Pgr

Summary

Gene Symbol: Pgr
Description: progesterone receptor
Alias: nuclear receptor subfamily 3 group C member 3
Species: rat

Top Publications

  1. doi Antagonists of the protein kinase A and mitogen-activated protein kinase systems and of the progestin receptor block the ability of vaginocervical/flank-perineal stimulation to induce female rat sexual behaviour
    O Gonzalez-Flores
    Centro de Investigacion en Reproduccion Animal, CINVESTAV Universidad Autónoma de Tlaxcala, Tlaxcala, Mexico
    J Neuroendocrinol 20:1361-7. 2008
  2. pmc An antiprogestin, CDB4124, blocks progesterone's attenuation of the negative effects of a mild stress on sexual behavior
    Lynda Uphouse
    Department of Biology, Texas Woman s University, United States
    Behav Brain Res 240:21-5. 2013
  3. doi Extra-nuclear activation of progesterone receptor in regulating arterial smooth muscle cell migration
    Sung Po Hsu
    Graduate Institute of Medical Sciences, Medical College, Taipei Medical University, Taipei, Taiwan
    Atherosclerosis 217:83-9. 2011
  4. ncbi Changes in alpha-estradiol receptor and progesterone receptor expression in the locus coeruleus and preoptic area throughout the rat estrous cycle
    Cleyde Vanessa Vega Helena
    Departamento de Fisiologia, Faculdade de Medicina de Ribeirao Preto Universidade de Sao Paulo, Ribeirao Preto, Brazil
    J Endocrinol 188:155-65. 2006
  5. ncbi [The changes of estrogen receptor (ER) and progesterone receptor (PR) mRNAs in endometrium with endometriosis]
    Hui Zheng
    Department of Physiology, Medical College of Jinan University, Guangzhou 510632, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 20:194-6. 2004
  6. pmc Anatomically-specific actions of oestrogen receptor in the developing female rat brain: effects of oestradiol and selective oestrogen receptor modulators on progestin receptor expression
    K L Gonzales
    Department of Psychology, Behavioral Neuroscience Program, University at Albany State University of New York, Albany, NY 12222, USA
    J Neuroendocrinol 24:285-91. 2012
  7. pmc Antagonism of progesterone receptor suppresses carotid body responses to hypoxia and nicotine in rat pups
    V Joseph
    Department of Pediatrics, Laval University, Centre de Recherche D0 711, Hôpital St François d Assise, 10 rue de l Espinay, QC, G1L 3L5, Canada
    Neuroscience 207:103-9. 2012
  8. pmc Distribution and estrogen regulation of membrane progesterone receptor-β in the female rat brain
    Damian G Zuloaga
    Department of Basic Medical Sciences, University of Arizona College of Medicine, 425 North 5th Street, Phoenix, Arizona 85004, USA
    Endocrinology 153:4432-43. 2012
  9. pmc Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17β-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis
    Namrata Bali
    University of Southern California Dornsife College of Letters, Arts and Sciences, Los Angeles, California 90089 0191, USA
    Endocrinology 153:759-69. 2012
  10. doi Distribution of membrane progesterone receptor alpha in the male mouse and rat brain and its regulation after traumatic brain injury
    D Meffre
    UMR 788 INSERM and University Paris Sud, 94276 Kremlin Bicêtre, France
    Neuroscience 231:111-24. 2013

Research Grants

  1. Neurobiological Control of Maternal Anxiety
    Joseph S Lonstein; Fiscal Year: 2010
  2. MECHANISMS OF REPRODUCTIVE AGING
    Darrell Brann; Fiscal Year: 2004
  3. Neurochemical control of maternal behavior
    JOSEPH LONSTEIN; Fiscal Year: 2002
  4. GENOMICS OF GnRH PRIMING
    JUDITH TURGEON; Fiscal Year: 2005
  5. Mechanisms of Estrogen Signaling and Neuroprotection
