PKC

Summary

Gene Symbol: PKC
Description: protein kinase C, alpha
Alias: Pkca, protein kinase C alpha type, PKC-A, PKC-alpha
Species: rat

Top Publications

  1. ncbi Arginine uptake is attenuated, through post-translational regulation of cationic amino acid transporter-1, in hyperlipidemic rats
    Idit F Schwartz
    Department of Nephrology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel
    Atherosclerosis 194:357-63. 2007
  2. pmc Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation
    Ranmali Nawaratne
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, UK
    Mol Endocrinol 20:1838-52. 2006
  3. ncbi Glucagon-like peptide 1 activates protein kinase C through Ca2+-dependent activation of phospholipase C in insulin-secreting cells
    Yuko Suzuki
    Department of Physiology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    J Biol Chem 281:28499-507. 2006
  4. ncbi PKC-alpha and TAK-1 are intermediates in the activation of c-Jun NH2-terminal kinase by hypoxia-reoxygenation
    Donna P Frazier
    Department of Molecular and Cellular Pharmacology, Vascular Biology Institute, University of Miami School of Medicine, Miami, Florida 33136, USA
    Am J Physiol Heart Circ Physiol 292:H1675-84. 2007
  5. ncbi The molecular heterogeneity of protein kinase C and its implications for cellular regulation
    Y Nishizuka
    Department of Biochemistry, Kobe University School of Medicine, Japan
    Nature 334:661-5. 1988
  6. pmc Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication
    P D Lampe
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Cell Biol 149:1503-12. 2000
  7. pmc Antigen-stimulated activation of phospholipase D1b by Rac1, ARF6, and PKCalpha in RBL-2H3 cells
    Dale J Powner
    Institute for Cancer Studies, Birmingham University, Birmingham, B15 2TA, United Kingdom
    Mol Biol Cell 13:1252-62. 2002
  8. ncbi Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha
    Gianfranco Alpini
    Department of Internal Medicine, Scott and White Hospital and The Texas A and M University System Health Science Center, College of Medicine and Central Texas Veterans Health Care System, Temple, TX 76504, USA
    Hepatology 35:1041-52. 2002
  9. ncbi Additional binding sites for anionic phospholipids and calcium ions in the crystal structures of complexes of the C2 domain of protein kinase calpha
    Wendy F Ochoa
    Instituto de Biologia Molecular de Barcelona CSIC, Jordi Girona Salgado 18 26, E 08034 Barcelona, Spain
    J Mol Biol 320:277-91. 2002
  10. ncbi Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity
    Gene D Lesage
    Department of Internal Medicine, Scott and White Hospital and The Texas A and M University System HSC COM, Temple, TX, USA
    Hepatology 36:641-51. 2002

Research Grants

  1. Proteomic Biomarkers of Health Behaviors
    Paul Lampe; Fiscal Year: 2005
  2. High Dose Alpha Tocopherol and Carotid Atherosclerosis
    Ishwarlal Jialal; Fiscal Year: 2004
  3. CRP, Diabetes, Atherothrombosis
    Ishwarlal Jialal; Fiscal Year: 2010
  4. PROTEIN KINASE C AND PHOTORECEPTORS
    ALEXANDRA NEWTON; Fiscal Year: 2002
  5. Prevention of Breast Cancer-Targeting COX-2 & PPARgamma
    ALAA BADAWI; Fiscal Year: 2003
  6. DAUs as IGF-1 Receptor Inhibitors in Breast Cancer
    Jack F Youngren; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications148 found, 100 shown here

  1. ncbi Arginine uptake is attenuated, through post-translational regulation of cationic amino acid transporter-1, in hyperlipidemic rats
    Idit F Schwartz
    Department of Nephrology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel
    Atherosclerosis 194:357-63. 2007
    ..We studied aortic arginine uptake, CAT-1 and CAT-2 mRNA expression, and CAT-1, and PKC alpha protein in: (a) control, untreated animals (CTL), (b) rats fed with 4% cholesterol+1% cholate and 2% corn oil ..
  2. pmc Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation
    Ranmali Nawaratne
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, UK
    Mol Endocrinol 20:1838-52. 2006
    ..Bioinformatic tools identify serine 24 (Ser24) as a putative substrate site for the protein kinase C (PKC) family of serine kinases. We demonstrate that this site is indeed a bona fide substrate for conventional PKC...
  3. ncbi Glucagon-like peptide 1 activates protein kinase C through Ca2+-dependent activation of phospholipase C in insulin-secreting cells
    Yuko Suzuki
    Department of Physiology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    J Biol Chem 281:28499-507. 2006
    ..We recently discovered that Ca(2+) influx alone can activate conventional protein kinase C (PKC) as well as novel PKC in insulin-secreting (INS-1) cells...
  4. ncbi PKC-alpha and TAK-1 are intermediates in the activation of c-Jun NH2-terminal kinase by hypoxia-reoxygenation
    Donna P Frazier
    Department of Molecular and Cellular Pharmacology, Vascular Biology Institute, University of Miami School of Medicine, Miami, Florida 33136, USA
    Am J Physiol Heart Circ Physiol 292:H1675-84. 2007
    ..Here we present evidence that protein kinase C (PKC) and transforming growth factor-beta-activated kinase-1 (TAK-1) are also components of this pathway...
  5. ncbi The molecular heterogeneity of protein kinase C and its implications for cellular regulation
    Y Nishizuka
    Department of Biochemistry, Kobe University School of Medicine, Japan
    Nature 334:661-5. 1988
    ....
  6. pmc Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication
    P D Lampe
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Cell Biol 149:1503-12. 2000
    Phorbol esters (e.g., TPA) activate protein kinase C (PKC), increase connexin43 (Cx43) phosphorylation, and decrease cell-cell communication via gap junctions in many cell types...
