Gene Symbol: Pcsk1n
Description: proprotein convertase subtilisin/kexin type 1 inhibitor
Alias: Saas, proSAAS, granin-like neuroendocrine peptide, pro-SAAS, proSAAS-like, proprotein convertase 1 inhibitor
Fricker L, McKinzie A, Sun J, Curran E, Qian Y, Yan L, et al
. Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing. J Neurosci. 2000;20:639-48 pubmed
..These peptides are produced from a single precursor, termed proSAAS, which is present in human, mouse, and rat...
Bures E, Courchesne P, Douglass J, Chen K, Davis M, Jones M, et al
. Identification of incompletely processed potential carboxypeptidase E substrates from CpEfat/CpEfat mice. Proteomics. 2001;1:79-92 pubmed
..The known CpE substrates identified included the recently discovered proSAAS, granin-like neuroendocrine peptide precursor that inhibits prohormone processing...
Morgan D, Mzhavia N, Peng B, Pan H, Devi L, Pintar J. Embryonic gene expression and pro-protein processing of proSAAS during rodent development. J Neurochem. 2005;93:1454-62 pubmed
In vitro assays have demonstrated that peptides derived from the recently-identified proSAAS precursor inhibit prohormone convertase 1 (PC1) suggesting that this novel peptide may function as an endogenous inhibitor of PC1...
Gouraud S, Heesom K, Yao S, Qiu J, Paton J, Murphy D. Dehydration-induced proteome changes in the rat hypothalamo-neurohypophyseal system. Endocrinology. 2007;148:3041-52 pubmed
..1alpha), NAP22 (neuronal axonal membrane protein 22), GRP58 (58 kDa glucose regulated protein), calretinin, and ProSAAS (proprotein convertase subtilisin/kexin type 1 inhibitor), have been confirmed using independent methods such as ..
Donadel G, Marinos N, DeSilva M, Lu J, Notkins A, Lan M. Molecular cloning and characterization of a highly basic protein, IA-4, expressed in pancreatic islets and brain. Neuroendocrinology. 1998;67:190-6 pubmed
..The high expression of IA-4 protein in neuroendocrine cells and its unique amino acid sequence suggest that IA-4 may have an important, but still undetermined, function in these special cell types. ..
Mzhavia N, Qian Y, Feng Y, Che F, Devi L, Fricker L. Processing of proSAAS in neuroendocrine cell lines. Biochem J. 2002;361:67-76 pubmed
b>ProSAAS, a recently discovered granin-like protein, potently inhibits prohormone convertase (PC)1, and might also perform additional functions...
Wada M, Ren C, Koyama S, Arawaka S, Kawakatsu S, Kimura H, et al
. A human granin-like neuroendocrine peptide precursor (proSAAS) immunoreactivity in tau inclusions of Alzheimer's disease and parkinsonism-dementia complex on Guam. Neurosci Lett. 2004;356:49-52 pubmed
..We have reported that the N-terminal fragment of a human granin-like neuroendocrine peptide precursor (N-proSAAS) is accumulated in Pick bodies...
Wei S, Feng Y, Che F, Pan H, Mzhavia N, Devi L, et al
. Obesity and diabetes in transgenic mice expressing proSAAS. J Endocrinol. 2004;180:357-68 pubmed
b>ProSAAS is a neuroendocrine peptide precursor that potently inhibits prohormone convertase 1 in vitro...
Qian Y, Devi L, Mzhavia N, Munzer S, Seidah N, Fricker L. The C-terminal region of proSAAS is a potent inhibitor of prohormone convertase 1. J Biol Chem. 2000;275:23596-601 pubmed
b>ProSAAS is a recently discovered 26-kDa neuroendocrine protein that was previously found to inhibit prohormone convertase (PC) 1 and not PC2...