    Ratna K Vadlamudi; Fiscal Year: 2010
  6. Neuroprotective and Neurogenic Actions of E2 and SERMs
    Darrell Brann; Fiscal Year: 2009
  7. LH Secretion Mechanisms
    JUDITH TURGEON; Fiscal Year: 2006
  8. ASTROCYTE-NEURON INTERACTIONS AND GNRH NEURONAL FUNCTION
    Darrell Brann; Fiscal Year: 2005
  9. EXCITATORY AMINO ACIDS: ROLE IN GNRH, LH & FSH SECRETION
    Darrell Brann; Fiscal Year: 2000
  10. LUTEINIZING HORMONE SECRETION MECHANISMS
    JUDITH TURGEON; Fiscal Year: 2000

Scientific Experts

  • Princy S Quadros
  • K L Gonzales
  • O González Flores
  • Lynda Uphouse
  • Vincent Joseph
  • Richard H Mills
  • JUDITH TURGEON
  • Toshiya Funabashi
  • Elizabeth M Waters
  • RONALD WIEHLE
  • C J Auger
  • Susan A Treloar
  • L Wasserman
  • J S Lonstein
  • D W Brann
  • Ratna K Vadlamudi
  • Christian Guerra-Araiza
  • Ignacio Camacho-Arroyo
  • Oscar Gonzalez-Flores
  • D Meffre
  • Damian G Zuloaga
  • Namrata Bali
  • F Labombarda
  • Sung Po Hsu
  • Telma Quintela
  • Luciano Mendoza-Garcés
  • Miyako Furuta
  • Jaclyn M Schwarz
  • P Anders Friberg
  • Toshihiro Konno
  • Francisco M Zurvarra
  • C M Leite
  • J Roa
  • Ana Gordon
  • V Jahagirdar
  • O Gonzalez-Flores
  • F J Steyn
  • Sergio Rodriguez-Cuenca
  • Anastasia Kariagina
  • R Guennoun
  • M Schumacher
  • A F De Nicola
  • Cleyde Vanessa Vega Helena
  • Hui Bing K Wu
  • Griselda Vallejo
  • Yao Yuan Hsieh
  • Hui Zheng
  • Aliesha González-Arenas
  • E Provenzano
  • M Shirai
  • R Aguilar
  • Jorge G Ramos
  • Meredith A Curran-Rauhut
  • Karen Francis
  • Akinobu Okada
  • B Delespierre
  • A Chastre
  • D G Stein
  • Todd E Morgan
  • Roberta D Brinton
  • Andrea Reyna
  • Caleb E Finch
  • Robert J Handa
  • Peter Thomas
  • Yefei Pang
  • Nahoko Iwata
  • Jason M Arimoto
  • Mario G Oyola
  • Sharon W Lin
  • Alicia M Quihuis
  • Liqin Zhao
  • Stephanie L Yahn
  • Shailaja K Mani
  • Jheng Jhe Lin
  • Yu Pei Chou
  • Wen Sen Lee
  • Nen Chun Chang
  • Tong Sheng Lee
  • Chun Ting Kuo
  • Li Ching Chen
  • Pedro Rocha
  • Isabel Goncalves
  • Celso Henrique Alves
  • Thay Hsiung Chen
  • Cecília Reis Alves Santos
  • Ana Martinho
  • Maria Joao Saraiva
  • Akane Sano
  • Jennifer K Ho-Chen
  • Margaret M McCarthy

Detail Information

Publications61

  1. doi Antagonists of the protein kinase A and mitogen-activated protein kinase systems and of the progestin receptor block the ability of vaginocervical/flank-perineal stimulation to induce female rat sexual behaviour
    O Gonzalez-Flores
    Centro de Investigacion en Reproduccion Animal, CINVESTAV Universidad Autónoma de Tlaxcala, Tlaxcala, Mexico
    J Neuroendocrinol 20:1361-7. 2008
    ....
  2. pmc An antiprogestin, CDB4124, blocks progesterone's attenuation of the negative effects of a mild stress on sexual behavior
    Lynda Uphouse
    Department of Biology, Texas Woman s University, United States
    Behav Brain Res 240:21-5. 2013
    ..These findings are consistent with the hypothesis that progesterone receptors mediate progesterone's ability to reduce the negative sexual behavioral effects of a mild stressor...
  3. doi Extra-nuclear activation of progesterone receptor in regulating arterial smooth muscle cell migration
    Sung Po Hsu
    Graduate Institute of Medical Sciences, Medical College, Taipei Medical University, Taipei, Taiwan
    Atherosclerosis 217:83-9. 2011
    ..These findings expend our knowledge of the basis of P4's effect on vascular smooth muscle cell migration and highlight novel pathways of signaling transduction of P4 through PR-mediated nongenomic mechanisms...