  7. pmc Antigen-stimulated activation of phospholipase D1b by Rac1, ARF6, and PKCalpha in RBL-2H3 cells
    Dale J Powner
    Institute for Cancer Studies, Birmingham University, Birmingham, B15 2TA, United Kingdom
    Mol Biol Cell 13:1252-62. 2002
    ..is phosphatidylinositol 4,5-bisphosphate dependent via an N-terminal PH domain and is stimulated by Rho, ARF, and PKC family proteins, combinations of which cooperatively increase this activity...
  8. ncbi Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha
    Gianfranco Alpini
    Department of Internal Medicine, Scott and White Hospital and The Texas A and M University System Health Science Center, College of Medicine and Central Texas Veterans Health Care System, Temple, TX 76504, USA
    Hepatology 35:1041-52. 2002
    ..In vitro UDCA and TUDCA inhibition of cholangiocyte growth and secretion required increased [Ca(2+)](i) and PKC alpha. In conclusion, activation of Ca(2+)-dependent PKC alpha is required for UDCA and TUDCA inhibition of ..
  9. ncbi Additional binding sites for anionic phospholipids and calcium ions in the crystal structures of complexes of the C2 domain of protein kinase calpha
    Wendy F Ochoa
    Instituto de Biologia Molecular de Barcelona CSIC, Jordi Girona Salgado 18 26, E 08034 Barcelona, Spain
    J Mol Biol 320:277-91. 2002
    ..Implications for PKCalpha activity of these structural results, in particular at the level of the binding affinity of the C2 domain to membranes, are discussed...
  10. ncbi Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity
    Gene D Lesage
    Department of Internal Medicine, Scott and White Hospital and The Texas A and M University System HSC COM, Temple, TX, USA
    Hepatology 36:641-51. 2002
    ..We evaluated (1) if insulin effects are associated with activation of PKC alpha and (2) if activation of PKC causes inhibition of secretin-stimulated cAMP levels and PKA activity...
  11. ncbi A new phosphatidylinositol 4,5-bisphosphate-binding site located in the C2 domain of protein kinase Calpha
    Senena Corbalan-Garcia
    Department de Bioquímica y Biología Molecular A, Facultad de Veterinaria, Universidad de Murcia, Apdo 4021, E 30100 Murcia, Spain
    J Biol Chem 278:4972-80. 2003
    ..The results obtained in this work point to a sequential activation model, in which protein kinase Calpha needs Ca(2+) before the PtdIns(4,5)P(2)-dependent activation of the enzyme can occur...
  12. ncbi Role of the Ca2+/phosphatidylserine binding region of the C2 domain in the translocation of protein kinase Calpha to the plasma membrane
    Stephen R Bolsover
    Department of Physiology, University College London, Gower St, United Kingdom
    J Biol Chem 278:10282-90. 2003
    Signal transduction via protein kinase C (PKC) is closely regulated by its subcellular localization...
  13. pmc The ATP-dependent membrane localization of protein kinase Calpha is regulated by Ca2+ influx and phosphatidylinositol 4,5-bisphosphate in differentiated PC12 cells
    Consuelo Marín-Vicente
    Departamento de Bioquimica y Biologia Molecular A, Facultad de Veterinaria, Universidad de Murcia, E 30100 Murcia, Spain
    Mol Biol Cell 16:2848-61. 2005
    ....
  14. ncbi Evidence that protein kinase Calpha interacts with and regulates the glial glutamate transporter GLT-1
    Marco I Gonzalez
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4318, USA
    J Neurochem 94:1180-8. 2005
    ..of the sodium-dependent neurotransmitter transporters are rapidly (within minutes) regulated by protein kinase C (PKC), with changes in activity being correlated with changes in transporter trafficking to or from the plasma membrane...
  15. doi The PtdIns(4,5)P2 ligand itself influences the localization of PKCalpha in the plasma membrane of intact living cells
    Consuelo Marín-Vicente
    Dpto de Bioquímica y Biología Molecular A, Facultad de Veterinaria, Universidad de Murcia, Apdo 4021, E 30100 Murcia, Spain
    J Mol Biol 377:1038-52. 2008
    ..In this work, we studied the effect of modulation of the PtdIns(4,5)P2 concentration on protein kinase C (PKC) alpha membrane localization in intact living cells...
  16. ncbi Protein kinase Calpha early activates splicing factor SC-35 during post-natal rat heart development
    S Zara
    Dipartimento Biomorfologia, Facolta di Farmacia, Universita G D Annunzio, Chieti Pescara, Italy
    J Biol Regul Homeost Agents 23:45-54. 2009
    ..Since the presence of Protein Kinase C (PKC) inside the nucleus could allow the enzyme to phosphorylate also proteins located on chromatin, on nuclear matrix ..
  17. ncbi Glutathione depletion induces apoptosis of rat hepatocytes through activation of protein kinase C novel isoforms and dependent increase in AP-1 nuclear binding
    C Domenicotti
    Department of Experimental Medicine, General Pathology Section, University of Genova, Genova, Italy
    Free Radic Biol Med 29:1280-90. 2000
    ..damage consequent to a pathophysiologic level of GSH depletion, the effects of this condition on protein kinase C (PKC) isoforms were investigated, since these are involved in the intracellular specific regulatory processes and are ..
  18. ncbi Alteration of protein kinase C isoforms in the liver of septic rat
    Chin Hsu
    Department of Physiology, Kaohsiung Medical University, Taiwan, ROC
    Shock 17:41-6. 2002
    The present study investigated the alteration of protein kinase C (PKC) isoforms in rat liver during the progression of sepsis...
  19. ncbi Direct binding of syndecan-4 cytoplasmic domain to the catalytic domain of protein kinase C alpha (PKC alpha) increases focal adhesion localization of PKC alpha
    Ssang Taek Lim
    Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
    J Biol Chem 278:13795-802. 2003
    ..4V; LGKKPIYKK) binds phosphatidylinositol 4,5-bisphosphate, and together they regulate protein kinase C alpha (PKC alpha) activity...
