Pdgfrb

Summary

Gene Symbol: Pdgfrb
Description: platelet derived growth factor receptor beta
Alias: PDGFR-1, platelet-derived growth factor receptor beta, CD140 antigen-like family member B, PDGF-R-beta, PDGFR-beta, Platelet-derived growth factor receptor, beta, beta platelet-derived growth factor receptor, beta-type platelet-derived growth factor receptor, platelet derived growth factor receptor, beta polypeptide, platelet-derived growth factor receptor 1, platelet-derived growth factor receptor beta variant 1
Species: rat
Products:     Pdgfrb

Top Publications

  1. Lechleider R, Sugimoto S, Bennett A, Kashishian A, Cooper J, Shoelson S, et al. Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor. J Biol Chem. 1993;268:21478-81 pubmed
    ..Our data suggest that binding of SH-PTP2 to the activated receptor in vivo should result in stimulation of SH-PTP2 activity. ..
  2. Klinghoffer R, Mueting Nelsen P, Faerman A, Shani M, Soriano P. The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions. Mol Cell. 2001;7:343-54 pubmed
    ..This observation provides a framework for discussing the evolution of receptor tyrosine kinase functional specificity. ..
  3. Borkham Kamphorst E, Herrmann J, Stoll D, Treptau J, Gressner A, Weiskirchen R. Dominant-negative soluble PDGF-beta receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis. Lab Invest. 2004;84:766-77 pubmed
  4. Hellstrom M, Kalén M, Lindahl P, Abramsson A, Betsholtz C. Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development. 1999;126:3047-55 pubmed
    ..Subsequent angiogenic sprouting and vessel enlargement involves PDGF-B-dependent vSMC/PC progenitor co-migration and proliferation, and/or PDGF-B-independent new induction of vSMC/PC, depending on tissue context. ..
  5. Chen Y, Lu C, Xie W, Zhang X, Zhang Z, Wei L, et al. Effects of ribozyme targeting platelet-derived growth factor receptor beta subunit gene on the proliferation and apoptosis of hepatic stellate cells in vitro. Chin Med J (Engl). 2005;118:982-8 pubmed
    ..These results suggest that inhibiting PDGFR-beta expression of HSC may be a new target for the therapy of liver fibrogenesis, and ribozyme may be a useful tool for inhibiting PDGFR-beta expression. ..
  6. Lindahl P, Hellstrom M, Kalén M, Karlsson L, Pekny M, Pekna M, et al. Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli. Development. 1998;125:3313-22 pubmed
  7. Chung R, Foster B, Zannettino A, Xian C. Potential roles of growth factor PDGF-BB in the bony repair of injured growth plate. Bone. 2009;44:878-85 pubmed publisher
    ..These results suggest that PDGF-BB contributes to growth plate injury repair by promoting mesenchymal progenitor cell infiltration, the chondrogenic and osteogenic responses, and remodelling of the repair tissues. ..
  8. Chen Q, Chen L, Kong D, Shao J, Wu L, Zheng S. Dihydroartemisinin alleviates bile duct ligation-induced liver fibrosis and hepatic stellate cell activation by interfering with the PDGF-βR/ERK signaling pathway. Int Immunopharmacol. 2016;34:250-258 pubmed publisher
    ..These data collectively revealed that DHA relieved liver fibrosis possibly by targeting HSCs via the PDGF-βR/ERK pathway. DHA may be a therapeutic antifibrotic agent for the treatment of hepatic fibrosis. ..
  9. Sarzani R, Arnaldi G, Takasaki I, Brecher P, Chobanian A. Effects of hypertension and aging on platelet-derived growth factor and platelet-derived growth factor receptor expression in rat aorta and heart. Hypertension. 1991;18:III93-9 pubmed
    ..The findings also provide further support for the concept that hypertension accelerates the arterial changes associated with aging. ..

More Information

Publications62

  1. Fan B, Ma L, Li Q, Wang L, Zhou J, Wu J. Role of PDGFs/PDGFRs signaling pathway in myocardial fibrosis of DOCA/salt hypertensive rats. Int J Clin Exp Pathol. 2014;7:16-27 pubmed
    ..PDGFR? and PDGFR? expressions increase in fibroblasts and myofibroblasts, suggesting that PDGF/PDGFR signaling pathway is involved in the myocardial fibrosis via stimulating fibroblasts to proliferate and transform into myofibroblasts. ..
