Pin1

Summary

Gene Symbol: Pin1
Description: peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Alias: peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
Species: rat
Products:     Pin1

Top Publications

  1. Lu P, Zhou X, Shen M, Lu K. Function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science. 1999;283:1325-8 pubmed
    ..WW domains of the essential mitotic prolyl isomerase Pin1 and the ubiquitin ligase Nedd4 bound to phosphoproteins, including physiological substrates of enzymes, in a ..
  2. Becker E, Bonni A. Pin1 mediates neural-specific activation of the mitochondrial apoptotic machinery. Neuron. 2006;49:655-62 pubmed
    ..Here, we report that the prolyl isomerase Pin1 interacts with Ser65-phosphorylated BIMEL in neurons...
  3. Kesavapany S, Patel V, Zheng Y, Pareek T, Bjelogrlic M, Albers W, et al. Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons. Mol Biol Cell. 2007;18:3645-55 pubmed
    ..Although localization of kinases and phosphatases is certainly implicated, another possibility involves Pin1 modulation of phosphorylation of the proline-directed serine/threonine residues...
  4. Ryo A, Nakamura M, Wulf G, Liou Y, Lu K. Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat Cell Biol. 2001;3:793-801 pubmed
    ..and the conformation of certain phosphorylated Ser/Thr-Pro bonds is regulated specifically by the prolyl isomerase Pin1. Whereas the inhibition of Pin1 induces apoptosis, Pin1 is strikingly overexpressed in a subset of human tumours...
  5. Nakano A, Koinuma D, Miyazawa K, Uchida T, Saitoh M, Kawabata M, et al. Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins. J Biol Chem. 2009;284:6109-15 pubmed publisher
    ..Here we identified Pin1, a peptidylprolyl cis-trans isomerase, as a novel protein binding Smads...
  6. Esnault S, Braun R, Shen Z, Xiang Z, Heninger E, Love R, et al. Pin1 modulates the type 1 immune response. PLoS ONE. 2007;2:e226 pubmed
    ..We now show that Pin1, a third member of the PPIase family mediates the post-transcriptional regulation of Th1 cytokines by activated T ..
  7. Rudrabhatla P, Zheng Y, Amin N, Kesavapany S, Albers W, Pant H. Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein. J Biol Chem. 2008;283:26737-47 pubmed publisher
    ..Previous studies have shown that Pin1, a peptidylprolyl cis/trans-isomerase, may be actively involved in the regulation of Tau hyperphosphorylation in AD...
  8. Galas M, Dourlen P, B├ęgard S, Ando K, Blum D, Hamdane M, et al. The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease. J Biol Chem. 2006;281:19296-304 pubmed
    Deregulation of Tau phosphorylation is a key question in Alzheimer disease pathogenesis. Recently, Pin1, a peptidylprolyl cis/trans-isomerase, was proposed to be a new modulator in Tau phosphorylation in Alzheimer disease...
  9. Hamdane M, Dourlen P, Bretteville A, Sambo A, Ferreira S, Ando K, et al. Pin1 allows for differential Tau dephosphorylation in neuronal cells. Mol Cell Neurosci. 2006;32:155-60 pubmed
    ..is of particular interest since it is associated with early stages of Alzheimer's disease and is a binding site of Pin1, a peptidyl-prolyl cis/trans isomerase mainly involved in cell cycle regulation...

