Gene Symbol: Pik3cg
Description: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Alias: Pi3k, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, phosphoinositide-3-kinase, catalytic, gamma polypeptide
Species: rat
Products:     Pik3cg

Top Publications

  1. Brock C, Schaefer M, Reusch H, Czupalla C, Michalke M, Spicher K, et al. Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma. J Cell Biol. 2003;160:89-99 pubmed
    Receptor-regulated class I phosphoinositide 3-kinases (PI3K) phosphorylate the membrane lipid phosphatidylinositol (PtdIns)-4,5-P2 to PtdIns-3,4,5-P3...
  2. Chang J, Sukhova G, Libby P, Schvartz E, Lichtenstein A, Field S, et al. Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. Proc Natl Acad Sci U S A. 2007;104:8077-82 pubmed
  3. Barber D, Bartolomé A, Hernandez C, Flores J, Fernandez Arias C, Rodríguez Borlado L, et al. Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion. J Immunol. 2006;176:589-93 pubmed
    Class I PI3K catalyzes formation of 3-poly-phosphoinositides. The family is divided into IA isoforms, activated by Tyr kinases and the IB isoform (PI3Kgamma), activated by G protein-coupled receptors...
  4. Becattini B, Marone R, Zani F, Arsenijevic D, Seydoux J, Montani J, et al. PI3K? within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance. Proc Natl Acad Sci U S A. 2011;108:E854-63 pubmed publisher
    ..The lipid kinase PI3K? is a central proinflammatory signal transducer that plays a major role in leukocyte chemotaxis, mast cell ..
  5. Gruen M, Rose C, König C, Gajda M, Wetzker R, Bräuer R. Loss of phosphoinositide 3-kinase gamma decreases migration and activation of phagocytes but not T cell activation in antigen-induced arthritis. BMC Musculoskelet Disord. 2010;11:63 pubmed publisher
  6. Randis T, Puri K, Zhou H, Diacovo T. Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils. Eur J Immunol. 2008;38:1215-24 pubmed publisher
    The p110delta isoform of class I phosphoinositide 3-kinase (PI3K) plays a major role in B cell receptor signaling, while its p110gamma counterpart is thought to predominate in leukocyte chemotaxis...
  7. Zhao S, Gao H, Wang Y, Xu Q, Guo C. Attenuation of High Glucose-Induced Rat Cardiomyocyte Apoptosis by Exendin-4 via Intervention of HO-1/Nrf-2 and the PI3K/AKT Signaling Pathway. Chin J Physiol. 2017;60:89-96 pubmed publisher
  8. Wang Y, Li Y, Huo S, Yin Z. Alpha-crystallin promotes rat olfactory ensheathing cells survival and proliferation through regulation of PI3K/Akt/mTOR signaling pathways. Neurosci Lett. 2012;531:170-5 pubmed publisher
    ..These findings indicated that ?-crystallin positively regulated the activation of PI3K/Akt/mTOR signaling pathway and promote the proliferation and survival of cultured OECs.
  9. Miao Y, Bi X, Zhao M, Jiang H, Liu J, Li D, et al. Acetylcholine inhibits tumor necrosis factor α activated endoplasmic reticulum apoptotic pathway via EGFR-PI3K signaling in cardiomyocytes. J Cell Physiol. 2015;230:767-74 pubmed publisher
    ..In addition, LY294002, a phosphatidylinositol-3-kinase (PI3K) inhibitor, displayed the similar trends as AG1478, suggesting that PI3K/Akt signaling may be the downstream of ..

More Information


  1. Sparks J, Magra A, Chamberlain J, O Dell C, Sparks C. Insulin dependent apolipoprotein B degradation and phosphatidylinositide 3-kinase activation with microsomal translocation are restored in McArdle RH7777 cells following serum deprivation. Biochem Biophys Res Commun. 2016;469:326-31 pubmed publisher
    ..In addition, insulin-stimulated Class I phosphatidylinositide 3-kinase (PI3K) activity of anti-pY immunoprecipitates is severely blunted...
  2. Qu W, Hao L, Chen Y, Zhou S. [Effect of chronic ethanol intake on insulin receptor, insulin receptor subsrate-1 and phosphoinositide 3-kinase mRNA expression in skeletal muscle of rats]. Wei Sheng Yan Jiu. 2007;36:172-5 pubmed
    ..05). The present results suggested that chronic ethanol intake could induce insulin resistance and down-regulated the expression of IR, IRS-land PI-3K mRNA in skeletal muscle could be the molecular mechanism. ..
  3. Rasmussen B, Breen D, Duca F, Côté C, Zadeh Tahmasebi M, Filippi B, et al. Jejunal leptin-PI3K signaling lowers glucose production. Cell Metab. 2014;19:155-61 pubmed publisher
    ..leptin administration activates jejunal leptin receptors and signals through a phosphatidylinositol 3-kinase (PI3K)-dependent and signal transducer and activator of transcription 3 (STAT3)-independent signaling pathway to lower ..
