Gene Symbol: Pcyt1b
Description: phosphate cytidylyltransferase 1, choline, beta
Alias: CCT-beta, CTB, Cctbeta, choline-phosphate cytidylyltransferase B, CCT B, CT B, CTP:phosphocholine cytidylyltransferase B, choline phosphate cytidylyltransferase 1 beta, phosphate cytidylyltransferase 1, choline, beta isoform, phosphorylcholine transferase B
Ridsdale R, Tseu I, Wang J, Post M. Functions of membrane binding domain of CTP:phosphocholine cytidylyltransferase in alveolar type II cells. Am J Respir Cell Mol Biol. 2010;43:74-87 pubmed publisher
..Thus, the M domain influences membrane binding, cellular distribution, and topology of CCTalpha, but the domain alone is not sufficient to confer CCT activity in alveolar type II cells in vivo. ..
Lee J, Johnson J, Ding Z, Paetzel M, Cornell R. Crystal structure of a mammalian CTP: phosphocholine cytidylyltransferase catalytic domain reveals novel active site residues within a highly conserved nucleotidyltransferase fold. J Biol Chem. 2009;284:33535-48 pubmed publisher
..Comparison of the CCT236 structure with those of other nucleotidyltransferases provides evidence for substrate-induced active site loop movements and a disorder-to-order transition of a loop element in the catalytic mechanism. ..
Xiong Y, Liu X, Wang Y, Du Y. Cloning of cytidine triphosphate: phosphocholine cytidylyltransferase mRNA upregulated by a neuropeptide arginine-vasopressin((4-8)) in rat hippocampus. Neurosci Lett. 2000;283:129-32 pubmed
Xiong Y, Wang Y, Liu X, Du Y. Cloning of a Gene in Rat Brain Induced to Be Expressed Differently by AVP(4-8) with Differential Display PCR. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 1999;31:509-512 pubmed
..Homology searching in Genebank showed that dd1 may be a new gene. Moreover, the results from Northern blot confirmed that dd1 is indeed a gene induced by AVP(4-8). ..
Karim M, Jackson P, Jackowski S. Gene structure, expression and identification of a new CTP:phosphocholine cytidylyltransferase beta isoform. Biochim Biophys Acta. 2003;1633:1-12 pubmed
..The CCTbeta isoforms are most highly expressed in brain and reproductive tissues...
Jackowski S, Rehg J, Zhang Y, Wang J, Miller K, Jackson P, et al
. Disruption of CCTbeta2 expression leads to gonadal dysfunction. Mol Cell Biol. 2004;24:4720-33 pubmed
..The results indicate that although CCTbeta2 is expressed at very low levels compared to the alpha-isoform, loss of CCTbeta2 expression causes a breakdown in the gonadal response to hormonal stimulation. ..
Carter J, Demizieux L, Campenot R, Vance D, Vance J. Phosphatidylcholine biosynthesis via CTP:phosphocholine cytidylyltransferase 2 facilitates neurite outgrowth and branching. J Biol Chem. 2008;283:202-12 pubmed
..These results highlight the importance of CTbeta2 in neurons for promoting neurite outgrowth and branching and represent the first identification of a lipid biosynthetic enzyme that facilitates these functions. ..