Pebp1

Summary

Gene Symbol: Pebp1
Description: phosphatidylethanolamine binding protein 1
Alias: HCNP, Pbp, Rkip, phosphatidylethanolamine-binding protein 1, 23 kDa morphine-binding protein, HCNPpp, P23K, PEBP-1, Raf-1 kinase inhibitor protein, hippocampal cholinergic neurostimulating peptide
Species: rat
Products:     Pebp1

Top Publications

  1. Tohdoh N, Tojo S, Agui H, Ojika K. Sequence homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid-binding protein. Brain Res Mol Brain Res. 1995;30:381-4 pubmed
    The hippocampal cholinergic neurostimulating peptide (HCNP) enhances acetylcholine synthesis in rat medial septal tissues...
  2. Hengst U, Albrecht H, Hess D, Monard D. The phosphatidylethanolamine-binding protein is the prototype of a novel family of serine protease inhibitors. J Biol Chem. 2001;276:535-40 pubmed
    ..PEBP immunoreactivity is found on the surface of Rat-1 fibroblast cells and although its sequence contains no secretion signal, PEBP-H(6) can be purified from the conditioned medium upon recombinant expression. ..
  3. Frayne J, Ingram C, Love S, Hall L. Localisation of phosphatidylethanolamine-binding protein in the brain and other tissues of the rat. Cell Tissue Res. 1999;298:415-23 pubmed
    ..The nature of this diversity, ranging from oligodendrocytes to plasma cells, whilst not precluding a role for PEBP in membrane biogenesis in some cell types, would imply that this is not the major function in others. ..
  4. George A, Holsinger R, McLean C, Tan S, Scott H, Cardamone T, et al. Decreased phosphatidylethanolamine binding protein expression correlates with Abeta accumulation in the Tg2576 mouse model of Alzheimer's disease. Neurobiol Aging. 2006;27:614-23 pubmed
    ..protein (PEBP) is a multifunctional protein, with proposed roles as the precursor protein of hippocampal cholinergic neurostimulating peptide (HCNP), and as the Raf kinase inhibitor protein (RKIP)...
  5. Dahl A, Eriksson P, Persson A, Karlsson G, Davidsson P, Ekman R, et al. Proteome analysis of conditioned medium from cultured adult hippocampal progenitors. Rapid Commun Mass Spectrom. 2003;17:2195-202 pubmed
    ..Identification of bioactive proteins in vitro is of potential importance for the understanding of the regulatory mechanisms of the cells in vivo. ..
  6. Ojika K, Ueki Y, Mitake S, Tsugu Y, Otsuka Y, Katada E. Demonstration of the biological activity of peptide fragments related to human and rat hippocampal cholinergic neurostimulating peptide (HCNP). Neurosci Lett. 1996;215:127-30 pubmed
    ..This in vitro system was used to test the bioactivity of short peptides containing human or rat HCNP sequences...
  7. Ma J, Li F, Liu L, Cui D, Wu X, Jiang X, et al. Raf kinase inhibitor protein inhibits cell proliferation but promotes cell migration in rat hepatic stellate cells. Liver Int. 2009;29:567-74 pubmed publisher
    ..Raf kinase inhibitor protein (RKIP), an inhibitor of extracellular signal-regulated kinases (ERK)/mitogen-activated protein kinase (MAPK) signalling ..
  8. Tsugu -, Ojika -, Matsukawa -, Iwase -, Otsuka -, Katada -, et al. High levels of hippocampal cholinergic neurostimulating peptide (HCNP) in the CSF of some patients with Alzheimer's disease. Eur J Neurol. 1998;5:561-569 pubmed
    b>Hippocampal cholinergic neurostimulating peptide (HCNP), originally purified from the hippocampus of young rats, enhances the cholinergic development of rat medial septal nuclei in vitro...
