Pdgfa

Summary

Gene Symbol: Pdgfa
Description: platelet derived growth factor subunit A
Alias: PDGFACP, platelet-derived growth factor subunit A, PDGF subunit A, PDGF-1, Platelet-derived growth factor A chain, platelet derived growth factor, alpha, platelet-derived growth factor alpha polypeptide
Species: rat
Products:     Pdgfa

Top Publications

  1. Bryckaert M, Rendu F, Tobelem G, Wasteson A. Collagen-induced binding to human platelets of platelet-derived growth factor leading to inhibition of P43 and P20 phosphorylation. J Biol Chem. 1989;264:4336-41 pubmed
    ..It is concluded that PDGF might be involved in a negative feed-back control of platelet activation. ..
  2. Arita Y, Kihara S, Ouchi N, Maeda K, Kuriyama H, Okamoto Y, et al. Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation. 2002;105:2893-8 pubmed
  3. Sim F, Zhao C, Penderis J, Franklin R. The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation. J Neurosci. 2002;22:2451-9 pubmed
  4. Heinig J, Wilhelm S, Muller H, Briese V, Bittorf T, Brock J. Determination of cytokine mRNA-expression in term human placenta of patients with gestational hypertension, intrauterine growth retardation and gestational diabetes mellitus using polymerase chain reaction. Zentralbl Gynakol. 2000;122:413-8 pubmed
    ..0029 and p = 0.008). Though these marked differences in cytokine mRNA levels between clinical groups were statistically proven, clear correlation of these differences with clinical data was not found. ..
  5. Dembinski A, Warzecha Z, Ceranowicz P, Dembinski M, Cieszkowski J, Pawlik W, et al. Effect of ischemic preconditioning on pancreatic regeneration and pancreatic expression of vascular endothelial growth factor and platelet-derived growth factor-A in ischemia/reperfusion-induced pancreatitis. J Physiol Pharmacol. 2006;57:39-58 pubmed
    ..This effect is associated with the increase in plasma concentration of anti-inflammatory interleukin-10, improvement of pancreatic blood flow and alteration of pancreatic immunohistochemical expression of PDGF-A and VEGF. ..
  6. Ball S, Shuttleworth C, Kielty C. Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J Cell Biol. 2007;177:489-500 pubmed
    ..This mechanism was also shown to mediate human dermal fibroblast (HDF) migration. VEGF-A/PDGFR signaling has the potential to regulate vascular cell recruitment and proliferation during tissue regeneration and disease. ..
  7. Katayose D, Ohe M, Yamauchi K, Ogata M, Shirato K, Fujita H, et al. Increased expression of PDGF A- and B-chain genes in rat lungs with hypoxic pulmonary hypertension. Am J Physiol. 1993;264:L100-6 pubmed
    ..These results suggest that the PDGF A- and B-chain products may be coordinately and sequentially involved in hypoxic pulmonary vascular remodeling...
  8. Clunn G, Refson J, Lymn J, Hughes A. Platelet-derived growth factor beta-receptors can both promote and inhibit chemotaxis in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 1997;17:2622-9 pubmed
  9. Ding H, Wu X, Bostrom H, Kim I, Wong N, Tsoi B, et al. A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nat Genet. 2004;36:1111-6 pubmed
    ..This phenotype was less severe than that of Pdgfra(-/-) embryos. Pdgfc(-/-) Pdgfa(-/-) embryos developed a cleft face, subepidermal blistering, deficiency of renal cortex mesenchyme, spina bifida ..

More Information

Publications62

  1. Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, et al. Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat Med. 2002;8:856-63 pubmed
    ..KLF5 thus seems to be a key element linking external stress and cardiovascular remodeling. ..
  2. Lowry M, Lotinun S, Leontovich A, Zhang M, Maran A, Shogren K, et al. Osteitis fibrosa is mediated by Platelet-Derived Growth Factor-A via a phosphoinositide 3-kinase-dependent signaling pathway in a rat model for chronic hyperparathyroidism. Endocrinology. 2008;149:5735-46 pubmed publisher
  3. Ricono J, Wagner B, Gorin Y, Arar M, Kazlauskas A, Choudhury G, et al. PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA. Am J Physiol Renal Physiol. 2009;296:F406-17 pubmed publisher
    ..During kidney development, PDGFR beta-mediated ROS generation and Ca(2+) influx suppress PDGF AA-induced chemotaxis in metanephric mesenchyme. ..