  4. ncbi Changes in alpha-estradiol receptor and progesterone receptor expression in the locus coeruleus and preoptic area throughout the rat estrous cycle
    Cleyde Vanessa Vega Helena
    Departamento de Fisiologia, Faculdade de Medicina de Ribeirao Preto Universidade de Sao Paulo, Ribeirao Preto, Brazil
    J Endocrinol 188:155-65. 2006
    ..This profile of alphaER and PR expression might be related to the ability of estradiol and progesterone in regulating the activity of LC neurons, which could be associated to the control mechanisms of LH and prolactin release...
  5. ncbi [The changes of estrogen receptor (ER) and progesterone receptor (PR) mRNAs in endometrium with endometriosis]
    Hui Zheng
    Department of Physiology, Medical College of Jinan University, Guangzhou 510632, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 20:194-6. 2004
    ..To explore the expression of ER and PR mRNAs in endometrium with endometriosis...
  6. pmc Anatomically-specific actions of oestrogen receptor in the developing female rat brain: effects of oestradiol and selective oestrogen receptor modulators on progestin receptor expression
    K L Gonzales
    Department of Psychology, Behavioral Neuroscience Program, University at Albany State University of New York, Albany, NY 12222, USA
    J Neuroendocrinol 24:285-91. 2012
    ..These findings demonstrate the anatomically-specific actions of oestradiol and its receptor to induce PR in two brain regions controlling different aspects of female reproductive behaviours in adulthood...
  7. pmc Antagonism of progesterone receptor suppresses carotid body responses to hypoxia and nicotine in rat pups
    V Joseph
    Department of Pediatrics, Laval University, Centre de Recherche D0 711, Hôpital St François d Assise, 10 rue de l Espinay, QC, G1L 3L5, Canada
    Neuroscience 207:103-9. 2012
    ..Immunohistochemical staining revealed that mifepristone treatment did not change carotid body morphology. We conclude that PR activity is a critical factor ensuring proper carotid body function in newborn rats...
  8. pmc Distribution and estrogen regulation of membrane progesterone receptor-β in the female rat brain
    Damian G Zuloaga
    Department of Basic Medical Sciences, University of Arizona College of Medicine, 425 North 5th Street, Phoenix, Arizona 85004, USA
    Endocrinology 153:4432-43. 2012
    ..Furthermore, E(2) regulation of mPRβ indicates a mechanism through which estrogens can regulate P(4) function within discrete brain regions to potentially impact behavior...
  9. pmc Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17β-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis
    Namrata Bali
    University of Southern California Dornsife College of Letters, Arts and Sciences, Los Angeles, California 90089 0191, USA
    Endocrinology 153:759-69. 2012
    ..neuronal expression of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr), by in situ hybridization and immunohistochemistry...
  10. doi Distribution of membrane progesterone receptor alpha in the male mouse and rat brain and its regulation after traumatic brain injury
    D Meffre
    UMR 788 INSERM and University Paris Sud, 94276 Kremlin Bicêtre, France
    Neuroscience 231:111-24. 2013
    ....
  11. pmc Ultrastructural localization of extranuclear progestin receptors in the rat hippocampal formation
    Elizabeth M Waters
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, USA
    J Comp Neurol 511:34-46. 2008
    ....
  12. doi Distribution of progesterone receptor immunoreactivity in the midbrain and hindbrain of postnatal rats
    Princy S Quadros
    Department of Biological Sciences, Delaware State University, Dover, DE 19901, USA
    Dev Neurobiol 68:1378-90. 2008
    ....
  13. doi Follicle-stimulating hormone responses to kisspeptin in the female rat at the preovulatory period: modulation by estrogen and progesterone receptors
    J Roa
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    Endocrinology 149:5783-90. 2008
    ....
  14. doi The ovary-mediated FSH attenuation of the LH surge in the rat involves a decreased gonadotroph progesterone receptor (PR) action but not PR expression
    Ana Gordon
    Departments of Cell Biology, Physiology and Immunology and Comparative Pathology, University of Cordoba, 14004 Cordoba, Spain IVI Madrid, Madrid, Spain
    J Endocrinol 196:583-92. 2008
    ..The action of such a factor seemed to be due to a blockade of gonadotroph PR action rather than to an inhibition of PR expression...