  9. Frayne J, McMillen A, Love S, Hall L. Expression of phosphatidylethanolamine-binding protein in the male reproductive tract: immunolocalisation and expression in prepubertal and adult rat testes and epididymides. Mol Reprod Dev. 1998;49:454-60 pubmed
    Phosphatidylethanolamine-binding protein (PBP) has been described previously in the male reproductive tract, where it has been implicated in the biogenesis and maintenance of antigen segregation of membranes...

More Information

Publications65

  1. Corbit K, Trakul N, Eves E, Diaz B, Marshall M, Rosner M. Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein. J Biol Chem. 2003;278:13061-8 pubmed
    ..Here we report that one mechanism involves dissociation of Raf kinase inhibitory protein (RKIP) from Raf-1. Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153)...
  2. Kobeissy F, Warren M, Ottens A, Sadasivan S, Zhang Z, Gold M, et al. Psychoproteomic analysis of rat cortex following acute methamphetamine exposure. J Proteome Res. 2008;7:1971-83 pubmed publisher
    ..Lastly, we used these differentially expressed protein subsets to construct a "psychoproteomic" spectrum map in an effort to uncover potential protein interactions relevant to acute METH neurotoxicity. ..
  3. Perry A, Hall L, Bell A, Jones R. Sequence analysis of a mammalian phospholipid-binding protein from testis and epididymis and its distribution between spermatozoa and extracellular secretions. Biochem J. 1994;301 ( Pt 1):235-42 pubmed
    The cellular origin of a soluble phospholipid-binding protein (PBP) in rat testicular and epididymal secretions has been investigated genetically and immunologically...
  4. Kim S, Ives K, Wang X, Davey R, Chao C, Hellmich M. Raf-1 kinase inhibitory protein (RKIP) mediates ethanol-induced sensitization of secretagogue signaling in pancreatic acinar cells. J Biol Chem. 2012;287:33377-88 pubmed
  5. Arthur S, Sundaram U. Protein kinase C-mediated phosphorylation of RKIP regulates inhibition of Na-alanine cotransport by leukotriene D(4) in intestinal epithelial cells. Am J Physiol Cell Physiol. 2014;307:C1010-6 pubmed publisher
    ..PKCα is known to phosphorylate Raf kinase inhibitor protein (RKIP), thus activating its downstream signaling pathway...
  6. Jones R, Hall L. A 23 kDa protein from rat sperm plasma membranes shows sequence similarity and phospholipid binding properties to a bovine brain cytosolic protein. Biochim Biophys Acta. 1991;1080:78-82 pubmed
    ..It is suggested that differential affinity of protein antigens towards asymmetrically aligned phospholipids in sperm plasma membranes could account for their organisation into specific regional domains. ..
  7. Su L, Zhang R, Chen Y, Zhu Z, Ma C. Raf Kinase Inhibitor Protein Attenuates Ischemic-Induced Microglia Cell Apoptosis and Activation Through NF-?B Pathway. Cell Physiol Biochem. 2017;41:1125-1134 pubmed publisher
    ..Raf-1 kinase inhibitory protein (RKIP) is a key molecule in cell response to survival or death stimuli...
  8. Biewenga P, Buist M, Moerland P, Ver Loren van Themaat E, van Kampen A, ten Kate F, et al. Gene expression in early stage cervical cancer. Gynecol Oncol. 2008;108:520-6 pubmed publisher
    ..Five genes (BANF1, LARP7, SCAMP1, CUEDC1 and PEBP1) showed differential expression between tumour samples from patients with and without lymph node metastasis...
  9. Eves E, Shapiro P, Naik K, Klein U, Trakul N, Rosner M. Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint. Mol Cell. 2006;23:561-74 pubmed
    Raf kinase inhibitory protein (RKIP or PEBP) is an inhibitor of the Raf/MEK/MAP kinase signaling cascade and a suppressor of cancer metastasis...