  4. Cook J, Marcheselli V, Alam J, Deininger P, Bazan N. Temporal changes in gene expression following cryogenic rat brain injury. Brain Res Mol Brain Res. 1998;55:9-19 pubmed
    ..In the present model, many genes demonstrate elevated RNA levels in the cortex prior to hippocampus, following injury. RNAs transcribed from late genes tend to be elevated concurrently in cortex and hippocampus. ..
  5. Karlsson L, Lindahl P, Heath J, Betsholtz C. Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis. Development. 2000;127:3457-66 pubmed
    ..The role of PDGF-A seems to be to secure renewal of PDGFR-(alpha) positive cells when they are consumed in the initial rounds of cluster formation. ..
  6. Kim T, Moon J, Savard C, Kuver R, Lee S. Effects of lipopolysaccharide on platelet-derived growth factor isoform and receptor expression in cultured rat common bile duct fibroblasts and cholangiocytes. J Gastroenterol Hepatol. 2009;24:1218-25 pubmed
    ..Intracellular and secreted PDGF-AB increased with LPS treatment in NRC. These results support a model in which chronic bacterial colonization of the biliary tree induces fibrosis through PDGF-dependent mechanisms. ..
  7. Lee Y, Ozeki M, Juhn S, Lin J. Expression of platelet-derived growth factor in the developing cochlea of rats. Acta Otolaryngol. 2004;124:558-62 pubmed
    ..Inhibition of the expression of PDGFs in the cultured progenitor hair cells with antisense oligonucleotides reduced the DNA synthesis. PDGFs and their receptors may play a role in the proliferation of developing cochlear hair cells. ..
  8. Hu J, Wu X, Feng Y, Xi G, Wang Z, Zhou J, et al. PDGF-AA and bFGF mediate B104CM-induced proliferation of oligodendrocyte precursor cells. Int J Mol Med. 2012;30:1113-8 pubmed publisher
    ..However, the inhibition of IGF-1R with AG1204 did not affect the proliferation of OPCs. Our study suggests that the PDGF-AA and bFGF in B104CM are 2 key factors that stimulate OPC proliferation. ..
  9. Saito Y, Hojo Y, Tanimoto T, Abe J, Berk B. Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor. J Biol Chem. 2002;277:23216-22 pubmed
    ..Because PDGF-mediated ERK activation is enhanced in Chinese hamster ovary cells that overexpress Gab1, Gab1 serves as an important link between PKC and ERK activation by PDGFbeta receptors in VSMC. ..
  10. Mangum J, Turpin E, Antao Menezes A, Cesta M, Bermudez E, Bonner J. Single-walled carbon nanotube (SWCNT)-induced interstitial fibrosis in the lungs of rats is associated with increased levels of PDGF mRNA and the formation of unique intercellular carbon structures that bridge alveolar macrophages in situ. Part Fibre Toxicol. 2006;3:15 pubmed
    ..Of greatest interest was the discovery of unique intercellular carbon structures composed of SWCNT that bridged lung macrophages. These "carbon bridges" offer a novel and easily identifiable biomarker of exposure. ..
  11. Cao W, Chai J, Yang Z, Wang D, Sheng Z. [The expression of platelet-derived growth factor-A and its receptor in acute radiation-induced skin ulcer in rats]. Zhonghua Shao Shang Za Zhi. 2005;21:359-62 pubmed
    ..3 +/- 1.0, and reduced gradually during scar formation period (55 days after radiation). The reduction of PDGF-A and PDGFR-expression may be partially involved in the mechanism of retarded healing of acute radiation-induced skin ulcers. ..
  12. Liang M, Wang H, Zhang Y, Lu S, Wang Z. Expression and functional analysis of platelet-derived growth factor in uterine leiomyomata. Cancer Biol Ther. 2006;5:28-33 pubmed
    ..PDGF may play a role in the pathogenesis of leiomyomas through a mechanism involved in not only the proliferation of leiomyoma cells but also excessive expression of extra cellular molecules. ..