  4. Lionetti V, Lisi A, Patrucco E, De Giuli P, Milazzo M, Ceci S, et al. Lack of phosphoinositide 3-kinase-gamma attenuates ventilator-induced lung injury. Crit Care Med. 2006;34:134-41 pubmed
    ..01). Silencing PI3Kgamma seems to attenuate functional and morphological consequences of ventilator-induced lung injury independently of inhibitory effects on cytokines release but through the enhancement of pulmonary apoptosis. ..
  5. Han J, Zhan X, Li X, Xia B, Wang Y, Zhang J, et al. Impaired PI3K/Akt signal pathway and hepatocellular injury in high-fat fed rats. World J Gastroenterol. 2010;16:6111-8 pubmed
    ..dysfunction resulting from high-fat diet is related to impairment of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt, also known as PKB) pathway...
  6. Cunha T, Souza G, Domingues A, Carreira E, Lotufo C, Funez M, et al. Stimulation of peripheral kappa opioid receptors inhibits inflammatory hyperalgesia via activation of the PI3K?/AKT/nNOS/NO signaling pathway. Mol Pain. 2012;8:10 pubmed publisher
    ..U50488 peripheral effect was also dependent on stimulation of PI3K?/AKT because inhibitors of these kinases also reduced peripheral antinociception induced by U50488...
  7. Tung W, Lee I, Hsieh H, Yang C. EV71 induces COX-2 expression via c-Src/PDGFR/PI3K/Akt/p42/p44 MAPK/AP-1 and NF-kappaB in rat brain astrocytes. J Cell Physiol. 2010;224:376-86 pubmed publisher
    ..and PGE(2) production were attenuated by pretreatment with the inhibitors of c-Src (PP1), PDGFR (AG1296), PI3K (Wortmannin), MEK1/2 (PD98059), NF-kappaB (helenalin), and AP-1 (Tanshinone) and transfection with shRNA or siRNA ..
  8. Hammerschmidt S, Kuhn H, Gessner C, Seyfarth H, Wirtz H. Stretch-induced alveolar type II cell apoptosis: role of endogenous bradykinin and PI3K-Akt signaling. Am J Respir Cell Mol Biol. 2007;37:699-705 pubmed
    ..and bradykinin receptor expression were measured by RT-PCR; Angiotensin II and phosphoinositol 3 OH-kinase (PI3K) activity (as phospho-Akt) were measured by enzyme-linked immunosorbent assay; and Bcl-2 and Bcl-X(L) were measured ..
  9. Passos G, Figueiredo C, Prediger R, Silva K, Siqueira J, Duarte F, et al. Involvement of phosphoinositide 3-kinase gamma in the neuro-inflammatory response and cognitive impairments induced by beta-amyloid 1-40 peptide in mice. Brain Behav Immun. 2010;24:493-501 pubmed publisher
    ..Our data suggests that inhibition of PI3Kgamma may represent a novel therapeutic target for treating AD patients. ..
  10. Pigeau G, Kolic J, Ball B, Hoppa M, Wang Y, Ruckle T, et al. Insulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cells. Diabetes. 2009;58:2084-92 pubmed publisher
    Phosphatidylinositol 3-OH kinase (PI3K) has a long-recognized role in beta-cell mass regulation and gene transcription and is implicated in the modulation of insulin secretion...
  11. Do K, Kim M, Kim J, Rhim B, Lee W, Kim C, et al. Angiotensin II-induced aortic ring constriction is mediated by phosphatidylinositol 3-kinase/L-type calcium channel signaling pathway. Exp Mol Med. 2009;41:569-76 pubmed publisher
    ..AngII-induced collagen gel contraction was blocked by pretreatment with a phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002) whereas ERK inhibitor (PD98059) was not effective...
  12. Zubcevic J, Waki H, Diez Freire C, Gampel A, Raizada M, Paton J. Chronic blockade of phosphatidylinositol 3-kinase in the nucleus tractus solitarii is prohypertensive in the spontaneously hypertensive rat. Hypertension. 2009;53:97-103 pubmed publisher
    Phosphatidylinositol 3-kinase (PI3K) within brain stem neurons has been implicated in hypertension in the spontaneously hypertensive rat (SHR)...
  13. Huang H, Chiang M, Lin C, Pu H. Lipopolysaccharide directly stimulates aldosterone production via toll-like receptor 2 and toll-like receptor 4 related PI(3)K/Akt pathway in rat adrenal zona glomerulosa cells. J Cell Biochem. 2010;111:872-80 pubmed publisher
    ..In conclusion, LPS-induced aldosterone production and SR-B1 proteins expression are through the TLR2 and TLR4 related PI(3)K/Akt pathways in adrenal ZG cells...
  14. Chen Y, Law P, Loh H. NGF/PI3K signaling-mediated epigenetic regulation of delta opioid receptor gene expression. Biochem Biophys Res Commun. 2008;368:755-60 pubmed publisher
    ..Our previous study identified PI3K/Akt/NF-kappaB signaling is a main downstream signaling pathway in nerve growth factor (NGF)-induced temporal ..