  15. pmc Regulation of progesterone receptor expression by estradiol is dependent on age, sex and region in the rat brain
    Princy S Quadros
    Department of Psychology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Endocrinology 149:3054-61. 2008
    ..In addition, the neonatal female VMN may provide a unique model in which to examine the mechanisms underlying the specificity of steroid-induced gene expression...
  16. doi Endogenous oestradiol regulates progesterone receptor expression in the brain of female rat fetuses: what is the source of oestradiol?
    V Jahagirdar
    Department of Psychology and Centre for Neuroscience Research, University at Albany, SUNY, Albany, NY 12222, USA
    J Neuroendocrinol 20:359-65. 2008
    ..Alternative sources of E(2) may be essential in ensuring the normal development of the female brain...
  17. ncbi Alpha-oestrogen and progestin receptor expression in the hypothalamus and preoptic area dopaminergic neurones during oestrous in cycling rats
    C M Leite
    Departamento de Fisiologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
    J Neuroendocrinol 20:110-9. 2008
    ....
  18. ncbi Sex steroid receptor expression profile in brown adipose tissue. Effects of hormonal status
    Sergio Rodriguez-Cuenca
    Grup de Metabolisme Energetic i Nutricio, Departament de Biologia Fonamental i Ciencies de la Salut, Institut Universitari d Investigacio en Ciencies de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain
    Cell Physiol Biochem 20:877-86. 2007
    ....
  19. ncbi Expression of ovarian steroid hormone receptors in tuberoinfundibular dopaminergic neurones during pregnancy and lactation
    F J Steyn
    Centre for Neuroendocrinology and Department of Anatomy and Structural Biology, University of Otago School of Medical Sciences, Dunedin, New Zealand
    J Neuroendocrinol 19:788-93. 2007
    ..The relatively stable level of expression during late pregnancy suggests that a shift in steroid receptor expression during late pregnancy does not contribute to the change in TIDA responsiveness to prolactin at this time...
  20. pmc Progestin receptor-mediated reduction of anxiety-like behavior in male rats
    Catherine J Auger
    Department of Psychology, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 3:e3606. 2008
    ....
  21. doi Role of progesterone receptor isoforms in female sexual behavior induced by progestins in rats
    Christian Guerra-Araiza
    Unidad de Investigacion Medica en Farmacologia, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico, D F
    Neuroendocrinology 90:73-81. 2009
    ..These results suggest that the PR-B isoform is essential for the display of the lordosis behavior in rats...
  22. ncbi Progestin receptors mediate progesterone suppression of epileptiform activity in tetanized hippocampal slices in vitro
    H E Edwards
    Department of Obstetrics Gynecology, The Toronto Hospital Research Institute, Toronto, Canada
    Neuroscience 101:895-906. 2000
    ..After tetanization, however, progesterone receptor-mediated responses become quantitatively more important as a mechanism for suppressing hippocampal electrical activity...
  23. doi CDB-4124, a progesterone receptor modulator, inhibits mammary carcinogenesis by suppressing cell proliferation and inducing apoptosis
    RONALD WIEHLE
    Repros Therapeutics, Inc, The Woodlands, TX 77380, USA
    Cancer Prev Res (Phila) 4:414-24. 2011
    ..Taken together, these data indicate that CDB-4124 can suppress the development of precancerous lesions and carcinogen-induced ER(+) mammary tumors in rats, and may have implications for prevention and treatment of human breast cancer...
  24. pmc Developmental and hormone-induced epigenetic changes to estrogen and progesterone receptor genes in brain are dynamic across the life span
    Jaclyn M Schwarz
    Program in Neuroscience, Department of Physiology, University of Maryland, Baltimore, 655 West Baltimore Street, 5 015, Baltimore, Maryland 21201, USA
    Endocrinology 151:4871-81. 2010
    ....
  25. pmc Subfertility linked to combined luteal insufficiency and uterine progesterone resistance
    Toshihiro Konno
    Institute of Maternal Fetal Biology, and Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Endocrinology 151:4537-50. 2010
    ..P4 resistance was associated with decreased transcript levels for the P4 receptor (Pgr), a P4 receptor chaperone (Fkbp4), and P4 receptor coactivators (Ncoa1 and Ncoa2)...