  13. Lindahl P, Karlsson L, Hellstrom M, Gebre Medhin S, Willetts K, Heath J, et al. Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development. Development. 1997;124:3943-53 pubmed
    ..We also propose that postnatal alveogenesis failure in PDGF-A(-/-) mice is due to a prenatal block in the distal spreading of PDGF-Ralpha+ cells along the tubular lung epithelium during the canalicular stage of lung development. ..
  14. Kowarik M, Onofri C, Colaco T, Stalla G, Renner U. Platelet-derived growth factor (PDGF) and PDGF receptor expression and function in folliculostellate pituitary cells. Exp Clin Endocrinol Diabetes. 2010;118:113-20 pubmed publisher
    ..Thus the PDGF/PDGF receptor system is expressed in folliculostellate cells and is involved in VEGF regulation. Its role in endocrine pituitary tumour cell lines and pituitary adenomas need to be clarified in future studies. ..
  15. Shim A, Liu H, Focia P, Chen X, Lin P, He X. Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex. Proc Natl Acad Sci U S A. 2010;107:11307-12 pubmed publisher
    ..The structural and biochemical data together offer insights into PDGF-PDGFR signaling, as well as strategies for PDGF-antagonism. ..
  16. Connolly N, Stokum J, Schneider C, Ozawa T, Xu S, Galisteo R, et al. Genetically engineered rat gliomas: PDGF-driven tumor initiation and progression in tv-a transgenic rats recreate key features of human brain cancer. PLoS ONE. 2017;12:e0174557 pubmed publisher
    ..Nestin promoter-driven tv-a (Ntv-a) transgenic Sprague-Dawley rat founder lines were created and RCAS PDGFA and p53 shRNA constructs were used to initiate intracranial brain tumor formation...
  17. Savolainen Peltonen H, Loubtchenkov M, Petrov L, Delafontaine P, Hayry P. Estrogen regulates insulin-like growth factor 1, platelet-derived growth factor A and B, and their receptors in the vascular wall. Transplantation. 2004;77:35-42 pubmed
    ..Our findings demonstrate that estrogen regulates IGF-1, PDGF-A, PDGF-B, and PDGF-Ralpha, which may be related to the vasculoprotective effect of estrogen, but has no effect on IGF-1R or PDGF-Rbeta. ..
  18. Frost E, Zhou Z, Krasnesky K, Armstrong R. Initiation of oligodendrocyte progenitor cell migration by a PDGF-A activated extracellular regulated kinase (ERK) signaling pathway. Neurochem Res. 2009;34:169-81 pubmed publisher
    ..These findings indicate PDGF-A may act to mobilize OP cells that then respond to distinct directional signals to distribute appropriately within the CNS. ..
  19. Xiangdong Jian -, Ming Li -, Yijing Zhang -, Yanjun Ruan -, Guangran Guo -, Hong Sui -, et al. Role of growth factors in acute lung injury induced by paraquat in a rat model. Hum Exp Toxicol. 2011;30:460-9 pubmed publisher
    ..The synergistic effects of these molecules are presumed to cause pulmonary damage due to PQ challenge and may become targets of treatment. ..
  20. Usui S, Sugimoto N, Takuwa N, Sakagami S, Takata S, Kaneko S, et al. Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. J Biol Chem. 2004;279:12300-11 pubmed
    ..These results reveal the S1P(1)-triggered, G(i)-Ras-ERK/p38 MAPK-KLF5-dependent, stimulatory regulation of PDGF gene transcription in vascular smooth muscle cells. ..
  21. Uzumcu M, Dirks K, Skinner M. Inhibition of platelet-derived growth factor actions in the embryonic testis influences normal cord development and morphology. Biol Reprod. 2002;66:745-53 pubmed
    ..Inhibition of PDGF actions does not inhibit cord formation but does alter normal cord development and morphology. The observations provide insight into the factors involved in male sex differentiation and embryonic testis development. ..
  22. Wagner W, Wehrmann M. Differential cytokine activity and morphology during wound healing in the neonatal and adult rat skin. J Cell Mol Med. 2007;11:1342-51 pubmed publisher
    ..Secondly, the data may recommend inhibition of PDGF A, basic FGF or TGF-beta1 as therapeutic targets in efforts to optimize wound healing in the adult organism. ..