  15. Song Z, Guo Y, Zhou M, Zhang X. The PI3K/p-Akt signaling pathway participates in calcitriol ameliorating podocyte injury in DN rats. Metabolism. 2014;63:1324-33 pubmed publisher
    The present study aimed to investigate the relationship between PI3K/p-Akt signaling pathway and podocyte impairment in DN rats as well as the protective effect of calcitriol...
  16. Ferrandi C, Ardissone V, Ferro P, Ruckle T, Zaratin P, Ammannati E, et al. Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment. J Pharmacol Exp Ther. 2007;322:923-30 pubmed
    ..Furthermore, we demonstrated that oral administration of either nonisoform-specific phosphoinositide 3-kinase (PI3K) inhibitor LY294002 (morpholin-4-yl-8-phenylchromen-4-one) or selective PI3Kgamma inhibitor AS041164 (5-benzo[1,3]..
  17. Gu C, Park S. The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner. Mol Cell Biol. 2001;21:4579-97 pubmed
  18. Zhang X, Mi J, Wetsel W, Davidson C, Xiong X, Chen Q, et al. PI3 kinase is involved in cocaine behavioral sensitization and its reversal with brain area specificity. Biochem Biophys Res Commun. 2006;340:1144-50 pubmed
    Phosphatidylinositol 3-kinase (PI3K) is an important signaling molecule involved in cell differentiation, proliferation, survival, and phagocytosis, and may participate in various brain functions...
  19. Roman E, Reis D, Romanatto T, Maimoni D, Ferreira E, Santos G, et al. Central leptin action improves skeletal muscle AKT, AMPK, and PGC1 alpha activation by hypothalamic PI3K-dependent mechanism. Mol Cell Endocrinol. 2010;314:62-9 pubmed publisher
    Central leptin action requires PI3K activity to modulate glucose homeostasis and peripheral metabolism. However, the mechanism behind this phenomenon is not clearly understood...
  20. Smirnova N, Gayral S, Pedros C, Loirand G, Vaillant N, Malet N, et al. Targeting PI3K? activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response. J Exp Med. 2014;211:1779-92 pubmed publisher
    ..We show that phosphoinositide 3-kinase ? (PI3K?) is a key player in IH formation and is a valid therapeutic target in its prevention/treatment...
  21. Yoshimura T, Arimura N, Kawano Y, Kawabata S, Wang S, Kaibuchi K. Ras regulates neuronal polarity via the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway. Biochem Biophys Res Commun. 2006;340:62-8 pubmed
    ..Taken together, these results suggest that Ras plays critical roles in establishing neuronal polarity upstream of the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway and mitogen-activated protein kinase cascade. ..
  22. Zhang Y, Zeng X, Zhang L, Zheng X. Stimulatory effect of puerarin on bone formation through activation of PI3K/Akt pathway in rat calvaria osteoblasts. Planta Med. 2007;73:341-7 pubmed
    ..osteoblastic growth, Akt activation and redistribution were significantly blocked by the specific PI3K inhibitor, LY294002...
  23. Prasad S, Russell M, Nowakowska M. Neuroprotection induced in vitro by ischemic preconditioning and postconditioning: modulation of apoptosis and PI3K-Akt pathways. J Mol Neurosci. 2011;43:428-42 pubmed publisher
    ..Using real-time RT-PCR arrays focused on genes of the apoptosis and PI3K-Akt pathways, we found that injurious OGD mainly induced apoptosis-related and repressed PI3K-Akt pathway-related ..
  24. Chen L, Xing T, Wang M, Miao Y, Tang M, Chen J, et al. Local infusion of ghrelin enhanced hippocampal synaptic plasticity and spatial memory through activation of phosphoinositide 3-kinase in the dentate gyrus of adult rats. Eur J Neurosci. 2011;33:266-75 pubmed publisher
    ..time-dependently increased the phosphorylation of Akt-Ser473, a downstream molecule of phosphoinositide 3-kinase (PI3K). Interestingly, PI3K inhibitors, but not NMDA receptor antagonist, inhibited ghrelin-induced potentiation...
  25. Liu Q, Yu H, Sun L, You L, Tao G, Qu B. Apelin-13 upregulates Egr-1 expression in rat vascular smooth muscle cells through the PI3K/Akt and PKC signaling pathways. Biochem Biophys Res Commun. 2015;468:617-21 pubmed publisher
    ..We also examined whether the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt) and protein kinase C (PKC) signaling pathways were involved in the regulation of Egr-1 by ..
  26. Baki L, Shioi J, Wen P, Shao Z, Schwarzman A, Gama Sosa M, et al. PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J. 2004;23:2586-96 pubmed
    Phosphatidylinositol 3-kinase (PI3K) promotes cell survival and communication by activating its downstream effector Akt kinase...
  27. Qiao X, Xu J, Yang Q, Du Y, Lei S, Liu Z, et al. Transient acidosis during early reperfusion attenuates myocardium ischemia reperfusion injury via PI3k-Akt-eNOS signaling pathway. Oxid Med Cell Longev. 2013;2013:126083 pubmed publisher
    In this paper, we concluded that transient acidosis reperfusion conferred cardioprotection against myocardial ischemia reperfusion injury in isolated rat hearts through activating PI3K-Akt-eNOS pathway.
