Gene Symbol: Pde6a
Description: phosphodiesterase 6A
Alias: rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha, phosphodiesterase 6A, cGMP-specific, rod, alpha
Species: rat
Products:     Pde6a

Top Publications

  1. Cote R. Characteristics of photoreceptor PDE (PDE6): similarities and differences to PDE5. Int J Impot Res. 2004;16 Suppl 1:S28-33 pubmed
    ..Most PDE5 inhibitors inhibit PDE6 with similar potency, and electroretinogram studies show modest effects of PDE5 inhibitors on visual function-an observation potentially important in designing PDE5-specific therapeutic agents. ..
  2. Bazhin A, Tambor V, Dikov B, Philippov P, Schadendorf D, Eichm├╝ller S. cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells. Cell Mol Life Sci. 2010;67:817-28 pubmed publisher
    ..Thus, the aberrant expression of PDE6 may control cGMP metabolism and calcium homeostasis in melanoma cells. ..
  3. Wright A, Chakarova C, Abd El Aziz M, Bhattacharya S. Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait. Nat Rev Genet. 2010;11:273-84 pubmed publisher
    ..Although genetic and mechanistic diversity creates challenges for therapy, some approaches--particularly gene-replacement therapy--are showing considerable promise. ..
  4. Won J, Shi L, Hicks W, Wang J, Naggert J, Nishina P. Translational vision research models program. Adv Exp Med Biol. 2012;723:391-7 pubmed publisher
    ..The new alleles described herein will be a useful resource to further examine the role of the affected molecules and the effects of their disruption within the retina. ..
  5. Daiger S, Sullivan L, Bowne S. Genes and mutations causing retinitis pigmentosa. Clin Genet. 2013;84:132-41 pubmed publisher
    ..In this review, we summarize the current approaches to gene discovery and mutation detection for RP, and indicate pitfalls and unsolved problems. Similar considerations apply to other forms of inherited retinal disease. ..