  2. Okuyama H, Shimahara Y, Kawada N, Seki S, Kristensen D, Yoshizato K, et al. Regulation of cell growth by redox-mediated extracellular proteolysis of platelet-derived growth factor receptor beta. J Biol Chem. 2001;276:28274-80 pubmed
    ..These results indicated that redox processes impact the cell's response to growth factors by regulating the turnover of growth factor receptors and that "redox therapy" is promising for fibrosis-related disease. ..
  3. Shimizu H, Nakagawa Y, Murakami C, Aoki N, Kim Mitsuyama S, Miyazaki H. Protein tyrosine phosphatase PTPepsilonM negatively regulates PDGF beta-receptor signaling induced by high glucose and PDGF in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2010;299:C1144-52 pubmed publisher
    ..Therefore, PTP?M negatively regulates PDGFR?-mediated signaling pathways that are crucial for the pathogenesis of atherosclerosis, and PTP?M may be involved in diabetes-accelerated atherosclerosis. ..
  4. Siegbahn A, Johnell M, Nordin A, Aberg M, Velling T. TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced chemotaxis in different cell types: involvement of Src and PLC. Arterioscler Thromb Vasc Biol. 2008;28:135-41 pubmed
    ..Similar behavior of 3 principally different cell types in our experimental setup may reflect a general function of TF in regulation of cell migration. ..
  5. Remmers E, Longman R, Du Y, O HARE A, Cannon G, Griffiths M, et al. A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. Nat Genet. 1996;14:82-5 pubmed
    ..These genes may also represent novel targets for therapy. ..
  6. Jones R, Capen D, Jacobson M. PDGF and microvessel wall remodeling in adult lung: imaging PDGF-Rbeta and PDGF-BB molecules in progenitor smooth muscle cells developing in pulmonary hypertension. Ultrastruct Pathol. 2006;30:267-81 pubmed
    ..In clear contrast to the RTK, constitutive expression levels of PDGF-BB were low in each progenitor cell type and remained restricted in the hypertensive lung. ..
  7. Guo S, Yu L, Cheng Y, Li C, Zhang J, An J, et al. PDGFR? triggered by bFGF promotes the proliferation and migration of endothelial progenitor cells via p-ERK signalling. Cell Biol Int. 2012;36:945-50 pubmed publisher
    ..The findings strongly suggest that a PDGFR?/p-ERK signalling pathway triggered by bFGF plays an important role in the proliferation and migration of EPCs. ..
  8. Platek A, Vassilev V, de Diesbach P, Tyteca D, Mettlen M, Courtoy P. Constitutive diffuse activation of phosphoinositide 3-kinase at the plasma membrane by v-Src suppresses the chemotactic response to PDGF by abrogating the polarity of PDGF receptor signalling. Exp Cell Res. 2007;313:1090-105 pubmed
    ..Thus, PDGF can further increase PDGFR auto-phosphorylation despite strong Src kinase activity, but diffuse downstream activation of PI3-K by Src abrogates cell polarization and chemotaxis: "signalling requires silence". ..
  9. Cartel N, Liu J, Wang J, Post M. PDGF-BB-mediated activation of p42(MAPK) is independent of PDGF beta-receptor tyrosine phosphorylation. Am J Physiol Lung Cell Mol Physiol. 2001;281:L786-98 pubmed
    ..These results suggest that PDGF-BB-mediated activation of p42(MAPK) requires the PDGFR-beta but is independent of its tyrosine phosphorylation...
  10. Takikita Suzuki M, Haneda M, Sasahara M, Owada M, Nakagawa T, Isono M, et al. Activation of Src kinase in platelet-derived growth factor-B-dependent tubular regeneration after acute ischemic renal injury. Am J Pathol. 2003;163:277-86 pubmed
    ..These findings suggest that active Src participates in PDGF-B-dependent regeneration of tubular cells from acute ischemic injury. ..