  28. Liu Z, Cai H, Zhang P, Li H, Liu H, Li Z. Activation of ERK1/2 and PI3K/Akt by IGF-1 on GAP-43 expression in DRG neurons with excitotoxicity induced by glutamate in vitro. Cell Mol Neurobiol. 2012;32:191-200 pubmed publisher
    ..and activates the extracellular signal-regulated protein kinase (ERK1/2) and the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways in DRG neurons with excitotoxicity induced by glutamate (Glu) remains unknown...
  29. Castor M, Rezende B, Bernardes P, Vieira A, Vieira E, Arantes R, et al. PI3K? controls leukocyte recruitment, tissue injury, and lethality in a model of graft-versus-host disease in mice. J Leukoc Biol. 2011;89:955-64 pubmed publisher
    ..In conclusion, PI(3)K? plays a critical role in GVHD by mediating leukocyte influx and activation in tissues. PI(3)K? inhibitors may be useful in the treatment of GVHD in patients undergoing BMT. ..
  30. Siragusa M, Katare R, Meloni M, Damilano F, Hirsch E, Emanueli C, et al. Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice. Circ Res. 2010;106:757-68 pubmed publisher
    Phosphoinositide 3-kinase (PI3K)gamma is expressed in hematopoietic cells, endothelial cells (ECs), and cardiomyocytes and regulates different cellular functions relevant to inflammation, tissue remodeling and cicatrization...
  31. Bareiss S, Dugan E, Brewer K. PI3K mediated activation of GSK-3β reduces at-level primary afferent growth responses associated with excitotoxic spinal cord injury dysesthesias. Mol Pain. 2015;11:35 pubmed publisher
    ..that SCI triggers inhibition of GSK-3β signaling resulting in enhanced DRG growth responses, and that PI3K mediated activation of GSK-3β can prevent this growth and the development of at-level pain syndromes...
  32. Milano G, von Segesser L, Morel S, Joncic A, Bianciardi P, Vassalli G, et al. Phosphorylation of phosphatidylinositol-3-kinase-protein kinase B and extracellular signal-regulated kinases 1/2 mediate reoxygenation-induced cardioprotection during hypoxia. Exp Biol Med (Maywood). 2010;235:401-10 pubmed publisher
    ..Selective inhibition of Akt and ERK1/2 phosphorylation abolishes the beneficial effects of the reoxygenation. Therefore, Akt and ERK1/2 have an important role to mediate cardioprotection by reoxygenation during CH in vivo. ..
  33. Feng Y, Huang J, Ding Y, Xie F, Shen X. Tamoxifen-induced apoptosis of rat C6 glioma cells via PI3K/Akt, JNK and ERK activation. Oncol Rep. 2010;24:1561-7 pubmed
    To elucidate the mechanism of TAM treatment on gliomas, we hypothesised that PI3K/Akt and MAPK signaling pathway may play important roles on TAM-induced apoptosis in C6 glioma cells...
  34. Kobayashi T, Puro D. Loss of insulin-mediated vasoprotection: early effect of diabetes on pericyte-containing microvessels of the retina. Invest Ophthalmol Vis Sci. 2007;48:2350-5 pubmed
    ..The authors propose that the loss of insulin-mediated vasoprotection may be a previously unappreciated mechanism by which diabetic retinopathy progresses. ..
  35. Sahu A, Koshinaka K, Sahu M. Phosphatidylinositol 3-kinase is an upstream regulator of the phosphodiesterase 3B pathway of leptin signalling that may not involve activation of Akt in the rat hypothalamus. J Neuroendocrinol. 2013;25:168-79 pubmed publisher
    ..pathways, including the signal transducer and activator of transcription (STAT)3, phosphatidylinositol 3-kinase (PI3K), and phosphodiesterase 3B (PDE3B)-cAMP signalling in the central nervous system and peripheral tissues...
  36. Spániková A, Ivanová M, Matejíková J, Ravingerová T, Barancik M. Influence of ischemia/reperfusion and modulation of PI3K/Akt kinase pathway on matrix metalloproteinase-2 in rat hearts. Gen Physiol Biophys. 2010;29:31-40 pubmed
    ..Wortmannin is a specific inhibitor of PI3K/Akt kinase pathway activation of which was found to play a role in infarct size limiting mechanisms in the rat ..
  37. Shao J, Wan X, Chen Y, Bi C, Chen H, Zhong Y, et al. H2S protects hippocampal neurons from anoxia-reoxygenation through cAMP-mediated PI3K/Akt/p70S6K cell-survival signaling pathways. J Mol Neurosci. 2011;43:453-60 pubmed publisher
    The study aims to investigate the effect of hydrogen sulfide (H(2)S) on the phosphatidylinositol 3-kinase (PI3K)/Akt/p70 ribosomal S6 kinase (p70S6K) signal transduction pathway after oxygen glucose deprivation/reoxygenation (OGD/R) in ..