  23. Rintala J, Savikko J, Palin N, Rintala S, Koskinen P, von Willebrand E. Oral Platelet-Derived Growth Factor and Vascular Endothelial Growth Factor Inhibitor Sunitinib Prevents Chronic Allograft Injury in Experimental Kidney Transplantation Model. Transplantation. 2016;100:103-10 pubmed publisher
  24. Basciani S, Mariani S, Arizzi M, Brama M, Ricci A, Betsholtz C, et al. Expression of platelet-derived growth factor (PDGF) in the epididymis and analysis of the epididymal development in PDGF-A, PDGF-B, and PDGF receptor beta deficient mice. Biol Reprod. 2004;70:168-77 pubmed
    ..Taken together, these data indicate that the PDGF system is highly expressed in the epididymis and suggest that PDGF could be involved in the maintenance of morphological structure and functional control of this organ. ..
  25. Fecteau K, Mrkonjich L, Mason J, Mendis Handagama S. Detection of platelet-derived growth factor-alpha (PDGF-A) protein in cells of Leydig lineage in the postnatal rat testis. Histol Histopathol. 2006;21:1295-302 pubmed publisher
  26. Langham R, Kelly D, Maguire J, Dowling J, Gilbert R, Thomson N. Over-expression of platelet-derived growth factor in human diabetic nephropathy. Nephrol Dial Transplant. 2003;18:1392-6 pubmed
  27. Konya D, Gercek A, Akakin A, Akakin D, Tural S, Cetinel S, et al. The effects of inflammatory response associated with traumatic spinal cord injury in cutaneous wound healing and on expression of transforming growth factor-beta1 (TGF-beta1) and platelet-derived growth factor (PDGF)-A at the wound site in rats. Growth Factors. 2008;26:74-9 pubmed publisher
    ..Based on the results on the parameters evaluated in the study, experimental SCI in rats results in delay in wound healing and low intensity of TGF-beta1 in the dorsal wound-tissue specimens. ..
  28. Liapis H, Yu H, Flath A, Steinhardt G. Increased expression of platelet-derived growth factor A and collagenous matrix proteins in congenital multicystic renal dysplasia. Nephron. 1997;76:161-70 pubmed
  29. Salazar K, Lankford S, Brody A. Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2009;297:L1002-11 pubmed publisher
    ..It will be essential to determine whether these factors can play a role in attempts to use MSC for therapeutic approaches. ..
  30. Savikko J, Kallio E, Taskinen E, von Willebrand E. The effect of acute rejection and cyclosporin A-treatment on induction of platelet-derived growth factor and its receptors during the development of chronic rat renal allograft rejection. Transplantation. 2002;73:506-11 pubmed
  31. Chen C, Wang L, Chou H, Lang Y. Oligohydramnios decreases platelet-derived growth factor expression in fetal rat lungs. Neonatology. 2007;92:187-93 pubmed
    ..A decreased PDGF expression may be important in the pathogenesis of oligohydramnios-induced pulmonary hypoplasia and suggests that supplementation may provide useful therapeutic strategies. ..
  32. Andrae J, Ehrencrona H, Gallini R, Lal M, Ding H, Betsholtz C. Analysis of mice lacking the heparin-binding splice isoform of platelet-derived growth factor A. Mol Cell Biol. 2013;33:4030-40 pubmed publisher
    ..two PDGF-A splice isoforms during early postnatal organ development in the mouse and report on the generation of a Pdgfa allele (Pdgfa(?ex6)) incapable of producing PDGF-Along due to a deletion of the exon 6 splice acceptor site...
  33. Breitkopf K, Roeyen C, Sawitza I, Wickert L, Floege J, Gressner A. Expression patterns of PDGF-A, -B, -C and -D and the PDGF-receptors alpha and beta in activated rat hepatic stellate cells (HSC). Cytokine. 2005;31:349-57 pubmed
    ..Given the dramatic changes in PDGF-C and -D expression, which may compensate for down-regulation of PDGF-B, we hypothesize that the new PDGF isoforms may fulfil specific functions in hepatic fibrogenesis. ..
