Gene Symbol: Pip5k1b
Description: phosphatidylinositol-4-phosphate 5-kinase type 1 beta
Alias: Pip5k1a, phosphatidylinositol 4-phosphate 5-kinase type-1 beta, PIP5K1-beta, PIP5KIalpha, PIP5KIbeta, phosphatidylinositol 4-phosphate 5-kinase type I alpha, phosphatidylinositol 4-phosphate 5-kinase type I beta, phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha, ptdIns(4)P-5-kinase 1 beta, ptdIns(4)P-5-kinase beta
Ishihara H, Shibasaki Y, Kizuki N, Katagiri H, Yazaki Y, Asano T, et al
. Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem. 1996;271:23611-4 pubmed
..Molecular identification of type I PI4P5K isoforms in insulin-secreting cells should provide insights into the role of phosphatidylinositol metabolism in regulated exocytosis of insulin-containing large dense core vesicles. ..
Vasudevan L, Jeromin A, Volpicelli Daley L, De Camilli P, Holowka D, Baird B. The beta- and gamma-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells. J Cell Sci. 2009;122:2567-74 pubmed publisher
Lee S, Kim B, Yoon S, Kim Y, Liu T, Woo J, et al
. Phosphatidylinositol 4-phosphate 5-kinase alpha is induced in ganglioside-stimulated brain astrocytes and contributes to inflammatory responses. Exp Mol Med. 2010;42:662-73 pubmed
..Together, these results suggest that PIP5K alpha is a novel inflammatory mediator that undergoes upregulation and contributes to immune responses by facilitating NF-kappaB activation in ganglioside-stimulated astrocytes. ..
Manes S, Fuentes G, Peregil R, Rojas A, Lacalle R. An isoform-specific PDZ-binding motif targets type I PIP5 kinase beta to the uropod and controls polarization of neutrophil-like HL60 cells. FASEB J. 2010;24:3381-92 pubmed publisher
..Its final 83 amino acids localize PIP5KIbeta to the uropod of chemotaxing neutrophils and T cells, and interact with ezrin-radixin-moesin (ERM) proteins and ..
Volpicelli Daley L, Lucast L, Gong L, Liu L, Sasaki J, Sasaki T, et al
. Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain. J Biol Chem. 2010;285:28708-14 pubmed publisher
Liu T, Lee S. Phosphatidylinositol 4-phosphate 5-kinase ? negatively regulates nerve growth factor-induced neurite outgrowth in PC12 cells. Exp Mol Med. 2013;45:e16 pubmed publisher
..Together, our results suggest that PIP5K? acts as a negative regulator of NGF-induced neurite outgrowth by inhibiting PI3K/Akt signaling pathway in PC12 cells. ..