  38. Gao S, Shah A, Oh Y, Park W, Kim S. Urotensin II stimulates high frequency-induced ANP secretion via PLC-PI 3K-PKC pathway. Peptides. 2010;31:164-9 pubmed publisher
    ..Pretreatment with urotensin receptor antagonist and inhibitor for phospholipase C (PLC), phosphoinositide 3-kinase (PI3K), or protein kinase C (PKC) attenuated hU-II-induced ANP secretion from atria paced with high frequency, but an ..
  39. Yu H, Hsieh Y, Suzuki T, Choudhry M, Schwacha M, Bland K, et al. The PI3K/Akt pathway mediates the nongenomic cardioprotective effects of estrogen following trauma-hemorrhage. Ann Surg. 2007;245:971-7 pubmed
    ..beneficial effect on cardiac function following trauma-hemorrhage and whether those effects are mediated via the PI3K/Akt pathway...
  40. Rakotoarisoa L, Carricaburu V, Leblanc C, Mironneau C, Mironneau J, Macrez N. Angiotensin II-induced delayed stimulation of phospholipase C gamma1 requires activation of both phosphatidylinositol 3-kinase gamma and tyrosine kinase in vascular myocytes. J Cell Mol Med. 2006;10:734-48 pubmed
    ..angiotensin II (AII) has been reported to activate phospholipase C (PLC) and phosphatidylinositol 3-kinase (PI3K)...
  41. Lin M, Shang D, Sun W, Li B, Xu X, Fang W, et al. Involvement of PI3K and ROCK signaling pathways in migration of bone marrow-derived mesenchymal stem cells through human brain microvascular endothelial cell monolayers. Brain Res. 2013;1513:1-8 pubmed publisher
    ..that a Rho-kinase (ROCK) inhibitor (Y27632) effectively promoted MSC transendothelial migration; conversely, a PI3K inhibitor (LY294002) blocked MSC transendothelial migration...
  42. Yin Q, Jin P, Liu X, Wei H, Lin X, Chi C, et al. SDF-1? inhibits hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells through PI3K/Akt and ERK1/2 signaling pathways. Mol Biol Rep. 2011;38:9-16 pubmed publisher
    ..Furthermore, the effect of SDF-1? on mitochondrial pathway was neutralized by using PI3K inhibitor (Wortmannin) and ERK1/2 inhibitor (U0126)...
  43. Jain V, Baitharu I, Prasad D, Ilavazhagan G. Enriched environment prevents hypobaric hypoxia induced memory impairment and neurodegeneration: role of BDNF/PI3K/GSK3? pathway coupled with CREB activation. PLoS ONE. 2013;8:e62235 pubmed publisher
    ..plays a major role in EE mediated neuroprotection and it effectively prevented neurodegeneration by activating PI3K/AKT pathway resulting in GSK3? inactivation which further inhibits apoptosis...
  44. Villarreal F, Epperson S, Ramirez Sanchez I, Yamazaki K, Brunton L. Regulation of cardiac fibroblast collagen synthesis by adenosine: roles for Epac and PI3K. Am J Physiol Cell Physiol. 2009;296:C1178-84 pubmed publisher
    ..Inhibition of phosphoinositol-3 kinase (PI3K) reduced the inhibitory effects of NECA on ANG II-induced collagen synthesis, suggesting that NECA acts via PI3K...
  45. May V, Lutz E, MacKenzie C, Schutz K, Dozark K, Braas K. Pituitary adenylate cyclase-activating polypeptide (PACAP)/PAC1HOP1 receptor activation coordinates multiple neurotrophic signaling pathways: Akt activation through phosphatidylinositol 3-kinase gamma and vesicle endocytosis for neuronal survival. J Biol Chem. 2010;285:9749-61 pubmed publisher
    ..The partitioning of PACAP-mediated Akt signaling in endosomes may be a key mechanism contributing to the high spatial and temporal specificity in signal transduction necessary for survival pathways. ..
  46. González García A, Sánchez Ruiz J, Flores J, Carrera A. Phosphatidylinositol 3-kinase gamma inhibition ameliorates inflammation and tumor growth in a model of colitis-associated cancer. Gastroenterology. 2010;138:1374-83 pubmed publisher
    ..Phosphatidylinositol 3-kinase (PI3K) is an enzyme that regulates the immune response and contributes to cell transformation in several tumor types...
  47. Baviera A, Zanon N, Navegantes L, Kettelhut I. Involvement of cAMP/Epac/PI3K-dependent pathway in the antiproteolytic effect of epinephrine on rat skeletal muscle. Mol Cell Endocrinol. 2010;315:104-12 pubmed publisher
    ..tested the hypothesis that epinephrine-induced inhibition of muscle proteolysis is mediated through the cAMP/Epac/PI3K-dependent pathway with the involvement of AKT and Foxo...
