Pex14

Summary

Gene Symbol: Pex14
Description: peroxisomal biogenesis factor 14
Alias: peroxisomal membrane protein PEX14, PTS1 receptor-docking protein, peroxin-14, peroxisomal membrane anchor protein PEX14
Species: rat
Products:     Pex14

Top Publications

  1. Will G, Soukupova M, Hong X, Erdmann K, Kiel J, Dodt G, et al. Identification and characterization of the human orthologue of yeast Pex14p. Mol Cell Biol. 1999;19:2265-77 pubmed
    ..The role of HsPex14p in mammalian peroxisome biogenesis makes HsPEX14 a candidate PBD gene for being responsible for an unrecognized complementation group of human peroxisome biogenesis disorders. ..
  2. Williams C, Schueller N, Thompson C, van den Berg M, van Haren S, Erdmann R, et al. The Peroxisomal Targeting Signal 1 in sterol carrier protein 2 is autonomous and essential for receptor recognition. BMC Biochem. 2011;12:12 pubmed publisher
    ..In this study, we have tested the contribution of a second, ancillary receptor-cargo binding site, which was found in addition to the characterised Peroxisomal Target Signal type 1...
  3. Oliveira M, Reguenga C, Gouveia A, Guimaraes C, Schliebs W, Kunau W, et al. Mammalian Pex14p: membrane topology and characterisation of the Pex14p-Pex14p interaction. Biochim Biophys Acta. 2002;1567:13-22 pubmed
    ..Heterologous expressed Pex14p was found to be a homopolymer of variable stoichiometry. Finally, in vitro binding assays indicate that homopolymerisation of Pex14p involves a domain comprising amino acid residues 147-278 of this peroxin. ..
  4. Su J, Takeda K, Tamura S, Fujiki Y, Miki K. Crystal structure of the conserved N-terminal domain of the peroxisomal matrix protein import receptor, Pex14p. Proc Natl Acad Sci U S A. 2009;106:417-21 pubmed publisher
    ..positions 35, 52, and 35/52, respectively, were defective in restoring the impaired peroxisomal protein import in pex14 Chinese hamster ovary mutant ZP161 cells...
  5. Fransen M, Amery L, Hartig A, Brees C, Rabijns A, Mannaerts G, et al. Comparison of the PTS1- and Rab8b-binding properties of Pex5p and Pex5Rp/TRIP8b. Biochim Biophys Acta. 2008;1783:864-73 pubmed publisher
    ..The implications of these findings for the possible peroxisome-related functions of Pex5Rp/TRIP8b are discussed. ..
  6. Shimizu N, Itoh R, Hirono Y, Otera H, Ghaedi K, Tateishi K, et al. The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis. J Biol Chem. 1999;274:12593-604 pubmed
    ..Pex14p from Hansenula polymorpha and Saccharomyces cerevisiae, respectively; therefore, we termed this cDNA rat PEX14 (RnPEX14)...
  7. Amery L, Mannaerts G, Subramani S, Van Veldhoven P, Fransen M. Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology. Comb Chem High Throughput Screen. 2001;4:545-52 pubmed
    ..These results further demonstrate the suitability of the gVI-cDNA phage display technology for cDNA expression cloning using an antibody as a probe. ..
  8. Shiozawa K, Konarev P, Neufeld C, Wilmanns M, Svergun D. Solution structure of human Pex5.Pex14.PTS1 protein complexes obtained by small angle X-ray scattering. J Biol Chem. 2009;284:25334-42 pubmed publisher
    ..These results suggest that the extended structure of Pex5p may play a role in interactions with other substrates such as lipids and membrane proteins during the formation of functional multiprotein complexes. ..
  9. Nagase T, Shimozawa N, Takemoto Y, Suzuki Y, Komori M, Kondo N. Peroxisomal localization in the developing mouse cerebellum: implications for neuronal abnormalities related to deficiencies in peroxisomes. Biochim Biophys Acta. 2004;1671:26-33 pubmed
    ..As peroxisomes in glial cells may control the development of neurons, the neuron-glial interaction and mechanisms of developing central nervous systems deserve ongoing attention. ..

More Information

Publications17

  1. Neufeld C, Filipp F, Simon B, Neuhaus A, Schüller N, David C, et al. Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19. EMBO J. 2009;28:745-54 pubmed publisher
    Protein import into peroxisomes depends on a complex and dynamic network of protein-protein interactions. Pex14 is a central component of the peroxisomal import machinery and binds the soluble receptors Pex5 and Pex19, which have ..
  2. Nenicu A, Lüers G, Kovacs W, David M, Zimmer A, Bergmann M, et al. Peroxisomes in human and mouse testis: differential expression of peroxisomal proteins in germ cells and distinct somatic cell types of the testis. Biol Reprod. 2007;77:1060-72 pubmed
    ..Our results suggest a cell type-specific metabolic function of peroxisomes in the testis and point to an important role for peroxisomes in spermiogenesis and in the lipid metabolism of Sertoli cells. ..
  3. Shimozawa N, Tsukamoto T, Nagase T, Takemoto Y, Koyama N, Suzuki Y, et al. Identification of a new complementation group of the peroxisome biogenesis disorders and PEX14 as the mutated gene. Hum Mutat. 2004;23:552-8 pubmed
    ..The peroxisomal membrane protein PEX14 is a key component of the peroxisomal import machinery and may be the initial docking site for the ..
  4. Gavva N, Wen S, Daftari P, Moniwa M, Yang W, Yang Feng L, et al. NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor. Genomics. 2002;79:423-31 pubmed
    ..The gene encoding NAPP2, PEX14, is located on chromosome 1p36 and is ubiquitously expressed...
  5. Reguenga C, Oliveira M, Gouveia A, Sa Miranda C, Azevedo J. Characterization of the mammalian peroxisomal import machinery: Pex2p, Pex5p, Pex12p, and Pex14p are subunits of the same protein assembly. J Biol Chem. 2001;276:29935-42 pubmed
    ..Taken together, our data indicate that Pex2p, Pex5p, Pex12p, and Pex14p, on one side, and Pex13p, on the other, are subunits of two stable protein complexes that probably interact with each other in the peroxisomal membrane. ..
  6. Nguyen T, Bjorkman J, Paton B, Crane D. Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance. J Cell Sci. 2006;119:636-45 pubmed
  7. Freitas M, Francisco T, Rodrigues T, Alencastre I, Pinto M, Grou C, et al. PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14. J Biol Chem. 2011;286:40509-19 pubmed publisher
    ..Interestingly, the PEX5-catalase interaction is disrupted by the N-terminal domain of PEX14, a component of the docking/translocation machinery...
  8. Fransen M, Brees C, Ghys K, Amery L, Mannaerts G, Ladant D, et al. Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay. Mol Cell Proteomics. 2002;1:243-52 pubmed