  26. doi Progesterone receptor immunoreactivity in the brains of ovariectomized aged rats
    Miyako Furuta
    Department of Physiology, St Marianna University School of Medicine, Miyamae ku, Kawasaki, Japan
    Neuroreport 21:777-81. 2010
    ..Therefore, the ability of estrogen to induce PR immunoreactivity in the hypothalamus in ovariectomized rats is attenuated in old rats compared with young rats...
  27. doi Progesterone enhances transthyretin expression in the rat choroid plexus in vitro and in vivo via progesterone receptor
    Telma Quintela
    Health Sciences Research Centre CICS, University of Beira Interior, Av Infante D Henrique, Covilha, Portugal
    J Mol Neurosci 44:152-8. 2011
    ..Our results reinforce the importance of ovarian hormones on the regulation of TTR, which may reflect on the processing of Aβ peptides and consequently on AD onset and progression...
  28. doi Effects of mating on progesterone receptor isoforms in rat hypothalamus
    Luciano Mendoza-Garcés
    Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Coyoacan, Mexico, D F, Mexico
    Neuroreport 21:513-6. 2010
    ..These data show that PR isoforms are differentially expressed throughout proestrus-estrus transition and that mating modifies PR isoforms expression in the hypothalamus of the rat...
  29. doi Transcriptional effects of progesterone receptor antagonist in rat granulosa cells
    P Anders Friberg
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Mol Cell Endocrinol 315:121-30. 2010
    Progesterone, acting via the nuclear progesterone receptor (PGR), reduces apoptosis in periovulatory granulosa cells, and is a likely mediator of the anti-atretic actions of LH...
  30. doi Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat
    Francisco M Zurvarra
    Department of Morphological Sciences and Center for Experimental Biology and Laboratory Animals Sciences, Faculty of Veterinary Sciences, Universidad Nacional del Litoral, Argentina
    Reprod Fertil Dev 21:827-39. 2009
    ....
  31. ncbi Distribution of progesterone receptor immunoreactivity in the fetal and neonatal rat forebrain
    Princy S Quadros
    Center for Neuroendocrine Studies and Neuroscience and Behavior Program, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Comp Neurol 504:42-56. 2007
    ..The presence PR expression in the developing forebrain implicates the involvement of progesterone and PR in fundamental mechanisms of neural development...
  32. ncbi Progesterone receptor isoforms and proliferation in the rat mammary gland during development
    Anastasia Kariagina
    Department of Physiology, 2201 Biomedical and Physical Sciences Building, Michigan State University, East Lansing, MI 48824, USA
    Endocrinology 148:2723-36. 2007
    ..From this observation, we conclude that these cells proliferate and that P acting through PRB may directly stimulate proliferation...
  33. ncbi Progesterone receptors activation after acute cocaine administration
    Hui Bing K Wu
    Department of Psychology, Hunter College, City University of New York, New York, NY 10021, USA
    Brain Res 1126:188-92. 2006
    ..Our results suggest that activation of progesterone receptors may be a mechanism by which cocaine mediates behavior through molecular alterations in the central nervous system...
  34. ncbi Regulation of sex differences in progesterone receptor expression in the medial preoptic nucleus of postnatal rats
    P S Quadros
    Center for Neuroendocrine Studies and Neuroscience and Behaviour Program, University of Massachusetts, Amherst, MA, USA
    J Neuroendocrinol 14:761-7. 2002
    ..These findings suggest that differences in steroid secretion by the neonatal male and female gonads are responsible for producing sex differences in the level of PR expression in the postnatal MPN...
  35. ncbi Effect of estrogens on ontogenetic expression of progesterone receptor in the fetal female rat reproductive tract
    Akinobu Okada
    Safety Research Laboratories, Yamanouchi Pharmaceutical Co Ltd, Tokyo, Japan
    Mol Cell Endocrinol 195:55-64. 2002
    ....
  36. ncbi Sex differences in progesterone receptor expression: a potential mechanism for estradiol-mediated sexual differentiation
    Princy S Quadros
    Center for Neuroendocrine Studies and Neuroscience and Behavior Program, University of Massachusetts, Amherst 01003, USA
    Endocrinology 143:3727-39. 2002
    ..This suggests that aromatization of T into E is crucial for the sex difference in PR expression in the MPN and AVPv during development...
