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Genomes and Genes | PgrSummaryGene Symbol: Pgr Description: progesterone receptor Alias: nuclear receptor subfamily 3 group C member 3 Species: rat Top Publications
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Publications
CDB-4124, a progesterone receptor modulator, inhibits mammary carcinogenesis by suppressing cell proliferation and inducing apoptosisRONALD WIEHLE
Repros Therapeutics, Inc, The Woodlands, TX 77380, USA
Cancer Prev Res (Phila) 4:414-24. 2011..Taken together, these data indicate that CDB-4124 can suppress the development of precancerous lesions and carcinogen-induced ER(+) mammary tumors in rats, and may have implications for prevention and treatment of human breast cancer...
Regulation of progesterone receptor expression by estradiol is dependent on age, sex and region in the rat brainPrincy S Quadros
Department of Psychology, University of Massachusetts, Amherst, Massachusetts 01003, USA
Endocrinology 149:3054-61. 2008..In addition, the neonatal female VMN may provide a unique model in which to examine the mechanisms underlying the specificity of steroid-induced gene expression...- Endogenous oestradiol regulates progesterone receptor expression in the brain of female rat fetuses: what is the source of oestradiol?V Jahagirdar
Department of Psychology and Centre for Neuroscience Research, University at Albany, SUNY, Albany, NY 12222, USA
J Neuroendocrinol 20:359-65. 2008..Alternative sources of E(2) may be essential in ensuring the normal development of the female brain... 
Alpha-oestrogen and progestin receptor expression in the hypothalamus and preoptic area dopaminergic neurones during oestrous in cycling ratsC M Leite
Departamento de Fisiologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
J Neuroendocrinol 20:110-9. 2008....- Sex steroid receptor expression profile in brown adipose tissue. Effects of hormonal statusSergio Rodriguez-Cuenca
Grup de Metabolisme Energetic i Nutricio, Departament de Biologia Fonamental i Ciencies de la Salut, Institut Universitari d Investigacio en Ciencies de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain
Cell Physiol Biochem 20:877-86. 2007.... - Expression of ovarian steroid hormone receptors in tuberoinfundibular dopaminergic neurones during pregnancy and lactationF J Steyn
Centre for Neuroendocrinology and Department of Anatomy and Structural Biology, University of Otago School of Medical Sciences, Dunedin, New Zealand
J Neuroendocrinol 19:788-93. 2007..The relatively stable level of expression during late pregnancy suggests that a shift in steroid receptor expression during late pregnancy does not contribute to the change in TIDA responsiveness to prolactin at this time... - Distribution of progesterone receptor immunoreactivity in the fetal and neonatal rat forebrainPrincy S Quadros
Center for Neuroendocrine Studies and Neuroscience and Behavior Program, University of Massachusetts, Amherst, Massachusetts 01003, USA
J Comp Neurol 504:42-56. 2007..The presence PR expression in the developing forebrain implicates the involvement of progesterone and PR in fundamental mechanisms of neural development... - Progesterone receptor isoforms and proliferation in the rat mammary gland during developmentAnastasia Kariagina
Department of Physiology, 2201 Biomedical and Physical Sciences Building, Michigan State University, East Lansing, MI 48824, USA
Endocrinology 148:2723-36. 2007..From this observation, we conclude that these cells proliferate and that P acting through PRB may directly stimulate proliferation... - Progesterone receptors activation after acute cocaine administrationHui Bing K Wu
Department of Psychology, Hunter College, City University of New York, New York, NY 10021, USA
Brain Res 1126:188-92. 2006..Our results suggest that activation of progesterone receptors may be a mechanism by which cocaine mediates behavior through molecular alterations in the central nervous system... - Association between polymorphisms in the progesterone receptor gene and endometriosisSusan A Treloar
Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Mol Hum Reprod 11:641-7. 2005..Further, analysis of our results pooled with those from two previous studies suggested that neither the T2 allele of the AluIns nor the T1/T2 genotype was associated with endometriosis... - Progestin activation of nongenomic pathways via cross talk of progesterone receptor with estrogen receptor beta induces proliferation of endometrial stromal cellsGriselda Vallejo