  10. Angelone T, Goumon Y, Cerra M, Metz Boutigue M, Aunis D, Tota B. The emerging cardioinhibitory role of the hippocampal cholinergic neurostimulating peptide. J Pharmacol Exp Ther. 2006;318:336-44 pubmed
    b>Hippocampal cholinergic neurostimulating peptide (HCNP), which derives from phosphatidylethanolamine-binding protein (also named Raf kinase inhibitor protein), enhances acetylcholine synthesis in the hippocampal medial septal nuclei...
  11. Hagan S, Al Mulla F, Mallon E, Oien K, Ferrier R, Gusterson B, et al. Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis. Clin Cancer Res. 2005;11:7392-7 pubmed
    Raf-1 kinase inhibitor protein (RKIP) was originally identified as the first physiologic inhibitor of the Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (ERK) pathway...
  12. Zuo H, Lin T, Wang D, Peng R, Wang S, Gao Y, et al. RKIP Regulates Neural Cell Apoptosis Induced by Exposure to Microwave Radiation Partly Through the MEK/ERK/CREB Pathway. Mol Neurobiol. 2015;51:1520-9 pubmed publisher
    In the present study, we investigated whether Raf-1 kinase inhibitory protein (RKIP) is important for neural cell apoptosis induced by microwave exposure and explored the role of MEK/ERK/CREB pathway regulated by RKIP in the apoptosis...
  13. Maki M, Matsukawa N, Yuasa H, Otsuka Y, Yamamoto T, Akatsu H, et al. Decreased expression of hippocampal cholinergic neurostimulating peptide precursor protein mRNA in the hippocampus in Alzheimer disease. J Neuropathol Exp Neurol. 2002;61:176-85 pubmed
    b>Hippocampal cholinergic neurostimulating peptide (HCNP) is involved in the phenotype development of the septo-hippocampal system...
  14. Zuo H, Wang D, Peng R, Wang S, Gao Y, Xu X, et al. [Influence of electromagnetic radiation on raf kinase inhibitor protein and its related proteins of hippocampus]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2008;26:533-7 pubmed
    To study the development of changes for Raf kinase inhibitor protein (RKIP) and its mRNA in rats hippocampus after electromagnetic radiation...
  15. Mitake S, Ojika K, Katada E, Otsuka Y, Matsukawa N, Fujimori O. Accumulation of hippocampal cholinergic neurostimulating peptide (HCNP)-related components in Hirano bodies. Neuropathol Appl Neurobiol. 1995;21:35-40 pubmed
    We have previously isolated from the hippocampus of young rats a novel peptide termed 'hippocampal cholinergic neurostimulating peptide' (HCNP) which specifically enhances the cholinergic activity of the septohippocampal system in vitro...
  16. Mizuno M, Kato D, Kanamori T, Toyoda T, Suzuki T, Ojika K, et al. Phosphorylation of collapsin response mediator protein-2 regulates its localization and association with hippocampal cholinergic neurostimulating peptide precursor in the hippocampus. Neurosci Lett. 2013;535:122-7 pubmed publisher
    b>Hippocampal cholinergic neurostimulating peptide (HCNP) induces the synthesis of acetylcholine in the medial septal nucleus in vitro and in vivo...
  17. Ojika K, Kojima S, Ueki Y, Fukushima N, Hayashi K, Yamamoto M. Purification and structural analysis of hippocampal cholinergic neurostimulating peptide. Brain Res. 1992;572:164-71 pubmed
    ..novel peptide is acetyl-Ala-Ala-Asp-Ile-Ser-Gln-Trp-Ala-Gly-Pro-Leu and we designated it as hippocampal cholinergic neurostimulating peptide (HCNP)...
  18. Yeung K, Seitz T, Li S, Janosch P, McFerran B, Kaiser C, et al. Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature. 1999;401:173-7 pubmed
    ..This protein inhibits the phosphorylation and activation of MEK by Raf-1 and is designated RKIP (Raf kinase inhibitor protein). In vitro, RKIP binds to Raf-1, MEK and ERK, but not to Ras...