  20. ncbi [Different roles of the spinal protein kinase C alpha and gamma in morphine dependence and naloxone-precipitated withdrawal]
    Jun Li Cao
    Department of Anesthesiology, Affiliated Hospital of First Clinical College, China Medical University, Shenyang 110001, China
    Sheng Li Xue Bao 57:161-8. 2005
    ..analysis and Western blot was used to detect the expression of cytosol and membrane fraction of PKC alpha and gamma in the rat spinal cord...
  21. ncbi Nuclear localization of protein kinase C-alpha induces thyroid hormone receptor-alpha1 expression in the cardiomyocyte
    Agnes Kenessey
    Institute for Medical Research, North Shore LIJ Health System, 350 Community Dr, Manhasset, NY 11030, USA
    Am J Physiol Heart Circ Physiol 290:H381-9. 2006
    ..rat ventricular myocytes were transduced with adenovirus (Ad) expressing wild-type (wt) or kinase-inactive (dn) PKC alpha or constitutively active (ca) PKC delta and PKC epsilon...
  22. ncbi Role of cAMP-response element-binding protein phosphorylation in hepatic apoptosis under protein kinase C alpha suppression during sepsis
    Ya Ching Hsieh
    Department of Physiology, Kaohsiung Medical University, Kaohsiung, 807 Taiwan
    Shock 24:357-63. 2005
    Previous studies have shown that a decrease in protein kinase C (PKC) alpha levels contributes to hepatic failure and/or apoptosis during sepsis, and suppression of PKCalpha plays a critical role in triggering caspase-dependent apoptosis,..
  23. ncbi PKC alpha-dependent regulation of the IGF1 receptor in adult and embryonic rat cardiomyocytes
    Ruchita Maniar
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Mol Cell Biochem 275:15-24. 2005
    ..resulted in activation of the IGF1 receptor's internal tyrosine kinase, and this was completely blocked by the PKC alpha inhibitor, Gö6976...
  24. ncbi Influence of PKC-alpha overexpression on HSP70 and cardioprotection
    Sonya D Coaxum
    Cardiovascular Institute, Loyola University Medical Center, 2160 S First Avenue, Maywood, IL 60153, USA
    Am J Physiol Heart Circ Physiol 292:H2220-6. 2007
    Recent research has indicated that the protein kinase C (PKC) isoforms and the heat shock proteins (HSPs) are involved in cardioprotection. We have investigated the possible interaction between these two protein families...
  25. ncbi Protein Kinase C- alpha/betaII, delta, and zeta/lambda involvement in ethanol-induced MAPK expression in vascular smooth muscle cells
    A L Johnson
    Department of Biological Sciences, Tennessee State University, Nashville, TN 37209, USA
    Cell Mol Biol (Noisy-le-grand) 53:38-44. 2007
    Protein Kinase C (PKC) exists as one of twelve serine/threonine isoforms and has been found to mediate ethanol-induced activation of the Mitogen-Activated Protein Kinase (MAPK) pathway...
  26. ncbi Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition
    Katherine Holmes
    North West Cancer Research Fund Institute, School of Biological Sciences, College of Natural Sciences, University of Wales, Bangor, UK
    Cell Signal 19:2003-12. 2007
    ..Furthermore, therapeutic inhibition of VEGFR-2 action is now having an impact in the clinic for the treatment of a number of diseases...
  27. pmc Myocardial Hsp70 phosphorylation and PKC-mediated cardioprotection following exercise
    C W James Melling
    School of Kinesiology, Faculty of Health Sciences, The University of Western Ontario, London, Ontario, Canada
    Cell Stress Chaperones 14:141-50. 2009
    Both protein kinase C (PKC) activation and Hsp70 expression have been shown to be key components for exercise-mediated myocardial protection during ischemia-reperfusion injury...
  28. doi Down-regulating protein kinase C alpha: functional cooperation between the proteasome and the endocytic system
    Semyon Melnikov
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel
    Cell Signal 21:1607-19. 2009
    Ubiquitination, proteasome, caveolae and endosomes have been implicated in controlling protein kinase C alpha (PKC alpha) down-regulation. However, the molecular mechanism remained obscure...
  29. pmc cAMP stimulates apical exocytosis of the renal Na(+)-K(+)-2Cl(-) cotransporter NKCC2 in the thick ascending limb: role of protein kinase A
    Paulo S Caceres
    Hypertension and Vascular Research Division, Henry Ford Hospital, Wayne State University, Detroit, Michigan 48202, USA
    J Biol Chem 284:24965-71. 2009
    ..We conclude that cAMP stimulates steady-state apical surface NKCC2 by stimulating exocytic insertion and that this process is highly dependent on PKA but not Epac...
  30. doi Cigarette smoke extract induced rat pulmonary artery smooth muscle cells proliferation via PKCα-mediated cyclin D1 expression
    Da Xiong Zeng
    Key Laboratory of Pulmonary Diseases of Ministry of Health, Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    J Cell Biochem 112:2082-8. 2011
    ..Although our previous study had implied the involvement of protein kinase Cα (PKCα), the molecular mechanism underlying PKCα pathway in this process is still unknown...
  31. pmc Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase A
    Aaron C Hinken
    Department of Physiology and Biophysics and Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    J Muscle Res Cell Motil 33:439-48. 2012
    Following activation by G-protein-coupled receptor agonists, protein kinase C (PKC) modulates cardiac myocyte function by phosphorylation of intracellular targets including myofilament proteins cardiac troponin I (cTnI) and cardiac ..
  32. pmc Agonist-induced down-regulation of endogenous protein kinase c α through an endolysosomal mechanism
    Michelle A Lum
    The Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198 5950, USA
    J Biol Chem 288:13093-109. 2013
    Protein kinase C (PKC) isozymes undergo down-regulation upon sustained stimulation. Previous studies have pointed to the existence of both proteasome-dependent and -independent pathways of PKCα processing...