Instituto de Biologia y Medicina Experimental IByME CONICET, Obligado 2490, 1428 Buenos Aires, Argentina
Mol Endocrinol 19:3023-37. 2005.... - The ovary-mediated FSH attenuation of the LH surge in the rat involves a decreased gonadotroph progesterone receptor (PR) action but not PR expressionAna Gordon
Departments of Cell Biology, Physiology and Immunology and Comparative Pathology, University of Cordoba, 14004 Cordoba, Spain IVI Madrid, Madrid, Spain
J Endocrinol 196:583-92. 2008..The action of such a factor seemed to be due to a blockade of gonadotroph PR action rather than to an inhibition of PR expression... - Follicle-stimulating hormone responses to kisspeptin in the female rat at the preovulatory period: modulation by estrogen and progesterone receptorsJ Roa
Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
Endocrinology 149:5783-90. 2008.... - Distribution of progesterone receptor immunoreactivity in the midbrain and hindbrain of postnatal ratsPrincy S Quadros
Department of Biological Sciences, Delaware State University, Dover, DE 19901, USA
Dev Neurobiol 68:1378-90. 2008.... - Developmental and hormone-induced epigenetic changes to estrogen and progesterone receptor genes in brain are dynamic across the life spanJaclyn M Schwarz
Program in Neuroscience, Department of Physiology, University of Maryland, Baltimore, 655 West Baltimore Street, 5 015, Baltimore, Maryland 21201, USA
Endocrinology 151:4871-81. 2010.... - Subfertility linked to combined luteal insufficiency and uterine progesterone resistanceToshihiro Konno
Institute of Maternal Fetal Biology, and Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
Endocrinology 151:4537-50. 2010..P4 resistance was associated with decreased transcript levels for the P4 receptor (Pgr), a P4 receptor chaperone (Fkbp4), and P4 receptor coactivators (Ncoa1 and Ncoa2)... - Progesterone receptor immunoreactivity in the brains of ovariectomized aged ratsMiyako Furuta
Department of Physiology, St Marianna University School of Medicine, Miyamae ku, Kawasaki, Japan
Neuroreport 21:777-81. 2010..Therefore, the ability of estrogen to induce PR immunoreactivity in the hypothalamus in ovariectomized rats is attenuated in old rats compared with young rats... - Progesterone enhances transthyretin expression in the rat choroid plexus in vitro and in vivo via progesterone receptorTelma Quintela
Health Sciences Research Centre CICS, University of Beira Interior, Av Infante D Henrique, Covilha, Portugal
J Mol Neurosci 44:152-8. 2011..Our results reinforce the importance of ovarian hormones on the regulation of TTR, which may reflect on the processing of Aβ peptides and consequently on AD onset and progression... - Effects of mating on progesterone receptor isoforms in rat hypothalamusLuciano Mendoza-Garcés
Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Coyoacan, Mexico, D F, Mexico
Neuroreport 21:513-6. 2010..These data show that PR isoforms are differentially expressed throughout proestrus-estrus transition and that mating modifies PR isoforms expression in the hypothalamus of the rat... - Transcriptional effects of progesterone receptor antagonist in rat granulosa cellsP Anders Friberg
Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Mol Cell Endocrinol 315:121-30. 2010Progesterone, acting via the nuclear progesterone receptor (PGR), reduces apoptosis in periovulatory granulosa cells, and is a likely mediator of the anti-atretic actions of LH... - Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in ratFrancisco M Zurvarra
Department of Morphological Sciences and Center for Experimental Biology and Laboratory Animals Sciences, Faculty of Veterinary Sciences, Universidad Nacional del Litoral, Argentina
Reprod Fertil Dev 21:827-39. 2009.... - Role of progesterone receptor isoforms in female sexual behavior induced by progestins in ratsChristian Guerra-Araiza
Unidad de Investigacion Medica en Farmacologia, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico, D F
Neuroendocrinology 90:73-81. 2009..These results suggest that the PR-B isoform is essential for the display of the lordosis behavior in rats... - Progestin receptor-mediated reduction of anxiety-like behavior in male ratsCatherine J Auger
Department of Psychology, University of Wisconsin, Madison, Wisconsin, United States of America
