelial cell line. Shock. 2003;19:582-7 pubmed
    Inactivation of protein kinase C (PKC)alpha plays an important role in modulating hepatic failure and/or apoptosis during sepsis...
  66. Slater S, Malinowski S, Stubbs C. The nature of the hydrophobic n-alkanol binding site within the C1 domains of protein kinase Calpha. Biochemistry. 2004;43:7601-9 pubmed
    The activator-binding sites within the C1 domains of protein kinase C (PKC) are also able to bind alcohols and anesthetics...
  67. Boncoeur E, Bouvet G, Migneault F, Tardif V, Ferraro P, Radzioch D, et al. Induction of nitric oxide synthase expression by lipopolysaccharide is mediated by calcium-dependent PKC?-?1 in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2013;305:L175-84 pubmed publisher
    ..Ca²? chelation and protein kinase C (PKC?-?1) inhibition suppressed iNOS mRNA induction by LPS, implicating Ca²?-dependent PKC signaling in this process...
  68. Maffucci T, Raimondi C, Abu Hayyeh S, Dominguez V, Sala G, Zachary I, et al. A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation. PLoS ONE. 2009;4:e8285 pubmed publisher
    ..This occurs through protein kinase C (PKC)alpha activation since dowregulation of PKCalpha expression using specific siRNA or blockade of its activity using ..
  69. Czeredys M, Samluk Ł, Michalec K, Tułodziecka K, Skowronek K, Nałęcz K. Caveolin-1--a novel interacting partner of organic cation/carnitine transporter (Octn2): effect of protein kinase C on this interaction in rat astrocytes. PLoS ONE. 2013;8:e82105 pubmed publisher
    ..Octn2 regulation by protein kinase C (PKC) was studied in rat astrocytes--cells in which ?-oxidation takes place in the brain...
  70. Lin C, Lee I, Wu W, Liu C, Hsieh H, Hsiao L, et al. Thrombin mediates migration of rat brain astrocytes via PLC, Ca²?, CaMKII, PKC?, and AP-1-dependent matrix metalloproteinase-9 expression. Mol Neurobiol. 2013;48:616-30 pubmed publisher
    ..GPAnt2), PC-PLC (D609), PI-PLC (U73122), Ca(2+)-ATPase (thapsigargin, TG), calmodulin (CaMI), CaMKII (KN62), PKC (Gö6976 or GF109203X), MEK1/2 (PD98059), p38 MAPK (SB202190), JNK1/2 (SP600125), or AP-1 (Tanshinone IIA) or the ..
  71. Hernández Méndez A, Alcántara Hernández R, Acosta Cervantes G, Martinez Ortiz J, Avendaño Vázquez S, García Sáinz J. Conventional protein kinase C isoforms mediate phorbol ester-induced lysophosphatidic acid LPA1 receptor phosphorylation. Eur J Pharmacol. 2014;723:124-30 pubmed publisher
    ..markedly decreased the amount of conventional (?, ?I, ?II and ?) and novel (?) but not atypical (?) immunodetected PKC isoforms, this treatment blocks the action of protein kinase on receptor function and phosphorylation...
  72. Leitges M. Functional PKC in vivo analysis using deficient mouse models. Biochem Soc Trans. 2007;35:1018-20 pubmed
    The aim of our group is to identify PKC (protein kinase C) in vivo function by analysing individual PKC knockouts we have generated over the past few years...
  73. Shu Q, Zhang J, Ma W, Lei Y, Zhou D. Orexin-A promotes Glu uptake by OX1R/PKC?/ERK1/2/GLT-1 pathway in astrocytes and protects co-cultured astrocytes and neurons against apoptosis in anoxia/hypoglycemic injury in vitro. Mol Cell Biochem. 2017;425:103-112 pubmed publisher
    ..Orexin-A significantly up-regulated the expressions of PKC? and ERK1/2 under anoxia/hypoglycemic conditions in astrocytes, whereas the OX1R antagonist markedly reversed the ..
  74. Ferguson A, Bolding K, Huie J, Hook M, Santillano D, Miranda R, et al. Group I metabotropic glutamate receptors control metaplasticity of spinal cord learning through a protein kinase C-dependent mechanism. J Neurosci. 2008;28:11939-49 pubmed publisher
    ..linked to group I metabotropic glutamate receptors (subtypes mGluR1 and mGluR5) and activation of protein kinase C (PKC)...