  33. pmc Phosphatidylinositol 4,5-bisphosphate decreases the concentration of Ca2+, phosphatidylserine and diacylglycerol required for protein kinase C α to reach maximum activity
    Antonio L Egea-Jiménez
    Departamento de Bioquimica y Biologia Molecular A, Facultad de Veterinaria, Regional Campus of International Excellence Campus Mare Nostrum, Universidad de Murcia, Murcia, Spain
    PLoS ONE 8:e69041. 2013
    The C2 domain of PKCα possesses two different binding sites, one for Ca(2+) and phosphatidylserine and a second one that binds PIP2 with very high affinity...
  34. pmc Role of PKCα activation of Src, PI-3K/AKT, and ERK in EGF-stimulated proliferation of rat and human conjunctival goblet cells
    Dayu Li
    Schepens Eye Research Institute Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts
    Invest Ophthalmol Vis Sci 54:5661-74. 2013
    ..To determine the order and components of the signaling pathway utilized by epidermal growth factor (EGF) to stimulate conjunctival goblet cell proliferation...
  35. pmc Caveolin-1--a novel interacting partner of organic cation/carnitine transporter (Octn2): effect of protein kinase C on this interaction in rat astrocytes
    Magdalena Czeredys
    Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Warsaw, Poland
    PLoS ONE 8:e82105. 2013
    ..Octn2 regulation by protein kinase C (PKC) was studied in rat astrocytes--cells in which β-oxidation takes place in the brain...
  36. doi Nrf2-regulated antioxidant response is activated by protein kinase C in postconditioned rat hearts
    Mabel Buelna-Chontal
    Department of Cardiovascular Biomedicine, National Institute of Cardiology I Ch, Mexico City 14080, DF, Mexico
    Free Radic Biol Med 74:145-56. 2014
    ..To unravel such association, in this work we focus on the participation of protein kinase C (PKC) and the transcription factor nuclear factor E2-related factor 2 (Nrf2) in the cardioprotective response elicited ..
  37. pmc Protein kinase C-mediated phosphorylation of RKIP regulates inhibition of Na-alanine cotransport by leukotriene D(4) in intestinal epithelial cells
    Subha Arthur
    Department of Clinical and Translational Sciences, Joan C Edwards School of Medicine, Marshall University, Huntington, West Virginia
    Am J Physiol Cell Physiol 307:C1010-6. 2014
    ..the present study, pretreatment with calcium chelator BAPTA-AM or inhibition of Ca(++)-dependent protein kinase C (PKC), specifically PKCα, resulted in the reversal of LTD4-mediated inhibition of ASCT1, revealing the involvement of ..
  38. doi Protein kinase Cα inhibits myocardin-induced cardiomyocyte hypertrophy through the promotion of myocardin phosphorylation
    Weizong Li
    Key Laboratory of Industrial Microbiology, Ministry of Education and Tianjin City, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
    Acta Biochim Biophys Sin (Shanghai) 47:687-95. 2015
    ..The expression of protein kinase Cα (PKCα) also induces cardiac hypertrophy...
  39. doi Orexin-A promotes Glu uptake by OX1R/PKCα/ERK1/2/GLT-1 pathway in astrocytes and protects co-cultured astrocytes and neurons against apoptosis in anoxia/hypoglycemic injury in vitro
    Qing Shu
    Department of Pharmacy, Ninth Hospital of Xi an, No 151 South Second Ring Road East, Xi an, 710054, Shaanxi, China
    Mol Cell Biochem 425:103-112. 2017
    ..Orexin-A significantly up-regulated the expressions of PKCα and ERK1/2 under anoxia/hypoglycemic conditions in astrocytes, whereas the OX1R antagonist markedly reversed the ..
  40. doi Melatonin regulates L-arginine transport and NADPH oxidase in young rats with bile duct ligation: role of protein kinase C
    You Lin Tain
    Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Pediatr Res 73:395-401. 2013
    ..We hypothesized that protein kinase C-α (PKC-α) is involved in the increases of L-arginine in melatonin-treated BDL rats...
  41. ncbi Role of two conserved cytoplasmic threonine residues (T410 and T412) in CD5 signaling
    J M Vila
    Servei d Immunologia, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    J Immunol 166:396-402. 2001
    ..These results strongly argue in favor of a role for T410 and T412 in the signaling mediated by CD5...
  42. ncbi Protein kinase C alpha expression is inversely related to ER status in endometrial carcinoma: possible role in AP-1-mediated proliferation of ER-negative endometrial cancer
    D B Fournier
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Gynecol Oncol 81:366-72. 2001
    ..We hypothesize that alterations of the PKC isozyme profile of endometrial carcinomas are similar to that of hormone-independent breast cancer and determine ..
  43. ncbi Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression
    Jing Du
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 24:6578-89. 2004
    ....
  44. ncbi Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaII
    Maria Nikodemova
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 282:15208-16. 2007
    ..Further experiments revealed that MHC II expression is down-regulated in the presence of the PKC(alpha) inhibitor Gö6976...
  45. ncbi [Effects of free fatty acids on insulin signaling proteins in rat islet cells]
    Qi Yu Guo
    Departmnent of Endocrinology, Navy General Hospital, Beijing 100037, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 18:283-6. 2002
    ..To investigate whether free fatty acid impair insulin signaling proteins to inhibit insulin action in rat islet cells...
  46. pmc pPKCα mediated-HIF-1α activation related to the morphological modifications occurring in neonatal myocardial tissue in response to severe and mild hyperoxia
    S Zara
    Section of Human Anatomy, Faculty of Pharmacy, University G D Annunzio Chieti Pescara, Via dei Vestini 31, 66100 Chieti, Italy
    Eur J Histochem 56:e2. 2012
    ..Upstream pPKC-α expression increase in newborn rats exposed to 95% oxygen can suggest PKC involvement in HIF-1α activation...
  47. pmc PKCα is required for inflammation-induced trafficking of extrasynaptic AMPA receptors in tonically firing lamina II dorsal horn neurons during the maintenance of persistent inflammatory pain
    Olga Kopach
    State Key Laboratory of Molecular and Cellular Biology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    J Pain 14:182-92. 2013
    ..that internalization of synaptic GluR2-containing AMPARs requires activation of spinal cord protein kinase C alpha (PKCα), but molecular mechanisms that underlie altered trafficking of extrasynaptic AMPARs are unclear...
