Genomes and Genes
Gene Symbol: Pcbp2
Description: poly(rC) binding protein 2
Alias: poly(rC)-binding protein 2
- Goller M, Funke B, Gehe Becker C, Kroger B, Lottspeich F, Horak I. Murine protein which binds preferentially to oligo-C-rich single-stranded nucleic acids. Nucleic Acids Res. 1994;22:1885-9 pubmed..Both are nuclear proteins of 35 and 55 kDa respectively. mCBP binds preferentially to oligo dC, mCTBP to oligo dCdT. mCBP was purified and its cDNA was isolated and sequenced. ..
- Shukla R, Qin B, Wan Y, Cheng K. PCBP2 siRNA reverses the alcohol-induced pro-fibrogenic effects in hepatic stellate cells. Pharm Res. 2011;28:3058-68 pubmed publisher..during liver fibrosis primarily because ?-complex protein-2 (?CP(2)), encoded by the poly(rC) binding protein 2 (PCBP2) gene, binds to the 3' end of the collagen mRNA and increases its half-life...
- Lane D, Merlot A, Huang M, Bae D, Jansson P, Sahni S, et al. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Biochim Biophys Acta. 2015;1853:1130-44 pubmed publisher..g., Friedreich's ataxia. Increased knowledge of the molecules and their mechanisms of action in iron processing pathways (e.g., ISC biogenesis) will shape the investigation of iron metabolism in human health and disease. ..
- Chen Z, Zhang W, Ni L, Wang G, Cao Y, Wu W, et al. Spatiotemporal Expression of Poly(rC)-Binding Protein PCBP2 Modulates Schwann Cell Proliferation After Sciatic Nerve Injury. Cell Mol Neurobiol. 2016;36:725-35 pubmed publisher..It was reported that PCBP2 contributed to gastric cancer proliferation and survival through miR-34a, and knockdown of PCBP2 inhibited glioma ..