  37. ncbi Cellular turnover in the rat uterine cervix and its relationship to estrogen and progesterone receptor dynamics
    Jorge G Ramos
    Laboratorio de Endocrinologia y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, 3000 Santa Fe, Argentina
    Biol Reprod 67:735-42. 2002
    ....
  38. ncbi Progesterone receptors and the sexual differentiation of the medial preoptic nucleus
    Princy S Quadros
    Center for Neuroendocrine Studies, Neuroscience and Behavior Program and Department of Psychology, Tobin Hall, Box 37720, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Neurobiol 51:24-32. 2002
    ..These results, taken together with the expression of PR in the MPNc, suggest that PR may influence the sexual differentiation of the MPNc volume...
  39. ncbi Progesterone receptor expression in the pregnant and parturient rat hypothalamus and brainstem
    Karen Francis
    Division of Biomedical and Clinical Laboratory Sciences, University of Edinburgh Medical School, Edinburgh EH8 9XD, UK
    Brain Res 927:18-26. 2002
    ..Upregulation of PR expression in the MPA during pregnancy and parturition may relate to the onset of maternal behavior and/or regulation of GnRH neuronal activity...
  40. ncbi Progesterone regulation of the progesterone receptor in rat gonadotropes
    J L Turgeon
    Department of Human Physiology, School of Medicine, University of California, Davis 95616, USA
    Endocrinology 141:3422-9. 2000
    ..These dynamic changes in nuclear PR levels coincide with the temporal extent of the preovulatory LH surge in rats and could provide a basis for progesterone's biphasic action on LH secretion...
  41. ncbi Immunocytochemical evidence for a progesterone receptor in neurons and glial cells of the rat spinal cord
    F Labombarda
    Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, Department of Biochemistry, University of Buenos Aires, Argentina
    Neurosci Lett 288:29-32. 2000
    ..This receptor may be implicated in some of the biological effects of progesterone described in the spinal cord...
  42. ncbi Hormonal regulation, localization, and functional activity of the progesterone receptor in granulosa cells of rat preovulatory follicles
    U Natraj
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
    Endocrinology 133:761-9. 1993
    ....
  43. ncbi Regulation of the progesterone receptor gene by gonadotropins and cyclic adenosine 3',5'-monophosphate in rat granulosa cells
    O K Park-Sarge
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208
    Endocrinology 134:709-18. 1994
    ....
  44. ncbi The ontogeny of gene expression of progestin receptors in the female rat brain
    J Kato
    Department of Obstetrics and Gynecology, Yamanashi Medical University, Japan
    J Steroid Biochem Mol Biol 47:173-82. 1993
    ..Moreover, lowered levels of the cortical PR mRNAs in the propylthiouracil-induced hypothyroid rat, together with suppressed PR level, indicate a possible regulatory role of thyroid hormone on gene expression of the cortical receptor...
  45. ncbi Cloning of the rat progesterone receptor gene 5'-region and identification of two functionally distinct promoters
    W L Kraus
    Department of Physiology and Biophysics, Urbana 61801
    Mol Endocrinol 7:1603-16. 1993
    ....
  46. ncbi Sex differences in the regulation of progesterone receptor isoforms expression in the rat brain
    Christian Guerra-Araiza
    Departamento de Biologia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
    Brain Res Bull 59:105-9. 2002
    ....
  47. ncbi Site-specific decrease of progesterone receptor mRNA expression in the hypothalamus of middle-aged persistently estrus rats
    Richard H Mills
    Department of Neurobiology, UCLA School of Medicine, Los Angeles, CA 90095 1763, USA
    Brain Res 955:200-6. 2002
    ..In acyclic, long-term PE rats, diminished estrogen-induced expression of progesterone receptors is correlated with a previously shown inability to respond to exogenous progesterone...
  48. ncbi Role of the progesterone receptor in restrained glutamic acid decarboxylase gene expression in the hypothalamus during the preovulatory luteinizing hormone surge
    Darrell W Brann
    Institute of Molecular Medicine and Genetics, and Department of Neurology, Neurobiology Program, Medical College of Georgia, Augusta, GA 30912, USA
    Neuroendocrinology 76:283-9. 2002
    ..These findings suggest that the progesterone receptor plays a role in restraining GAD expression in the hypothalamus during proestrus, and that this effect may be important for the production of the GnRH and LH surge...
