Gene Symbol: Pex16
Description: peroxisomal biogenesis factor 16
Alias: peroxisomal biogenesis factor 16, peroxisome biogenesis factor 16
Honsho M, Tamura S, Shimozawa N, Suzuki Y, Kondo N, Fujiki Y. Mutation in PEX16 is causal in the peroxisome-deficient Zellweger syndrome of complementation group D. Am J Hum Genet. 1998;63:1622-30 pubmed
..We have isolated a human PEX16 cDNA (HsPEX16) by performing an expressed-sequence-tag homology search on a human DNA database, by using yeast ..
Brocard C, Boucher K, Jedeszko C, Kim P, Walton P. Requirement for microtubules and dynein motors in the earliest stages of peroxisome biogenesis. Traffic. 2005;6:386-95 pubmed
..Our aim was to determine the role of microtubules in the biogenesis of peroxisomes. Fusion experiments between human PEX16- and PEX1-mutant cells in the presence of nocodazol implied that microtubules were not required for import of ..
South S, Gould S. Peroxisome synthesis in the absence of preexisting peroxisomes. J Cell Biol. 1999;144:255-66 pubmed
..We also identified human PEX16, a novel integral peroxisomal membrane protein, and found that PBD061 had inactivating mutations in the PEX16 gene...
Honsho M, Hiroshige T, Fujiki Y. The membrane biogenesis peroxin Pex16p. Topogenesis and functional roles in peroxisomal membrane assembly. J Biol Chem. 2002;277:44513-24 pubmed
Previously we isolated human PEX16 encoding 336-amino acid-long peroxin Pex16p and showed that its dysfunction was responsible for Zellweger syndrome of complementation group D (group 9)...
Kim P, Mullen R, Schumann U, Lippincott Schwartz J. The origin and maintenance of mammalian peroxisomes involves a de novo PEX16-dependent pathway from the ER. J Cell Biol. 2006;173:521-32 pubmed
..We further show that PEX16 regulates this process by being cotranslationally inserted into the ER and serving to recruit other peroxisomal ..
Fransen M, Vastiau I, Brees C, Brys V, Mannaerts G, Van Veldhoven P. Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis. J Mol Biol. 2005;346:1275-86 pubmed
..Finally, our observation that Pex19p contains two distinct binding sites for Pex3p suggests that the peroxin may bind PMPs in multiple places and for multiple purposes. ..
Matsuzaki T, Fujiki Y. The peroxisomal membrane protein import receptor Pex3p is directly transported to peroxisomes by a novel Pex19p- and Pex16p-dependent pathway. J Cell Biol. 2008;183:1275-86 pubmed publisher
..Based on these novel findings, we suggest a model for the import of PMPs that provides new insights into the molecular mechanisms underlying the biogenesis of peroxisomes and its regulation involving Pex3p, Pex19p, and Pex16p. ..
Toro A, Araya C, Córdova G, Arredondo C, Cárdenas H, Moreno R, et al
. Pex3p-dependent peroxisomal biogenesis initiates in the endoplasmic reticulum of human fibroblasts. J Cell Biochem. 2009;107:1083-96 pubmed publisher
..These results indicate that Pex3p follows the ER-to-peroxisomal route in mammalian cells and provides new clues to understand its function. ..
Yonekawa S, Furuno A, Baba T, Fujiki Y, Ogasawara Y, Yamamoto A, et al
. Sec16B is involved in the endoplasmic reticulum export of the peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in mammalian cells. Proc Natl Acad Sci U S A. 2011;108:12746-51 pubmed publisher
..Concomitant with the overexpression of Sec16B, peroxisomal membrane biogenesis factors peroxin 3 (Pex3) and Pex16 were redistributed from peroxisomes to Sec16B-positive ER membranes...