Gene Symbol: Pcbp2
Description: poly(rC) binding protein 2
Alias: poly(rC)-binding protein 2
Species: rat
Products:     Pcbp2

Top Publications

  1. Hahm K, Kim G, Turck C, Smale S. Isolation of a murine gene encoding a nucleic acid-binding protein with homology to hnRNP K. Nucleic Acids Res. 1993;21:3894 pubmed
  2. Funke B, Zuleger B, Benavente R, Schuster T, Goller M, Stevenin J, et al. The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins. Nucleic Acids Res. 1996;24:3821-8 pubmed
    ..The interaction between mCBP and splicing factor 9G8 was confirmed in vivo. These results suggest a function of mCBP in RNA metabolism. ..
  3. Walter B, Parsley T, Ehrenfeld E, Semler B. Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replication. J Virol. 2002;76:12008-22 pubmed
    ..protein that plays a role in both translation initiation and viral RNA synthesis is poly(rC) binding protein 2 (PCBP2)...
  4. Weidensdorfer D, Stöhr N, Baude A, Lederer M, Köhn M, Schierhorn A, et al. Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. RNA. 2009;15:104-15 pubmed publisher
    ..Complex formation at the CRD presumably limits the transfer of c-myc mRNA to the polysomal fraction and subsequent translation-coupled decay. ..
  5. You F, Sun H, Zhou X, Sun W, Liang S, Zhai Z, et al. PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. Nat Immunol. 2009;10:1300-8 pubmed publisher
    ..MAVS regulation is essential for the prevention of excessive harmful immune responses. Here we identify PCBP2 as a negative regulator in MAVS-mediated signaling...
  6. Boschi N, Takeuchi K, Sterling C, Tank A. Differential expression of polycytosine-binding protein isoforms in adrenal gland, locus coeruleus and midbrain. Neuroscience. 2015;286:1-12 pubmed publisher
    ..Our results suggest that: (1) PCBP2 is the predominant isoform in TH-positive cells of the rat midbrain; (2) PCBP3 is the predominant isoform in TH-..
  7. Bogdan A, Miyazawa M, Hashimoto K, Tsuji Y. Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease. Trends Biochem Sci. 2016;41:274-286 pubmed publisher
    ..We also discuss emerging roles of iron in apoptosis and a novel iron-dependent cell death pathway termed 'ferroptosis', the dysregulation of iron metabolism in human pathologies, and the use of iron chelators in cancer therapy. ..
  8. Mao X, Liu J, Chen C, Zhang W, Qian R, Chen X, et al. PCBP2 Modulates Neural Apoptosis and Astrocyte Proliferation After Spinal Cord Injury. Neurochem Res. 2016;41:2401-14 pubmed publisher
    b>PCBP2, a member of the poly(C)-binding protein (PCBP) family, plays a pivotal role in posttranscriptional and translational regulation by interacting with single-stranded poly(C) motifs in target mRNAs...
  9. Leffers H, Dejgaard K, Celis J. Characterisation of two major cellular poly(rC)-binding human proteins, each containing three K-homologous (KH) domains. Eur J Biochem. 1995;230:447-53 pubmed
    ..Escherichia coli expressed proteins also bound poly(rG), albeit at a lower level. In addition, PCBP-2 bound poly(rU), whereas very little binding to poly(rA) was observed for both proteins. ..

More Information


  1. Goller M, Funke B, Gehe Becker C, Kroger B, Lottspeich F, Horak I. Murine protein which binds preferentially to oligo-C-rich single-stranded nucleic acids. Nucleic Acids Res. 1994;22:1885-9 pubmed
    ..Both are nuclear proteins of 35 and 55 kDa respectively. mCBP binds preferentially to oligo dC, mCTBP to oligo dCdT. mCBP was purified and its cDNA was isolated and sequenced. ..
  2. Shukla R, Qin B, Wan Y, Cheng K. PCBP2 siRNA reverses the alcohol-induced pro-fibrogenic effects in hepatic stellate cells. Pharm Res. 2011;28:3058-68 pubmed publisher
    ..during liver fibrosis primarily because ?-complex protein-2 (?CP(2)), encoded by the poly(rC) binding protein 2 (PCBP2) gene, binds to the 3' end of the collagen mRNA and increases its half-life...
  3. Lane D, Merlot A, Huang M, Bae D, Jansson P, Sahni S, et al. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Biochim Biophys Acta. 2015;1853:1130-44 pubmed publisher
    ..g., Friedreich's ataxia. Increased knowledge of the molecules and their mechanisms of action in iron processing pathways (e.g., ISC biogenesis) will shape the investigation of iron metabolism in human health and disease. ..
  4. Chen Z, Zhang W, Ni L, Wang G, Cao Y, Wu W, et al. Spatiotemporal Expression of Poly(rC)-Binding Protein PCBP2 Modulates Schwann Cell Proliferation After Sciatic Nerve Injury. Cell Mol Neurobiol. 2016;36:725-35 pubmed publisher
    ..It was reported that PCBP2 contributed to gastric cancer proliferation and survival through miR-34a, and knockdown of PCBP2 inhibited glioma ..