  19. Hahm J, Ahn J, Noh H, Baek S, Ha J, Jung T, et al. Comparative analysis of fat and muscle proteins in fenofibrate-fed type II diabetic OLETF rats: the fenofibrate-dependent expression of PEBP or C11orf59 protein. BMB Rep. 2010;43:337-43 pubmed
    ..We suggest here that these proteins might be involved in controlling lipid or carbohydrate metabolism in diabetes via PPARalpha activation. ..
  20. Huang Q, Wei L, Liang C, Nie J, Lu S, Lu C, et al. Loss of Raf kinase inhibitor protein is associated with malignant progression in hepatic fibrosis. Biomed Pharmacother. 2016;82:669-76 pubmed publisher
    Raf kinase inhibitory protein (RKIP), besides regulating important intracellular signaling cascades, was described to be associated with progression, metastasis and prognosis in several human neoplasms...
  21. Brackley A, Gomez R, Akopian A, Henry M, Jeske N. GRK2 Constitutively Governs Peripheral Delta Opioid Receptor Activity. Cell Rep. 2016;16:2686-2698 pubmed publisher
    ..Importantly, bradykinin stimulates GRK2 movement away from DOR and onto Raf kinase inhibitory protein (RKIP)...
  22. Fu Z, Smith P, Zhang L, Rubin M, Dunn R, Yao Z, et al. Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis. J Natl Cancer Inst. 2003;95:878-89 pubmed
    Raf kinase inhibitor protein (RKIP), an inhibitor of Raf-mediated activation of mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK), is expressed at lower levels in human C4-2B metastatic prostate cancer cells ..
  23. Kato D, Mitake S, Mizuno M, Kanamori T, Suzuki T, Ojika K, et al. Co-localization of hippocampal cholinergic neurostimulating peptide precursor with collapsin response mediator protein-2 at presynaptic terminals in hippocampus. Neurosci Lett. 2012;517:92-7 pubmed publisher
    b>Hippocampal cholinergic neurostimulating peptide (HCNP) induces the synthesis of acetylcholine in medial septal nucleus in vitro and in vivo...
  24. Zhao J, O Donnell V, Balzar S, St Croix C, Trudeau J, Wenzel S. 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells. Proc Natl Acad Sci U S A. 2011;108:14246-51 pubmed publisher
    ..kinase (MEK)/ERK activation is regulated by interactions of Raf-1 with phosphatidylethanolamine-binding protein 1 (PEBP1)...
  25. Lorenz K, Lohse M, Quitterer U. Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2. Nature. 2003;426:574-9 pubmed
    ..In our search for a control mechanism for this vital kinase, here we show that the Raf kinase inhibitor protein (RKIP) is a physiological inhibitor of GRK-2...
  26. Iwase T, Ojika K, Matsukawa N, Nishino H, Yamamoto T, Okada H, et al. Muscarinic cholinergic and glutamatergic reciprocal regulation of expression of hippocampal cholinergic neurostimulating peptide precursor protein gene in rat hippocampus. Neuroscience. 2001;102:341-52 pubmed
    b>Hippocampal cholinergic neurostimulating peptide, an undecapeptide originally isolated from the hippocampus of young rats, enhances acetylcholine synthesis in rat medial septal nucleus in vitro...
  27. Zuo H, Wang D, Peng R, Wang S, Gao Y, Zhang Z, et al. [The role of RKIP mediated ERK pathway in hippocampus neurons injured by electromagnetic radiation]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008;24:660-2 pubmed
    To study the effects of electromagnetic radiation on RKIP and phosphorylated ERK in primary cultured hippocampus neurons. The inhibitor of MEK U0126 was applied to investigate the role of RKIP mediated ERK pathway in radiation injury...