  49. ncbi Association between polymorphisms in the progesterone receptor gene and endometriosis
    Susan A Treloar
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Mol Hum Reprod 11:641-7. 2005
    ..Further, analysis of our results pooled with those from two previous studies suggested that neither the T2 allele of the AluIns nor the T1/T2 genotype was associated with endometriosis...
  50. ncbi Progestin activation of nongenomic pathways via cross talk of progesterone receptor with estrogen receptor beta induces proliferation of endometrial stromal cells
    Griselda Vallejo
    Instituto de Biologia y Medicina Experimental IByME CONICET, Obligado 2490, 1428 Buenos Aires, Argentina
    Mol Endocrinol 19:3023-37. 2005
    ....
  51. ncbi PROGINS Alu sequence insertion is associated with hyperprolactinaemia but not leiomyoma susceptibility
    Yao Yuan Hsieh
    Department of Biological Science and Technology, National Chiao Tung University, 75 Po Ai Street, Hsinchu 300, Taiwan
    Clin Endocrinol (Oxf) 62:492-7. 2005
    Leiomyoma and hyperprolactinaemia are both progesterone-dependent diseases. Hormone-related genes, such as the progesterone receptor (PGR), might be involved in their pathogenesis.
  52. ncbi Sexual dimorphism in the content of progesterone and estrogen receptors, and their cofactors in the lung of adult rats
    Aliesha González-Arenas
    Departamento de Biologia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Coyoacan 04510, Mexico, D F, Mexico
    Steroids 69:351-6. 2004
    ..Our results suggest a sexual dimorphism in the content of PR, ER-beta, and SMRT in the rat lung as well as a relation of their content to the physiological levels of progesterone and estradiol...
  53. ncbi Immunocytochemical investigation of nuclear progestin receptor expression within dopaminergic neurones of the female rat brain
    J S Lonstein
    Program in Neuroscience, Department of Psychology, Michigan State University, East Lansing, MI, USA
    J Neuroendocrinol 16:534-43. 2004
    ....
  54. ncbi The 26S proteasome participates in the sequential inhibition of estrous behavior induced by progesterone in rats
    Oscar Gonzalez-Flores
    Centro de Investigacion en Reproduccion Animal, Centro de Investigacion y de Estudios Avanzados Universidad Autonoma de Tlaxcala, Tlaxcala 90140, Mexico
    Endocrinology 145:2328-36. 2004
    ..In contrast, PSI and TLCK significantly increased PR content in both structures. Our results suggest that PR degradation by the 26S proteasome participates in the expression of P-induced SI in female rats...
  55. ncbi p-Nonylphenol, 4-tert-octylphenol and bisphenol A increase the expression of progesterone receptor mRNA in the frontal cortex of adult ovariectomized rats
    T Funabashi
    Neuroendocrinology, Yokohama City University Graduate School of Medicine, Fukuura, Yokohama, Japan
    J Neuroendocrinol 16:99-104. 2004
    ..These results suggest that, even in adult rats, endocrine disrupters alter the neocortical function by affecting the PR system, although the physiological significance of PR in the affected area is unknown...
  56. ncbi Downregulation of androgen, estrogen and progesterone receptor genes and protein is involved in aging-related erectile dysfunction
    M Shirai
    VA Medical Center and UCSF, Urology, San Francisco, California 94121, USA
    Int J Impot Res 15:391-6. 2003
    ..This is the first study to demonstrate that downregulation of sex hormone receptors in aging rat crura is associated with erectile dysfunction...
  57. ncbi Correlates of obesity in postmenopausal women with breast cancer: comparison of genetic, demographic, disease-related, life history and dietary factors
    L Wasserman
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0639, USA
    Int J Obes Relat Metab Disord 28:49-56. 2004
    ..If genetic factors contribute to obesity, and the PR and AIB1 genes influence estrogenic, insulin and IGF pathways, then genetic patterns resulting from PR and AIB1 polymorphisms may be associated with obesity in postmenopausal women...
  58. ncbi The role of estrogen-dependent progesterone receptor in protein kinase C-mediated LH secretion and GnRH self-priming in rat anterior pituitary glands
    R Aguilar
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    J Endocrinol Invest 26:527-32. 2003
    ..Also, the results are suggestive of an interaction of PKC signaling pathway with E-dependent PR in a ligand-independent activation manner in the gonadotrope...