  11. Holmgren L, Flam F, Larsson E, Ohlsson R. Successive activation of the platelet-derived growth factor beta receptor and platelet-derived growth factor B genes correlates with the genesis of human choriocarcinoma. Cancer Res. 1993;53:2927-31 pubmed
  12. Son D, Kang J, Kim T, Song H, Sung K, Yun D, et al. Melittin, a major bioactive component of bee venom toxin, inhibits PDGF receptor beta-tyrosine phosphorylation and downstream intracellular signal transduction in rat aortic vascular smooth muscle cells. J Toxicol Environ Health A. 2007;70:1350-5 pubmed
  13. Seo K, Lee S, Kim Y, Bae J, Park S, Bae S, et al. Mechanical stretch increases MMP-2 production in vascular smooth muscle cells via activation of PDGFR-?/Akt signaling pathway. PLoS ONE. 2013;8:e70437 pubmed publisher
    ..Collectively, our data indicate that MS induces MMP-2 production in VSMC via activation of Akt pathway, that is mediated by activation of PDGFR-? signaling pathways. ..
  14. Ozturk O, Cetin A, Tokay A, Uzuner F, Tanriover G, Yesilkaya A. PDGF-? receptor and PKC have no effect on angiotensin II-induced JAK2 and STAT1 phosphorylation in vascular smooth muscle cells under high glucose condition. J Recept Signal Transduct Res. 2011;31:340-9 pubmed publisher
    ..According to our findings, Ang II-stimulated JAK2 and STAT1 phosphorylation under either NG or HG condition do not proceed via a different pathway rather than PKC and PDGF-? receptor. ..
  15. Chen C, Li Y, Yeh Y, Lee P, Usami S, Chien S, et al. Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells. Proc Natl Acad Sci U S A. 2006;103:2665-70 pubmed
    ..Our findings provide insights into the mechanism of SMC phenotypic modulation from contractile to synthetic, e.g., in atherosclerosis. ..
  16. Nakagawa T, Sasahara M, Haneda M, Kataoka H, Nakagawa H, Yagi M, et al. Role of PDGF B-chain and PDGF receptors in rat tubular regeneration after acute injury. Am J Pathol. 1999;155:1689-99 pubmed
    ..These findings suggest that the PDGF-B/PDGFRs axis is involved in the proliferation of injured tubular cells and plays an important role in the regeneration of tubular cells from acute ischemic injury. ..
  17. Vanlandewijck M, Lebouvier T, Andaloussi Mäe M, Nahar K, Hornemann S, Kenkel D, et al. Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification. PLoS ONE. 2015;10:e0143407 pubmed publisher
    ..by progressive pericapillary calcifications, has recently been linked to heterozygous mutations in PDGFB and PDGFRB genes. Here, we functionally analyzed several of these mutations in vitro...
  18. Wang L, Ma L, Fan H, Yang Z, Li L, Wang H. MicroRNA-9 regulates cardiac fibrosis by targeting PDGFR-β in rats. J Physiol Biochem. 2016;72:213-23 pubmed publisher
    ..Overexpression of miR-9 inhibited cardiac fibrosis by targeting PDGFR-β, indicating that miR-9 might play a role in the treatment of cardiac fibrosis. ..
  19. Tallquist M, French W, Soriano P. Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development. PLoS Biol. 2003;1:E52 pubmed
    ..The combined in vivo and biochemical data suggest that the summation of pathways associated with the PDGFRbeta signal transduction determines the expansion of developing v/p cells. ..
  20. Liu J, Bai H, Xing D, Sun Y, Wu L. Role of platelet-derived growth factor receptor-mediated signal transduction in myocardial hypertrophy of spontaneously hypertensive rats. Sheng Li Xue Bao. 2002;54:159-64 pubmed
    ..These findings suggest that PDGF beta receptor may play an important role in the myocardial hypertrophy of spontaneously hypertensive rats. ..
  21. Sano H, Sudo T, Yokode M, Murayama T, Kataoka H, Takakura N, et al. Functional blockade of platelet-derived growth factor receptor-beta but not of receptor-alpha prevents vascular smooth muscle cell accumulation in fibrous cap lesions in apolipoprotein E-deficient mice. Circulation. 2001;103:2955-60 pubmed
    ..These results indicate that PDGFR-beta plays a significant role in formation of fibrous atherosclerotic lesions and that regulation of the signal transduction through PDGFR-beta could affect atherogenesis in mice. ..