  28. McCubrey J, Steelman L, Chappell W, Abrams S, Wong E, Chang F, et al. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta. 2007;1773:1263-84 pubmed
  29. Burgula S, Medisetty R, Jammulamadaka N, Musturi S, Ilavazhagan G, Singh S. Downregulation of PEBP1 in rat brain cortex in hypoxia. J Mol Neurosci. 2010;41:36-47 pubmed publisher
    ..4 and molecular weight 21 kDa, identified as phosphatidylethanolamine binding protein (PEBP1), was consistently lowered (54%) in hypoxic cortex samples...
  30. Weitzdörfer R, Hoger H, Shim K, Cekici L, Pollak A, Lubec G. Changes of hippocampal signaling protein levels during postnatal brain development in the rat. Hippocampus. 2008;18:807-13 pubmed publisher
    ..These data contribute to the understanding that different time points may use different signaling cascades. ..
  31. Melle C, Camacho J, Surber R, Betge S, von Eggeling F, Zimmer T. Region-specific alterations of global protein expression in the remodelled rat myocardium. Int J Mol Med. 2006;18:1207-15 pubmed
    ..the metabolic enzyme triosephosphate isomerase (TIM), the cell signalling protein Raf-1 kinase inhibitory protein (RKIP), also known as phosphatidylethanolamine binding protein (PEBP), and the small heat shock protein alphaB-crystallin...
  32. Ojika K, Mitake S, Tohdoh N, Appel S, Otsuka Y, Katada E, et al. Hippocampal cholinergic neurostimulating peptides (HCNP). Prog Neurobiol. 2000;60:37-83 pubmed
    ..these components, originally purified from young rat hippocampus, is a novel undecapeptide (hippocampal cholinergic neurostimulating peptide; HCNP); this enhances the production of ChAT, but not of AchE...
  33. Park S, Yeung M, Beach S, Shields J, Yeung K. RKIP downregulates B-Raf kinase activity in melanoma cancer cells. Oncogene. 2005;24:3535-40 pubmed
    ..We have previously identified Raf kinase inhibitor protein (RKIP) as a negative regulator of the Raf-MEK-ERK signaling pathway by specifically binding to the Raf-1 isoform...
  34. Grandy D, Hanneman E, Bunzow J, Shih M, Machida C, Bidlack J, et al. Purification, cloning, and tissue distribution of a 23-kDa rat protein isolated by morphine affinity chromatography. Mol Endocrinol. 1990;4:1370-6 pubmed
    A 23-kDa (p23k) rat brain protein was stereospecifically eluted from a 14 beta-bromoacetamidomorphine affinity column, purified to apparent homogeneity by reverse phase HPLC, and partially sequenced...
  35. Turner K, McKinnell C, McLaren T, Qureshi S, Saunders P, Foster P, et al. Detection of germ cell-derived proteins in testicular interstitial fluid: potential for monitoring spermatogenesis in vivo. J Androl. 1996;17:127-36 pubmed
    ..g., PEBP and ARP-2) should enable more definitive assessment of whether proteins secreted by the seminiferous epithellum can be measured in blood and thus provide a potential means of monitoring spermatogenesis. ..
  36. Yamamoto T, Fukushima T, Kikkawa R, Yamada H, Horii I. Protein expression analysis of rat testes induced testicular toxicity with several reproductive toxicants. J Toxicol Sci. 2005;30:111-26 pubmed
    ..Therefore, the proteins identified in this study could potentially serve as biomarkers to evaluate male reproductive toxicity at an early stage of drug discovery and development. ..
  37. Morishita M, Otsuka Y, Matsukawa N, Suzuki H, Nakazawa H, Maki M, et al. Specific binding of 125I-hippocampal cholinergic neurostimulating peptide (HCNP) to rat brain membranes: characterization and regional distribution. Brain Res. 2003;965:194-202 pubmed
    An undecapeptide-hippocampal cholinergic neurostimulating peptide (HCNP), originally purified from young rat hippocampus, enhances cholinergic phenotype development in the medial septal nucleus in vitro...