  34. Anan K, Morisaki T, Katano M, Ikubo A, Kitsuki H, Uchiyama A, et al. Vascular endothelial growth factor and platelet-derived growth factor are potential angiogenic and metastatic factors in human breast cancer. Surgery. 1996;119:333-9 pubmed
    ..Analysis of these mRNAs by reverse transcriptase-polymerase chain reaction may be useful for assessing the biologic behavior of a breast tumor before surgical treatment. ..
  35. Szabo P, Weksler D, Whittington E, Weksler B. The age-dependent proliferation of rat aortic smooth muscle cells is independent of differential splicing of PDGF A-chain mRNA. Mech Ageing Dev. 1993;67:79-89 pubmed
  36. Liu C, Zhao W, Meng W, Zhao T, Chen Y, Ahokas R, et al. Platelet-derived growth factor blockade on cardiac remodeling following infarction. Mol Cell Biochem. 2014;397:295-304 pubmed publisher
    ..Further, this study suggests the potential therapeutic effects of PDGFR blockade on interstitial fibrosis of the infarcted heart. ..
  37. Ha J, Yun S, Kim Y, Jin S, Lee H, Song S, et al. Platelet-derived growth factor regulates vascular smooth muscle phenotype via mammalian target of rapamycin complex 1. Biochem Biophys Res Commun. 2015;464:57-62 pubmed publisher
    ..Inhibition of mTORC1 by rapamycin or by silencing of Raptor significantly blocked PDGF-induced proliferation of VSMCs. Taken together, we suggest that mTORC1 plays an essential role in PDGF-dependent phenotypic changes of VSMCs. ..
  38. Torok D, Patel N, Jebailey L, Thong F, Randhawa V, Klip A, et al. Insulin but not PDGF relies on actin remodeling and on VAMP2 for GLUT4 translocation in myoblasts. J Cell Sci. 2004;117:5447-55 pubmed
    ..These results suggest that insulin and PDGF rely differently on the actin cytoskeleton and on tetanus-toxin-sensitive VAMPs for mobilizing GLUT4. ..
  39. Basciani S, Mariani S, Arizzi M, Ulisse S, Rucci N, Jannini E, et al. Expression of platelet-derived growth factor-A (PDGF-A), PDGF-B, and PDGF receptor-alpha and -beta during human testicular development and disease. J Clin Endocrinol Metab. 2002;87:2310-9 pubmed
    ..Finally, the expression of PDGF ligands and receptor proteins in Leydig cell tumors suggests a relationship of the PDGF system to tumorigenesis or tumor progression in this testicular neoplasm. ..
  40. Czarkowska Paczek B, Zendzian Piotrowska M, Bartlomiejczyk I, Przybylski J, Gorski J. The influence of physical exercise on the generation of TGF-?1, PDGF-AA, and VEGF-A in adipose tissue. Eur J Appl Physiol. 2011;111:875-81 pubmed publisher
    ..0002). However, the protein levels remained constant. In conclusion, prolonged physical exercise increases growth factor mRNA in adipose tissue but not protein levels. ..
  41. Luo Y, Zhang M, Zhang J, Zhang J, Chen C, Chen Y, et al. Platelet-derived growth factor induces Rad expression through Egr-1 in vascular smooth muscle cells. PLoS ONE. 2011;6:e19408 pubmed publisher
    ..Direct binding of Egr-1 to the Rad promoter region was further confirmed by chromatin immunoprecipitation assays. Our results demonstrate that Rad is regulated by PDGF through the transcriptional factor Egr-1 in RASMCs. ..
  42. Pang H, Wen Y, Ma N, Wang Y, Shi L. Protective role of a novel erythrocyte-derived depressing factor on blood vessels of renovascular hypertensive rats. Clin Exp Pharmacol Physiol. 2007;34:393-8 pubmed
    ..The effects may be mediated, in part, by enhanced expression of p21 (Cip1) and the inhibition of ERK1/2 phosphorylation and the expression of cyclin D1/CDK4 and PDGF-A...