  48. ncbi The common structure and activities of four subspecies of rat brain protein kinase C family
    U Kikkawa
    Department of Biochemistry, Kobe University School of Medicine, Japan
    FEBS Lett 223:212-6. 1987
    ..gamma-Subspecies is expressed after birth apparently only in the central nervous tissue, implying its role in the regulation of specific neuronal functions...
  49. ncbi Invasive human pituitary tumors express a point-mutated alpha-protein kinase-C
    V Alvaro
    Centre CNRS INSERM de Pharmacologie et d Endocrinologie, Montpellier, France
    J Clin Endocrinol Metab 77:1125-9. 1993
    ..6-fold), suggesting a dysfunction in PKC in these tumors. Here, we show that the PKC alpha-isoform (alpha PKC) is overexpressed in human pituitary tumors...
  50. ncbi Molecular cloning and characterization of a novel protein kinase C-interacting protein with structural motifs related to RBCC family proteins
    C Tokunaga
    Biosignal Research Center, Faculty of Science, Kobe University, Japan
    Biochem Biophys Res Commun 244:353-9. 1998
    A novel protein kinase C (PKC)-interacting protein was identified by the yeast two-hybrid screening using the regulatory domain of PKC beta I as a bait...
  51. ncbi Phase I study of an antisense oligonucleotide to protein kinase C-alpha (ISIS 3521/CGP 64128A) in patients with cancer
    A R Yuen
    Oncology Division, Stanford University School of Medicine, California 94305, USA
    Clin Cancer Res 5:3357-63. 1999
    Protein kinase C (PKC) is an attractive target in cancer therapy. It is overexpressed in a variety of cancers, and nonspecific inhibitors of PKC have demonstrated antitumor activity...
  52. ncbi PICK1 interacts with and regulates PKC phosphorylation of mGLUR7
    K K Dev
    Department of Biological Sciences, Kyoto University, Faculty of Medicine, Kyoto, 606 8501, Japan
    J Neurosci 20:7252-7. 2000
    ..been shown to bind protein kinase C alpha-subunit (PKCalpha), and mGluR7a is known to be phosphorylated by PKC. We show a relationship between these three proteins using recombinant PICK1, mGluR7, and PKCalpha, where they were ..
  53. ncbi Possible involvement of PKC isoforms in signalling placental apoptosis in intrauterine growth retardation
    M C Sugden
    Department of Diabetes and Metabolic Medicine, Division of General and Developmental Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary, University of London, London E1 4NS, UK
    Mol Cell Endocrinol 185:119-26. 2001
    ..Specific protein kinase C (PKC) isoforms regulate apoptosis in other cell types...
  54. ncbi Protein kinase C (PKC) delta regulates PKCalpha activity in a Syndecan-4-dependent manner
    Masahiro Murakami
    Angiogenesis Research Center and Section of Cardiology, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Biol Chem 277:20367-71. 2002
    ..4,5-bisphosphate (PIP(2)), the capacity of the tail to multimerize, and its ability to activate protein kinase C (PKC) alpha...
  55. ncbi Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor
    Yuji Saito
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 277:23216-22. 2002
    ..Studies using antisense protein kinase C (PKC) oligonucleotides and specific inhibitors showed that PKCalpha and PKCepsilon are required for Gab1 tyrosine ..
  56. ncbi Decreased cholinergic stimulation of insulin secretion by islets from rats fed a low protein diet is associated with reduced protein kinase calpha expression
    Fabiano Ferreira
    Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, SP, Brasil
    J Nutr 133:695-9. 2003
    ..In conclusion, a reduced expression of PKCalpha and PLCbeta(1) may be involved in the decreased insulin secretion by islets from LP rats after stimulation with CCh and PMA...
  57. ncbi Alterations in protein kinase C isoenzyme expression and autophosphorylation during the progression of pressure overload-induced left ventricular hypertrophy
    Allison L Bayer
    The Cardiovascular Institute and Department of Physiology, Loyola University Chicago Stritch School of Medicine, Maywood, IL 60153, USA
    Mol Cell Biochem 242:145-52. 2003
    Cardiomyocytes express several isoenzymes of protein kinase C (PKC), which as a group have been implicated in the induction of left ventricular hypertrophy (LVH) and its transition to heart failure...
  58. ncbi PKC alpha mediates maternal touch regulation of growth-related gene expression in infant rats
    Saul M Schanberg
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 28:1026-30. 2003
    ..Also, it could provide a basis for developing therapeutic interventions to maximize growth potential in children failing-to-thrive despite normal maternal care...
  59. ncbi Protein kinase C isoform expression in ovarian carcinoma correlates with indicators of poor prognosis
    Wilko Weichert
    Institute of Pathology, Charite Hospital, Schumannstrasse 20 21, 10117 Berlin, Germany
    Int J Oncol 23:633-9. 2003
    ..The findings of this study, together with data from functional studies by other groups suggest that alteration of PKC isoform expression may be involved in progression of ovarian carcinomas.
  60. ncbi Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism
    Claudia Miele
    Dipartimento di Biologia e Patologia Cellulare e Molecolare and Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Universita di Napoli Federico II, Via S Pansini, 5, 80131 Naples, Italy
    J Biol Chem 278:47376-87. 2003
    ..The use of antibodies specific to PKC isoforms shows that this effect appears to be mediated by activated PKC alpha, independent of reactive oxygen species production...
  61. ncbi Protein kinase C alpha requirement in the activation of p38 mitogen-activated protein kinase, which is linked to the induction of tumor necrosis factor alpha in lipopolysaccharide-stimulated microglia
    Kazuyuki Nakajima
    Neurobiology Lab, Department of Bioinformatics, Faculty of Engineering, Soka University, 1 236 Tangi machi, Hachioji, Tokyo 192 8577, Japan
    Neurochem Int 44:205-14. 2004
    ..These results suggest that PKC alpha activity as well as p38MAPK activity is associated with TNF alpha induction in LPS-stimulated microglia...