  38. Singh A, Gupta S, Jiang Y. Oxidative stress and protein oxidation in the brain of water drinking and alcohol drinking rats administered the HIV envelope protein, gp120. J Neurochem. 2008;104:1478-93 pubmed
    ..Total protein-carbonyl and carbonylated hippocampal cholinergic neurostimulating peptide precursor protein levels, but not N-acetylaspartate or N-acetyl aspartylglutamate or total ..
  39. Trakul N, Menard R, Schade G, Qian Z, Rosner M. Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation. J Biol Chem. 2005;280:24931-40 pubmed
    Raf kinase inhibitory protein (RKIP; also known as phosphatidylethanolamine-binding protein or PEBP) is a modulator of the Raf/MAPK signaling cascade and a suppressor of metastatic cancer...
  40. Katada E, Ojika K, Mitake S, Ueda R. Neuronal distribution and subcellular localization of HCNP-like immunoreactivity in rat small intestine. J Neurocytol. 2000;29:199-207 pubmed
    A novel peptide, hippocampal cholinergic neurostimulating peptide (HCNP), originally purified from young rat hippocampus, affects the development of specific cholinergic neurons of the central nervous system in vitro...
  41. Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, et al. Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy. Nat Med. 2015;21:1298-306 pubmed publisher
    ..Here we show that modest overexpression of the Raf kinase inhibitor protein (RKIP), encoded by Pebp1 in mice, produces a well-tolerated, persistent increase in cardiac contractility that is mediated by the β1-..
  42. Deiss K, Kisker C, Lohse M, Lorenz K. Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2. J Biol Chem. 2012;287:23407-17 pubmed publisher
    ..Raf kinase inhibitor protein (RKIP) is a multifaceted kinase modulator, but it is not well understood how this small protein (21 kDa) can coordinate ..
  43. Ishihara K, Nakata K, Yamagishi N, Iwasaki S, Kiriike N, Hatayama T. A comparative proteomic analysis of the rat brain during rebound hyperphagia induced by space-restriction. Mol Cell Biochem. 2005;276:21-9 pubmed
    ..In this study, we first demonstrated that three brain proteins changed in rats during enhanced rebound hyperphagia. These proteins might have pathophysiologic relevance to binge eating. ..
  44. Gibbons R, Adeoya Osiguwa S, Fraser L. A mouse sperm decapacitation factor receptor is phosphatidylethanolamine-binding protein 1. Reproduction. 2005;130:497-508 pubmed
    ..sequencing of DF-R has identified this approximately 23 kDa protein as phosphatidylethanolamine-binding protein 1 (PEBP 1)...
  45. Tohdoh N, Tojo S, Kimura M, Ishii T, Ojika K. Mechanism of expression of the rat HCNP precursor protein gene. Brain Res Mol Brain Res. 1997;45:24-32 pubmed
    The hippocampal cholinergic neurostimulating peptide (HCNP), isolated from hippocampal tissue of 10- to 12-day-old rats, enhances the in vitro synthesis of acetylcholine in medial septal tissue explants...
  46. Turner T, Riley T, Vagnetti M, Flickinger C, Caldwell J, Hunt D. Postvasectomy alterations in protein synthesis and secretion in the rat caput epididymidis are not repaired after vasovasostomy. J Androl. 2000;21:276-90 pubmed
    ..All 3 of these proteins occur in the epididymides of multiple species and have been associated with sperm fertilizing capacity. ..
  47. Scholler N, Gross J, Garvik B, Wells L, Liu Y, Loch C, et al. Use of cancer-specific yeast-secreted in vivo biotinylated recombinant antibodies for serum biomarker discovery. J Transl Med. 2008;6:41 pubmed publisher
    ..fragments of complement factors, EMILIN2, Von Willebrand factor and phosphatidylethanolamine-binding protein 1 (PEBP1 or RKIP) in patient sera. To our knowledge, this is the first report of a soluble form of PEBP1 in human...
