Gene Symbol: Pikfyve
Description: phosphoinositide kinase, FYVE-type zinc finger containing
Alias: Pip5k3, 1-phosphatidylinositol-3-phosphate 5-kinase, 1-phosphatidylinositol 3-phosphate 5-kinase, phosphatidylinositol-3-phosphate 5-kinase type III, phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III, phosphoinositide kinase, FYVE finger containing
Species: rat
Products:     Pikfyve

Top Publications

  1. Rutherford A, Traer C, Wassmer T, Pattni K, Bujny M, Carlton J, et al. The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport. J Cell Sci. 2006;119:3944-57 pubmed
    ..and its mammalian orthologue Pip5k3 encode the phosphatidylinositol 3-phosphate [PtdIns(3)P] 5-kinases Fab1p and PIKfyve, respectively, enzymes that generates phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P(2)]...
  2. Sbrissa D, Ikonomov O, Fu Z, Ijuin T, Gruenberg J, Takenawa T, et al. Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex. J Biol Chem. 2007;282:23878-91 pubmed
    ..Vac14 and human Vac14 (ArPIKfyve), which activate yeast and mammalian PtdIns(3,5)P2-producing enzymes, Fab1 and PIKfyve, respectively...
  3. Shisheva A, Rusin B, Ikonomov O, DeMarco C, Sbrissa D. Localization and insulin-regulated relocation of phosphoinositide 5-kinase PIKfyve in 3T3-L1 adipocytes. J Biol Chem. 2001;276:11859-69 pubmed
    The mammalian phosphoinositide kinase PIKfyve catalyzes the synthesis of phosphatidylinositol 5-P and phosphatidylinositol 3,5-P(2), thought essential in cellular functions, including membrane trafficking...
  4. Ikonomov O, Sbrissa D, Foti M, Carpentier J, Shisheva A. PIKfyve controls fluid phase endocytosis but not recycling/degradation of endocytosed receptors or sorting of procathepsin D by regulating multivesicular body morphogenesis. Mol Biol Cell. 2003;14:4581-91 pubmed
    The mammalian phosphatidylinositol (PtdIns) 5-P/PtdIns 3,5-P2-producing kinase PIKfyve has been implicated in maintaining endomembrane homeostasis in mammalian cells...
  5. Carpenter C. Btk-dependent regulation of phosphoinositide synthesis. Biochem Soc Trans. 2004;32:326-9 pubmed
    ..This complex provides a novel shuttling mechanism that allows Btk to regulate the production of the substrate required by both its upstream activator phosphoinositide 3-kinase and its downstream target phospholipase Cgamma2. ..
  6. Berwick D, Dell G, Welsh G, Heesom K, Hers I, Fletcher L, et al. Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles. J Cell Sci. 2004;117:5985-93 pubmed
    ..Here we report that serine318 on the FYVE domain-containing PtdIns3P 5-kinase (PIKfyve) is a novel substrate for PKB, and show that phosphorylation stimulates the PtdIns3P 5-kinase activity of the ..
  7. Shisheva A, Sbrissa D, Ikonomov O. Cloning, characterization, and expression of a novel Zn2+-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cells. Mol Cell Biol. 1999;19:623-34 pubmed
    ..In conclusion, the mouse p235 protein determines an important novel class of phosphoinositide kinases that seems to be targeted to specific intracellular loci by a Zn-dependent mechanism. ..
  8. Cabezas A, Pattni K, Stenmark H. Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1. Gene. 2006;371:34-41 pubmed
    ..Here we have cloned and sequenced the cDNA for the human homologue of Fab1, PIKfyve. The cDNA has an open reading frame of 6294 bp and encodes a 2098-amino acid protein with a calculated molecular ..
  9. Kim J, Jahng W, Di Vizio D, Lee J, Jhaveri R, Rubin M, et al. The phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleus. Cancer Res. 2007;67:9229-37 pubmed
    ..of EGFR immune complexes from a transitional carcinoma cell line (TCCSUP) identified the phosphoinositide kinase, PIKfyve, as a potential component of the EGFR trafficking mechanism...

More Information


  1. Ikonomov O, Fligger J, Sbrissa D, Dondapati R, Mlak K, Deeb R, et al. Kinesin adapter JLP links PIKfyve to microtubule-based endosome-to-trans-Golgi network traffic of furin. J Biol Chem. 2009;284:3750-61 pubmed publisher
    ..JLP(L) (JNK-interacting leucine zipper protein) in yeast-two hybrid screens with the phosphoinositide kinase PIKfyve. The interaction was confirmed by pulldown and coimmunoprecipitation assays in native cells...
  2. Tsuruta F, Green E, Rousset M, Dolmetsch R. PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death. J Cell Biol. 2009;187:279-94 pubmed publisher
    ..Ca(V)1.2 internalization and degradation requires binding to phosphatidylinositol 3-phosphate 5-kinase (PIKfyve), a lipid kinase which generates phosphatidylinositol (3,5)-bisphosphate (PtdIns(3,5)P(2)) and regulates endosome ..
  3. Alesutan I, Ureche O, Laufer J, Klaus F, Zurn A, Lindner R, et al. Regulation of the glutamate transporter EAAT4 by PIKfyve. Cell Physiol Biochem. 2010;25:187-94 pubmed publisher
    ..CreaT (SLC6A8) has recently been shown to involve the mammalian phosphatidylinositol-3-phosphate-5-kinase PIKfyve (PIP5K3)...
  4. Vaccari I, Dina G, Tronchère H, Kaufman E, Chicanne G, Cerri F, et al. Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies. PLoS Genet. 2011;7:e1002319 pubmed publisher
    ..Reduction of Fig4 by null heterozygosity and downregulation of PIKfyve both rescue Mtmr2-null myelin outfoldings in vivo and in vitro.
  5. Vicinanza M, Korolchuk V, Ashkenazi A, Puri C, Menzies F, Clarke J, et al. PI(5)P regulates autophagosome biogenesis. Mol Cell. 2015;57:219-34 pubmed publisher
    ..PI(5)P synthesis by the phosphatidylinositol 5-kinase PIKfyve was required for autophagosome biogenesis, and it increased levels of PI(5)P, stimulated autophagy, and reduced ..
  6. Tsuruta F, Dolmetsch R. PIKfyve mediates the motility of late endosomes and lysosomes in neuronal dendrites. Neurosci Lett. 2015;605:18-23 pubmed publisher
    ..Here, we report that phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) mediates the motility of late endosomes and lysosomes in neuronal dendrites...