  48. Kaminski A, Welters H, Kaminski E, Morgan N. Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways. Biosci Rep. 2009;30:169-75 pubmed publisher
    ..65%. This effect was abrogated by the presence of the PI3K (phosphoinositide 3-kinase) inhibitor, wortmannin, suggesting that activation of the PI3K pathway is involved...
  49. Dai R, Xia Y, Mao L, Mei Y, Xue Y, Hu B. Involvement of PI3K/Akt pathway in the neuroprotective effect of Sonic hedgehog on cortical neurons under oxidative stress. J Huazhong Univ Sci Technolog Med Sci. 2012;32:856-860 pubmed publisher
    ..pre-treat the neurons 30 min before H(2)O(2) treatment and selectively inhibit the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. The cell viability was measured by MTT and apoptosis rate by flow cytometry analysis...
  50. Lee C, Huang C, Hsu K. Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways. Neuropharmacology. 2011;61:867-79 pubmed publisher
    ..Pharmacological blockade of phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway and the small GTPase Rac1 specifically prevented the ..
  51. Sheu M, Shen C, Jheng J, Chiang C. Activation of PI3K in response to high glucose leads to regulation of SOCS-3 and STAT1/3 signals and induction of glomerular mesangial extracellular matrix formation. Oncotarget. 2017;8:16925-16938 pubmed publisher
    ..The selective phosphoinositide 3-kinase (PI3K) inhibitor LY294002 and dominant negative p85 vector (DN?p85) transfection effectively abolished these HG-induced ..
  52. Nguyen T, Chai J, Li A, Akahoshi T, Tanigawa T, Tarnawski A. Novel roles of local insulin-like growth factor-1 activation in gastric ulcer healing: promotes actin polymerization, cell proliferation, re-epithelialization, and induces cyclooxygenase-2 in a phosphatidylinositol 3-kinase-dependent manner. Am J Pathol. 2007;170:1219-28 pubmed
    ..The up-regulation of IGF-1 in gastric ulcer margin accelerates gastric ulcer healing by promoting cell re-epithelization, proliferation, and COX-2 expression via the phosphatidylinositol 3-kinase pathway. ..
  53. Wu D, Pei D, Wang Q, Zhang G. Down-regulation of PTEN by sodium orthovanadate inhibits ASK1 activation via PI3-K/Akt during cerebral ischemia in rat hippocampus. Neurosci Lett. 2006;404:98-102 pubmed
    ..Taken together, we concluded that sodium orthovanadate could increase the tyrosine posphorylation of PTEN and further inhibit the activation of ASK1 via activating Akt during cerebral ischemia. ..
  54. Horie T, Ono K, Nagao K, Nishi H, Kinoshita M, Kawamura T, et al. Oxidative stress induces GLUT4 translocation by activation of PI3-K/Akt and dual AMPK kinase in cardiac myocytes. J Cell Physiol. 2008;215:733-42 pubmed publisher
    ..These results demonstrate that AMPK and PI3-K/Akt have an additive effect on oxidative stress-mediated GLUT4 translocation. ..
  55. Cheng K, Xia P, Lin Q, Shen S, Gao M, Ren S, et al. Effects of low-intensity pulsed ultrasound on integrin-FAK-PI3K/Akt mechanochemical transduction in rabbit osteoarthritis chondrocytes. Ultrasound Med Biol. 2014;40:1609-18 pubmed publisher
    ..matrix (ECM) production via modulation of the integrin/focal adhesion kinase (FAK)/phosphatidylinositol 3-kinase (PI3K)/Akt pathway has been investigated in previous studies in normal chondrocytes, but not in osteoarthritis (OA)...
  56. Lin Y, Zhang N, Guo H, Kong D, Jiang T, Liang W, et al. Recombinant tissue factor pathway inhibitor induces apoptosis in cultured rat mesangial cells via its Kunitz-3 domain and C-terminal through inhibiting PI3-kinase/Akt pathway. Apoptosis. 2007;12:2163-73 pubmed
    ..Our findings suggest that rTFPI has the potential usefulness in inducing apoptosis of MsCs under inflammatory conditions. ..
  57. Strijdom H, Friedrich S, Hattingh S, Chamane N, Lochner A. Hypoxia-induced regulation of nitric oxide synthase in cardiac endothelial cells and myocytes and the role of the PI3-K/PKB pathway. Mol Cell Biochem. 2009;321:23-35 pubmed publisher
    ..Hypoxia-induced PKB and eNOS activation occurred simultaneously in both cell types, and the PI3-K/PKB pathway was associated with hypoxia-induced NO production via eNOS activation. ..
  58. Suwanabol P, Seedial S, Zhang F, Shi X, Si Y, Liu B, et al. TGF-? and Smad3 modulate PI3K/Akt signaling pathway in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2012;302:H2211-9 pubmed publisher
    ..These findings provide a potential mechanism for the substantial effect of TGF-? on intimal hyperplasia and suggest new targets for chemical or molecular prevention of vascular restenosis. ..
  59. Gukovsky I, Cheng J, Nam K, Lee O, Lugea A, Fischer L, et al. Phosphatidylinositide 3-kinase gamma regulates key pathologic responses to cholecystokinin in pancreatic acinar cells. Gastroenterology. 2004;126:554-66 pubmed
    ..We here report that these responses are regulated by phosphatidylinositide 3-kinase (PI3K) gamma...