  43. Shepherd J, Stamper E, Matheson P, Galganski L, Garrison R, Madden K, et al. Alterations in platelet-derived growth factor expression in the pathophysiology of necrotizing enterocolitis. J Surg Res. 2015;198:377-83 pubmed publisher
    ..Dysregulation of PDGF during intestinal maturation could contribute to the development of NEC. Further investigation into this pathway could yield new therapeutic targets for this devastating disease. ..
  44. Tao W, Filippi M, Bailey J, Atkinson S, Connors B, Evan A, et al. The TRQQKRP motif located near the C-terminus of Rac2 is essential for Rac2 biologic functions and intracellular localization. Blood. 2002;100:1679-88 pubmed
    ..These data suggest that precise localization of Rac2 protein in intracellular compartments and/or with other proteins/lipids is a prerequisite for its diverse functions. ..
  45. Herren B, Weyer K, Rouge M, Lötscher P, Pech M. Conservation in sequence and affinity of human and rodent PDGF ligands and receptors. Biochim Biophys Acta. 1993;1173:294-302 pubmed
    ..Dissociation constants were identical to those of their human homologs. Thus, high affinity binding of human PDGF-BB to extracellular domains does not depend on species origin but only on receptor type. ..
  46. Karlsson L, Bondjers C, Betsholtz C. Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. Development. 1999;126:2611-21 pubmed
    ..Such embryos fail to form pre-papilla aggregates of postmitotic PDGF-Ralpha-positive cells, suggesting that shh has a critical role in the assembly of the dermal papilla. ..
  47. Ricono J, Arar M, Choudhury G, Abboud H. Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells. Am J Physiol Renal Physiol. 2002;282:F211-9 pubmed
    ..Collectively, the data may have implications related to the failure of PDGF AA to rescue mesangial cell phenotype in PDGF B-chain or PDGF-beta-receptor deficiency. ..
  48. Fudge K, Wang C, Stearns M. Immunohistochemistry analysis of platelet-derived growth factor A and B chains and platelet-derived growth factor alpha and beta receptor expression in benign prostatic hyperplasias and Gleason-graded human prostate adenocarcinomas. Mod Pathol. 1994;7:549-54 pubmed
    ..The data suggest that PDGF A and alpha receptor genes may be preferentially turned on in epithelial and stromal prostate tumor cells. ..
  49. Mo B, Liu W, Yang L, Jiao J. [Modulation of expression of platelet-derived growth factor by nuclear transcription factor-kappaB in rats retina]. Zhonghua Yan Ke Za Zhi. 2007;43:49-54 pubmed
    ..Upregulation of PDGF may play an important role in the occurrence of intraocular inflammation and the different isoform of PDGF may have different impact on various ocular diseases. ..
  50. Lim J, Cho H, Hong H, Kwon H, Mook Jung I, Kwon Y. Upregulation of amyloid precursor protein by platelet-derived growth factor in hippocampal precursor cells. Neuroreport. 2007;18:1225-9 pubmed
    ..These results suggest that the neurotrophic effect of platelet-derived growth factor is mediated in part via upregulation of the expression and release of secreted amyloid precursor protein alpha. ..
  51. Abbaszadeh H, Tiraihi T, Delshad A, Saghedizadeh M, Taheri T, Kazemi H, et al. Differentiation of neurosphere-derived rat neural stem cells into oligodendrocyte-like cells by repressing PDGF-α and Olig2 with triiodothyronine. Tissue Cell. 2014;46:462-9 pubmed publisher
    ..The OLCs were co-cultured with motoneurons resulted in induction of MOG and MBP, which were expressed in functional OLCs. The latter can be generated from BMSCs-derive NS with high yield. ..
  52. Le Bras B, Barallobre M, Homman Ludiye J, Ny A, Wyns S, Tammela T, et al. VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nat Neurosci. 2006;9:340-8 pubmed
    ..VEGF-C thus has a new, evolutionary conserved function as a growth factor selectively required by neural progenitor cells expressing its receptor VEGFR-3. ..
  53. Womer R, Frick K, Mitchell C, Ross A, Bishayee S, Scher C. PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication. J Cell Physiol. 1987;132:65-72 pubmed
    ..Thus MG-63 cells are a naturally occurring cell variant in which PDGF stimulates c-myc expression but does not modulate mitogenesis. ..