  75. Schwartz I, Chernichovski T, Schwartz D. Aortic arginine transport is attenuated, through post-translational modulation of CAT-1 by PKCalpha, in old male rats. Vasc Med. 2010;15:55-9 pubmed publisher
    ..Phosphorylated PKCalpha was significantly increased in old rats of both sexes. alphaTocopherol, a PKC inhibitor, produced a significant increase in arginine transport in old males only...
  76. Mahadev K, Vemuri M. Selective changes in protein kinase C isoforms and phosphorylation of endogenous substrate proteins in rat cerebral cortex during pre- and postnatal ethanol exposure. Arch Biochem Biophys. 1998;356:249-57 pubmed
    The effect of pre- and postnatal ethanol exposure on protein kinase C (PKC) activity, immunochemical analysis of PKC alpha, betaI, betaII, gamma, delta, epsilon, eta, and zeta by isoform-specific antibodies, and in vitro phosphorylation ..
  77. Halet G. PKC signaling at fertilization in mammalian eggs. Biochim Biophys Acta. 2004;1742:185-9 pubmed
    Protein kinase C (PKC) has been proposed to regulate major egg activation events during mammalian fertilization...
  78. Basu N, Kole L, Basu M, Chakraborty K, Mitra P, Owens I. The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C. J Biol Chem. 2008;283:23048-61 pubmed publisher
    ..in UGTs and protein kinase Cepsilon (PKCepsilon), following treatment of LS180 cells with curcumin or the PKC inhibitor calphostin-C, suggested UGT phosphorylation is supported by active PKC(s)...
  79. Martin T, Mitin N, Cox A, Yeh J, Der C. Phosphorylation by protein kinase C? regulates RalB small GTPase protein activation, subcellular localization, and effector utilization. J Biol Chem. 2012;287:14827-36 pubmed publisher
    ..Here, we determined that RalB function is regulated by protein kinase C? (PKC?) phosphorylation...
  80. Tabuchi A, Yoshioka A, Higashi T, Shirakawa R, Nishioka H, Kita T, et al. Direct demonstration of involvement of protein kinase Calpha in the Ca2+-induced platelet aggregation. J Biol Chem. 2003;278:26374-9 pubmed
    ..Pharmacological experiments have demonstrated that protein kinase C (PKC) plays an important role in platelet aggregation...
  81. Cao J, Ding H, He J, Zhang L, Wang J, Zeng Y. [Different roles of the spinal protein kinase C alpha and gamma in morphine dependence and naloxone-precipitated withdrawal]. Sheng Li Xue Bao. 2005;57:161-8 pubmed
    ..analysis and Western blot was used to detect the expression of cytosol and membrane fraction of PKC alpha and gamma in the rat spinal cord...
  82. Viczenczová C, Szeiffova Bacova B, Egan Benova T, Kura B, Yin C, Weismann P, et al. Myocardial connexin-43 and PKC signalling are involved in adaptation of the heart to irradiation-induced injury: Implication of miR-1 and miR-21. Gen Physiol Biophys. 2016;35:215-22 pubmed publisher
    ..Implication of miR-21 that regulates expression of extracellular matrix proteins and PKC signalling that may affect Cx43-mediated coupling was examined as well...
  83. Pavan Kumar P, Purbey P, Sinha C, Notani D, Limaye A, Jayani R, et al. Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo. Mol Cell. 2006;22:231-43 pubmed
    ..We show here that phosphorylation by PKC acts as a switch to determine whether SATB1 interacts with HDAC1 or PCAF...
  84. Wientzek M, Allen B, McDonald Jones G, Katz S. Characterization of calcium-dependent forms of protein kinase C in adult rat ventricular myocytes. Mol Cell Biochem. 1997;166:11-23 pubmed
    ..Isoform-specific antisera indicated both PKC alpha and PKC beta were present...