PLoS ONE 3:e3606. 2008.... - Ultrastructural localization of extranuclear progestin receptors in the rat hippocampal formationElizabeth M Waters
Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, USA
J Comp Neurol 511:34-46. 2008.... - PROGINS Alu sequence insertion is associated with hyperprolactinaemia but not leiomyoma susceptibilityYao Yuan Hsieh
Department of Biological Science and Technology, National Chiao Tung University, 75 Po Ai Street, Hsinchu 300, Taiwan
Clin Endocrinol (Oxf) 62:492-7. 2005Leiomyoma and hyperprolactinaemia are both progesterone-dependent diseases. Hormone-related genes, such as the progesterone receptor (PGR), might be involved in their pathogenesis. - Sexual dimorphism in the content of progesterone and estrogen receptors, and their cofactors in the lung of adult ratsAliesha González-Arenas
Departamento de Biologia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Coyoacan 04510, Mexico, D F, Mexico
Steroids 69:351-6. 2004..Our results suggest a sexual dimorphism in the content of PR, ER-beta, and SMRT in the rat lung as well as a relation of their content to the physiological levels of progesterone and estradiol... - Immunocytochemical investigation of nuclear progestin receptor expression within dopaminergic neurones of the female rat brainJ S Lonstein
Program in Neuroscience, Department of Psychology, Michigan State University, East Lansing, MI, USA
J Neuroendocrinol 16:534-43. 2004.... - Cellular turnover in the rat uterine cervix and its relationship to estrogen and progesterone receptor dynamicsJorge G Ramos
Laboratorio de Endocrinologia y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, 3000 Santa Fe, Argentina
Biol Reprod 67:735-42. 2002.... - Progesterone receptors and the sexual differentiation of the medial preoptic nucleusPrincy S Quadros
Center for Neuroendocrine Studies, Neuroscience and Behavior Program and Department of Psychology, Tobin Hall, Box 37720, University of Massachusetts, Amherst, Massachusetts 01003, USA
J Neurobiol 51:24-32. 2002..These results, taken together with the expression of PR in the MPNc, suggest that PR may influence the sexual differentiation of the MPNc volume... - Progesterone receptor expression in the pregnant and parturient rat hypothalamus and brainstemKaren Francis
Division of Biomedical and Clinical Laboratory Sciences, University of Edinburgh Medical School, Edinburgh EH8 9XD, UK
Brain Res 927:18-26. 2002..Upregulation of PR expression in the MPA during pregnancy and parturition may relate to the onset of maternal behavior and/or regulation of GnRH neuronal activity... - Progestin receptors mediate progesterone suppression of epileptiform activity in tetanized hippocampal slices in vitroH E Edwards
Department of Obstetrics Gynecology, The Toronto Hospital Research Institute, Toronto, Canada
Neuroscience 101:895-906. 2000..After tetanization, however, progesterone receptor-mediated responses become quantitatively more important as a mechanism for suppressing hippocampal electrical activity... - Progesterone regulation of the progesterone receptor in rat gonadotropesJ L Turgeon
Department of Human Physiology, School of Medicine, University of California, Davis 95616, USA
Endocrinology 141:3422-9. 2000..These dynamic changes in nuclear PR levels coincide with the temporal extent of the preovulatory LH surge in rats and could provide a basis for progesterone's biphasic action on LH secretion... - Immunocytochemical evidence for a progesterone receptor in neurons and glial cells of the rat spinal cordF Labombarda
Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, Department of Biochemistry, University of Buenos Aires, Argentina
Neurosci Lett 288:29-32. 2000..This receptor may be implicated in some of the biological effects of progesterone described in the spinal cord... - Hormonal regulation, localization, and functional activity of the progesterone receptor in granulosa cells of rat preovulatory folliclesU Natraj
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
Endocrinology 133:761-9. 1993.... - Regulation of the progesterone receptor gene by gonadotropins and cyclic adenosine 3',5'-monophosphate in rat granulosa cellsO K Park-Sarge
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208
Endocrinology 134:709-18. 1994.... - The ontogeny of gene expression of progestin receptors in the female rat brainJ Kato
Department of Obstetrics and Gynecology, Yamanashi Medical University, Japan