  62. ncbi The essential role of PKCalpha in the protective effect of heat-shock pretreatment on TNFalpha-induced apoptosis in hepatic epithelial cell line
    Rei Cheng Yang
    Department of Pediatrics, Chung Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Exp Cell Res 296:276-84. 2004
    ..that hepatic apoptosis during sepsis may be due to the failure to induce expression of Hsp72, which is activated by PKC-phosphorylated HSF...
  63. ncbi Protein kinase Calpha translocates to the perinuclear region to activate phospholipase D1
    Tianhui Hu
    Howard Hughes Medical Institute and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA
    J Biol Chem 279:35702-8. 2004
    The inhibition of phorbol ester activation of phospholipase D1 (PLD1) by protein kinase C (PKC) inhibitors has been considered proof of phosphorylation-dependent activation of PLD1 by PKCalpha...
  64. ncbi Depolarization of skeletal muscle cells induces phosphorylation of cAMP response element binding protein via calcium and protein kinase Calpha
    Cesar Cardenas
    Centro de Estudios Moleculares de la Célula, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 7, Chile
    J Biol Chem 279:39122-31. 2004
    ..Here we investigated whether such signals regulate CREB phosphorylation via protein kinase C (PKC)-dependent pathways...
  65. ncbi Protein kinase C-alpha-induced hypertrophy of neonatal rat ventricular myocytes
    Kalpana Vijayan
    Cardiovascular Institute, Loyola Univ Medical Center, Bldg 110, Rm 5232, 2160 S First Ave, Maywood, IL 60153, USA
    Am J Physiol Heart Circ Physiol 287:H2777-89. 2004
    Protein kinase C (PKC) isoenzymes play a critical role in cardiomyocyte hypertrophy...
  66. ncbi Regulation of protein kinase C isozymes in volume overload cardiac hypertrophy
    Martin U Braun
    Department of Cardiology, Medical Clinic II, University of Technology Dresden, Germany
    Mol Cell Biochem 262:135-43. 2004
    Protein kinase C (PKC) is a family of at least 11 isozymes and known to play a crucial role in myocardial growth...
  67. ncbi Protein kinase C isozymes in hypertension and hypertrophy: insight from SHHF rat hearts
    Dustin D Johnsen
    Cardiovascular Research Institute, University of South Dakota and Sioux Valley Hospital and Health Systems, Sioux Falls, South Dakota 57105, USA
    Mol Cell Biochem 270:63-9. 2005
    Chronic hypertension results in cardiac hypertrophy and may lead to congestive heart failure. The protein kinase C (PKC) family has been identified as a signaling component promoting cardiac hypertrophy...
  68. ncbi Prostaglandin E2 stimulates fibronectin expression through EP1 receptor, phospholipase C, protein kinase Calpha, and c-Src pathway in primary cultured rat osteoblasts
    Chih Hsin Tang
    Departments of Pharmacology and Orthopaedics, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Biol Chem 280:22907-16. 2005
    ..Protein kinase C (PKC) inhibitor (GF109203X) also inhibited the potentiating action of PGE(2)...
  69. ncbi Role of protein kinase C-alpha in superficial bladder carcinoma recurrence
    Chuize Kong
    Department of Urology, No 1 Hospital, China Medical University, Shenyang, People s Republic of China
    Urology 65:1228-32. 2005
    ..To investigate the role of protein kinase C-alpha (PKCalpha) in the recurrence of superficial bladder carcinoma...
  70. ncbi [The role of protein kinase C alpha in recurrence of superficial bladder carcinoma]
    Yu yan Zhu
    Department of Urology, The First Affiliated Hospital, China Medical University, Shenyang 110001, China
    Zhonghua Wai Ke Za Zhi 43:662-6. 2005
    ..To investigate the relationship of protein kinase C-alpha (PKCalpha) expression/activation with tumor differentiation and resistance to chemotherapy drugs in superficial bladder carcinoma...
  71. ncbi Retinoic acid as a modulator of the activity of protein kinase Calpha
    María José López-Andreo
    Departamento de Bioquimica y Biologia Molecular A, Facultad de Veterinaria, Universidad de Murcia, Apartado de Correos 4021, E 30080 Murcia, Spain
    Biochemistry 44:11353-60. 2005
    ....
  72. ncbi Effects of blocking the renin-angiotensin system on expression and translocation of protein kinase C isoforms in the kidney of diabetic rats
    Li Zhang
    Department of Nephrology, First Affiliated Hospital of Nanjing Medical University, Jiangsu, China
    Nephron Exp Nephrol 104:e103-11. 2006
    High glucose and angiotensin II (Ang II) can activate protein kinase C (PKC) in diabetes mellitus. However, it is not clear which isoform of PKC is activated by glucose or Ang II...
  73. ncbi Expression of protein kinase C isoforms in cardiac hypertrophy and heart failure due to volume overload
    Emmanuelle Sentex
    Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre and Department of Physiology, Faculty of Medicine University of Manitoba, 351 Tache Avenue, Winnipeg, MB R2H 2A6, Canada
    Can J Physiol Pharmacol 84:227-38. 2006
    The present study determined whether changes in the activity and isoforms of protein kinase C (PKC) are associated with cardiac hypertrophy and heart failure owing to volume overload induced by aortocaval shunt (AVS) in rats...
  74. ncbi Involvement of PKCalpha in insulin-induced PKCdelta expression: Importance of SP-1 and NFkappaB transcription factors
    Miriam Horovitz-Fried
    The Faculty of Life Sciences, Department of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Biochem Biophys Res Commun 352:78-83. 2007
    ..Inhibition of PKCdelta reduced IkappaBalpha phosphorylation as well as NFkappaB activation. Thus, PKCalpha regulates insulin-induced PKCdelta expression levels and this regulation involves activation of SP-1 and NFkappaB...
  75. ncbi Persistent activation of protein kinase Calpha is not necessary for expression of cerebellar long-term depression
    S Tsuruno
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Mol Cell Neurosci 35:38-48. 2007
    ..The sequential activation model for classical PKC states that PKCalpha translocates to the plasma membrane by binding Ca(++) and then becomes fully activated by ..