  22. Ricono J, Wagner B, Gorin Y, Arar M, Kazlauskas A, Choudhury G, et al. PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA. Am J Physiol Renal Physiol. 2009;296:F406-17 pubmed publisher
    ..During kidney development, PDGFR beta-mediated ROS generation and Ca(2+) influx suppress PDGF AA-induced chemotaxis in metanephric mesenchyme.
  23. Chen S, Zhang X, Wang C, Chen W, Xie W, Chen Y. RNA interference targeting the platelet-derived growth factor receptor beta subunit ameliorates experimental hepatic fibrosis in rats. Liver Int. 2008;28:1446-57 pubmed publisher
    ..Platelet-derived growth factor receptor-beta subunit siRNA may be presented as an effective antifibrogenic gene therapeutic method for hepatic fibrosis. ..
  24. Vrekoussis T, Stathopoulos E, Kafousi M, Navrozoglou I, Zoras O. Expression of endothelial PDGF receptors alpha and beta in breast cancer: up-regulation of endothelial PDGF receptor beta. Oncol Rep. 2007;17:1115-9 pubmed
    ..05). No statistical difference was revealed by studying PDGFRalpha expression. In conclusion, our findings support the thesis of possible anti-PDGFRbeta anti-angiogenic therapy, in cases of endothelial PDGFRbeta-expressing breast cancer. ..
  25. Dong N, Wang W, Tian J, Xie Z, Lv B, Dai J, et al. MicroRNA-182 prevents vascular smooth muscle cell dedifferentiation via FGF9/PDGFR? signaling. Int J Mol Med. 2017;39:791-798 pubmed publisher
    ..These data suggest that miR?182 may be a novel SMC phenotypic marker and a modulator that may be used to prevent SMC dedifferentiation via FGF9/PDGFR? signaling. ..
  26. Herren B, Weyer K, Rouge M, Lötscher P, Pech M. Conservation in sequence and affinity of human and rodent PDGF ligands and receptors. Biochim Biophys Acta. 1993;1173:294-302 pubmed
    ..Dissociation constants were identical to those of their human homologs. Thus, high affinity binding of human PDGF-BB to extracellular domains does not depend on species origin but only on receptor type. ..
  27. Johansson A, Jones J, Pietras K, Kilter S, Skytt A, Rudolfsson S, et al. A stroma targeted therapy enhances castration effects in a transplantable rat prostate cancer model. Prostate. 2007;67:1664-76 pubmed
    ..The stroma in highly differentiated androgen sensitive Dunning tumors is apparently androgen insensitive. If this unresponsive stroma is targeted the effects of castration can be enhanced. ..
  28. Liu S, Tieche C, Tang D, Alkema P. Pattern formation of vascular smooth muscle cells subject to nonuniform fluid shear stress: role of PDGF-beta receptor and Src. Am J Physiol Heart Circ Physiol. 2003;285:H1081-90 pubmed
    ..These observations suggest that PDGF-beta receptor and Src possibly serve as mediating factors in nonuniform shear-induced formation of cell density gradients and alignment of SMCs in the neointima of vascular polymer implants. ..
  29. Zhou L, Takayama Y, Boucher P, Tallquist M, Herz J. LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation. PLoS ONE. 2009;4:e6922 pubmed publisher
    ..Thus, regulation of PI3 Kinase by PDGFRbeta is essential for maintaining vascular integrity, and for the prevention of atherosclerosis as well as Marfan syndrome. ..
  30. Takahashi Y, Morales F, Kreimann E, Georgescu M. PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling. EMBO J. 2006;25:910-20 pubmed
    ..These data indicate that, in normal cells, NHERF proteins recruit PTEN to PDGFR to restrict the activation of the PI3K. ..
  31. Nakatsuji T. Better-surviving liver grafts by the injection of anti-CD2 antibody: the important roles of host CD8+ and CD2+CD28+ T cells in chronic graft rejection and beta type platelet-derived growth factor receptor (PDGFR-beta) expression on apoptotic liver gr. Tohoku J Exp Med. 1999;187:215-25 pubmed
    ..Prolonged graft survival was observed in only one of the 9 rats. Anti-CD2 MAb was effective for prolonging the liver graft survival with suppressed CD28 antigen, but anti-PDGFR-beta Ab and splenectomy were not. ..