More Information

Publications28

  1. Lonati E, Brambilla A, Milani C, Masserini M, Palestini P, Bulbarelli A. Pin1, a new player in the fate of HIF-1? degradation: an hypothetical mechanism inside vascular damage as Alzheimer's disease risk factor. Front Cell Neurosci. 2014;8:1 pubmed publisher
    ..HIF-1? degradation might be mediated by a synergic action of Gsk-3? and peptidyl-prolyl cis/trans isomerase (Pin1)...
  2. Freed Pastor W, Prives C. Mutant p53: one name, many proteins. Genes Dev. 2012;26:1268-86 pubmed publisher
    ..Here we review mechanisms by which mutant p53 exerts its cellular effects, with a particular focus on the burgeoning mutant p53 transcriptome, and discuss the biological and clinical consequences of mutant p53 gain of function. ..
  3. Buschdorf J, Chew L, Soh U, Liou Y, Low B. Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons. PLoS ONE. 2008;3:e2686 pubmed publisher
    ..Here we describe the identification and characterization of the binding between BNIP-H and Pin1, a peptidyl-prolyl cis/trans isomerase...
  4. Sakai S, Shimojo N, Kimura T, Tajiri K, Maruyama H, Homma S, et al. Involvement of peptidyl-prolyl isomerase Pin1 in the inhibitory effect of fluvastatin on endothelin-1-induced cardiomyocyte hypertrophy. Life Sci. 2014;102:98-104 pubmed publisher
    ..One of their common intracellular pathways is the phosphorylation cascade of MEK signaling. Pin1 specifically isomerizes the phosphorylated protein with Ser/Thr-Pro bonds and regulates their activity through ..
  5. Rudrabhatla P, Albers W, Pant H. Peptidyl-prolyl isomerase 1 regulates protein phosphatase 2A-mediated topographic phosphorylation of neurofilament proteins. J Neurosci. 2009;29:14869-80 pubmed publisher
    ..Peptidyl-prolyl isomerase Pin1 inhibits the dephosphorylation of NF by PP2A in vitro...
  6. van der Horst A, Khanna K. The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through Cep55. Cancer Res. 2009;69:6651-9 pubmed publisher
    ..The peptidyl-prolyl isomerase Pin1, which is deregulated in many tumors, regulates several processes, including cell cycle progression...
  7. Shen Z, Esnault S, Rosenthal L, Szakaly R, Sorkness R, Westmark P, et al. Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic lung fibrosis. J Clin Invest. 2008;118:479-90 pubmed publisher
    ..We investigated the regulation of TGF-beta1 and show here that the peptidyl-prolyl isomerase (PPIase) Pin1 promoted the stability of TGF-beta1 mRNA in human Eos...
  8. Pan C, Liou Y, Low B. Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration. J Cell Sci. 2010;123:903-16 pubmed publisher
    ..Here, we show that the RhoGAP domain of BPGAP1 interacts with the peptidyl-prolyl cis/trans isomerase (PPI) Pin1, leading to enhanced GAP activity towards RhoA...
  9. Atabay K, Karabay A. Pin1 inhibition activates cyclin D and produces neurodegenerative pathology. J Neurochem. 2012;120:430-9 pubmed publisher
    Abnormal cell cycle events are increasingly becoming important attributes of neurodegenerative pathology. Pin1 is a crucial target of neurodegeneration in relation to its functions regarding these abnormal cell cycle events in neurons...
  10. Toko H, Konstandin M, Doroudgar S, Ormachea L, Joyo E, Joyo A, et al. Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1. Circ Res. 2013;112:1244-52 pubmed publisher
    ..the nonmyocyte context, control of folding, activity, and stability of proteins is mediated by the prolyl isomerase Pin1, but the role of Pin1 in the heart is unknown. To establish the role of Pin1 in the heart...
  11. Atchison F, Capel B, Means A. Pin1 regulates the timing of mammalian primordial germ cell proliferation. Development. 2003;130:3579-86 pubmed
    ..5 to 13.5 days post coitum (dpc). We show that a peptidyl-prolyl isomerase, Pin1, is involved in the regulation of mammalian PGC proliferation...
  12. Nechama M, Uchida T, Mor Yosef Levi I, Silver J, Naveh Many T. The peptidyl-prolyl isomerase Pin1 determines parathyroid hormone mRNA levels and stability in rat models of secondary hyperparathyroidism. J Clin Invest. 2009;119:3102-14 pubmed publisher
    ..As the peptidyl-prolyl isomerase (PPIase) Pin1 has recently been shown to regulate the turnover of multiple cytokine mRNAs, we investigated the role of Pin1 in ..
  13. Beckerman R, Prives C. Transcriptional regulation by p53. Cold Spring Harb Perspect Biol. 2010;2:a000935 pubmed publisher
    ..How p53 is able to discriminate between these different loci is the subject of intense research. Here, we describe key aspects of the fundamentals of p53-mediated transcriptional regulation and target gene promoter selectivity. ..
  14. Rajbhandari P, Finn G, Solodin N, Singarapu K, Sahu S, Markley J, et al. Regulation of estrogen receptor ? N-terminus conformation and function by peptidyl prolyl isomerase Pin1. Mol Cell Biol. 2012;32:445-57 pubmed publisher
    ..tamoxifen (antagonist), and growth factors results in recruitment of the peptidyl prolyl cis/trans isomerase Pin1. Phosphorylation of S118 is critical for Pin1 binding, and mutation of S118 to alanine prevents this association...
  15. Zhu J, Dagostino E, Rejto P, Mroczkowski B, Murray B. Identification and characterization of a novel and functional murine Pin1 isoform. Biochem Biophys Res Commun. 2007;359:529-35 pubmed
    b>Pin1, a phosphorylation-dependent peptidyl-prolyl cis/trans isomerase (PPIase), regulates the activity of a number of cell cycle regulators, transcription factors, and microtubule-associated tau...
  16. Kim S, Lee M, Lim S, Hien T, Kim J, Ahn S, et al. Role of Pin1 in neointima formation: down-regulation of Nrf2-dependent heme oxygenase-1 expression by Pin1. Free Radic Biol Med. 2010;48:1644-53 pubmed publisher
    ..b>Pin1, a peptidyl prolyl isomerase recognizing phosphorylated Ser/Thr-Pro, isomerizes the peptide bond...
  17. Nakamura K, Kosugi I, Lee D, Hafner A, Sinclair D, Ryo A, et al. Prolyl isomerase Pin1 regulates neuronal differentiation via ?-catenin. Mol Cell Biol. 2012;32:2966-78 pubmed publisher
    ..b>Pin1 is a prolyl isomerase that regulates cell signaling uniquely by controlling protein conformation after ..
  18. Xiong Y, Wang D, Tan L, Wang X, Chen L, Gong C, et al. Inhibition of glycogen synthase kinase-3 reverses tau hyperphosphorylation induced by Pin1 down-regulation. CNS Neurol Disord Drug Targets. 2013;12:436-43 pubmed
    ..the brain of AD patients, the levels of the phosphorylationdependent protein peptidyl-prolyl cis-trans isomerase (Pin1) were found to be low...
  19. Chiasson V, Munshi N, Chatterjee P, Young K, Mitchell B. Pin1 deficiency causes endothelial dysfunction and hypertension. Hypertension. 2011;58:431-8 pubmed publisher
    b>Pin1 is a peptidyl prolyl cis-trans isomerase that only binds to and isomerizes phosphorylated serine/threonine-proline motifs, inducing conformational changes that alter target protein function and phosphorylation...