  48. West A, McKinnell C, Sharpe R, Saunders P. Pituitary adenylate cyclase activating polypeptide can regulate testicular germ cell protein synthesis in vitro. J Endocrinol. 1995;144:215-23 pubmed
    ..The results show that PACAP can regulate synthesis of both secreted and intracellular proteins by spermatids and spermatocytes in vitro.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  49. Feldmann R, Maurer M, Hunzinger C, Lewicka S, Buergers H, Kalenka A, et al. Reduction in rat phosphatidylethanolamine binding protein-1 (PEBP1) after chronic corticosterone treatment may be paralleled by cognitive impairment: a first study. Stress. 2008;11:134-47 pubmed publisher
    ..stress affects psychometric performance and the expression of the phosphatidylethanolamine binding protein (PEBP1) in the adult hippocampus of one-year-old male rats...
  50. Chen W, Viidik A, Skalicky M, Hoger H, Lubec G. Hippocampal signaling cascades are modulated in voluntary and treadmill exercise rats. Electrophoresis. 2007;28:4392-400 pubmed
    ..These results form the basis for functional studies elucidating mechanisms and links between exercise and hippocampal signaling and function. ..
  51. Jammulamadaka N, Burgula S, Medisetty R, Ilavazhagan G, Rao S, Singh S. ?-N-oxalyl-L-?,?-diaminopropionic acid regulates mitogen-activated protein kinase signaling by down-regulation of phosphatidylethanolamine-binding protein 1. J Neurochem. 2011;118:176-86 pubmed publisher
    ..results in a decreased expression and increased phosphorylation of phosphatidylehthanolamine-binding protein 1 (PEBP1) up to 4 h which however, returns to normal by 8 h...
  52. Woods Ignatoski K, Grewal N, Markwart S, Vellaichamy A, Chinnaiyan A, Yeung K, et al. Loss of Raf kinase inhibitory protein induces radioresistance in prostate cancer. Int J Radiat Oncol Biol Phys. 2008;72:153-60 pubmed publisher
    ..Raf kinase inhibitory protein (RKIP) is a metastasis suppressor whose expression is reduced in approximately 50% of localized PCa tissues and is absent ..
  53. Li L, Zhao Y, Zeng J, Fan F, Wang X, Zhou Y, et al. Rituximab regulates the expression of the Raf kinase inhibitor protein via NF-?B in renal tissue of rats with diabetic nephropathy. Genet Mol Res. 2013;12:2973-81 pubmed publisher
    This study aimed to investigate the expression levels of the Raf kinase inhibitor protein (RKIP) and NF-?B in renal tissues of diabetic nephropathy (DN) rats, and to determine the underlying molecular targets of rituximab (RTX), with the ..
  54. Charntikov S, Pittenger S, Thapa I, Bastola D, Bevins R, Pendyala G. Ibudilast reverses the decrease in the synaptic signaling protein phosphatidylethanolamine-binding protein 1 (PEBP1) produced by chronic methamphetamine intake in rats. Drug Alcohol Depend. 2015;152:15-23 pubmed publisher
    ..the PFC identified one potential hit; the synaptic signaling protein phosphatidylethanolamine-binding protein 1 (PEBP1)...
  55. Kazuki Y, Kimura M, Nishigaki R, Kai Y, Abe S, Okita C, et al. Human chromosome 21q22.2-qter carries a gene(s) responsible for downregulation of mlc2a and PEBP in Down syndrome model mice. Biochem Biophys Res Commun. 2004;317:491-9 pubmed
    ..Thus, this chromosome engineering technology is a useful tool for identification or mapping of genes that contribute to the DS phenotypes. ..
  56. Yeung K, Rose D, Dhillon A, Yaros D, Gustafsson M, Chatterjee D, et al. Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation. Mol Cell Biol. 2001;21:7207-17 pubmed
    The Raf kinase inhibitor protein (RKIP) acts as a negative regulator of the mitogen-activated protein (MAP) kinase (MAPK) cascade initiated by Raf-1...