Gene Symbol: Pcbp1
Description: poly(rC) binding protein 1
Alias: RGD1561319, poly(rC)-binding protein 1
Species: rat
Products:     Pcbp1

Top Publications

  1. Ko J, Loh H. Poly C binding protein, a single-stranded DNA binding protein, regulates mouse mu-opioid receptor gene expression. J Neurochem. 2005;93:749-61 pubmed
    ..Collectively, above results suggest that PCBP participates in neuronal MOR gene expression. ..
  2. Kiledjian M, Wang X, Liebhaber S. Identification of two KH domain proteins in the alpha-globin mRNP stability complex. EMBO J. 1995;14:4357-64 pubmed
    ..As such this represents the first example of a specific function for this class of proteins and suggests potential roles for other members of this protein family. ..
  3. Aasheim H, Loukianova T, Deggerdal A, Smeland E. Tissue specific expression and cDNA structure of a human transcript encoding a nucleic acid binding [oligo(dC)] protein related to the pre-mRNA binding protein K. Nucleic Acids Res. 1994;22:959-64 pubmed
    ..In conclusion, this study presents the cDNA sequence of a novel transcript which shows tissue specific expression and encodes a protein with oligo(dC) binding specificity in vitro. ..
  4. ANTONY A, Tang Y, Khan R, Biju M, Xiao X, Li Q, et al. Translational upregulation of folate receptors is mediated by homocysteine via RNA-heterogeneous nuclear ribonucleoprotein E1 interactions. J Clin Invest. 2004;113:285-301 pubmed
    ..Collectively, these results suggest that homocysteine is the key modulator of translational upregulation of FRs and establishes the linkage between perturbed folate metabolism and coordinated upregulation of FRs. ..
  5. Kosturko L, Maggipinto M, Korza G, Lee J, Carson J, Barbarese E. Heterogeneous nuclear ribonucleoprotein (hnRNP) E1 binds to hnRNP A2 and inhibits translation of A2 response element mRNAs. Mol Biol Cell. 2006;17:3521-33 pubmed
    ..These results are consistent with a model where hnRNP E1 recruited to A2RE RNA granules by binding to hnRNP A2 inhibits translation of A2RE RNA during granule transport. ..
  6. Bogdan A, Miyazawa M, Hashimoto K, Tsuji Y. Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease. Trends Biochem Sci. 2016;41:274-286 pubmed publisher
    ..We also discuss emerging roles of iron in apoptosis and a novel iron-dependent cell death pathway termed 'ferroptosis', the dysregulation of iron metabolism in human pathologies, and the use of iron chelators in cancer therapy. ..
  7. Leffers H, Dejgaard K, Celis J. Characterisation of two major cellular poly(rC)-binding human proteins, each containing three K-homologous (KH) domains. Eur J Biochem. 1995;230:447-53 pubmed
    ..Escherichia coli expressed proteins also bound poly(rG), albeit at a lower level. In addition, PCBP-2 bound poly(rU), whereas very little binding to poly(rA) was observed for both proteins. ..
  8. Walter B, Parsley T, Ehrenfeld E, Semler B. Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replication. J Virol. 2002;76:12008-22 pubmed
    ..b>PCBP1, a highly homologous isoform of PCBP2, binds to poliovirus stem-loop I with an affinity similar to that of PCBP2; ..
  9. Berry A, Flock K, Loh H, Ko J. Molecular basis of cellular localization of poly C binding protein 1 in neuronal cells. Biochem Biophys Res Commun. 2006;349:1378-86 pubmed

More Information


  1. Lane D, Merlot A, Huang M, Bae D, Jansson P, Sahni S, et al. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Biochim Biophys Acta. 2015;1853:1130-44 pubmed publisher
    ..g., Friedreich's ataxia. Increased knowledge of the molecules and their mechanisms of action in iron processing pathways (e.g., ISC biogenesis) will shape the investigation of iron metabolism in human health and disease. ..