Gene Symbol: Pip5k1a
Description: phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha
Alias: Pip5k1b, phosphatidylinositol 4-phosphate 5-kinase type-1 alpha, 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase, PIP5K1-alpha, PIP5KIalpha, phosphatidylinositol 4-phosphate 5-kinase type I alpha, phosphatidylinositol-4-phosphate 5-kinase, type 1 beta, ptdIns(4)P-5-kinase 1 alpha
Species: rat
Products:     Pip5k1a

Top Publications

  1. Ishihara H, Shibasaki Y, Kizuki N, Katagiri H, Yazaki Y, Asano T, et al. Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem. 1996;271:23611-4 pubmed
    ..Molecular identification of type I PI4P5K isoforms in insulin-secreting cells should provide insights into the role of phosphatidylinositol metabolism in regulated exocytosis of insulin-containing large dense core vesicles. ..
  2. Kisseleva M, Feng Y, Ward M, Song C, Anderson R, Longmore G. The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha. Mol Cell Biol. 2005;25:3956-66 pubmed
    ..Thus, in addition to its effects upon Rac activity Ajuba can also influence cell migration through regulation of PI(4,5)P2 synthesis through direct activation of PIPKIalpha enzyme activity. ..
  3. Mellman D, Gonzales M, Song C, Barlow C, Wang P, Kendziorski C, et al. A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs. Nature. 2008;451:1013-7 pubmed publisher
    ..The results reveal a mechanism for the integration of nuclear phosphoinositide signals and a method for regulating gene expression. ..
  4. Luo B, Prescott S, Topham M. Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism. Cell Signal. 2004;16:891-7 pubmed
    ..Here we show that expression of DGKzeta significantly enhances PIP5KIalpha activity in thrombin-stimulated HEK293 cells, and DGK activity is required for this stimulation...
  5. Gonzales M, Mellman D, Anderson R. CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs. J Biol Chem. 2008;283:12665-73 pubmed publisher
    ..The Star-PAP complex therefore represents a location where multiple signaling pathways converge to regulate the expression of specific mRNAs. ..
  6. Volpicelli Daley L, Lucast L, Gong L, Liu L, Sasaki J, Sasaki T, et al. Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain. J Biol Chem. 2010;285:28708-14 pubmed publisher
  7. Chao W, Daquinag A, Ashcroft F, Kunz J. Type I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activation. J Cell Biol. 2010;190:247-62 pubmed publisher
    ..Thus, our study defines the role of PIPKI-alpha in cell migration and describes a new mechanism for the spatial regulation of Rac1 activity that is critical for cell migration. ..