  60. Haubner B, Neely G, Voelkl J, Damilano F, Kuba K, Imai Y, et al. PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway. PLoS ONE. 2010;5:e9350 pubmed publisher
    ..Thus, clinical development of specific PI3Kgamma blockers should proceed with caution. ..
  61. Lowry M, Lotinun S, Leontovich A, Zhang M, Maran A, Shogren K, et al. Osteitis fibrosa is mediated by Platelet-Derived Growth Factor-A via a phosphoinositide 3-kinase-dependent signaling pathway in a rat model for chronic hyperparathyroidism. Endocrinology. 2008;149:5735-46 pubmed publisher
  62. Yune T, Park H, Lee J, Oh T. Estrogen-induced Bcl-2 expression after spinal cord injury is mediated through phosphoinositide-3-kinase/Akt-dependent CREB activation. J Neurotrauma. 2008;25:1121-31 pubmed publisher
    ..Here, we investigated whether, after SCI, the phosphatidylinositol-3 kinase (PI3K)/Akt and extracellular signal-regulated kinase (ERK) pathways are involved in estrogen-induced expression of Bcl-2...
  63. Du F, Wang L, Qian W, Liu S. Loss of enteric neurons accompanied by decreased expression of GDNF and PI3K/Akt pathway in diabetic rats. Neurogastroenterol Motil. 2009;21:1229-e114 pubmed publisher
    ..in diabetic rats and the role of glia cell line-derived neurotrophic factor (GDNF) and its signalling pathway PI3K/Akt in regulating enteric neurons survival...
  64. Chen C, Chen C, Jian C, Lin P, Chou J, Teng H, et al. Attenuation of exercise effect on inflammatory responses via novel role of TLR4/PI3K/Akt signaling in rat splenocytes. J Appl Physiol (1985). 2016;121:870-877 pubmed publisher
    ..Phosphoinositide 3-kinase (PI3K)/Akt, a crucial downstream protein of toll-like receptor 4 (TLR4), may modulate inflammation...
  65. Perrino C, Naga Prasad S, Patel M, Wolf M, Rockman H. Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression. J Am Coll Cardiol. 2005;45:1862-70 pubmed
    ..Desensitization and down-regulation of beta-adrenergic receptors (betaARs) are prominent features of heart failure largely mediated by increased levels of betaAR kinase-1 (betaARK1)...
  66. Serajee F, Nabi R, Zhong H, Mahbubul Huq A. Association of INPP1, PIK3CG, and TSC2 gene variants with autistic disorder: implications for phosphatidylinositol signalling in autism. J Med Genet. 2003;40:e119 pubmed
  67. Kazi A, Tao J, Feinstein S, Zhang L, Fisher A, Bates S. Role of the PI3-kinase signaling pathway in trafficking of the surfactant protein A receptor P63 (CKAP4) on type II pneumocytes. Am J Physiol Lung Cell Mol Physiol. 2010;299:L794-807 pubmed publisher
    ..The results add to the growing body of evidence that P63 is critical for SP-A receptor-mediated interactions with type II pneumocytes and the resultant regulation of surfactant turnover. ..
  68. Zhao M, Yang J, Wang X, Tang C, Du J, Jin H. The PI3K/Akt pathway mediates the protection of SO(2) preconditioning against myocardial ischemia/reperfusion injury in rats. Acta Pharmacol Sin. 2013;34:501-6 pubmed publisher
    ..The activities of caspase-3 and -9 in myocardium were assayed using a commercial kit, and the levels of p-Akt, Akt, PI3K and p-PI3K were examined with Western blotting...
  69. Yuan G, Deng J, Wang T, Zhao C, Xu X, Wang P, et al. Tissue kallikrein reverses insulin resistance and attenuates nephropathy in diabetic rats by activation of phosphatidylinositol 3-kinase/protein kinase B and adenosine 5'-monophosphate-activated protein kinase signaling pathways. Endocrinology. 2007;148:2016-26 pubmed
    ..Together, these findings demonstrate that rAAV-HK delivery can efficiently attenuate hypertension, insulin resistance, and diabetic nephropathy in streptozotocin-induced diabetic rats. ..
  70. Zhang X, Zanello L. Vitamin D receptor-dependent 1 alpha,25(OH)2 vitamin D3-induced anti-apoptotic PI3K/AKT signaling in osteoblasts. J Bone Miner Res. 2008;23:1238-48 pubmed publisher
    ..of an Akt survival cascade downstream of 1,25D nongenomic stimulation of phosphatidylinositide-3'-kinase (PI3K) in osteoblastic cells...
  71. Dutra R, Cola M, Leite D, Bento A, Claudino R, Nascimento A, et al. Inhibitor of PI3K? ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4+CD25+FoxP3+ regulatory T cells. Br J Pharmacol. 2011;163:358-74 pubmed publisher
    Phosphoinositide 3-kinase-? (PI3K?) is implicated in many pathophysiological conditions, and recent evidence has suggested its involvement in colitis...