  59. ncbi The distribution of progestin receptor mRNA in rat brainstem
    Meredith A Curran-Rauhut
    Center for Neuroendocrine Studies, Neuroscience and Behavior Graduate Program, and Department of Biology, 221 Morrill Science Center, University of Massachusetts, Amherst, MA 01003, USA
    Brain Res Gene Expr Patterns 1:151-7. 2002
    Hypothalamic sites wherein P4, through progestin receptor, (Pgr; commonly abbreviated PR), maximizes the expression of female sexual behaviors and gonadotropin surge release have been studied intensively...
  60. ncbi Biological markers that predict clinical recurrence in ductal carcinoma in situ of the breast
    E Provenzano
    Molecular Pathology Laboratory, Victorian Breast Cancer Research Consortium, The University of Melbourne, Parkville, Victoria 3052, Australia
    Eur J Cancer 39:622-30. 2003
    ..These data identify clinically and biologically relevant subcategories of DCIS lesions, an essential basis for improving management...
  61. ncbi Transient expression of progesterone receptor messenger RNA in ovarian granulosa cells after the preovulatory luteinizing hormone surge
    O K Park
    Department of Biochemistry, Molecular Biology, Northwestern University, Evanston, Illinois 60208
    Mol Endocrinol 5:967-78. 1991
    ..This transient, hormonally regulated, and cell-specific expression of the PR gene in the rat ovary strongly suggests an important intraovarian function for progesterone during the rat reproductive cycle...

Research Grants46

  1. Neurobiological Control of Maternal Anxiety
    Joseph S Lonstein; Fiscal Year: 2010
    ..Determining how physical contact with infants modulates maternal neurochemistry in a way that alleviates anxiety will help improve the diagnosis and treatment of women suffering from a postpartum anxiety disorder. ..
  2. MECHANISMS OF REPRODUCTIVE AGING
    Darrell Brann; Fiscal Year: 2004
    ..As a whole, the proposed studies will provide important insights as to why glutamate signaling is compromised in the hypothalamus of the middle-aged rat, and will advance our understanding of reproductive aging. ..
  3. Neurochemical control of maternal behavior
    JOSEPH LONSTEIN; Fiscal Year: 2002
    ..These results will provide much needed insight into how the brain controls nurturant behavior, which is a complex social behavior that is often critical for survival in many mammalian species. ..
  4. GENOMICS OF GnRH PRIMING
    JUDITH TURGEON; Fiscal Year: 2005
    ....
  5. Mechanisms of Estrogen Signaling and Neuroprotection
    Ratna K Vadlamudi; Fiscal Year: 2010
    ....
  6. Neuroprotective and Neurogenic Actions of E2 and SERMs
    Darrell Brann; Fiscal Year: 2009
    ..Correlation to functional neurological outcomes will also be determined. As a whole, the proposed studies would significantly advance our understanding of the neuroprotective and neurogenic actions of E2 and SERMs in the injured brain. ..
  7. LH Secretion Mechanisms
    JUDITH TURGEON; Fiscal Year: 2006
    ..Cell models will be cultured gonadotropes from rats and wild-type and PR-knockout (PRKO) mice and the LbetaT2 gonadotrope cell line. ..
  8. ASTROCYTE-NEURON INTERACTIONS AND GNRH NEURONAL FUNCTION
    Darrell Brann; Fiscal Year: 2005
    ....
  9. EXCITATORY AMINO ACIDS: ROLE IN GNRH, LH & FSH SECRETION
    Darrell Brann; Fiscal Year: 2000
    ..These studies will enhance our understanding of the complex neuroendocrine mechanisms controlling GnRH and LH secretion in the female. ..
  10. LUTEINIZING HORMONE SECRETION MECHANISMS
    JUDITH TURGEON; Fiscal Year: 2000
    ....
  11. GONADOTROPIN SECRETION IN VITRO
    JUDITH TURGEON; Fiscal Year: 1980
    ....
  12. GONADOTROPIN SECRETION IN VITRO
    JUDITH TURGEON; Fiscal Year: 1992
    ..These studies will provide insight into the mechanisms of action of LHRH in that modulation of specific intracellular events will be related to physiological effects of the hormone...