  32. Dahlman I, Lorentzen J, de Graaf K, Stefferl A, Linington C, Luthman H, et al. Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern. Eur J Immunol. 1998;28:2188-96 pubmed
    ..We conclude that Cia3 and Oia2 regulate MOG-induced EAE in rats. Furthermore, since both EAE and arthritis phenotypes co-localize to these gene regions, they may harbor genes which are key regulators of pathogenic immune responses. ..
  33. Beazely M, Lim A, Li H, Trepanier C, Chen X, Sidhu B, et al. Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-D-aspartate receptors in CA1 hippocampal neurons. J Biol Chem. 2009;284:8054-63 pubmed publisher
    ..We conclude that PDGFbetaR signaling, by preferentially targeting NR2B receptors, provides an important mechanism for neuroprotection by growth factors in the central nervous system. ..
  34. Kirca M, Oguz N, Cetin A, Uzuner F, Yesilkaya A. Uric acid stimulates proliferative pathways in vascular smooth muscle cells through the activation of p38 MAPK, p44/42 MAPK and PDGFR?. J Recept Signal Transduct Res. 2017;37:167-173 pubmed publisher
  35. Biswas S, Zhao Y, Nagalingam A, Gardner T, Sandirasegarane L. PDGF- and insulin/IGF-1-specific distinct modes of class IA PI 3-kinase activation in normal rat retinas and RGC-5 retinal ganglion cells. Invest Ophthalmol Vis Sci. 2008;49:3687-98 pubmed publisher
    ..PDGF-induced PI 3-kinase/PIP3/Akt axis may provide new therapeutic approaches to ameliorate cell death in diabetic retinopathy and other retinal neurodegenerations. ..
  36. Schmahl J, Rizzolo K, Soriano P. The PDGF signaling pathway controls multiple steroid-producing lineages. Genes Dev. 2008;22:3255-67 pubmed publisher
    ..Therefore, PDGF signaling may constitute a common mechanism in the control of multiple steroidogenic lineages. ..
  37. Liu X, Ciumas C, Huang Y, Steffensen K, Lian H, Link H, et al. Autoantigen-pulsed dendritic cells constitute a beneficial cytokine and growth factor network in ameliorating experimental allergic encephalomyelitis. Mult Scler. 2005;11:381-9 pubmed
    ..In line with the suppression of EAE induced by MBP-pulsed DC, the dynamic change of cytokines and growth factors in spinal cords should constitute a beneficial microenvironment against EAE. ..
  38. Ranganna K, Joshi T, Yatsu F. Sodium butyrate inhibits platelet-derived growth factor-induced proliferation of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 1995;15:2273-83 pubmed
    ..However, SB by itself had no significant effect on c-fos, c-jun, and c-myc transcription.(ABSTRACT TRUNCATED AT 400 WORDS) ..
  39. Lucero H, Ravid K, Grimsby J, Rich C, DiCamillo S, Maki J, et al. Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells. J Biol Chem. 2008;283:24103-17 pubmed publisher
    ..These novel findings suggest that LOX activity is essential to generate optimal chemotactic sensitivity of cells to chemoattractants by oxidizing specific cell surface proteins, such as PDGFR-beta. ..
  40. Souza P, Tanswell A, Post M. Different roles for PDGF-alpha and -beta receptors in embryonic lung development. Am J Respir Cell Mol Biol. 1996;15:551-62 pubmed
    ..These data suggest that PDGF-BB stimulation of both receptors leads to lung growth, whereas PDGF-AA stimulation of the alpha-receptor induces transduction pathways that lead lung branching. ..
  41. Arimura K, Ago T, Kamouchi M, Nakamura K, Ishitsuka K, Kuroda J, et al. PDGF receptor ? signaling in pericytes following ischemic brain injury. Curr Neurovasc Res. 2012;9:1-9 pubmed
    ..Thus, the PDGFR?-Akt signaling in brain pericytes may play various important roles leading to neuroprotection after ischemic stroke. ..
  42. Wang Y, Culty M. Identification and distribution of a novel platelet-derived growth factor receptor beta variant: effect of retinoic acid and involvement in cell differentiation. Endocrinology. 2007;148:2233-50 pubmed
    ..These results suggest that the expression of V1-PDGFRbeta is tightly regulated during differentiation and that it may play an active role in germ cell differentiation. ..
