Gene Symbol: Paxip1
Description: PAX interacting protein 1
Alias: PAX-interacting protein 1, PAX interacting (with transcription-activation domain) protein 1
Lechner M, Levitan I, Dressler G. PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin. Nucleic Acids Res. 2000;28:2741-51 pubmed
..Pax2 and PTIP co-localize in the cell nucleus to actively expressed chromatin and the nuclear matrix fraction. For the first time, these results point to a link between Pax transcription factors and active chromatin. ..
Jowsey P, Doherty A, Rouse J. Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. J Biol Chem. 2004;279:55562-9 pubmed
..Lowering hPTIP levels also increased cellular sensitivity to IR, suggesting that this protein plays a critical role in maintaining genome stability. ..
Starnes L, Su D, Pikkupeura L, Weinert B, Santos M, Mund A, et al
. A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Genes Dev. 2016;30:149-63 pubmed publisher
..These results further our understanding of how multifunctional chromatin-modifying complexes are organized by subcomplexes that harbor unique and distinct activities. ..
Munoz I, Jowsey P, Toth R, Rouse J. Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage. Nucleic Acids Res. 2007;35:5312-22 pubmed
..Thus, the BRCT domains of hPTIP play important roles in the cellular response to DNA damage. ..
Patel S, Kim D, Levitan I, Dressler G. The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Dev Cell. 2007;13:580-92 pubmed
..Embryonic lethal ptip-null mutants and conditional mutants both show reduced levels of methylated H3K4. Thus, PTIP bridges DNA-binding developmental regulators to histone methyltransferase-dependent epigenetic regulation. ..
Mu W, Wang W, Schimenti J. An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development. Mol Cell Biol. 2008;28:6439-51 pubmed publisher
Pax transactivation domain-interacting protein (PTIP, or PAXIP1) is required for mouse development and has been implicated in DNA damage responses and histone modification...
Issaeva I, Zonis Y, Rozovskaia T, Orlovsky K, Croce C, Nakamura T, et al
. Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth. Mol Cell Biol. 2007;27:1889-903 pubmed
..ALR appears to be involved in the regulation of adhesion-related cytoskeletal events, which might affect cell growth and survival. ..
Gohler T, Munoz I, Rouse J, Blow J. PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage. DNA Repair (Amst). 2008;7:775-87 pubmed publisher
..Our results suggest that PTIP/Swift is an important new regulator of DNA damage avoidance in metazoans. ..
Gong Z, Cho Y, Kim J, Ge K, Chen J. Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage. J Biol Chem. 2009;284:7284-93 pubmed publisher
..Taken together, we propose that a subset of PTIP.PA1 complex is recruited to DNA damage sites via the RNF8-dependent pathway and is required for cell survival in response to DNA damage. ..