  76. ncbi Expression of specific protein kinase C (PKC) isoforms and ligand-specific activation of PKCalpha in late gestation fetal lung
    Dina Villanueva-García
    Division of Neonatology, Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico
    Exp Lung Res 33:185-96. 2007
    ..The authors hypothesized that specific protein kinase C (PKC) isoforms are expressed and activated by epidermal growth factor (EGF) and transforming growth factor alpha (..
  77. pmc Differential phosphorylation of NG2 proteoglycan by ERK and PKCalpha helps balance cell proliferation and migration
    Irwan T Makagiansar
    Cancer Center, The Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    J Cell Biol 178:155-65. 2007
    ..Thus, phosphorylation and the resulting site of NG2-integrin localization may determine the specific downstream effects of integrin signaling...
  78. ncbi Mitochondrial protein phosphatase 2A regulates cell death induced by simulated ischemia in kidney NRK-52E cells
    Chun Chui Tsao
    Division of Cell Signaling, Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center, Houston, Texas, USA
    Cell Cycle 6:2377-85. 2007
    ..Previous data have shown that PKC alpha negatively regulates B56 alpha protein expression...
  79. ncbi nPKCepsilon, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells
    Camille Ehre
    CCystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599 7248, USA
    Am J Physiol Cell Physiol 293:C1445-54. 2007
    ..acting through Gq/PLC, inositol-1,4,5-trisphosphate (IP(3)), diacylglycerol, Ca(2+) and protein kinase C (PKC)...
  80. ncbi In vitro evidence of the role of hemoglobin during vasospasm on the modifications of the expression of PKCalpha and zeta
    Florence Lefranc
    Department of Neurosurgery, Erasme University Hospital, Brussels, Belgium
    Int J Mol Med 20:415-9. 2007
    ..vasospasm after subarachnoid hemorrhage (SAH) are poorly understood, although the family of protein kinase C (PKC) is already known to play crucial roles in this pathology...
  81. ncbi Effect of phorbol ester and platelet-derived growth factor on protein kinase C in rat hepatic stellate cells
    Yoshimasa Kobayashi
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University Liver Center, Saint Louis University School of Medicine, St Louis, MO, USA
    Liver Int 27:1066-75. 2007
    ..This study investigated the expression and regulation of protein kinase C (PKC) in HSC.
  82. ncbi H2S preconditioning-induced PKC activation regulates intracellular calcium handling in rat cardiomyocytes
    Ting Ting Pan
    Cardiovascular Biology Research Group, Department of Pharmacology, National University of Singapore, Singapore
    Am J Physiol Cell Physiol 294:C169-77. 2008
    The present study was aimed to investigate the regulatory effect of protein kinase C (PKC) on intracellular Ca(2+) handling in hydrogen sulfide (H(2)S)-preconditioned cardiomyocytes and its consequent effects on ischemia challenge...
  83. ncbi Signaling mechanisms of daidzein-induced axonal outgrowth in hippocampal neurons
    Pei Wang
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei 10051, Taiwan
    Biochem Biophys Res Commun 366:393-400. 2008
    ..Taken together, our data suggest that Dz triggers an ERbeta/PKCalpha/GAP-43 signaling cascade to promote axonal outgrowths in cultured hippocampal neurons...
  84. ncbi Role of protein kinase C alpha and cyclin D1 in the proliferation of airway smooth muscle in asthmatic rats
    Li Fen Qiao
    Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    Chin Med J (Engl) 121:2070-6. 2008
    ..In this study, the central role of PKCalpha and cyclin D1 in ASM proliferation in asthmatic rats was explored...
  85. doi Protein kinase C-Fyn kinase cascade mediates the oleic acid-induced disassembly of neonatal rat cardiomyocyte adherens junctions
    Kwan Lih Hsu
    Department of Internal Medicine, E Da Hospital, Department of Nursing, I Shou University, Kaohsiung, Taiwan
    Int J Biochem Cell Biol 41:1536-46. 2009
    ..OA induced activation of protein kinase C(PKC)-alpha and -epsilon and Src family kinase, and all three kinases were involved in the oleic acid-induced ..
  86. ncbi Transient upregulation of protein kinase C in pressure-overloaded neonatal rat myocardium
    B Hamplova
    Charles University, Faculty of Science, Department of Cell Biology, Prague, Czech Republic
    Physiol Res 59:25-33. 2010
    Protein kinase C (PKC) appears to play a significant role in the signal transduction of cardiac growth and development...
  87. doi Involvement of Cpi-17 and zipper-interacting protein kinase in the regulation of protein kinase C-alpha, protein kinase C-epsilon on vascular calcium sensitivity after hemorrhagic shock
    Jing Xu
    State Key Laboratory of Trauma, Burns and Combined Injury, The 2nd Department of Research Institute of Surgery, Daping Hospital, People s Republic of China
    Shock 33:49-55. 2010
    Our previous studies have found that protein kinase C (PKC) alpha and epsilon take part in the regulation of calcium sensitization and vascular reactivity after hemorrhagic shock. However, the regulatory mechanism is still unclear...
  88. doi Endothelin-I and angiotensin II inhibit arterial voltage-gated K+ channels through different protein kinase C isoenzymes
    Richard D Rainbow
    Department of Cardiovascular Sciences, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Cardiovasc Res 83:493-500. 2009
    ..arterial smooth muscle (ASM) modulate arterial tone and are inhibited by vasoconstrictors through protein kinase C (PKC)...
  89. doi Activated PKCalpha/ERK1/2 signaling inhibits tamoxifen-induced apoptosis in C6 cells
    Fen Tian
    Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, Guangdong Province, China
    Cancer Invest 27:802-8. 2009
    ....