J Steroid Biochem Mol Biol 47:173-82. 1993..Moreover, lowered levels of the cortical PR mRNAs in the propylthiouracil-induced hypothyroid rat, together with suppressed PR level, indicate a possible regulatory role of thyroid hormone on gene expression of the cortical receptor... - Cloning of the rat progesterone receptor gene 5'-region and identification of two functionally distinct promotersW L Kraus
Department of Physiology and Biophysics, Urbana 61801
Mol Endocrinol 7:1603-16. 1993.... - Sex differences in progesterone receptor expression: a potential mechanism for estradiol-mediated sexual differentiationPrincy S Quadros
Center for Neuroendocrine Studies and Neuroscience and Behavior Program, University of Massachusetts, Amherst 01003, USA
Endocrinology 143:3727-39. 2002..This suggests that aromatization of T into E is crucial for the sex difference in PR expression in the MPN and AVPv during development... - Effect of estrogens on ontogenetic expression of progesterone receptor in the fetal female rat reproductive tractAkinobu Okada
Safety Research Laboratories, Yamanouchi Pharmaceutical Co Ltd, Tokyo, Japan
Mol Cell Endocrinol 195:55-64. 2002.... - Regulation of sex differences in progesterone receptor expression in the medial preoptic nucleus of postnatal ratsP S Quadros
Center for Neuroendocrine Studies and Neuroscience and Behaviour Program, University of Massachusetts, Amherst, MA, USA
J Neuroendocrinol 14:761-7. 2002..These findings suggest that differences in steroid secretion by the neonatal male and female gonads are responsible for producing sex differences in the level of PR expression in the postnatal MPN... - The 26S proteasome participates in the sequential inhibition of estrous behavior induced by progesterone in ratsOscar Gonzalez-Flores
Centro de Investigacion en Reproduccion Animal, Centro de Investigacion y de Estudios Avanzados Universidad Autonoma de Tlaxcala, Tlaxcala 90140, Mexico
Endocrinology 145:2328-36. 2004..In contrast, PSI and TLCK significantly increased PR content in both structures. Our results suggest that PR degradation by the 26S proteasome participates in the expression of P-induced SI in female rats... - p-Nonylphenol, 4-tert-octylphenol and bisphenol A increase the expression of progesterone receptor mRNA in the frontal cortex of adult ovariectomized ratsT Funabashi
Neuroendocrinology, Yokohama City University Graduate School of Medicine, Fukuura, Yokohama, Japan
J Neuroendocrinol 16:99-104. 2004..These results suggest that, even in adult rats, endocrine disrupters alter the neocortical function by affecting the PR system, although the physiological significance of PR in the affected area is unknown... - Downregulation of androgen, estrogen and progesterone receptor genes and protein is involved in aging-related erectile dysfunctionM Shirai
VA Medical Center and UCSF, Urology, San Francisco, California 94121, USA
Int J Impot Res 15:391-6. 2003..This is the first study to demonstrate that downregulation of sex hormone receptors in aging rat crura is associated with erectile dysfunction... - Correlates of obesity in postmenopausal women with breast cancer: comparison of genetic, demographic, disease-related, life history and dietary factorsL Wasserman
Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0639, USA
Int J Obes Relat Metab Disord 28:49-56. 2004..If genetic factors contribute to obesity, and the PR and AIB1 genes influence estrogenic, insulin and IGF pathways, then genetic patterns resulting from PR and AIB1 polymorphisms may be associated with obesity in postmenopausal women... - The role of estrogen-dependent progesterone receptor in protein kinase C-mediated LH secretion and GnRH self-priming in rat anterior pituitary glandsR Aguilar
Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
J Endocrinol Invest 26:527-32. 2003..Also, the results are suggestive of an interaction of PKC signaling pathway with E-dependent PR in a ligand-independent activation manner in the gonadotrope... - The distribution of progestin receptor mRNA in rat brainstemMeredith A Curran-Rauhut
Center for Neuroendocrine Studies, Neuroscience and Behavior Graduate Program, and Department of Biology, 221 Morrill Science Center, University of Massachusetts, Amherst, MA 01003, USA
Brain Res Gene Expr Patterns 1:151-7. 2002Hypothalamic sites wherein P4, through progestin receptor, (Pgr; commonly abbreviated PR), maximizes the expression of female sexual behaviors and gonadotropin surge release have been studied intensively... - Biological markers that predict clinical recurrence in ductal carcinoma in situ of the breastE Provenzano