  43. Minatogawa M, Takenouchi T, Tsuyusaki Y, Iwasaki F, Uehara T, Kurosawa K, et al. Expansion of the phenotype of Kosaki overgrowth syndrome. Am J Med Genet A. 2017;173:2422-2427 pubmed publisher
    ..a novel overgrowth syndrome (Kosaki overgrowth syndrome, OMIM #616592) arising from a de novo mutation in PDGFRB, that is, c.1751C>G p.(Pro584Arg)...
  44. Uehara G, Suzuki D, Toyoda M, Umezono T, Sakai H. Glomerular expression of platelet-derived growth factor (PDGF)-A, -B chain and PDGF receptor-alpha, -beta in human diabetic nephropathy. Clin Exp Nephrol. 2004;8:36-42 pubmed
    ..The present study was designed to determine the expression of PDGF and PDGF receptor (PDGFR) mRNA in the renal tissues of type 2 diabetic patients with DN. ..
  45. Wang Y, Barker K, Shi S, Diaz M, Mo B, Gutstein H. Blockade of PDGFR-? activation eliminates morphine analgesic tolerance. Nat Med. 2012;18:385-7 pubmed publisher
    ..PDGFR-? inhibitors are widely used and well tolerated, suggesting that clinical translation of our findings could reduce the suffering endured by individuals with intractable pain. ..
  46. Akiyama N, Naruse K, Kobayashi Y, Nakamura N, Hamada Y, Nakashima E, et al. High glucose-induced upregulation of Rho/Rho-kinase via platelet-derived growth factor receptor-beta increases migration of aortic smooth muscle cells. J Mol Cell Cardiol. 2008;45:326-32 pubmed publisher
    ..The inhibition of Rho/Rho-kinase may be a new target for the treatment of diabetic macroangiopathy. ..
  47. Savikko J, Kallio E, Taskinen E, von Willebrand E. The effect of acute rejection and cyclosporin A-treatment on induction of platelet-derived growth factor and its receptors during the development of chronic rat renal allograft rejection. Transplantation. 2002;73:506-11 pubmed
  48. Shimizu H, Hagio M, Iwaya H, Tsuneki I, Lee J, Fukiya S, et al. Deoxycholic acid is involved in the proliferation and migration of vascular smooth muscle cells. J Nutr Sci Vitaminol (Tokyo). 2014;60:450-4 pubmed publisher
    ..These findings suggest that elevated serum concentrations of DCA are involved in the pathogenesis of atherosclerosis in HF-induced obesity. ..
  49. Seifert R, Hart C, Phillips P, Forstrom J, Ross R, Murray M, et al. Two different subunits associate to create isoform-specific platelet-derived growth factor receptors. J Biol Chem. 1989;264:8771-8 pubmed
    ..Both the absolute and relative numbers of these two PDGF receptor subunits vary on different cell types and correspond to differences in the mitogenic sensitivity of cells to the different PDGF isoforms. ..
  50. Kim S, Jin Y, Lim Y, Kim J, Cho M, Hong J, et al. Inhibition of PDGF beta-receptor tyrosine phosphorylation and its downstream intracellular signal transduction in rat aortic vascular smooth muscle cells by kaempferol. Planta Med. 2005;71:599-603 pubmed
  51. Ricono J, Arar M, Choudhury G, Abboud H. Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells. Am J Physiol Renal Physiol. 2002;282:F211-9 pubmed
    ..Collectively, the data may have implications related to the failure of PDGF AA to rescue mesangial cell phenotype in PDGF B-chain or PDGF-beta-receptor deficiency. ..
  52. Shepherd J, Stamper E, Matheson P, Galganski L, Garrison R, Madden K, et al. Alterations in platelet-derived growth factor expression in the pathophysiology of necrotizing enterocolitis. J Surg Res. 2015;198:377-83 pubmed publisher
    ..Dysregulation of PDGF during intestinal maturation could contribute to the development of NEC. Further investigation into this pathway could yield new therapeutic targets for this devastating disease. ..
  53. Cartel N, Wang J, Post M. Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt. Biochem J. 2002;363:19-28 pubmed
    ..These data suggest that Akt is an integral protein involved in PDGF-BB-mediated GAG regulation in fetal lung fibroblasts. ..