  90. doi The activation of matrix metalloproteinase-2 induced by protein kinase C alpha in decidualization
    Jen Hsiang Tsai
    Department of Physical Therapy, School of Medical and Health Sciences, Fooyin University, Kaohsiung 83102, Taiwan
    J Cell Biochem 108:547-54. 2009
    ..To further investigate the correlation between MMP-2 and protein kinase C alpha (PKC alpha), the expression of MMP-2 in the 12-O-tetradecanoylphorbol 13-acetate (TPA)-treated organotypic culture of ..
  91. pmc PKC-alpha mediates flow-stimulated superoxide production in thick ascending limbs
    Nancy J Hong
    Department of Internal Medicine, Hypertension and Vascular Research Division, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202, USA
    Am J Physiol Renal Physiol 298:F885-91. 2010
    ..Protein kinase C (PKC) activates NADPH oxidase activity in phagocytes, cardiomyocytes, aortic endothelial cells, vascular smooth muscle ..
  92. ncbi [Protective effects of hypoxia-inducible factor-1 alpha on myocardial ischemia/reperfusion injury in rat and the role of protein kinase C in signal pathway]
    Tie Sheng Niu
    Department of Cardiology, the Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:101-4. 2010
    To study the expression of hypoxia-inducible factor-1 alpha (HIF-1 alpha) in a rat model of myocardial ischemia/reperfusion injury (IRI) and the role of protein kinase C (PKC) in signal pathway.
  93. ncbi [Role of protein kinase C in protecting rats against pulmonary ischemia reperfusion injury through opening of mitochondrial ATP sensitive potassium channel]
    De Qin Lu
    Department of Pathophysiology, Guiyang Medical College, Guiyang 550004, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 41:436-40. 2010
    To investigate the effect of opening of mitochondrial ATP-sensitive potassium channel on inducing lung protection against ischemia reperfusion injury (I/R) and the role of PKC in the protective effect.
  94. doi ATP enhances neuronal differentiation of PC12 cells by activating PKCα interactions with cytoskeletal proteins
    Consuelo Marín-Vicente
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    J Proteome Res 10:529-40. 2011
    b>PKCα is a key mediator of the neuronal differentiation controlled by NGF and ATP. However, its downstream signaling pathways remain to be elucidated...
  95. pmc Early endosomal antigen 1 (EEA1) is an obligate scaffold for angiotensin II-induced, PKC-alpha-dependent Akt activation in endosomes
    Rafal Robert Nazarewicz
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 286:2886-95. 2011
    ..Both Akt and phosphorylated Akt (p-Akt) interact with EEA1. We also found that PKC-α is required for organizing Ang II-induced, EEA1-dependent Akt phosphorylation in VSMC early endosomes...
  96. pmc Nucleotide sequences of cDNAs for alpha and gamma subspecies of rat brain protein kinase C
    Y Ono
    Central Research Division, Takeda Chemical Industries, Osaka, Japan
    Nucleic Acids Res 16:5199-200. 1988
  97. ncbi Characterization of calcium-dependent forms of protein kinase C in adult rat ventricular myocytes
    M Wientzek
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
    Mol Cell Biochem 166:11-23. 1997
    ..Isoform-specific antisera indicated both PKC alpha and PKC beta were present...
  98. ncbi Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart
    N Bowling
    Cardiovascular Research, Eli Lilly and Co, Indianapolis, Ind 46285 0520, USA
    Circulation 99:384-91. 1999
    Increased expression of Ca2+-sensitive protein kinase C (PKC) isoforms may be important markers of heart failure. Our aim was to determine the relative expression of PKC-beta1, -beta2, and -alpha in failed and nonfailed myocardium.
  99. ncbi PKC-alpha shows variable patterns of translocation in response to different stimulatory agents
    C Li
    Department of Physiology, The Joan Edwards School of Medicine, Marshall University, Huntington, WV 25704, USA
    Acta Physiol Scand 174:237-46. 2002
    ..2001). Confocal microscopy and PKC alpha-enhanced green fluorescent protein (PKC alpha-EGFP) fusion protein expression were utilized to investigate the ..
  100. ncbi Molecular characterization of protein kinase C-alpha binding to lamin A
    Alberto M Martelli
    Dipartimento di Scienze Anatomiche Umane e Fisiopatologia dell Apparato Locomotore, Sezione di Anatomia Umana, Cell Signaling Laboratory, Universita di Bologna, Via Irnerio 48, Italy
    J Cell Biochem 86:320-30. 2002
    Previous results from our laboratory have identified lamin A as a protein kinase C (PKC)-binding protein. Here, we have identified the regions of PKC-alpha that are crucial for this binding...

Research Grants6

  1. Proteomic Biomarkers of Health Behaviors
    Paul Lampe; Fiscal Year: 2005
    ..abstract_text> ..
  2. High Dose Alpha Tocopherol and Carotid Atherosclerosis
    Ishwarlal Jialal; Fiscal Year: 2004
    ..This study has the additional novelty of correlating biomarkers of oxidative stress and inflammation with a cardiovascular endpoint and will establish whether high dose AT decreases atherosclerosis progression. ..
  3. CRP, Diabetes, Atherothrombosis
    Ishwarlal Jialal; Fiscal Year: 2010
    ..CRP augments oxidative stress and inflammation in the diabetic milieu will eventually lead to therapies targeted at reducing inflammation and oxidative stress in diabetes and resulting in a decrease in vasculopathies ..
  4. PROTEIN KINASE C AND PHOTORECEPTORS
    ALEXANDRA NEWTON; Fiscal Year: 2002
    ..Specifically, the effect of this phosphorylation on rhodopsin s macromolecular interactions (transducin coupling, arrestin binding) will be explored. ..
  5. Prevention of Breast Cancer-Targeting COX-2 & PPARgamma
    ALAA BADAWI; Fiscal Year: 2003
    ..abstract_text> ..
  6. DAUs as IGF-1 Receptor Inhibitors in Breast Cancer
    Jack F Youngren; Fiscal Year: 2010
    ..other kinases, and characterize the biological effects of altering the specificity of DAUs for the IGF-1 R. Together these studies will result in the production of well-characterized DAU-based compounds for anti-cancer drug development. ..