  85. Pascale A, Amadio M, Scapagnini G, Lanni C, Racchi M, Provenzani A, et al. Neuronal ELAV proteins enhance mRNA stability by a PKCalpha-dependent pathway. Proc Natl Acad Sci U S A. 2005;102:12065-70 pubmed
    ..proteins (HuB, HuC, and HuD) are up-regulated and redistributed by 15 min of treatment with the activators of PKC phorbol esters and bryostatin-1...
  86. Zeng Z, Li Y, Jiao Z, Yao J, Xue Y. The cross talk between cGMP signal pathway and PKC in pulmonary endothelial cell angiogenesis. Int J Mol Sci. 2014;15:10185-98 pubmed publisher
    ..endothelial cells induced by TGF-?1, and that this process was reversed by PKG (protein kinase G) inhibitor and PKC (protein kinase C) inhibitor...
  87. Tokunaga C, Kuroda S, Tatematsu K, Nakagawa N, Ono Y, Kikkawa U. Molecular cloning and characterization of a novel protein kinase C-interacting protein with structural motifs related to RBCC family proteins. Biochem Biophys Res Commun. 1998;244:353-9 pubmed
    A novel protein kinase C (PKC)-interacting protein was identified by the yeast two-hybrid screening using the regulatory domain of PKC beta I as a bait...
  88. Badawi A, Liu Y, Eldeen M, Morrow W, Razak Z, Maradeo M, et al. Age-associated changes in the expression pattern of cyclooxygenase-2 and related apoptotic markers in the cancer susceptible region of rat prostate. Carcinogenesis. 2004;25:1681-8 pubmed
    ..Subsequently, COX-2 inhibitors can be considered as a promising class of agents to attenuate the increased cell survival and, hence, protect against tumorigenesis in the aging prostate. ..
  89. Hu T, Exton J. Mechanisms of regulation of phospholipase D1 by protein kinase Calpha. J Biol Chem. 2003;278:2348-55 pubmed
    It has been suggested that protein-protein interaction is important for protein kinase C (PKC) alpha to activate phospholipase D1 (PLD1)...
  90. Hsu K, Fan H, Chen Y, Huang Y, Chen C, Wu J, et al. Protein kinase C-Fyn kinase cascade mediates the oleic acid-induced disassembly of neonatal rat cardiomyocyte adherens junctions. Int J Biochem Cell Biol. 2009;41:1536-46 pubmed publisher
    ..OA induced activation of protein kinase C(PKC)-alpha and -epsilon and Src family kinase, and all three kinases were involved in the oleic acid-induced ..
  91. Dahlman I, Lorentzen J, de Graaf K, Stefferl A, Linington C, Luthman H, et al. Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern. Eur J Immunol. 1998;28:2188-96 pubmed
    ..We conclude that Cia3 and Oia2 regulate MOG-induced EAE in rats. Furthermore, since both EAE and arthritis phenotypes co-localize to these gene regions, they may harbor genes which are key regulators of pathogenic immune responses. ..
  92. Hizli A, Black A, Pysz M, Black J. Protein kinase C alpha signaling inhibits cyclin D1 translation in intestinal epithelial cells. J Biol Chem. 2006;281:14596-603 pubmed
    ..Together, these post-transcriptional effects ensure rapid disappearance of the potent mitogenic molecule cyclin D1 during PKCalpha-induced cell cycle withdrawal in the intestinal epithelium. ..
  93. Domenicotti C, Paola D, Vitali A, Nitti M, d Abramo C, Cottalasso D, et al. Glutathione depletion induces apoptosis of rat hepatocytes through activation of protein kinase C novel isoforms and dependent increase in AP-1 nuclear binding. Free Radic Biol Med. 2000;29:1280-90 pubmed
    ..damage consequent to a pathophysiologic level of GSH depletion, the effects of this condition on protein kinase C (PKC) isoforms were investigated, since these are involved in the intracellular specific regulatory processes and are ..
  94. Cardenas C, Müller M, Jaimovich E, Perez F, Buchuk D, Quest A, et al. Depolarization of skeletal muscle cells induces phosphorylation of cAMP response element binding protein via calcium and protein kinase Calpha. J Biol Chem. 2004;279:39122-31 pubmed
    ..Here we investigated whether such signals regulate CREB phosphorylation via protein kinase C (PKC)-dependent pathways...