Molecular Pathology Laboratory, Victorian Breast Cancer Research Consortium, The University of Melbourne, Parkville, Victoria 3052, Australia
Eur J Cancer 39:622-30. 2003..These data identify clinically and biologically relevant subcategories of DCIS lesions, an essential basis for improving management... - Role of the progesterone receptor in restrained glutamic acid decarboxylase gene expression in the hypothalamus during the preovulatory luteinizing hormone surgeDarrell W Brann
Institute of Molecular Medicine and Genetics, and Department of Neurology, Neurobiology Program, Medical College of Georgia, Augusta, GA 30912, USA
Neuroendocrinology 76:283-9. 2002..These findings suggest that the progesterone receptor plays a role in restraining GAD expression in the hypothalamus during proestrus, and that this effect may be important for the production of the GnRH and LH surge... - Site-specific decrease of progesterone receptor mRNA expression in the hypothalamus of middle-aged persistently estrus ratsRichard H Mills
Department of Neurobiology, UCLA School of Medicine, Los Angeles, CA 90095 1763, USA
Brain Res 955:200-6. 2002..In acyclic, long-term PE rats, diminished estrogen-induced expression of progesterone receptors is correlated with a previously shown inability to respond to exogenous progesterone... - Sex differences in the regulation of progesterone receptor isoforms expression in the rat brainChristian Guerra-Araiza
Departamento de Biologia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
Brain Res Bull 59:105-9. 2002.... - Transient expression of progesterone receptor messenger RNA in ovarian granulosa cells after the preovulatory luteinizing hormone surgeO K Park
Department of Biochemistry, Molecular Biology, Northwestern University, Evanston, Illinois 60208
Mol Endocrinol 5:967-78. 1991..This transient, hormonally regulated, and cell-specific expression of the PR gene in the rat ovary strongly suggests an important intraovarian function for progesterone during the rat reproductive cycle...
Research Grants
- Neurobiological Control of Maternal AnxietyJoseph S Lonstein; Fiscal Year: 2010..Determining how physical contact with infants modulates maternal neurochemistry in a way that alleviates anxiety will help improve the diagnosis and treatment of women suffering from a postpartum anxiety disorder. ..
- MECHANISMS OF REPRODUCTIVE AGINGDarrell Brann; Fiscal Year: 2004..As a whole, the proposed studies will provide important insights as to why glutamate signaling is compromised in the hypothalamus of the middle-aged rat, and will advance our understanding of reproductive aging. ..
- Neurochemical control of maternal behaviorJOSEPH LONSTEIN; Fiscal Year: 2002..These results will provide much needed insight into how the brain controls nurturant behavior, which is a complex social behavior that is often critical for survival in many mammalian species. ..
- GENOMICS OF GnRH PRIMINGJUDITH TURGEON; Fiscal Year: 2005....
- Mechanisms of Estrogen Signaling and NeuroprotectionRatna K Vadlamudi; Fiscal Year: 2010....
- Neuroprotective and Neurogenic Actions of E2 and SERMsDarrell Brann; Fiscal Year: 2009..Correlation to functional neurological outcomes will also be determined. As a whole, the proposed studies would significantly advance our understanding of the neuroprotective and neurogenic actions of E2 and SERMs in the injured brain. ..
- LH Secretion MechanismsJUDITH TURGEON; Fiscal Year: 2006..Cell models will be cultured gonadotropes from rats and wild-type and PR-knockout (PRKO) mice and the LbetaT2 gonadotrope cell line. ..
- ASTROCYTE-NEURON INTERACTIONS AND GNRH NEURONAL FUNCTIONDarrell Brann; Fiscal Year: 2005....
- EXCITATORY AMINO ACIDS: ROLE IN GNRH, LH & FSH SECRETIONDarrell Brann; Fiscal Year: 2000..These studies will enhance our understanding of the complex neuroendocrine mechanisms controlling GnRH and LH secretion in the female. ..
- LUTEINIZING HORMONE SECRETION MECHANISMSJUDITH TURGEON; Fiscal Year: 2000....
- GONADOTROPIN SECRETION IN VITROJUDITH TURGEON; Fiscal Year: 1980....
- GONADOTROPIN SECRETION IN VITROJUDITH TURGEON; Fiscal Year: 1992..These studies will provide insight into the mechanisms of action of LHRH in that modulation of specific intracellular events will be related to physiological effects of the hormone...