  72. Zhang H, Gao Y, Dai Z, Meng T, Tu S, Yan Y. IGF-1 reduces BACE-1 expression in PC12 cells via activation of PI3-K/Akt and MAPK/ERK1/2 signaling pathways. Neurochem Res. 2011;36:49-57 pubmed publisher
    ..Our data indicated that IGF-1-induced reduction of BACE-1 might involve the PI3-K/Akt and MAPK/ERK1/2 signaling pathways. ..
  73. Wu L, Liu W, Bayaer N, Gu W, Song J. Exogenous leptin administered intramuscularly induces sex hormone disorder and Ca loss via downregulation of Gnrh and PI3K expression. Exp Anim. 2014;63:447-57 pubmed
    ..hormone receptor (Gnrhr) mRNA expression; and western blotting analysis of enzyme phosphatidylinositol-3-kinase (PI3K)...
  74. Ravingerová T, Matejíková J, Neckar J, Andelová E, Kolar F. Differential role of PI3K/Akt pathway in the infarct size limitation and antiarrhythmic protection in the rat heart. Mol Cell Biochem. 2007;297:111-20 pubmed
    ..Activation of phosphatidylinositol 3-kinase (PI3K)/Akt is involved in antiapoptotic effects, however, it is not clear whether it is required for overall heart ..
  75. Song L, Jiang W, Qing Y, Hu X, Li Y, Tong Q, et al. [The antagonistic effect of PI3K-gamma inhibitor AS605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2011;42:471-4 pubmed
    ..05). AS605240 may be an effective antagonist for cardiac hypertrophy and cardiac fibrosis. ..
  76. Baragli A, Ghè C, Arnoletti E, Granata R, Ghigo E, Muccioli G. Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase ? and phosphodiesterase 3B. Biochim Biophys Acta. 2011;1811:386-96 pubmed publisher
    ..AG and UAG binding to a still unidentified receptor, which determines the activation of phosphoinositide 3-kinase (PI3K), protein kinase B (AKT), and mitogen-activated protein kinase (MAPK) ERK1/2...
  77. Deng J, Han Y, Yan C, Tian X, Tao J, Kang J, et al. Overexpressing cellular repressor of E1A-stimulated genes protects mesenchymal stem cells against hypoxia- and serum deprivation-induced apoptosis by activation of PI3K/Akt. Apoptosis. 2010;15:463-73 pubmed publisher
    ..Effects of CREG were investigated in the absence or presence of inhibitors that target phosphoinositide 3-kinase (PI3K)...
  78. Tosaka S, Makita T, Tosaka R, Maekawa T, Cho S, Hara T, et al. Cardioprotection induced by olprinone, a phosphodiesterase III inhibitor, involves phosphatidylinositol-3-OH kinase-Akt and a mitochondrial permeability transition pore during early reperfusion. J Anesth. 2007;21:176-80 pubmed
    Ischemic preconditioning is mediated by the activation of phosphatidylinositol-3-OH kinase-Akt (PI3K-Akt) and by the inhibition of the opening of a mitochondrial permeability transition pore (mPTP) during early reperfusion...
  79. He F, Wu L, Shu K, Liu F, Yang L, Zhou X, et al. HGF protects cultured cortical neurons against hypoxia/reoxygenation induced cell injury via ERK1/2 and PI-3K/Akt pathways. Colloids Surf B Biointerfaces. 2008;61:290-7 pubmed
    ..It is likely that Bcl-2 and Bcl-xL contribute to the protective effects of HGF. ..
  80. Wu J, Wang R, Yang D, Tang W, Chen Z, Sun Q, et al. Hydrogen postconditioning promotes survival of rat retinal ganglion cells against ischemia/reperfusion injury through the PI3K/Akt pathway. Biochem Biophys Res Commun. 2018;495:2462-2468 pubmed publisher
    ..Simultaneously, HPC treatment markedly increased the phosphorylations of Akt. Blockade of PI3K activity by inhibitors (LY294002) dramatically abolished its anti-apoptotic effect and lowered both visual function ..
  81. Li S, Yau S, Chen B, Tay D, Lee V, Pu M, et al. Enhanced survival of melanopsin-expressing retinal ganglion cells after injury is associated with the PI3 K/Akt pathway. Cell Mol Neurobiol. 2008;28:1095-107 pubmed publisher
    ..In this study, we report that mRGCs were injury-resistant to a more severe type of injury, the optic nerve transection. More importantly, the PI3 K/Akt pathway was found to play a role in maintaining the survival of mRGCs after injury. ..
  82. Subramaniam S, Strelau J, Unsicker K. GDNF prevents TGF-beta-induced damage of the plasma membrane in cerebellar granule neurons by suppressing activation of p38-MAPK via the phosphatidylinositol 3-kinase pathway. Cell Tissue Res. 2008;331:373-83 pubmed
    ..In addition, PI3K (phosphatidylinositol 3-kinase) inhibitors abolish the GDNF effect...